The International journal of risk & safety in medicine最新文献_第3页

Risk factors associated with anti-tubercular therapy-induced hepatitis in human immunodeficiency virus seropositive and seronegative patients in India. 印度人类免疫缺陷病毒血清阳性和血清阴性患者抗结核治疗性肝炎的相关危险因素

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The International journal of risk & safety in medicine Pub Date : 2026-02-01 Epub Date: 2025-11-24 DOI: 10.1177/09246479251401359

Aneez Jamal Km, Ashutosh Bhosale, Muralidhar Varma, Rajesh Radhakrishnan

{"title":"Risk factors associated with anti-tubercular therapy-induced hepatitis in human immunodeficiency virus seropositive and seronegative patients in India.","authors":"Aneez Jamal Km, Ashutosh Bhosale, Muralidhar Varma, Rajesh Radhakrishnan","doi":"10.1177/09246479251401359","DOIUrl":"10.1177/09246479251401359","url":null,"abstract":"BackgroundPeople living with Human Immunodeficiency Virus (PLW-HIV) on anti-retroviral therapy are more likely to develop tuberculosis as compared to people without HIV. The objective of the study is to evaluate the risk factors, prevalence, and management pattern of Anti-tubercular therapy-induced hepatitis (ATT-IH) in PLW-HIV with Anti-Retroviral Therapy (ART) in comparison with HIV-SNP.MethodologyA retrospective observational cohort study was conducted at a university teaching hospital for Anti-tubercular therapy-induced hepatitis ATT-IH. Patients were screened based on International Classification of Diseases codes 10. A total of N = 431 patients with ATT-IH (250 males and 181 females) were included in the study. The severity grading of ATT-IH was assessed by Liver Tox. The risk factors associated with ATT-IH in HIV-SPP and HIV-SNP were assessed and determined at a p value <0.05.ResultsOut of 431 patients with ATT-IH, 231 patients experienced ATT-IH in the HIV-SP group and 200 patients in the HIV-SN group. Zero-inflated regression analysis identified risk factors for ATT-IH in HIV-SPP in comparison with HIV-SNP, including BMI, hepatitis B, and smoking habits. The prevalence of ATT-IH in HIV-SPP was 53.6% and 46.4% in HIV-SNP. A higher incidence of 23 (10 %) of ATT-IH was reported with the Tenofovir + Lamivudine + Lopinavir+ Ritonavir ART regimen.ConclusionClinicians must focus on early detection of risk factors for ATT-IH in HIV-SPP in comparison with HIV-SNP to prevent significant hepatic complications.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"131-143"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's response: Rates of successful conceptions according to COVID-19 vaccination status: Data from the Czech Republic. 提交人的答复：根据COVID-19疫苗接种状况确定的受孕成功率：来自捷克共和国的数据。

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The International journal of risk & safety in medicine Pub Date : 2026-02-01 Epub Date: 2025-09-09 DOI: 10.1177/09246479251378936

Vibeke Manniche, Tomáš Fürst, Max Schmeling, Jonathan D Gilthorpe, Peter Riis Hansen

引用次数: 0

Successful management of therapy-resistant chronic refractory atopic dermatitis and alopecia universalis with oral tofacitinib in a girl. 口服托法替尼成功治疗难治性慢性难治性特应性皮炎和普遍脱发1例。

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The International journal of risk & safety in medicine Pub Date : 2026-02-01 Epub Date: 2025-10-18 DOI: 10.1177/09246479251391089

Shreya K Gowda, Bhini Ameta, Akash Agarwal, Biswanath Behera

引用次数: 0

Rectal shedding of SARS-CoV-2 in patients with negative COVID-19 nasopharyngeal RT-PCR test. 2019冠状病毒病鼻咽RT-PCR阴性患者- cov -2直肠脱落的研究

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The International journal of risk & safety in medicine Pub Date : 2026-02-01 Epub Date: 2025-11-01 DOI: 10.1177/09246479251394918

Svetlana Doris Brincat, Matthew Sammut, Neville Spiteri, Graziella Zahra, Christopher Barbara, Victor Grech, Jo-Etienne Abela, Charles Cini

{"title":"Rectal shedding of SARS-CoV-2 in patients with negative COVID-19 nasopharyngeal RT-PCR test.","authors":"Svetlana Doris Brincat, Matthew Sammut, Neville Spiteri, Graziella Zahra, Christopher Barbara, Victor Grech, Jo-Etienne Abela, Charles Cini","doi":"10.1177/09246479251394918","DOIUrl":"10.1177/09246479251394918","url":null,"abstract":"BackgroundCOVID-19, caused by the novel coronavirus SARS-CoV-2, was first identified in China in December 2019 and rapidly spread worldwide, primarily affecting the respiratory system. Although RT-PCR on nasopharyngeal swabs is the standard diagnostic method, emerging evidence suggests that SARS-CoV-2 RNA may be detected in rectal swabs even if respiratory samples test negative.ObjectiveTo assess the ability of rectal swabs to detect SARS-CoV-2 viral shedding in participants with negative nasopharyngeal swabs.MethodAdult patients scheduled for colonoscopy at Mater Dei Hospital between June 2020 and April 2021 were enrolled. All participants had a confirmed negative nasopharyngeal swab for SARS-CoV-2 by RT-PCR within 72 h before enrolment and provided informed consent. Data on demographics, epidemiology and clinical symptoms were collected through structured interviews and medical record reviews. Prior to colonoscopy, rectal swabs were obtained and all samples were processed following standardised laboratory protocols.Results200 participants were enrolled. None of the patients had prior COVID-19 history. 7.5% (n = 15) tested positive on rectal swabs despite having a negative nasopharyngeal swab in the preceding 72 h.ConclusionWhile combining nasopharyngeal and rectal swab sampling may improve COVID-19 diagnosis, routine use of both methods might not be cost-effective. Nonetheless, rectal swabs could prove beneficial for symptomatic patients with negative nasopharyngeal results or those with known exposure to COVID-19.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"114-119"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145427192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient viewpoint: The case for exploring non-seizure alternatives to ECT. 患者观点：探索非癫痫发作替代ECT的案例。

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The International journal of risk & safety in medicine Pub Date : 2026-02-01 Epub Date: 2025-09-05 DOI: 10.1177/09246479251377340

Christopher James Dubey

引用次数: 0

Safety analysis of adverse events associated with high-flow nasal cannula therapy: A retrospective study using Japan's national adverse event database. 高流量鼻插管治疗相关不良事件的安全性分析：一项使用日本国家不良事件数据库的回顾性研究。

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The International journal of risk & safety in medicine Pub Date : 2026-02-01 Epub Date: 2025-10-16 DOI: 10.1177/09246479251389210

Keizo Wauchi, Sho Tomisaki, Hirohito Imada

{"title":"Safety analysis of adverse events associated with high-flow nasal cannula therapy: A retrospective study using Japan's national adverse event database.","authors":"Keizo Wauchi, Sho Tomisaki, Hirohito Imada","doi":"10.1177/09246479251389210","DOIUrl":"10.1177/09246479251389210","url":null,"abstract":"ObjectiveThis study aimed to extract incident and accident reports associated with high-flow nasal cannula (HFNC) therapy from the publicly available database maintained by the Japan Council for Quality Health Care (JCQHC) and to identify contributing factors using the P-mSHEL model (Patient-management-Software-Hardware-Environment-Liveware), with the goal of providing insights for improving HFNC safety.MethodsAmong 94,069 incident reports (defined as cases without patient harm) and 56,783 accident reports (cases with patient harm) submitted between 2010 and 2023, a total of 170 HFNC-related cases (131 incidents and 39 accidents) were identified. Quantitative variables included the time of occurrence, patient demographics, and involvement of healthcare professionals. Qualitative data were classified into six categories (P, m, S, H, E, L) using the P-mSHEL model. For accident cases, the presence or absence of sequelae was analyzed using logistic regression.ResultsIn accident cases, the Patient (P) factor (odds ratio = 2.65, p = 0.006) and the Management (m) factor (odds ratio = 2.46, p = 0.033) were significantly associated with the occurrence of sequelae. In incident cases, the Liveware (L) factor (i.e., human error) was involved in 80.2% of reports, and the Hardware (H) factor (i.e., medical devices) in 52.7%, highlighting the critical roles of human and device-related factors.ConclusionTo ensure the safe use of HFNC, it is essential to implement risk mitigation strategies targeting the Patient and Management factors, such as comprehensive patient screening and strengthened organizational systems. Furthermore, given the high involvement of the Liveware and Hardware factors, structured educational programs and practical interventions for medical device operation are warranted.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"95-105"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Audit of referrals of patients on oral antithrombotic therapy to a hospital oral surgery service for simple tooth extractions. 对因简单拔牙而接受口腔抗栓治疗的患者转介到医院口腔外科服务的审计。

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The International journal of risk & safety in medicine Pub Date : 2026-02-01 Epub Date: 2025-10-15 DOI: 10.1177/09246479251389205

Lea Vuletić, Monika Burja Vladić, Ivan Salarić, Ena Zdunić, Berislav Perić

{"title":"Audit of referrals of patients on oral antithrombotic therapy to a hospital oral surgery service for simple tooth extractions.","authors":"Lea Vuletić, Monika Burja Vladić, Ivan Salarić, Ena Zdunić, Berislav Perić","doi":"10.1177/09246479251389205","DOIUrl":"10.1177/09246479251389205","url":null,"abstract":"ObjectiveTo assess the proportion of patients referred to a hospital oral surgery department for procedures that could have been managed in primary care.MethodThis cross-sectional audit included 41 outpatients on oral antithrombotic therapy who were referred to the University Hospital Dubrava in Zagreb, Croatia, for simple tooth extraction(s). Information about additional factors that may affect the complexity of the intervention was collected using a questionnaire. Any instructions regarding patients' antithrombotic therapy regimens were also recorded. An oral surgeon evaluated whether each surgical procedure could have been safely performed in primary care.ResultsThe oral surgeon estimated that in 75.6% (31/41) of the cases, the indicated extractions could have been safely managed in primary care, provided the clinician had relevant training and confidence. Instructions to discontinue antithrombotic therapy prior to the procedure were frequently encountered and, in most cases, issued by the patients' dentists.ConclusionThe findings of this study support the need for more comprehensive studies on the quality, appropriateness and underlying reasons for referrals to oral surgery departments. Such research would provide evidence to guide the development and implementation of measures aimed to enhance dentists' clinical skills, self-confidence, and interdisciplinary collaboration, ultimately improving patient care.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"106-113"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feelings of guilt and circles of support: Community physicians' experiences following adverse events. 内疚感和支持圈：不良事件后社区医生的经验。

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The International journal of risk & safety in medicine Pub Date : 2026-02-01 Epub Date: 2025-08-29 DOI: 10.1177/09246479251372328

Ariela Popper-Giveon, Yael Keshet, Tamar Adar

{"title":"Feelings of guilt and circles of support: Community physicians' experiences following adverse events.","authors":"Ariela Popper-Giveon, Yael Keshet, Tamar Adar","doi":"10.1177/09246479251372328","DOIUrl":"10.1177/09246479251372328","url":null,"abstract":"BackgroundInvolvement in adverse events negatively impacts physicians and might harm their job performance and lead to emotional stress and burnout. Sources of support are therefore crucial, especially for community physicians who often work alone or in small clinics.ObjectiveTo examine community physicians' feelings following adverse events and to map their various sources of support.MethodsIn-depth interviews were conducted with 20 community physicians, comprising 10 family physicians and 10 other specialists.FindingsInterviewees described painful negative feelings following adverse events. Guilt was mentioned as the dominant emotion, accompanied by self-doubt, anger, frustration, and shame. They described various circles of support, both personal and professional, with whom they share and consult following adverse events: family members, friends, colleagues, clinic staff, risk management units, and other professional authorities. Support was described as most effective when given by those with whom the physicians had both personal and professional relations.ConclusionsFormal support for \"second victim\" community physicians is essential, preferably from those with whom they have both personal and professional relations. Practical recommendations regarding how to better support them following adverse events are offered.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"40-48"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Further studies comparing ECT to potential alternatives may reveal confounding by its non-seizure components. 进一步的研究将ECT与潜在的替代方法进行比较，可能会揭示其非癫痫成分的混淆。

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The International journal of risk & safety in medicine Pub Date : 2026-02-01 Epub Date: 2025-09-29 DOI: 10.1177/01410768251381771

Christopher James Dubey

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Artificial intelligence, clinical science, and clinical practice. 人工智能，临床科学，临床实践。

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The International journal of risk & safety in medicine Pub Date : 2026-02-01 Epub Date: 2025-09-24 DOI: 10.1177/09246479251381514

David Healy

引用次数: 0