The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association最新文献

{"title":"Speech Outcomes of a National Cohort of Children with Orofacial Cleft at 5 and 10 Years of age.","authors":"Maeve M Morrison,&nbsp;Nicola T Mason,&nbsp;Bryony L Forde,&nbsp;Peter R Stone,&nbsp;Peter V Fowler,&nbsp;John M D Thompson","doi":"10.1177/10556656211044939","DOIUrl":"https://doi.org/10.1177/10556656211044939","url":null,"abstract":"<p><strong>Objective: </strong>To assess speech outcomes at five and ten years of age in a nationwide study of children with orofacial cleft.</p><p><strong>Design: </strong>Prospective study.</p><p><strong>Participants: </strong>Children born with orofacial cleft and having primary surgery in New Zealand. Speech samples were available for 151 five-year-old, and 163 ten-year-old children.</p><p><strong>Main outcome measures: </strong>Intelligibility, Acceptability, Velopharyngeal function, Hypernasality, Hyponasality, severity of airflow evaluated by perceptual speech assessment (using the standardised Rhinocleft assessment), and overall assessment of requirement for clinical intervention.</p><p><strong>Results: </strong>A large proportion of five-year-old children had speech that was considered to be not completely intelligible, was not acceptable, and had inadequate velopharyngeal function. The noted deficiencies led to a clinical judgement that further speech and/or surgical intervention was required in 85% with cleft lip and palate, 65% with cleft palate and 26% with cleft lip. The proportion of children with poor speech outcomes in the ten-year-old children was lower, though of clinical importance, further intervention required for 25% with CLP, 15% with CP and 3% with CL. The number of sound production errors in both age groups followed the same pattern with fewest in those with CL and most in those with CLP.</p><p><strong>Conclusions: </strong>A significant proportion of children with orofacial cleft were found to have poor speech outcomes requiring further treatment. The outcomes are poor compared to centres reported in the UK and Scandinavia. New Zealand requires a review of the current services for individuals born with cleft to improve speech outcomes and interdisciplinary care.</p>","PeriodicalId":520794,"journal":{"name":"The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association","volume":" ","pages":"1400-1412"},"PeriodicalIF":1.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39539288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Use of Ketorolac Improves Pain Management and Decreases Narcotic Use Following Primary Cleft Palate Surgery.","authors":"Samuel Dudley,&nbsp;Matthew Spence,&nbsp;Robert Frederick,&nbsp;Rosemary Stocks","doi":"10.1177/10556656211042168","DOIUrl":"https://doi.org/10.1177/10556656211042168","url":null,"abstract":"<p><strong>Objective: </strong>To study the efficacy and safety profile of ketorolac in cleft palate surgery.</p><p><strong>Design: </strong>Retrospective analysis of patients who underwent primary cleft palate surgery and received either postoperative ketorolac or opioids.</p><p><strong>Setting: </strong>Tertiary care children's hospital.</p><p><strong>Patients, participants: </strong>Eighty-nine patients enrolled who were all younger than 36 months of age, not dependent on a gastrostomy tube, with no history of bleeding disorders, and had undergone their primary cleft palate procedure by one specific surgeon between January 2010 and June 2019.</p><p><strong>Interventions: </strong>n/a.</p><p><strong>Main outcome measure: </strong>Morphine equivalent dose (MED), Face, Legs, Activity, Cry, Consolability (FLACC) score, length of stay (LOS), total oral intake (mL), total oral intake/LOS, and postoperative adverse events between ketorolac and no ketorolac groups.</p><p><strong>Results: </strong>MED, FLACC score, and LOS were significantly lower in the ketorolac group compared to the no ketorolac group. One patient in the ketorolac group had a bleeding event.</p><p><strong>Conclusions: </strong>Use of ketorolac significantly decreased narcotic usage and pain scores as reported by the FLACC score. Moreover, postoperative bleeding was rare in both ketorolac and no ketorolac groups.</p>","PeriodicalId":520794,"journal":{"name":"The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association","volume":" ","pages":"1371-1376"},"PeriodicalIF":1.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39411837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Race-Based Differences in the Utilization and Timing of Secondary Cleft Procedures in the United States.","authors":"Connor J Peck,&nbsp;Navid Pourtaheri,&nbsp;Yassmin Parsaei,&nbsp;Arvind U Gowda,&nbsp;Jenny Yang,&nbsp;Joseph Lopez,&nbsp;Derek M Steinbacher","doi":"10.1177/10556656211047134","DOIUrl":"https://doi.org/10.1177/10556656211047134","url":null,"abstract":"<p><p>Primary CL/P repair, revisions, and secondary procedures-cleft rhinoplasty, speech surgery, and alveolar bone grafting (ABG)-performed from 2014-2018 were identified from the Pediatric National Surgical Quality Improvement Program (NSQIP) database. Utilization estimates were derived via univariable and multivariable logistic regression. A Kruskal-Wallis rank-sum test and multivariable linear regression were used to assess differences in timing for each procedure cohort.</p><p><p>The primary outcome measures were the odds of a patient being a certain race/ethnicity, and the age at which patients of different race/ethnicity receive surgery.</p><p><p>There were 23 780 procedures analyzed. After controlling for sex, diagnosis, and functional status, there were significant differences in utilization estimates across procedure groups. Primarily, utilization was lowest in patient who were Black for cleft rhinoplasty (OR = 0.70, <i>P</i> = .023), ABG (OR = 0.44, <i>P</i> < .001) and speech surgery (OR = 0.57, <i>P</i> = .012), and highest in patients who were Asian patients in all surgery cohorts (OR 2.05-4.43). Timing of surgery also varied by race, although differences were minimal.</p><p><strong>Conclusions: </strong>Estimates of utilization and timing of secondary cleft procedures varied by race, particularly among patients who were Black (poor utilization) or Asian (high utilization). Further studies should identify the causes and implications of underutilized and/or delayed cleft care.</p>","PeriodicalId":520794,"journal":{"name":"The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association","volume":" ","pages":"1413-1421"},"PeriodicalIF":1.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39553717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next Generation Sequencing and Cytogenetic Based Evaluation of Indian Pierre Robin Sequence Families Reveals CNV Regions of Modest Effect and a Novel <i>LOXL3</i> Mutation.","authors":"Anubhuti Sood,&nbsp;Uzma Shamim,&nbsp;Om P Kharbanda,&nbsp;Madhulika Kabra,&nbsp;Neerja Gupta,&nbsp;Aradhana Mathur,&nbsp;Aditi Joshi,&nbsp;Shaista Parveen,&nbsp;Sana Zahra,&nbsp;Pooja Sharma,&nbsp;Malika Seth,&nbsp;Afreen Khan,&nbsp;Mohammed Faruq,&nbsp;Deepika Mishra","doi":"10.1177/10556656211052781","DOIUrl":"https://doi.org/10.1177/10556656211052781","url":null,"abstract":"<p><strong>Background: </strong>Pierre Robin Sequence (PRS) affects approximately 1 per 8500 to 14000 new-borns worldwide. Although the clinical entity is well defined, the pathogenesis of PRS is debated. The present study aims to understand the contribution of genomic imbalances and genetic variants in patients clinically diagnosed of PRS.</p><p><strong>Methodology: </strong>A total of 7 independent patients with nonsyndromic PRS thoroughly evaluated by a medical geneticist at a tertiary care hospital, were included in the study. Blood samples were collected from these patients and their family members. Array CGH was performed on all 7 patients and their respective family members for detection of underlying cytogenetic defects. Whole exome sequencing (WES) was performed for 5 families to capture single nucleotide variants or small indels.</p><p><strong>Results: </strong>Cytogenetic analyses did not detect any previously reported gross chromosomal aberrations for PRS in the patient cohort. However, copy number variations (CNVs) of size <1 Mb were detected in patients which may have implications in PRS. The present study provided evidence for the occurrence of <i>de novo</i> deletions at 7p14.1 locus in PRS patients: further validating the candidate loci susceptibility in oral clefts. WES data identified <i>LOXL3</i> as candidate gene, carrying novel deleterious variant, which is suggestive of the role of point mutations in the pathogenesis of PRS.</p><p><strong>Conclusion: </strong>The present study offered considerable insight into the contribution of cytogenetic defects and novel point mutation in the etiology of nonsyndromic PRS. Studies comprising large number of cases are required to fully elucidate the genetic mechanisms underlying the PRS phenotype.</p>","PeriodicalId":520794,"journal":{"name":"The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association","volume":" ","pages":"1329-1339"},"PeriodicalIF":1.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39884674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between <i>MTHFD1</i> 1958G > A Variant and non-Syndromic Cleft lip and Palate: An Updated Meta-Analysis.","authors":"Manas R Purohit,&nbsp;Lakkakula Saikrishna,&nbsp;Henu Verma,&nbsp;L V K S Bhaskar,&nbsp;Syed A Hussain","doi":"10.1177/10556656211046486","DOIUrl":"https://doi.org/10.1177/10556656211046486","url":null,"abstract":"<p><strong>Introduction: </strong>Non-syndromic cleft lip and palate (NSCLP) is one of the most common and challenging congenital deformities worldwide. Previous research has linked the methylenetetrahydrofolate dehydrogenase1 (MTHFD1) gene to orofacial cleft (OFC) susceptibility via a complex metabolism. Studies analyzing the <i>MTHFD1</i> 1958G > A variant and NSCLP are contradictory. This study aims to evaluate the association between the <i>MTHFD1</i> 1958G > A variant and NSCLP by meta-analysis.</p><p><strong>Methods: </strong>PubMed, Web of Science, MEDLINE, and Google Scholar databases were searched to retrieve the eligible studies. A fixed- or random-effect model was used to calculate pooled odds ratio (OR) and 95% confidence interval (CI). All analyses were calculated by Metagenyo software. To detect heterogeneity, the Cochrane Q and I² statistics were used. The publication bias was estimated using funnel plots and Egger's test.</p><p><strong>Results: </strong>Our study suggested that the <i>MTHFD1</i> 1958G > A variant allele \"A\" does not appear to increase the risk of NSCLP (A vs G random effect model: Overall <i>P</i>  = .501, OR  =  1.07, CI  =  0.88-1.31; Asians <i>P</i>  = .245, OR  =  1.29, CI  =  0.84-1.97; Caucasians <i>P</i>  = .658, OR  =  0.95, CI  =  0.76-1.19). Similarly, mutant genotypes also did not exhibit increased risk for NSCLP in the overall populations as well in subgroup analysis by ethnicity (AA  +  AG vs GG: Overall <i>P</i>  = .684, OR  =  1.06, CI  =  0.80-1.39; Asians <i>P</i>  = .240, OR  =  1.47, CI  =  0.77-2.78; Caucasians <i>P</i>  = .923, OR  =  0.99, CI  =  0.85-1.16).</p><p><strong>Conclusions: </strong>Our data suggest no association between the <i>MTHFD1</i> 1958G > A variant and NSCLP. Additional well-designed studies are needed to better understand the role of <i>MTHFD1</i> polymorphisms in the etiopathogenesis of NSCLP.</p>","PeriodicalId":520794,"journal":{"name":"The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association","volume":" ","pages":"1422-1427"},"PeriodicalIF":1.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39722720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Change in Oral Microbiota of Children With Cleft Lip and Palate After Alveolar Bone Grafting.","authors":"Kejia Zhang,&nbsp;Xuan Zhou,&nbsp;Jinwei Qin,&nbsp;Weibing Zhang,&nbsp;Yongchu Pan,&nbsp;Hua Wang,&nbsp;Jiuxiang Lin,&nbsp;Luwei Liu,&nbsp;Yilin Jia","doi":"10.1177/10556656211044396","DOIUrl":"https://doi.org/10.1177/10556656211044396","url":null,"abstract":"<p><p>To investigate the longitudinal influence of alveolar bone grafting on the oral microbiota of children with cleft lip and palate (CLP).</p><p><p>Twenty-eight children with nonsyndromic CLP were recruited and underwent secondary alveolar bone grafting at the first time. Unstimulated saliva and plaque samples were collected from the subjects preoperatively and at 2 days, 1 month, and 3 months postoperatively. The v3-v4 hypervariable regions of the <i>16S rRNA</i> gene from bacterial DNA were sequenced using the Illumina MiSeq sequencing platform.</p><p><p>The alpha diversity of the saliva and plaque microbiota was significantly decreased at 2 days postoperatively and then increased at 1 and 3 months postoperatively. The saliva and plaque microbiota compositions at 2 days postoperatively differed from those at the other time points, and the microbiota compositions at 1 and 3 months postoperatively showed a gradual shift toward the preoperative composition. The saliva, but not plaque, microbiota composition 3 months postoperatively was similar to that preoperatively.</p><p><p>The effect of secondary alveolar bone grafting on the plaque microbiota in children with CLP lasted longer than the saliva microbiota. Alveolar bone grafting altered the saliva microbiota in children with CLP within 3 months postoperatively.</p>","PeriodicalId":520794,"journal":{"name":"The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association","volume":" ","pages":"1352-1360"},"PeriodicalIF":1.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39417982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Outcome in Bilateral Cleft lip and Palate Patients Evaluated With the Huddart-Bodenham Scoring System and the Bilateral Cleft lip and Palate Yardstick: A Systematic Review.","authors":"Wenying Kuang,&nbsp;Miranda Aarts,&nbsp;Anne Marie Kuijpers-Jagtman,&nbsp;Hong He,&nbsp;Edwin M Ongkosuwito","doi":"10.1177/10556656211041883","DOIUrl":"https://doi.org/10.1177/10556656211041883","url":null,"abstract":"<p><strong>Objectives: </strong>To assess treatment outcome (transversal and sagittal dental arch relationships) and its determinants in complete bilateral cleft lip and palate (BCLP) evaluated with the modified Huddart-Bodenham scoring system and the BCLP Yardstick.</p><p><strong>Materials and methods: </strong>Multiple electronic databases were searched without time limitation. Randomized clinical trials, cohort and case control studies using BCLP Yardstick and/or modified Huddart-Bodenham system to judge treatment outcome of patients with BCLP were included. The Risk of Bias in Nonrandomized Studies of Interventions tool and Grading of Recommendations, Assessment, Development, and Evaluation was used.</p><p><strong>Results: </strong>Of the 528 studies identified by the electronic search, only eight retrospective studies met the inclusion criteria and were included. A total of 12 cleft centers were represented. All treatment protocols differed and background information was underreported. The results for the BCLP yardstick showed that all except the centers in New Zealand had a mean score lower than 3, indicating good treatment results. However, these studies had a moderate to high risk of bias. The modified Huddart-Bodenham scores were negative in all studies. No further meta-analysis was done due to heterogeneity and high risk of bias. The quality of evidence was graded as very low.</p><p><strong>Conclusion: </strong>Results for the dental arch relationship of studies in complete BCLP and possible determinants were not synthesized due to very low quality of evidence. Clinical research for patients with BCLP should focus on sound methodological designs to enable evidence-based decision making to improve treatment for patients with BCLP and thereby hopefully their quality of life.</p>","PeriodicalId":520794,"journal":{"name":"The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association","volume":" ","pages":"1377-1390"},"PeriodicalIF":1.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39527683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost of Cleft Team Care at an Academic Children's Hospital.","authors":"Jennifer Lee,&nbsp;Gary B Skolnick,&nbsp;Sybill D Naidoo,&nbsp;Sibyl Scheve,&nbsp;Cheryl Grellner,&nbsp;Alison Snyder-Warwick,&nbsp;Kamlesh B Patel","doi":"10.1177/10556656211046815","DOIUrl":"https://doi.org/10.1177/10556656211046815","url":null,"abstract":"<p><strong>Background: </strong>The financial burden of cleft-craniofacial team care is substantial, and high costs can hinder successful completion of team care.</p><p><strong>Solution: </strong>Collaboration with multiple stakeholders including providers, insurers, and patient guardians, as well as hospital administrators, is critical to increase patient retention and improve final clinical outcomes.</p><p><strong>What we do that is new: </strong>At our cleft and craniofacial center, charges for a team care visit fall into one of three categories-hospital fees, professional fees, or external fees. There are four types of hospital fees depending on (1) whether the patient is new or returning, and (2) whether the patient saw ≤4 or ≥5 providers. To further elucidate the financial burden (out-of-pocket costs) directly borne by families of children with cleft lip and/or palate, we conducted a retrospective review of billing records of team care visits made between September 2019 and March 2020. Out-of-pocket costs for a single team care visit (on a commercial insurance plan) ranged from $4 to approximately $1220 and had a median (IQR) of $445 ($118, $749).</p>","PeriodicalId":520794,"journal":{"name":"The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association","volume":" ","pages":"1428-1432"},"PeriodicalIF":1.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39492225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life and Temporomandibular Disorders in Patients With Skeletal Class III Malocclusion With Cleft Lip and Palate.","authors":"Bernardo Olsson,&nbsp;Isabela Polesi Bergamaschi,&nbsp;Erika Calvano Küchler,&nbsp;Aline Monise Sebastiani,&nbsp;Guilherme Dos Santos Trento,&nbsp;Delson Joao da Costa,&nbsp;Nelson Luis Barbosa Rebellato,&nbsp;Rafaela Scariot","doi":"10.1177/10556656211043429","DOIUrl":"https://doi.org/10.1177/10556656211043429","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to assess the quality of life (QOL), oral health-related QOL (OHRQOL), temporomandibular disorders (TMDs), and psychological factors in patients with skeletal Class III malocclusion with cleft lip and palate (CLP) and without CLP.</p><p><strong>Design: </strong>Case-control.</p><p><strong>Setting: </strong>Primary care, institutional practice.</p><p><strong>Patients: </strong>One hundred thirty-six patients with skeletal Class III malocclusion with CLP (n = 68) and without CLP (n = 68).</p><p><strong>Main outcome measures: </strong>QOL and OHRQOL were assessed using the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire and the Oral Health Impact Profile-14 questionnaire, respectively. TMDs and psychological factors were assessed using the Research Diagnostic Criteria for TMD (RDC/TMD).</p><p><strong>Results: </strong>No differences in QOL were found between the groups (<i>P </i>><i> </i>0.05). Patients with CLP reported a better OHRQOL (<i>P</i> = 0.025) in the physical pain, physical disability, and psychological disability domains (<i>P </i><<i> </i>0.05). Patients with CLP presented with less myofascial pain (OR, 0.28; 95% CI, 0.11-0.71] and other articular conditions (OR 0.24; 95% CI 0.06-0.90]. More patients with CLP reported no chronic pain (<i>P</i> = 0.012). The QOL of patients with CLP with no depression or with no nonspecific physical symptoms including pain (NSPSIP) was better than that of patients without CLP. The OHRQOL of patients with CLP without TMDs or no psychological factors was better than that of patients without CLP.</p><p><strong>Conclusions: </strong>Patients with skeletal Class III malocclusion who require orthognathic surgery with CLP have better OHRQOL and present with fewer TMDs than those patients without CLP.</p>","PeriodicalId":520794,"journal":{"name":"The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association","volume":" ","pages":"1391-1399"},"PeriodicalIF":1.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39507792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Rehabilitation of Bilateral Cleft Lip and Palate Patient with Simultaneous LeFort I Osteotomy and Zygomatic Implants: A Case Report.","authors":"Funda Goker,&nbsp;Emma Grecchi,&nbsp;Massimo Del Fabbro,&nbsp;Francesco Grecchi","doi":"10.1177/10556656211050002","DOIUrl":"https://doi.org/10.1177/10556656211050002","url":null,"abstract":"<p><p>The aim of this study is to evaluate Le Fort I Osteotomy and zygomatic implantation without any graft placement for management of a cleft lip and palate patient. This case report describes oral rehabilitation of a 33-year-old patient with bilateral cleft lip-palate and oronasal fistula and atrophic pre-maxilla. As treatment, the patient received simultaneous Le Fort I osteotomy, palatoplasty and two zygomatic implant insertions. The prosthetic superstructure included zygomatic implant-supported removable hybrid prosthesis on bar locator and metal-ceramic fixed bridges in the posterior region. As conclusion, this protocol can be promising for management of patients with cleft lip-palate and malocclusion.</p>","PeriodicalId":520794,"journal":{"name":"The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association","volume":" ","pages":"1433-1438"},"PeriodicalIF":1.1,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39676901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}