The British journal of dermatology最新文献

{"title":"The amphiregulin-epidermal growth factor receptor axis: a new driver and therapeutic target in keloids.","authors":"Stavroula Tekkela, Emanuel Rognoni","doi":"10.1093/bjd/ljag321","DOIUrl":"10.1093/bjd/ljag321","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"722-723"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the therapeutic landscape of sCD83 in hair disorders.","authors":"Dmytro Royzman, Alexander Steinkasserer","doi":"10.1093/bjd/ljag328","DOIUrl":"10.1093/bjd/ljag328","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"720-722"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond expertise: building trustworthy acne education for young people.","authors":"John S Barbieri","doi":"10.1093/bjd/ljag301","DOIUrl":"10.1093/bjd/ljag301","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"718-719"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated cutaneous gout in a young man.","authors":"Man Li, Hsin-Yi Huang","doi":"10.1093/bjd/ljag294","DOIUrl":"10.1093/bjd/ljag294","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"890"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148538068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to 'Can a treatment-responsive molecular clock independently timestamp psoriatic skin?'","authors":"Wenyan He","doi":"10.1093/bjd/ljag361","DOIUrl":"10.1093/bjd/ljag361","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"886"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148836114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What the animal kingdom teaches us about skin: lessons from nature's own experiments.","authors":"John A McGrath","doi":"10.1093/bjd/ljag313","DOIUrl":"10.1093/bjd/ljag313","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"715-717"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BAP1-tumour predisposition syndrome.","authors":"Peter Robinson, Neil Rajan","doi":"10.1093/bjd/ljag265","DOIUrl":"10.1093/bjd/ljag265","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"888"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of haematopoietic mosaic loss of chromosome Y with dermatitis and eczema risk: an analysis in a large-scale prospective cohort study.","authors":"Yajia Li, Qiangxiang Li, Ziqin Cao, Yunsheng Liang","doi":"10.1093/bjd/ljag219","DOIUrl":"10.1093/bjd/ljag219","url":null,"abstract":"<p><strong>Background: </strong>Evidence regarding the role of haematopoietic mosaic loss of chromosome Y (mLOY) in the risk of incident dermatitis and eczema (DE), and its contribution to male susceptibility to DE, remains limited.</p><p><strong>Objectives: </strong>To evaluate the associations of mLOY with incident DE and to assess whether mLOY may contribute to sex differences in DE susceptibility.</p><p><strong>Methods: </strong>This prospective study included 189 572 men enrolled in UK Biobank who were free of DE at baseline, recruited between 2006 and 2010. Haematopoietic mLOY was derived from genotyping intensity data and analysed as both categorical mLOY status and continuous mLOY percentage (mLOY%). Cox proportional hazards models were used to estimate associations with incident DE. Sex susceptibility was evaluated in a 1 : 1 propensity score-matched male-female cohort. Genetic modification was assessed using a DE polygenic risk score (PRS), and mediation by circulating metabolites was explored via metabolomics analyses.</p><p><strong>Results: </strong>During follow-up, 9608 men developed DE. In fully adjusted models, both low mLOY (8-20%) and high mLOY (>20%) were associated with increased DE risk, with the strongest association found for high mLOY [adjusted hazard ratio (aHR) 1.44, 95% confidence interval (CI) 1.26-1.66; P  < 0.001]. Compared with women, men without detectable mLOY had a similar risk of DE, whereas men with low mLOY and high mLOY had progressively higher risks [aHR 1.14 (95% CI 1.07-1.21) and aHR 1.52 (95% CI 1.32-1.74), respectively], supporting a contribution of mLOY to male susceptibility to DE. In age-mLOY discordance analyses, younger men with high mLOY showed a DE risk approaching that of older men without high mLOY, consistent with accelerated biologic ageing. The greatest risk was found in men with high mLOY and high PRS (aHR 1.85, 95% CI 1.49-2.31; P  < 0.001). In metabolomic analyses, 98 circulating metabolites significantly mediated the mLOY-DE association, predominantly lipoprotein-related traits.</p><p><strong>Conclusions: </strong>Haematopoietic mLOY was associated with an increased risk of incident DE and may contribute to late-life sex differences in DE susceptibility. Lipoprotein-centric mediation signals implicate modifiable metabolic pathways and support integrating mLOY status and lipid profiling into the risk assessment for older men.</p>","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"793-805"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148045433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-specific incidence patterns and latitude-associated variation of skin cancer in Japan: a nationwide registry study.","authors":"Akihiko Yuki, Sumiko Takatsuka, Tatsuya Takenouchi","doi":"10.1093/bjd/ljag333","DOIUrl":"10.1093/bjd/ljag333","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"872-874"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148715023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence and the third dimension: towards objective outcome assessment in vitiligo.","authors":"Yijian Zhu, Chengfeng Zhang","doi":"10.1093/bjd/ljag329","DOIUrl":"10.1093/bjd/ljag329","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"723-724"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}