The Annals of otology, rhinology, and laryngology最新文献

{"title":"Deep Cervical Lipomas: Case Series and Scoping Review of the Literature.","authors":"Meghana Bhaskara, Emily H Chestnut, Brent Molden, Diane W Chen, David A Campbell, Avinash Mantravadi, Michael Moore, Michael W Sim, Jessica A Yesensky, Janice L Farlow","doi":"10.1177/00034894261467355","DOIUrl":"https://doi.org/10.1177/00034894261467355","url":null,"abstract":"<p><strong>Introduction: </strong>Management of deep cervical lipomas (DCLs) is described only in case reports and series in the literature. We aim to present a scoping review of this literature and the largest case series of surgically resected DCLs to describe presentation, workup, and efficacy of transcervical resection for DCLs.</p><p><strong>Methods: </strong>A systematic search for surgically resected solitary DCLs was conducted in PubMed, Embase (Elsevier), Scopus, and Cochrane library on 12/19/2025 using PRISMA methodology. Study protocol was registered in PROSPERO (CRD420251052065) and articles were screened independently by 2 authors, with conflicts resolved by a third reviewer. All solitary DCLs resected via a transcervical approach at a tertiary center from 2014 to 2025 were reviewed.</p><p><strong>Results: </strong>From a total of 1459 articles, 144 studies met criteria, and 163 cases (median age 45 years, 25.2% pediatric, 67.5% male) were included. The most common presenting symptom was swelling (81.6%), and 63.2% were enlarging. A total of 232 imaging studies, most commonly CT (n = 102), were conducted amongst 90.8% of patients for an average of 1.4 imaging studies per patient. Biopsy was performed in 27.6% of patients, with 43.4% of biopsies being inconclusive or inconsistent with benign fatty tumor. Postoperative complaints were noted for 9.8% of patients, with only 3.1% (n = 5) having persistent complaints. Two recurrences were noted. The institutional cohort of 10 patients (median age 55 years, 10% pediatric, 90% male, 90% non-Hispanic White) mirrored the literature, with the most common presenting symptom being palpable neck mass (80%), at least one imaging study per patient on average, no persistent complaints, and one recurrence.</p><p><strong>Conclusion: </strong>DCLs are less common than subcutaneous lipomas but follow a similar clinical course. Presentation most commonly occurs as a palpable mass, most of which are enlarging. Imaging without biopsy is often sufficient for workup. Transcervical resection is diagnostic and therapeutic with minimal morbidity.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"34894261467355"},"PeriodicalIF":0.0,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent Type 1 Cartilage Tympanoplasty: Factors Affecting Surgical Outcome.","authors":"Isil Taylan Cebi, Erdinc Cekic, Husamettin Yasar","doi":"10.1177/00034894261428816","DOIUrl":"10.1177/00034894261428816","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the success rate of type 1 cartilage tympanoplasty in adolescents and identify the factors influencing surgical outcomes.</p><p><strong>Materials and methods: </strong>The medical records of 70 adolescent patients, who underwent cartilage type 1 tympanoplasty between 2018 and 2023, were reviewed retrospectively. Age, gender, size and type of tympanic membrane perforation, status of the opposite ear, middle ear status, history of previous ventilation tube (VT) insertion and adenoidectomy, preoperative and postoperative hearing levels, anatomical and functional success rates were analyzed.</p><p><strong>Results: </strong>Eighty-four ears of 70 patients were enrolled in the study. Anatomical success was achieved in 83.3% and surgical success was achieved in 67.9% of all ears. Adhesive otitis media, previous VT insertion and the size of perforation were detected to be the most important negative prognostic factors affecting the surgical outcome (<i>P</i> < .001, <i>P</i> = .012 and <i>P</i> = .046, respectively). No correlation between surgical success and risk factors such as age, gender, perforation type or location, status of the opposite ear was detected.</p><p><strong>Conclusion: </strong>Tympanoplasty in adolescent age group has high success rates with correct technique and detail-oriented surgery. Given its impact on outcomes, careful evaluation and potentially staged treatment for adhesive otitis media may enhance the success rate. Cartilage should be the graft material of choice in such patients because of its durability and resistance to retraction.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"514-521"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exparel^® (Bupivacaine Liposome Injectable Suspension) as Adjunctive Pain Control in Adult Tonsillectomy: Reducing Post-Operative Opioid Use.","authors":"Sarah M Dermody, Rebecca Harvey, Ilana P Fischer, Paul T Hoff","doi":"10.1177/00034894261423285","DOIUrl":"10.1177/00034894261423285","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effects of using Exparel^® bupivacaine liposome suspension 1.3% (13.3 mg/mL) as an adjunct to standard of care medication in adult tonsillectomy patients.</p><p><strong>Study design: </strong>Randomized controlled trial.</p><p><strong>Setting: </strong>Community Hospital.</p><p><strong>Methods: </strong>The study arm (n = 22) received Exparel^® bupivacaine liposome suspension 1.3% (13.3 mg/mL) as an adjunct to the standard of care (SOC) medication bupivacaine HCl 0.25% (2.5 mg/mL) with epinephrine (5 μg/mL). The control group (n = 20) received SOC bupivacaine HCl 0.25% with epinephrine (5 μg/mL). All injections were administered after the excision of the tonsil, prior to conclusion of the operative procedure. Pre- and post-operative clinicopathologic variables of interest were collated from electronic medical records and daily pain diaries. Results were analyzed via standard univariate statistics, linear mixed models, and Poisson regression.</p><p><strong>Results: </strong>The Exparel^® + SOC group experienced significantly less pain at post operative day (POD) 3 compared to the control group (<i>P</i> < .05). Mean pain score <i>decreased</i> on average by 1.23 points in the Exparel^® + SOC group and <i>increased</i> on average by 0.39 points in the control group (adj. <i>P</i>-value < .001). Similarly, analysis showed that maximum pain score decreased on average by 0.64 points in the Exparel^® + SOC and increased on average by 0.61 points the control group (adj. <i>P</i>-value < .001). There was a statistically significant decrease in dose of oxycodone use between POD 3 and POD 5 within the Exparel^® + SOC group (16.39 vs 7.22 mg, <i>P</i>-value = .035). The relative proportion of patients who took oxycodone was less in the Exparel^® + SOC group compared to the control group across all PODs.</p><p><strong>Conclusion: </strong>Use of Exparel^® in adult tonsillectomy may decrease post-operative opioid use compared to standard of care treatment. These findings may serve as guidance for best practices in adult tonsillectomy.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"522-529"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimal Clinically Important Difference of the Sinonasal Outcome Test in Sinonasal Malignancy.","authors":"Sabrina L Maoz, Michelle Lee, Jakob Louis Fischer, Garret Choby, Peter H Hwang, Eric W Wang, Edward C Kuan, Nithin D Adappa, Mathew Geltzeiler, Anne E Getz, Ian M Humphreys, Christopher H Le, Carlos D Pinheiro-Neto, Erik P Chan, Pooya Roozdar, Waleed M Abuzeid, Eugene H Chang, Aria Jafari, Todd T Kingdom, Michael A Kohanski, Jivianne T Lee, Jillian Lazor, Ali Nabavizadeh, Jayakar V Nayak, James N Palmer, Zara M Patel, Adam C Resnick, Tim L Smith, Carl H Snyderman, Maie A St John, Phillip B Storm, Jeffrey D Suh, Marilene B Wang, Myung S Sim, Daniel M Beswick","doi":"10.1177/00034894261428393","DOIUrl":"10.1177/00034894261428393","url":null,"abstract":"<p><strong>Background: </strong>Sinonasal malignancies (SNM) are rare cancers associated with poor prognosis and impaired quality of life (QOL). The 22-question Sino-Nasal Outcome Test (SNOT-22) has been used to assess QOL in patients with SNM.</p><p><strong>Objective: </strong>To determine the minimal clinically important difference (MCID) for the SNOT-22 in patients with SNM.</p><p><strong>Methods: </strong>About 264 patients with SNM were drawn from a prospective, longitudinal, multi-institutional study. SNOT-22 scores were collected at pre-treatment baseline and follow-up through 5 years post-treatment. Cronbach's alpha was used to assess the internal consistency of the SNOT-22. Distribution-based approaches were used to estimate the MCID. Multivariable regression identified factors associated with SNOT-22 improvement exceeding the determined MCID.</p><p><strong>Results: </strong>Cronbach's alpha was >.85. The estimated MCIDs were: 1.44 (Cohen's effect size), 1.32 (standard error of the mean), 10.45 (1/2 of baseline standard deviation), and 3.67 (minimum detectable change). The mean MCID across methods was 4.22. Multivariable regression demonstrated higher odds of clinically meaningful improvement from baseline in patients with early-stage disease (odds ratio (OR) 3.510, <i>P</i> = .035), no neck irradiation (OR 11.050, <i>P</i> = .014), and neoadjuvant therapy (OR 16.667, <i>P</i> = .047).</p><p><strong>Conclusions: </strong>The SNOT-22 MCID was estimated as 4.22 in a large multi-center cohort of patients with SNM, suggesting that relatively small QOL changes are clinically relevant. When applying the MCID to the current cohort, advanced stage, treatment of neck disease, and not requiring neoadjuvant therapy were predictive of worse QOL.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"543-549"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle Ear Neuroendocrine Tumors: A Case Series Highlighting Diagnostic and Management Challenges.","authors":"Savannah Lukkes, Ellise Minneker, Oscar Velazquez Castro, Karen Kam Hoi, Rodney C Diaz, Karleen Meiklejohn, Gavriel Kohlberg, Doron Sagiv","doi":"10.1177/00034894251412369","DOIUrl":"10.1177/00034894251412369","url":null,"abstract":"<p><strong>Objective: </strong>Middle ear neuroendocrine tumors (MeNETs) are rare lesions that may mimic more common middle ear pathology. Although typically indolent, they have potential for local invasion and delayed recurrence. This study aims to expand understanding of MeNETs by characterizing their presentation, management, histopathology, and long-term outcomes.</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Setting: </strong>Two tertiary, university-affiliated medical centers.</p><p><strong>Methods: </strong>Five patients with histologically confirmed MeNETs were identified through retrospective chart review. Data collected included demographics, presenting symptoms, imaging, operative reports, pathology, and follow-up. Histological evaluation involved hematoxylin and eosin staining and immunohistochemistry.</p><p><strong>Results: </strong>All patients presented with unilateral middle ear symptoms such as hearing loss, tinnitus, or otalgia. Imaging demonstrated soft tissue masses in the middle ear cavity, occasionally with ossicular erosion. All underwent tympanomastoidectomy, and each required at least 1 additional operation, either a second-look or revision for residual or recurrent disease. Histopathology confirmed low-grade neuroendocrine tumors with characteristic immunostaining, and no metastases were identified. Two patients developed delayed local recurrence years after initial surgery.</p><p><strong>Conclusion: </strong>MeNETs are uncommon, low-grade tumors that can be mistaken for other middle ear lesions. Management requires surgical excision, and revision surgery is frequently necessary. While overall prognosis is favorable, the potential for delayed recurrence underscores the importance of long-term follow-up and consideration of a planned second-look procedure. This case series contributes to the limited literature guiding diagnosis and treatment of these rare tumors.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"498-505"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Embolization for Sinonasal Angiosarcoma Optimized Intraoperative and Postoperative Outcomes: A Case Report.","authors":"Ahmad Muhammad Al-Arman, Hisham Atef Ebada, Mohamed M Elrakhawy, Ahmed Musaad Abd-Elfattah","doi":"10.1177/00034894251408283","DOIUrl":"10.1177/00034894251408283","url":null,"abstract":"<p><strong>Background: </strong>Angiosarcoma is a rare and aggressive malignancy, representing less than 1% of head and neck cancers. Primary sinonasal angiosarcoma is exceedingly uncommon, with fewer than 40 cases reported. It carries a poor prognosis due to early recurrence and metastatic potential, and no standard treatment exists.</p><p><strong>Case report: </strong>A 33-year-old male presented with a 2-year history of progressive nasal obstruction, later accompanied by epistaxis, facial pain, and headache. Imaging revealed a large vascular sinonasal mass extending into the nasopharynx, sphenoid, and ethmoid sinuses with bone destruction. Histopathology and immunohistochemistry confirmed sinonasal angiosarcoma. Preoperative embolization of feeding vessels achieved near-complete devascularization, enabling safe endoscopic resection with negative margins. The patient received adjuvant radiotherapy and has remained disease-free for more than 65 months, representing one of the longest reported survivals for this tumor.</p><p><strong>Conclusion: </strong>Sinonasal angiosarcoma is a rare but aggressive tumor that should be included in the differential diagnosis of vascular sinonasal lesions. Preoperative embolization is an essential adjunct to reduce intraoperative bleeding and facilitate safe resection. Early diagnosis, multimodal treatment, and long-term follow-up are critical for improved outcomes.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"550-554"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145867309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes Following Surgical Management of Advanced Oral Cavity Cancers in Patients with Scleroderma: A Case Series.","authors":"Warren L Luo, Subhi Saibaba, Nitika V Tripathi, Michael J Reilly, Matthew Pierce, Jonathan P Giurintano","doi":"10.1177/00034894261426954","DOIUrl":"10.1177/00034894261426954","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the surgical outcomes and perioperative complications in patients with systemic sclerosis (SSc) undergoing surgical resection with free flap reconstruction for advanced oral cavity squamous cell carcinoma (OCSCC).</p><p><strong>Methods: </strong>Retrospective review of SSc patients who underwent surgical resection with free flap reconstruction for oral cavity SCC from 2008 to 2023. Data extracted included demographics, SSc subtype, cancer characteristics, surgical details, postoperative complications, and long-term outcomes.</p><p><strong>Results: </strong>Four female patients over age 50 were identified; 2 had diffuse SSc and 2 had limited SSc. All presented with pathologic stage IV OCSCC. Free flap reconstruction included scapular (n = 2), radial forearm (n = 1), and fibular (n = 1) flaps. No patients experienced flap failure. All patients experienced at least 1 postoperative complication. Major morbidity, defined as prolonged ICU admission (>7 days), prolonged tracheostomy dependence (>30 days), cardiopulmonary arrest, or death within 1 year, occurred exclusively in patients with diffuse SSc (50%). Both diffuse SSc patients required hospitalization exceeding 35 days and died within 1 year of surgery. Patients with limited SSc had shorter stays and more favorable outcomes.</p><p><strong>Conclusions: </strong>Microvascular free flap reconstruction is feasible in SSc patients with OCSCC; however, those with diffuse SSc may experience higher morbidity and mortality. SSc subtype should be considered in preoperative planning. Further multicenter studies are needed to guide management in this high-risk population.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"555-560"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airways Without Borders: Establishing Global Airways Units for Integrated Care.","authors":"Diego M Conti, Rosario B Spuches, Eduardo J Correa","doi":"10.1177/00034894261426729","DOIUrl":"10.1177/00034894261426729","url":null,"abstract":"<p><p>Chronic respiratory diseases continue to be managed within fragmented specialty-based structures despite robust evidence supporting the \"global airways\" concept, which recognizes allergic rhinitis, chronic rhinosinusitis, and asthma as interconnected manifestations of a shared inflammatory continuum. Advances in endotype-driven classification, the treatable traits framework, and the cross-efficacy of biologic therapies have reinforced the scientific and therapeutic rationale for integrated care; however, implementation remains largely theoretical. This editorial advocates for the establishment of Global Airways Units (GAUs), a pragmatic, multidisciplinary model in which otolaryngologists, pulmonologists, and allergists jointly evaluate patients within a unified diagnostic and therapeutic framework. By aligning healthcare organization with established pathophysiological knowledge and evolving guideline recommendations, GAUs represent a feasible, cost-effective strategy to operationalize precision medicine across the entire airway spectrum and translate consensus into tangible clinical benefit.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"561-562"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147278017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tinnitus, Dizziness and Hearing Status During Hypertension Diagnosis and Treatment.","authors":"Hüseyin Kandemir, Süheyla Kandemir, Selçuk Öztürk","doi":"10.1177/00034894251409648","DOIUrl":"10.1177/00034894251409648","url":null,"abstract":"<p><strong>Objective: </strong>High blood pressure (BP) or hypertension (HTN) can impair hearing, causes tinnitus and dizziness. We hypothesized that there is an association between increased BP and hearing impairment (HI), tinnitus and dizziness, and decrease in BP improves these parameters and symptoms.</p><p><strong>Methods: </strong>The study included 100 newly-diagnosed HTN patients (systolic BP (SBP) ≥140 mmHg and/or diastolic BP (DBP) ≥90 mmHg) and 100 patients without HTN. Tinnitus and dizziness were evaluated through Tinnitus Handicap Inventory (THI) and Dizziness Handicap Inventory (DHI). The auditory status of all patients was assessed for both right ear (RE) and left ear (LE). BP measurements, THI, DHI, and audiometry tests were repeated at follow-up visit during treatment in HTN patients and delta (Δ) values were obtained.</p><p><strong>Results: </strong>The median of THI and DHI score and thresholds for hearing parameters were higher in HTN group. At follow-up visit, SBP, DBP, THI, DHI, and most of the hearing parameters significantly improved. ΔSBP significantly correlated with ΔRE average _{(logarithmically transformed (log10))} and ΔLE average _(log10) in partial correlation analysis adjusted for age and Brinkman index. Multivariate linear regression analysis yielded an independent association of ΔRE average _(log10) (Beta Coefficient (BC): 12.07, 95% Confidence Interval (CI): 1.86-22.29, <i>P</i> = .021) and ΔLE average _(log10) (BC: 14.89, 95% CI: 5.45-24.33, <i>P</i> = .003) with ΔSBP. However, none of the parameters demonstrated an independent association with ΔDBP.</p><p><strong>Conclusion: </strong>HTN patients suffer from tinnitus, dizziness and HI, and BP decrease is associated with improvements in these symptoms and hearing status. Decrease in SBP rather than DBP is associated with improvements in hearing status.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"489-497"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Pneumococcal and Hemophilus Influenza Type B Antibody Deficiency in Children With Persistent Ear, Nose, and Throat Infections.","authors":"Katherine Claire Babin, Camille Martin, Marlee Wadsworth, Jeffrey Carron","doi":"10.1177/00034894261416576","DOIUrl":"10.1177/00034894261416576","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective of this study is to determine the prevalence of Hib and Pneumococcal antibody deficiencies in pediatric patients with persistent or recurrent ENT infections, namely recurrent otitis media and recurrent sinusitis, following ear tube placement or adenoidectomy.</p><p><strong>Study design: </strong>This is an IRB approved, single institution, retrospective chart review using the electronic medical record at University of Mississippi Medical Center from January 2013 to December 2023.</p><p><strong>Setting: </strong>University of Mississippi Medical Center, a tertiary referral hospital.</p><p><strong>Methods: </strong>This study included 43 patients who had undergone either ear tube placement or adenoidectomy with a history of PCV and Hib titers data. Demographic data was obtained and complete vaccination records were confirmed. Prevalence of PCV and Hib titer deficiency was calculated, and statistical analysis was performed using Chi-square tests, Fischer exact test or independent t-test, depending on the variables.</p><p><strong>Results: </strong>More than half (55%) of these patients were found to be indeterminate or have non-protective titers against Hemophilus influenzae type B, and 43% had titers considered non-protective against Pneumococcus. Given vaccination response rates are approximately 95% for the Hib vaccine and 97% to 100% for Prevnar vaccine, this demonstrates that children with recurrent ENT infections are approximately 11 times more likely to have indeterminate or non-protective titers to Hib and 14 times more likely to have non-protective titers to Pneumococcus.</p><p><strong>Conclusion: </strong>This study highlights the potential role of testing these titers in pediatric patients with recurrent ear and sinus infections despite surgical management, and sheds light on the potential role of booster vaccinations in this population.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"506-513"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}