Research (Washington, D.C.)最新文献_第6页

Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death. Caspase-1和Gasdermin D在NLRP1b炎症小体诱导的细胞死亡中提供了不同的开关策略的最佳靶点。

IF 11

Research (Washington, D.C.) Pub Date : 2022-07-19 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9838341

Xiang Li, Peipei Zhang, Zhiyong Yin, Fei Xu, Zhang-Hua Yang, Jun Jin, Jing Qu, Zhilong Liu, Hong Qi, Chenggui Yao, Jianwei Shuai

{"title":"Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death.","authors":"Xiang Li, Peipei Zhang, Zhiyong Yin, Fei Xu, Zhang-Hua Yang, Jun Jin, Jing Qu, Zhilong Liu, Hong Qi, Chenggui Yao, Jianwei Shuai","doi":"10.34133/2022/9838341","DOIUrl":"https://doi.org/10.34133/2022/9838341","url":null,"abstract":"Inflammasomes are essential complexes of innate immune system, which form the first line of host defense against pathogens. Mounting evidence accumulates that inflammasome signaling is highly correlated with coronavirus disease 2019 (COVID-19). However, there remains a significant gap in our understanding of the regulatory mechanism of inflammasome signaling. Combining mathematical modeling with experimental analysis of NLRP1b inflammasome signaling, we found that only the expression levels of caspase-1 and GSDMD have the potential to individually switch cell death modes. Reduction of caspase-1 or GSDMD switches cell death from pyroptosis to apoptosis. Caspase-1 and GSDMD present different thresholds and exert distinct pathway choices in switching death modes. Pyroptosis switches to apoptosis with an extremely low threshold level of caspase-1, but with a high threshold of GSDMD. Caspase-1-impaired cells employ ASC-caspase-8-dependent pathway for apoptosis, while GSDMD-impaired cells primarily utilize caspase-1-dependent pathway. Additionally, caspase-1 and GSDMD can severally ignite the cooccurrence of pyroptosis and apoptosis. Landscape topography unravels that the cooccurrence is dramatically different in caspase-1- and GSDMD-impaired cells. Besides pyroptosis state and apoptosis state, a potential new \"coexisting\" state in single cells is proposed when GSDMD acts as the driving force of the landscape. The \"seesaw model\" is therefore proposed, which can well describe the death states that are controlled by caspase-1 or GSDMD in single cells. Our study sheds new light on NLRP1b inflammasome signaling and uncovers the switching mechanisms among various death modes, providing potential clues to guide the development of more rational control strategies for diseases.","PeriodicalId":520765,"journal":{"name":"Research (Washington, D.C.)","volume":" ","pages":"9838341"},"PeriodicalIF":11.0,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40690123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Reconfigurable Mechanochromic Patterns into Chameleon-Inspired Photonic Papers. 变色龙启发光子纸的可重构机械变色模式。

IF 11

Research (Washington, D.C.) Pub Date : 2022-07-19 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9838071

Dongpeng Yang, Yang Hu, Dekun Ma, Jianping Ge, Shaoming Huang

{"title":"Reconfigurable Mechanochromic Patterns into Chameleon-Inspired Photonic Papers.","authors":"Dongpeng Yang, Yang Hu, Dekun Ma, Jianping Ge, Shaoming Huang","doi":"10.34133/2022/9838071","DOIUrl":"https://doi.org/10.34133/2022/9838071","url":null,"abstract":"Photonic crystal (PC) patterns have shown wide applications in optical devices, information encryption, anticounterfeiting, etc. Unfortunately, it is still a great challenge to reconfigure the PC patterns once fabricated. Herein, a new strategy is presented to reconfigure self-recordable PC patterns by printing local patterns into the chameleon-inspired PC papers using the phase change material (PCM) as ink and then erasing the patterns in ethanol. Multicolor and high-resolution (25 and 75 μm for dot and lines, respectively) patterns can be efficiently and repeatedly reconfigured. In addition, the photonic patterns based on the PC paper and PCM combinations are gifted with mechanochromic characteristics and can show programmable and reversible color change under pressure. The high melting point of the ink, nonclosely packed structures of the PC paper, and the similar solubility parameter of PC paper, PCM, and ethanol are the keys for all these characteristics. This work offers a simple, flexible, efficient way to reconfigure PC patterns with mechanochromic properties and could open up exciting applications for novel hand-operation-based anticounterfeiting and optical devices.","PeriodicalId":520765,"journal":{"name":"Research (Washington, D.C.)","volume":" ","pages":"9838071"},"PeriodicalIF":11.0,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40703151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Recent Growth of Wettability Gradient Surfaces: A Review. 润湿性梯度表面研究进展综述。

IF 11

Research (Washington, D.C.) Pub Date : 2022-07-16 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9873075

Raza Gulfam, Yongping Chen

{"title":"Recent Growth of Wettability Gradient Surfaces: A Review.","authors":"Raza Gulfam, Yongping Chen","doi":"10.34133/2022/9873075","DOIUrl":"https://doi.org/10.34133/2022/9873075","url":null,"abstract":"This review reports the recent progress and future prospects of wettability gradient surfaces (WGSs), particularly focusing on the governing principles, fabrication methods, classification, characterization, and applications. While transforming the inherent wettability into artificial wettability via bioinspiration, topographic micro/nanostructures are produced with changed surface energy, resulting in new droplet wetting regimes and droplet dynamic regimes. WGSs have been mainly classified in dry and wet surfaces, depending on the apparent surface states. Wettability gradient has long been documented as a surface phenomenon inducing the droplet mobility in the direction of decreasing wettability. However, it is herein critically emphasized that the wettability gradient does not always result in droplet mobility. Indeed, the sticky and slippery dynamic regimes exist in WGSs, prohibiting or allowing the droplet mobility, respectively. Lastly, the stringent bottlenecks encountered by WGSs are highlighted along with solution-oriented recommendations, and furthermore, phase change materials are strongly anticipated as a new class in WGSs. In all, WGSs intend to open up new technological insights for applications, encompassing water harvesting, droplet and bubble manipulation, controllable microfluidic systems, and condensation heat transfer, among others.","PeriodicalId":520765,"journal":{"name":"Research (Washington, D.C.)","volume":" ","pages":"9873075"},"PeriodicalIF":11.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40588266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Enhanced Thermal Conductivities of Liquid Crystal Polyesters from Controlled Structure of Molecular Chains by Introducing Different Dicarboxylic Acid Monomers. 通过引入不同的二羧酸单体控制分子链结构来增强液晶聚酯的导热性。

IF 11

Research (Washington, D.C.) Pub Date : 2022-07-16 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9805686

Xiao Zhong, Kunpeng Ruan, Junwei Gu

{"title":"Enhanced Thermal Conductivities of Liquid Crystal Polyesters from Controlled Structure of Molecular Chains by Introducing Different Dicarboxylic Acid Monomers.","authors":"Xiao Zhong, Kunpeng Ruan, Junwei Gu","doi":"10.34133/2022/9805686","DOIUrl":"https://doi.org/10.34133/2022/9805686","url":null,"abstract":"Enhancing thermal conductivity coefficient (λ) of liquid crystal polyesters would further widen their application in electronics and electricals. In this work, a kind of biphenyl-based dihydroxy monomer is synthesized using 4, 4'-biphenyl (BP) and triethylene glycol (TEG) as raw material, which further reacts with three different dicarboxylic acids (succinic acid, p-phenylenediacetic acid, and terephthalic acid, respectively) by melt polycondensation to prepare intrinsically highly thermally conductive poly 4', 4\"'-[1, 2-ethanediyl-bis(oxy-2, 1-ethanediyloxy)]-bis(p-hydroxybiphenyl) succinate (PEOS), poly 4', 4\"'-[1, 2-ethanediyl-bis(oxy-2, 1-ethanediyloxy)]-bis(p-hydroxybiphenyl) p-phenyldiacetate (PEOP) and poly 4', 4\"'-[1, 2-ethanediyl-bis(oxy-2, 1-ethanediyloxy)]-bis(p-hydroxybiphenyl) terephthalate (PEOT), collectively called biphenyl-based liquid crystal polyesters (B-LCPE). The results show that B-LCPE possess the desired molecular structure, exhibit smectic phase in liquid crystal range and semicrystalline polymers at room temperature, and possess excellent intrinsic thermal conductivities, thermal stabilities, and mechanical properties. λ of PEOT is 0.51 W/(m·K), significantly exceeds that of polyethylene terephthalate (0.15 W/(m·K)) which has similar molecular structure with PEOT, and also higher than that of PEOS (0.32 W/(m·K)) and PEOP (0.38 W/(m·K)). The corresponding heat resistance index (T HRI), elasticity modulus, and hardness of PEOT are 174.6°C, 3.6 GPa, and 154.5 MPa, respectively, and also higher than those of PEOS (162.2°C, 1.8 GPa, and 83.4 MPa) and PEOP (171.8°C, 2.3 GPa, and 149.6 MPa).","PeriodicalId":520765,"journal":{"name":"Research (Washington, D.C.)","volume":" ","pages":"9805686"},"PeriodicalIF":11.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40591522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Time-Modulated Transmissive Programmable Metasurface for Low Sidelobe Beam Scanning. 用于低旁瓣波束扫描的时调制传输可编程元表面。

IF 10.7

Research (Washington, D.C.) Pub Date : 2022-07-09 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9825903

Xudong Bai, Fuli Zhang, Li Sun, Anjie Cao, Jin Zhang, Chong He, Longhai Liu, Jianquan Yao, Weiren Zhu

{"title":"Time-Modulated Transmissive Programmable Metasurface for Low Sidelobe Beam Scanning.","authors":"Xudong Bai, Fuli Zhang, Li Sun, Anjie Cao, Jin Zhang, Chong He, Longhai Liu, Jianquan Yao, Weiren Zhu","doi":"10.34133/2022/9825903","DOIUrl":"10.34133/2022/9825903","url":null,"abstract":"Programmable metasurfaces have great potential for the implementation of low-complexity and low-cost phased arrays. Due to the difficulty of multiple-bit phase control, conventional programmable metasurfaces suffer a relatively high sidelobe level (SLL). In this manuscript, a time modulation strategy is introduced in the 1-bit transmissive programmable metasurface for reducing the SLLs of the generated patterns. After the periodic time modulation, harmonics are generated in each reconfigurable unit and the phase of the first-order harmonic can be dynamically controlled by applying different modulation sequences onto the corresponding unit. Through the high-speed modulation of the real-time periodic coding sequences on the metasurface by the programmable bias circuit, the equivalent phase shift accuracy to each metasurface unit can be improved to 6-bit and thus the SLLs of the metasurface could be reduced remarkably. The proposed time-modulated strategy is verified both numerically and experimentally with a transmissive programmable metasurface, which obtains an aperture efficiency over 34% and reduced SLLs of about -20 dB. The proposed design could offer a novel approach of a programmable metasurface framework for radar detection and secure communication applications.","PeriodicalId":520765,"journal":{"name":"Research (Washington, D.C.)","volume":" ","pages":"9825903"},"PeriodicalIF":10.7,"publicationDate":"2022-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40671770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-Programmable Assemblies of Isotropic Micromotors. 各向同性微电机的轻型可编程组件。

IF 11

Research (Washington, D.C.) Pub Date : 2022-07-06 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9816562

Shengping Che, Jianhua Zhang, Fangzhi Mou, Xia Guo, Joshua E Kauffman, Ayusman Sen, Jianguo Guan

{"title":"Light-Programmable Assemblies of Isotropic Micromotors.","authors":"Shengping Che, Jianhua Zhang, Fangzhi Mou, Xia Guo, Joshua E Kauffman, Ayusman Sen, Jianguo Guan","doi":"10.34133/2022/9816562","DOIUrl":"https://doi.org/10.34133/2022/9816562","url":null,"abstract":"\"Life-like\" nonequilibrium assemblies are of increasing significance, but suffering from limited steerability as they are generally based on micro/nanomotors with inherent asymmetry in chemical composition or geometry, of which the vigorous random Brownian rotations disturb the local interactions. Here, we demonstrate that isotropic photocatalytic micromotors, due to the persistent phoretic flow from the illuminated to shadowed side irrespective of their Brownian rotations, experience light-programmable local interactions (reversibly from attraction to repulsion and/or alignment) depending on the direction of the incident lights. Thus, they can be organized into a variety of tunable nonequilibrium assemblies, such as apolar solids (i.e., immobile colloidal crystal), polar liquids (i.e., phototactic colloidal stream), and polar solids (i.e., phototactic colloidal crystal), which can further be \"cut\" into a predesigned pattern by utilizing the switching motor-motor interactions at superimposed-light edges. This work facilitates the development of active matters and motile functional microdevices.","PeriodicalId":520765,"journal":{"name":"Research (Washington, D.C.)","volume":" ","pages":"9816562"},"PeriodicalIF":11.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40671769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization. lncRNA HITT通过抑制PKM2寡聚化抑制乳酸生成，从而降低肿瘤生长和巨噬细胞极化。

IF 11

Research (Washington, D.C.) Pub Date : 2022-07-05 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9854904

Kunming Zhao, Xingwen Wang, Dong Zhao, Qingyu Lin, Yi Zhang, Ying Hu

{"title":"lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization.","authors":"Kunming Zhao, Xingwen Wang, Dong Zhao, Qingyu Lin, Yi Zhang, Ying Hu","doi":"10.34133/2022/9854904","DOIUrl":"https://doi.org/10.34133/2022/9854904","url":null,"abstract":"Lactic acid acidifies the tumor microenvironment and promotes multiple critical oncogenic processes, including immune evasion. Pyruvate kinase M2 (PKM2) is a dominant form of pyruvate kinase (PK) expressed in cancers that plays essential roles in metabolic reprograming and lactate production, rendering it as an attractive therapeutic target of cancer. However, the mechanism underlying PKM2 regulation remains unclear. Here, we show that long noncoding RNA (lncRNA) HIF-1α inhibitor at transcription level (HITT) inhibits lactate production in a PKM2-dependent manner. Mechanistically, it physically interacts with PKM2 mapped to a region that has been involved in both dimer (less-active) and tetramer (more-active) formation, inhibiting PKM2 oligomerization and leading to dramatic reduction of PK activity. Under glucose starvation, HITT was reduced as a result of miR-106 induction, which subsequently facilitates PKM2 oligomerization and increases vulnerability to apoptosis under glucose starvation stress. In addition, the interaction also reduces lactate secretion from cancer cells, which subsequently polarizes macrophages toward an M2-like anti-inflammatory phenotype and thus possibly contributes to immune escape in vivo. This study highlights an important role of an lncRNA in regulating PKM2 activity and also reveals a metabolic regulatory effect of PKM2 on macrophage polarization.","PeriodicalId":520765,"journal":{"name":"Research (Washington, D.C.)","volume":" ","pages":"9854904"},"PeriodicalIF":11.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40570432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Ultrahigh Performance Triboelectric Nanogenerator Enabled by Charge Transmission in Interfacial Lubrication and Potential Decentralization Design. 界面润滑中电荷传输与电位分散设计的超高性能摩擦电纳米发电机。

IF 11

Research (Washington, D.C.) Pub Date : 2022-07-05 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9812865

Wencong He, Wenlin Liu, Shaoke Fu, Huiyuan Wu, Chuncai Shan, Zhao Wang, Yi Xi, Xue Wang, Hengyu Guo, Hong Liu, Chenguo Hu

{"title":"Ultrahigh Performance Triboelectric Nanogenerator Enabled by Charge Transmission in Interfacial Lubrication and Potential Decentralization Design.","authors":"Wencong He, Wenlin Liu, Shaoke Fu, Huiyuan Wu, Chuncai Shan, Zhao Wang, Yi Xi, Xue Wang, Hengyu Guo, Hong Liu, Chenguo Hu","doi":"10.34133/2022/9812865","DOIUrl":"https://doi.org/10.34133/2022/9812865","url":null,"abstract":"Triboelectric nanogenerator (TENG) is a promising strategy for harvesting low frequency mechanical energy. However, the bottlenecks of limited electric output by air/dielectric breakdown and poor durability by material abrasion seriously restrict its further improvement. Herein, we propose a liquid lubrication promoted sliding mode TENG to address both issues. Liquid lubrication greatly reduces interface material abrasion, and its high breakdown strength and charge transmission effect further enhance device charge density. Besides, the potential decentralization design by the voltage balance bar effectively suppresses the dielectric breakdown. In this way, the average power density up to 87.26 W·m-2·Hz-1, energy conversion efficiency of 48%, and retention output of 90% after 500,000 operation cycles are achieved, which is the highest average power density and durability currently. Finally, a cell phone is charged to turn on by a palm-sized TENG device at 2 Hz within 25 s. This work has a significance for the commercialization of TENG-based self-powered systems.","PeriodicalId":520765,"journal":{"name":"Research (Washington, D.C.)","volume":" ","pages":"9812865"},"PeriodicalIF":11.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40572922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Porous Single-Crystalline Monolith to Enhance Catalytic Activity and Stability. 多孔单晶单体提高催化活性和稳定性。

IF 11

Research (Washington, D.C.) Pub Date : 2022-07-05 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9861518

Xiaoyan Yu, Fangyuan Cheng, Xiuyun Duan, Kui Xie

{"title":"Porous Single-Crystalline Monolith to Enhance Catalytic Activity and Stability.","authors":"Xiaoyan Yu, Fangyuan Cheng, Xiuyun Duan, Kui Xie","doi":"10.34133/2022/9861518","DOIUrl":"https://doi.org/10.34133/2022/9861518","url":null,"abstract":"Engineering the catalytic activity and stability of materials would require the identification of the structural features that can tailor active sites at surfaces. Porous single crystals combine the ordered lattice structures and disordered interconnected pores, and they would therefore provide the advantages of precise structure features to identify and engineer the active sites at surfaces. Herein, we fabricate porous single-crystalline vanadium nitride (VN) at centimeter scale and further dope Fe (Fe0.1V0.9N) and Co (Co0.1V0.9N) in lattice to engineer the active sites at surface. We demonstrate that the active surface is composed of unsaturated coordination of V-N, Fe-N, and Co-N structures which lead to the generation of high-density active sites at the porous single-crystalline monolith surface. The interconnected pores aid the pore-enhanced fluxion to facilitate species diffusion in the porous architectures. In the nonoxidative dehydrogenation of ethane to ethylene, we demonstrate the outstanding performance with ethane conversion of 36% and ethylene selectivity of 99% at 660°C. Remarkably stability as a result of their single-crystalline structure, the monoliths achieve the outstanding performance without degradation being observed even after 200 hours of a continuous operation in a monolithic reactor. This work not only demonstrates the effective structural engineering to simultaneously enhance the stability and overall performance for practically useful catalytic materials but also provide a new route for the element doping of porous single crystals at large scale for the potential application in other fields.","PeriodicalId":520765,"journal":{"name":"Research (Washington, D.C.)","volume":" ","pages":"9861518"},"PeriodicalIF":11.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40670822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

3D Printed Bioinspired Stents with Photothermal Effects for Malignant Colorectal Obstruction. 具有光热效应的3D打印生物启发支架用于恶性结直肠癌。

IF 11

Research (Washington, D.C.) Pub Date : 2022-07-01 eCollection Date: 2022-01-01 DOI: 10.34133/2022/9825656

Cheng Lin, Zhipeng Huang, Qinglong Wang, Wantao Wang, Wenbo Wang, Zhen Wang, Liwu Liu, Yanju Liu, Jinsong Leng

{"title":"3D Printed Bioinspired Stents with Photothermal Effects for Malignant Colorectal Obstruction.","authors":"Cheng Lin, Zhipeng Huang, Qinglong Wang, Wantao Wang, Wenbo Wang, Zhen Wang, Liwu Liu, Yanju Liu, Jinsong Leng","doi":"10.34133/2022/9825656","DOIUrl":"https://doi.org/10.34133/2022/9825656","url":null,"abstract":"Stent placement is an effective palliation therapy for malignant colorectal obstruction. However, recurrent obstruction is a common severe complication caused by tumor ingrowth into the stent lumen. Conventional covered stents play a part in preventing the tumor from growing inward but at the expense of significantly increasing the risk of stent migration. Therefore, there is an urgent demand to develop stents with sustained antitumor and antimigration abilities. Herein, we propose a facile method for fabricating multifunctional bioinspired colorectal stents using 3D printing technology. Inspired by high-adhesion biological structures (gecko feet, tree frog toe pads, and octopus suckers) in nature, different types of bioinspired colorectal stents are designed to reduce migration. After functionalization with graphene oxide (GO), bioinspired colorectal stents show excellent and controllable photothermal performance, which is validated by effective ablation of colon cancer cells in vitro and tumors in vivo. Besides, the bioinspired colorectal stents demonstrate the feasibility of transanal placement and opening of the obstructed colon. More importantly, the facile manufacturing process of multifunctional bioinspired colorectal stents is appealing for mass production. Hence, the developed multifunctional bioinspired colorectal stents exhibit a highly promising potential in clinical applications.","PeriodicalId":520765,"journal":{"name":"Research (Washington, D.C.)","volume":" ","pages":"9825656"},"PeriodicalIF":11.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40570433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4