Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology最新文献

{"title":"Severe vaccine-acquired rotavirus infection in an infant with primary intestinal lymphangiectasia.","authors":"Maria Cabrerizo, Inmaculada Hidalgo-Montes, Ana Mendez-Echevarria, Rebeca Rodrieguez-Pena, Guillermo Ruiz-Carrascoso, Eva Martinez-Ojinaga, Teresa Del Rosal, Laura G Pastrian, Maria Dolores Fernandez-Garcia","doi":"10.1111/pai.13834","DOIUrl":"https://doi.org/10.1111/pai.13834","url":null,"abstract":"We would like to thank Luis Allende at Hospital Universitario 12 de Octubre for the quantification of TRECs; María Bravo Garcia-Morato at La Paz University Hospital for the genetic analysis of PID genes for their contribution to the management and diagnosis of the patient.","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":" ","pages":"e13834"},"PeriodicalIF":4.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40424367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could a bite trigger the onset of cat allergy?","authors":"Gualtiero Leo, Cristoforo Incorvaia, Stefania Arasi","doi":"10.1111/pai.13841","DOIUrl":"https://doi.org/10.1111/pai.13841","url":null,"abstract":"To the Editor, The prevalence of cat allergy varies among different countries; in Europe, it has been estimated that about 26% of adults searching care for suspected inhalant allergy are sensitized to cats.1 The growing prevalence makes cat allergy a significant human health problem; furthermore, it can be serious and debilitating for many patients.1,2 The skin may represent a sensitization path to environmental allergens when there is a barrier defect at the epithelial level, as in atopic dermatitis.3 If skin barrier dysfunction is considered a risk factor for sensitization to food allergens, the possibility of developing sensitization to inhalant allergens through the skin is controversial. Herein, we report the clinical case of a 7yearold girl who developed cat allergy after being bitten by a cat. She had been followed up from the age of 18 months for frequent respiratory tract infections with rhinitis, nasal mucous secretions, and cough. Clinical history was negative for atopic dermatitis and food allergy. There were no pets at home. At the age of 2 years and 10 months, an allergy examination was performed due to the recurrence of respiratory infections associated with bronchial obstruction. Skin prick tests (SPT) with commercial allergen extracts were performed according to the indications of international guidelines.4 In detail, each extract drop was applied to the front surface of the forearm on which SPT was performed with a lancet. The result was read after 15 minutes by measuring the average length between the maximum diameter and its orthogonal. A reaction of 3 mm or greater was considered positive. SPT were performed for inhalant allergens, including pollens, dust mites, molds, and cats (ALKAbellò, Lainate, Italy), with negative results. The positive control (histamine 10 mg/mL) had an average wheal diameter of 5 mm. Since September 2019, therapy with inhaled steroids (fluticasone 50 mcg/die) has been started on medical advice as longterm treatment of asthma to prevent exacerbations in the course of upper respiratory tract infections. In early September 2021 (at the age of 5 years and 11 months), SPT were repeated with positive results for grasses (5 mm), olive tree (5 mm), Dermatophagoides farinae (6 mm), and Dermatophagoides pteronissinus (6 mm). Skin test to cat extract was negative. In November 2021, in a friend's house with a cat, and previously attended, the girl was bitten for the first time by the pet on the back of her right hand. Two erythematosus spots immediately occurred on the injured skin with no bleeding. After about 2 months, when she returned in there, she experienced conjunctival redness, sneezing, and breathing difficulties after about 30– 60 min. A further episode of asthma occurred after 1 month in another house with a cat. Since then, the child's parents have avoided to expose her daughter to environments with cats. At the end of March 2022, during an allergy checkup, SPT to cat turned positive (cat dander: 8 mm","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":" ","pages":"e13841"},"PeriodicalIF":4.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/eb/PAI-33-0.PMC9541892.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40424360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cord blood IgE predicts allergic sensitization, elevation of exhaled nitric oxide, and asthma in schoolchildren.","authors":"Hsin-Ju Lee,&nbsp;Hui-Ju Tsai,&nbsp;Hsin-Yi Huang,&nbsp;Chun-Chun Gau,&nbsp;Chia-Hua Ho,&nbsp;Jing-Long Huang,&nbsp;Tsung-Chieh Yao","doi":"10.1111/pai.13838","DOIUrl":"https://doi.org/10.1111/pai.13838","url":null,"abstract":"<p><strong>Background: </strong>Few data are available in Asian children regarding the validity of cord blood immunoglobulin E (IgE) in predicting allergic sensitization and pulmonary function. The relationship between cord blood IgE and fraction of exhaled nitric oxide (FeNO) remains unknown. This study investigated the associations of cord blood IgE with allergic sensitization, FeNO, pulmonary function, and allergic diseases in Asian children.</p><p><strong>Methods: </strong>Five hundred and sixty-six Asian children with valid cord blood IgE measurements at birth participated a 6-year follow-up visit including a questionnaire, serum total and allergen-specific IgE, FeNO measurement, and spirometry. Regression-based analyses with covariates adjustment were applied.</p><p><strong>Results: </strong>Cord blood IgE levels were significantly associated with FeNO levels (β = 0.131, p < .001) and serum total IgE levels (β = 0.325, p < .001). Cord blood IgE levels were positively associated with allergic sensitization (adjusted odds ratio [AOR] = 2.22, p < .001), and sensitization to mites (p = .002), animals (p = .023), and foods (p = .048). Subjects with cord blood IgE ≥0.24 kU/L (the optimal cutoff) were significantly associated with an increased risk of allergic sensitization (AOR = 2.63, p < .001) and asthma (AOR = 2.35, p = .024) than those with cord blood IgE <0.24 kU/L. Subjects with cord blood IgE ≥0.24 kU/L had significantly higher FeNO levels than those with cord blood IgE <0.24 kU/L (p = .028). There were no significant associations between cord blood IgE levels and pulmonary function parameters.</p><p><strong>Conclusion: </strong>Cord blood IgE ≥0.24 kU/L predicts allergic sensitization, FeNO elevation, and asthma among Asian schoolchildren, suggesting cord blood IgE would be useful for identifying newborns at risk of subsequent allergic sensitization and allergic airway inflammation.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":" ","pages":"e13838"},"PeriodicalIF":4.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/5c/PAI-33-0.PMC9541746.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40424363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 infection and treatment in a cohort of patients with inborn errors of immunity.","authors":"Francesca Conti,&nbsp;Lucia Pacillo,&nbsp;Donato Amodio,&nbsp;Beatrice Rivalta,&nbsp;Mattia Moratti,&nbsp;Caterina Campoli,&nbsp;Daniele Zama,&nbsp;Ilaria Corsini,&nbsp;Carmela Giancotta,&nbsp;Stefania Bernardi,&nbsp;Samuele Naviglio,&nbsp;Maria Pia Cicalese,&nbsp;Marco Rabusin,&nbsp;Alessandro Aiuti,&nbsp;Caterina Cancrini,&nbsp;Marcello Lanari,&nbsp;Pierluigi Viale,&nbsp;Paolo Palma,&nbsp;Andrea Pession,&nbsp;Andrea Finocchi","doi":"10.1111/pai.13833","DOIUrl":"https://doi.org/10.1111/pai.13833","url":null,"abstract":"of the of these did not observe substantial differences in terms of infection clearance (2 days spared) and symptom recovery (1 day spared) between untreated patients p - value 0.86); ob-served a faster mean time clearance in patients who had received at least 2 vaccination doses respect to the rest of our IEI cohort (17 versus 24 days).","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":" ","pages":"e13833"},"PeriodicalIF":4.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/e7/PAI-33-0.PMC9538295.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40424366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ana o 3 sIgE and diagnostic algorithms reduce cost of cashew allergy diagnosis in children compared with skin prick test: A cost comparison analysis.","authors":"Tim Brettig,&nbsp;Kim Dalziel,&nbsp;Jennifer J Koplin,&nbsp;Thanh Dang,&nbsp;Lars Lange,&nbsp;Vicki McWilliam,&nbsp;Sakura Sato,&nbsp;Savvas Savvatianos,&nbsp;Kirsten P Perrett","doi":"10.1111/pai.13839","DOIUrl":"https://doi.org/10.1111/pai.13839","url":null,"abstract":"<p><strong>Background: </strong>In the absence of a clear clinical history of reaction, diagnosis of cashew allergy using skin prick tests (SPT) or cashew-specific IgE requires a high number of oral food challenges (OFC). By using Ana o 3 sIgE alone, or a two-step diagnostic algorithm using cashew sIgE followed by Ana o 3 sIgE, there is a reduced need for OFC. We aimed to perform a cost comparison for both of these approaches compared with cashew SPT alone.</p><p><strong>Methods: </strong>Pooled individual-level data from 6 studies were used to determine diagnostic accuracy and OFC rate. Two studies used cashew SPT (n = 567, 198 allergic), with 95% positive and negative predictive values of ≥12 mm and <3 mm. Four studies were included in the pathways for Ana o 3 sIgE alone or a 2-step algorithm incorporating cashew and Ana o 3 sIgE (n = 271, 156 allergic). Cut-offs used were ≥8.5kUA/L and ≤0.1kUA/L for cashew sIgE and ≥0.35kUA/L and ≤0.1kUA/L for Ana o 3 sIgE. Costs were constructed based on unit prices from hospital inpatient admissions, expenses incurred by families, individual patient data on allergic reaction types and rates, and adrenaline autoinjector carriage, applying a health system perspective.</p><p><strong>Results: </strong>Modeled data through the Ana o 3 pathway resulted in a 46.43% cost reduction (€307,406/1000 patients) compared with using cashew SPT alone (€573,854/1000 patients). The 2-step algorithm resulted in a 44.94% cost reduction compared with SPT alone (€315,952.82/1000 patients). Both the Ana o 3 pathway and 2-step algorithm resulted in a 79%-80% reduction in OFCs compared with SPT.</p><p><strong>Conclusions: </strong>Using Ana o 3 as a standalone test for cashew allergy diagnosis or a 2-step algorithm incorporating cashew sIgE and Ana o 3 sIgE is accurate and results in a large reduction in both OFCs and health system costs compared with cashew SPT alone.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40424361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects elicited by the probiotic Lacticaseibacillus rhamnosus GG in children with atopic dermatitis. The results of the ProPAD trial.","authors":"Laura Carucci,&nbsp;Rita Nocerino,&nbsp;Lorella Paparo,&nbsp;Francesca De Filippis,&nbsp;Serena Coppola,&nbsp;Veronica Giglio,&nbsp;Tommaso Cozzolino,&nbsp;Vincenzo Valentino,&nbsp;Giuseppina Sequino,&nbsp;Giorgio Bedogni,&nbsp;Roberto Russo,&nbsp;Danilo Ercolini,&nbsp;Roberto Berni Canani","doi":"10.1111/pai.13836","DOIUrl":"https://doi.org/10.1111/pai.13836","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% of the pediatric population associated with alteration of skin and gut microbiome. Probiotics have been proposed for AD treatment. The ProPAD study aimed to investigate the therapeutic effects of the probiotic Lacticaseibacillus rhamnosus GG (LGG) in children with AD.</p><p><strong>Methods: </strong>In total, 100 AD patients aged 6-36 months were enrolled in a randomized, double-blind, controlled trial to receive placebo (Group A) or LGG (1 x 10¹⁰ CFU/daily) (Group B) for 12 weeks. The primary outcome was the evaluation of the efficacy of LGG supplementation on AD severity comparing the Scoring Atopic Dermatitis (SCORAD) index at baseline (T0) and at 12-week (T12). A reduction of ≥8.7 points on the SCORAD index was considered as minimum clinically important difference (MCID). The secondary outcomes were the SCORAD index evaluation at 4-week (T16) after the end of LGG treatment, number of days without rescue medications, changes in Infant Dermatitis Quality Of Life questionnaire (IDQOL), gut microbiome structure and function, and skin microbiome structure.</p><p><strong>Results: </strong>The rate of subjects achieving MCID at T12 and at T16 was higher in Group B (p < .05), and remained higher at T16 (p < .05)The number of days without rescue medications was higher in Group B. IDQOL improved at T12 in the Group B (p < .05). A beneficial modulation of gut and skin microbiome was observed only in Group B patients.</p><p><strong>Conclusions: </strong>The probiotic LGG could be useful as adjunctive therapy in pediatric AD. The beneficial effects on disease severity and quality of life paralleled with a beneficial modulation of gut and skin microbiome.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":" ","pages":"e13836"},"PeriodicalIF":4.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/53/PAI-33-0.PMC9542056.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40424365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitization to house dust mite and cockroach may mediate the racial difference in shellfish allergy.","authors":"Neil Thivalapill, Aame B Andy-Nweye, Lucy A Bilaver, Mary C Tobin, Hemant P Sharma, Amal H Assa'ad, Christopher Warren, Jialing Jiang, Annika Chura, Ruchi S Gupta, Mahboobeh Mahdavinia","doi":"10.1111/pai.13837","DOIUrl":"10.1111/pai.13837","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":" ","pages":"e13837"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40424362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inborn errors of immunity caused by defects in the DNA damage response pathways: Importance of minimizing treatment-related genotoxicity.","authors":"Benjamin Fournier,&nbsp;Nizar Mahlaoui,&nbsp;Despina Moshous,&nbsp;Jean-Pierre de Villartay","doi":"10.1111/pai.13820","DOIUrl":"https://doi.org/10.1111/pai.13820","url":null,"abstract":"<p><p>Several primary immunodeficiencies are caused by defects in the general DNA repair machinery as exemplified by the T-B- radiosensitive SCID condition owing to impaired resolution of programmed DNA double-strand breaks introduced by RAG1/2 during V(D)J recombination. The genome instability generally associated with these conditions results in an increased propensity to develop malignancies requiring genotoxic-based anti-cancer treatments. Moreover, the extent of immune deficiency often calls for hematopoietic stem cell transplantation as a definitive treatment, also requiring genotoxic-based conditioning regimen prior to transplantation. In both cases, the underlying general DNA repair defect may result in catastrophic iatrogenic consequences. It is, therefore, of paramount importance to assess the functionality of the DNA repair apparatus prior to any genotoxic treatment when the exact molecular cause of the disease is unknown. For this purpose, two simple assays can be used on patients derived peripheral blood lymphocytes: (1) the PROMIDISα biomarker, based on the next-generation sequencing analysis of the TCRα repertoire, will highlight specific signatures of DNA repair deficiencies; (2) direct analysis of the sensitivity of peripheral lymphocytes to ionizing radiation will formally identify patients at risk to develop toxicity toward genotoxic-based treatments.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":" ","pages":"e13820"},"PeriodicalIF":4.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/1d/PAI-33-0.PMC9327728.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40400343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental influences on childhood allergies and asthma - The Farm effect.","authors":"Remo Frei,&nbsp;Kristina Heye,&nbsp;Caroline Roduit","doi":"10.1111/pai.13807","DOIUrl":"https://doi.org/10.1111/pai.13807","url":null,"abstract":"<p><p>Asthma and allergies are major health problems and exert an enormous socioeconomic burden. Besides genetic predisposition, environmental factors play a crucial role in the development of these diseases in childhood. Multiple worldwide epidemiological studies have shown that children growing up on farms are immune to allergic diseases and asthma. Farm-related exposures shape children's immune homeostasis, via mediators such as N-glycolylneuraminic acid or arabinogalactan, or by diverse environmental microbes. Moreover, nutritional factors, such as breastfeeding or farm milk and food diversity, inducing short-chain fatty acids-producing bacteria in the intestine, contribute to farm-related effects. All farm-related exposures induce an anti-inflammatory response of the innate immunity and increase the differentiation of regulatory T cells and T helper cell type 1. A better understanding of the components of the farm environment, that are protective to the development of allergy and asthma, and their underlying mechanisms, will help to develop new strategies for the prevention of allergy and asthma.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":" ","pages":"e13807"},"PeriodicalIF":4.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/b2/PAI-33-0.PMC9327508.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40396359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of physical condition with lung function and asthma in adolescents from the general population.","authors":"Sara M Mensink-Bout,&nbsp;Marc R Jahangir,&nbsp;Johan C de Jongste,&nbsp;Hein Raat,&nbsp;Vincent W V Jaddoe,&nbsp;Liesbeth Duijts","doi":"10.1111/pai.13811","DOIUrl":"https://doi.org/10.1111/pai.13811","url":null,"abstract":"<p><strong>Background: </strong>The relation of physical condition with respiratory outcomes in adolescents is unclear. We examined the hypothesis that adolescents with a lower physical condition represented by a lower cardiorespiratory fitness and physical activity, and a higher screen time have a lower lung function and higher risk of asthma.</p><p><strong>Methods: </strong>In a population-based prospective cohort study on 4854 children aged 13 years, we assessed cardiorespiratory fitness by using the peak work rate measured by the steep ramp test. Information on physical activity and screen time was obtained by self-reported questionnaires. Lung function was measured by spirometry and current asthma was assessed by a parental-reported questionnaire.</p><p><strong>Results: </strong>Taking sociodemographic, lifestyle, and growth-related confounders and multiple hypothesis testing into account, a 1 SD lower cardiorespiratory fitness was associated with a lower FEV₁ , FVC, and FEF₇₅ (Z-score difference (95% CI): -0.31 (-0.35, -0.28), -0.30 (-0.33, -0.26), -0.13 (-0.17, -0.10), respectively), and a higher risk of asthma (Odds Ratio (95% CI) 1.25 (1.06, 1.46)). A 1 SD higher screen time was associated with a lower FVC (Z-score difference (95% CI): -0.06 (-0.10, -0.03)). Physical activity and screen time were not related to asthma. Results did not materially change after additional adjustment for respiratory outcomes at an earlier age.</p><p><strong>Conclusion: </strong>Adolescents with a lower cardiorespiratory fitness had a lower lung function and a higher risk of asthma. Those with a higher screen time had a lower FVC. Further studies are needed to explore the effect of improvements in physical condition on long-term respiratory outcomes.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/33/af/PAI-33-0.PMC9328392.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40398763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}