Otolaryngologia polska = The Polish otolaryngology最新文献

{"title":"Biologic Therapy for Chronic Rhinosinusitis with Nasal Polyps: Case Analysis and Proposal of a Qualification Scheme.","authors":"Grażyna Stryjewska-Makuch, Maria Humeniuk-Arasiewicz, Marcelina Niemiec-Urbańczyk, Marta Michalak-Kolarz, Joanna Glȕck","doi":"10.5604/01.3001.0055.4321","DOIUrl":"https://doi.org/10.5604/01.3001.0055.4321","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Primary chronic rhinosinusitis with nasal polyps (CRSwNP) is a severe, often uncontrolled disease whose pathomechanism involves type 2 inflammation (T2). Biologic drugs targeting interleukin 4 and 13 (dupilumab) receptors and blocking interleukin 5 (mepolizumab) have been approved for the treatment of the T2 endotype.&lt;b&gt;Aim:&lt;/b&gt; Presentation of the authors' suggestions that guided the choice of an appropriate biologic agent when initiating qualification for the treatment of patients with CRSwNP, based on the authors' experience and data from the literature related to biologic therapy.&lt;b&gt;Materials and methods:&lt;/b&gt; Patients with CRSwNP were qualified for biological treatment in accordance with the EPOS (European Position Paper on Rhinosinusitis) guidelines and the criteria of the B.156 drug program. The choice of an appropriate biologic was based on medical history data, such as the level of asthma control, presence of allergies, and the occurrence of N-ERD (nonsteroidal anti-inflammatory drug-exacerbated respiratory disease), as well as biomarker results: total IgE concentration and absolute blood eosinophil count.&lt;b&gt;Results:&lt;/b&gt; The study included 43 patients (23 treated with mepolizumab, 20 treated with dupilumab). Groups of patients were comparable in terms of age, sex, number of sinonasal surgeries, prevalence of asthma, NSAIDs (non-steroidal anti-inflammatory drugs) sensitivity, atopy and initial SNOT-22 (Sinonasal Outcome Test-22), VAS (Visual Analog Scale), NPS (Nasal Polyp Score), and L-K score (Lund-Kennedy score). Eosinophilia total range was 250-1000 cells/microL. Baseline peripheral blood eosinophil count was significantly higher in the mepolizumab-treated group. In the dupilumab-treated group, increases in eosinophil counts up to 3500 cells/μl were observed during therapy; however, no patient developed clinical features of hypereosinophilic syndrome.&lt;b&gt;Conclusions:&lt;/b&gt; When selecting a biologic drug for the treatment of CRSwNP, it is recommended to consider not only the values of available biomarkers, but also the degree of asthma control, the cumulative dose of oral corticosteroids (OCSs), the patient's age, and treatment convenience for the patient.</p>","PeriodicalId":520738,"journal":{"name":"Otolaryngologia polska = The Polish otolaryngology","volume":"79 6","pages":"1-8"},"PeriodicalIF":0.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145717203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Vestibular-Evoked Myogenic Potentials (cVEMPs) in Parkinson&apos;s Disease Patients: Prospective, Case-Control study.","authors":"Ahmed Ismail Abbas, Soliman S Ghanem, Elsayed Elsayed Abed, Ahmed Farag Ibrahim El-Adawy, Mohamed Hamed Rashad, Hayam Abdel-Tawab Mawad, Hossam Adel Hussein Hussein, Ibrahim Hassan Abdelhamid Mohamed, Mohammad Sayed Ali","doi":"10.5604/01.3001.0055.3301","DOIUrl":"10.5604/01.3001.0055.3301","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Postural stability depends on the integration of various neural circuits, including somatosensory, motor, visual, vestibular, and cognitive systems, which enable flexible posture and gait control. However, the understanding of vestibular otolith function and its brain connections remains limited.&lt;b&gt;Aim:&lt;/b&gt; To elucidate the anomalies of cervical vestibular-evoked myogenic potentials (cVEMPs) and their clinical correlation with symptoms associated with brainstem involvement in individuals with Parkinson's disease (PD).&lt;b&gt;Methods:&lt;/b&gt; This prospective, observational, case-control study consisted of 62 subjects: 31 idiopathic PD patients (cases) and 31 healthy volunteers (controls). Each participant underwent an otological examination, hearing evaluation, cVEMP test, and pull test. We also recorded the affected side, previous frequent falls, and illnesses duration.&lt;b&gt;Results:&lt;/b&gt; The mean Revised Movement Disorder Society Unified Parkinson's Disease Rating Scale Section III score was 14.10 8.42, and the mean scale of Hoehn and Yahr was 1.77 0.62. A statistically significant difference (P &lt; 0.001) was found between the two groups in cVEMP identification, with presence of response in almost two thirds of Parkinson's disease patients. In the case group, there was a considerable delay in the mean P13 and N23 latencies (P &lt; 0.001) and a significant reduction in the mean P13-N23 amplitude (P = 0.001).&lt;b&gt;Conclusions:&lt;/b&gt; cVEMP is a quick, easy, and noninvasive method to investigate brainstem dysfunction and the pathophysiological dynamics of the saccular section of the otolith and its central connection in patients with PD.</p>","PeriodicalId":520738,"journal":{"name":"Otolaryngologia polska = The Polish otolaryngology","volume":"79 6","pages":"9-14"},"PeriodicalIF":0.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biobanking of Salivary Gland Tumours: Insights from the Polish Salivary Gland Network Towards Future Digital Integration and Image-Based Research.","authors":"Małgorzata Wierzbicka, Wioletta Pietruszewska, Hanna Klimza, Dominik Stodulski, Jarosław Markowski, Aleksandra Piernicka-Dybich, Katarzyna Radomska, Alicja Chańko, Paweł Burduk, Daniel Majszyk, Boguslaw Mikaszewski, Patrycja Gazinska","doi":"10.5604/01.3001.0055.2973","DOIUrl":"https://doi.org/10.5604/01.3001.0055.2973","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Salivary gland tumours (SGTs) remain poorly represented in large-scale research due to low incidence and anatomical heterogeneity. Biobanking and data integration for SGTs remain particularly limited, as these tumours are often excluded from malignant tumour registries; even when data are collected centrally, they frequently lack sufficient detail and standardization, hindering harmonization and meaningful analysis.&lt;b&gt;Aim:&lt;/b&gt; To present the design and early implementation of the Polish Salivary Gland Network (PSGN), a multicentre initiative linking standardized clinical data with ISO 20387-compliant biobanking infrastructure for SGTs.&lt;b&gt;Materials and methods:&lt;/b&gt; The PSGN collects harmonized clinical, surgical, and pathological data from eight academic university departments across Poland (2017-2025). The data are managed using NorayBanks software, ensuring full traceability, regulatory compliance, and standardized data governance. This infrastructure lays the foundation for future digital integration, image-based research, and AI-supported analyses. Additional efforts focus on data quality assurance, process mapping, and dataset harmonization to enable multicentre interoperability and research scalability.&lt;b&gt;Results:&lt;/b&gt; As of 2025, the PSGN holds data on 3,654 patients with SGT (mean age: 58.3 years; 62% female), including &gt;70 clinicopathological variables per case. While parotid tumours dominate, ~3.7% involve rare sites such as the parapharyngeal space. The registry includes treatment details and key outcomes such as DFS, OS, and recurrence. Early findings suggest potential to inform clinical decision-making and uncover diagnostic challenges.&lt;b&gt;Conclusions:&lt;/b&gt; The PSGN is the first structured platform for SGT biobanking. It provides a foundation for data-driven research and sets the stage for future digital and molecular advancements in rare cancer studies.</p>","PeriodicalId":520738,"journal":{"name":"Otolaryngologia polska = The Polish otolaryngology","volume":"79 5","pages":"51-57"},"PeriodicalIF":0.6,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145423876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of physician experience on geriatric ENT care in ambulatory practice.","authors":"Dorota Świątek, Wioletta Pietruszewska, Kamila Sroka, Karolina Dżaman, Katarzyna Radomska, Małgorzata Wierzbicka","doi":"10.5604/01.3001.0055.2560","DOIUrl":"https://doi.org/10.5604/01.3001.0055.2560","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; As the global population continues to age, ear, nose, throat (ENT) physicians are confronted with increasing challenges in the management of elderly patients. On the other hand, it has been confirmed that physician experience plays a pivotal role in the care of certain demanding patient groups, including the elderly.&lt;b&gt;Aim:&lt;/b&gt; To evaluate the impact of physician experience, years in practice, and clinical caseload on the quality of otolaryngologic outpatient care in elderly patients.&lt;b&gt;Materials and methods:&lt;/b&gt; A nationwide survey of 115 Polish ENT physicians was conducted (March-June 2025) using a 29-question online form covering physician experience, elderly patient volume, symptoms, and care needs. Associations were analysed using Chi-square and Fisher's exact tests (p &lt; 0.05).&lt;b&gt;Results:&lt;/b&gt; In proportion to the increasing number of elderly patients attending outpatient clinics, the prevalence of certain ENT conditions rise, particularly hearing loss (p = 0.00042), dizziness (p = 0.00339), chronic sore throat (p = 0.00002), \"runny nose\" (p = 0.00048), dysphagia (p = 0.0361), and dysphonia (p = 0.00765). Clinics with more seniors needed more support staff and prescriptions. Senior physicians, compared to younger specialists, reported significantly higher monthly numbers of geriatric ENT conditions, including hearing loss (p = 0.00002), dizziness (p = 0.00171), chronic sore throat (p = 0.00000), and runny nose (p = 0.00845). Experienced doctors also better recognized side effects (p = 0.0243). Early-career physicians were more likely to support dedicated geriatric ENT services (special consultation hours and screening programs) (p = 0.0372). They also reported major difficulties related to access barriers (p = 0.0394). However, the majority across all experience levels recognized value for dedicated services (72%) and identified access barriers (78%).&lt;b&gt;Discussion:&lt;/b&gt; Physician experience influences how the needs of elderly patients are addressed. Senior doctors show stronger clinical judgment, while younger ones focus on system improvements. Findings highlight the need for elevating the skills for tailored multidisciplinary care in senior-heavy clinics.&lt;b&gt;Conclusions:&lt;/b&gt; Physician experience significantly affected the recognition of ENT conditions and medication side effects, while early-career physicians were more likely to support dedicated geriatric ENT services and reported more difficulties related to access barriers. The findings reflect a strong professional consensus on the need for tailored geriatric strategies in ambulatory settings and intensive training in this field. As demand rises, adapting ENT practice to meet the needs of older adults will be essential.</p>","PeriodicalId":520738,"journal":{"name":"Otolaryngologia polska = The Polish otolaryngology","volume":"79 5","pages":"45-50"},"PeriodicalIF":0.6,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145423917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental analysis of allergenic tree pollen deposition in a three-dimensional anatomical model of the adult nasal cavity.","authors":"Anna Rapiejko, Tomasz R Sosnowski, Krzysztof Sosnowski, Dariusz Jurkiewicz","doi":"10.5604/01.3001.0055.2572","DOIUrl":"https://doi.org/10.5604/01.3001.0055.2572","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Exposure to pollen allergens is one of the key environmental factors determining the occurrence of allergic rhinitis. In Central Europe, tree pollen plays a significant role in triggering symptoms of inhalant allergy in the spring months.Aim: This study evaluated the deposition of tree pollen grains in a 3D anatomical model of the adult nasal cavity under varying flow rates (5 L/min, 7.5 L/min, and 20 L/min per nostril).&lt;b&gt;Material and methods:&lt;/b&gt; Original methods of analysis were developed, including macroscopic analysis of photographs reflecting tree pollen deposits on the surface of the lateral wall of a printed 3D anatomical model of the nasal cavity and nasal septum, and microscopic evaluation of pollen collected from selected parts of the nasal geometry. The macroscopic analysis was supplemented with original software for the quantitative determination of areas covered with pollen deposits.&lt;b&gt;Results:&lt;/b&gt; The results showed statistically significant differences in the regional deposition of pollen grains of different sizes in the nasal cavity, depending on the flow conditions. The deposition of birch, alder, and hazel pollen grains in the nasal cavity exhibits similar characteristics, with significant differences between the individual segments of the lateral wall and the nasal septum. While the middle segment of the lateral wall accounted for the largest segment share of the total lateral wall deposition, the highest relative pollen deposition in relation to the segment area was found in the front segment. The posterior segment of the lateral wall showed a marginal contribution to the deposition process. The most significant percentage of the segment area of the nasal septum covered with pollen was recorded in the anterior segment. However, the posterior segment accounted for a larger share of the total septal deposition due to its larger surface area. Consistent findings describe deposits of large pollen grains from pine and spruce trees. The values of segmental pollen deposition in the anterior segment were significantly higher than in the other segments. The deposition on the nasal septum was significantly greater in the anterior than in the posterior segment. Lateral wall share % and septal share % tended to increase with increasing airflow through the nasal cavity, reaching their highest values at 20 L/min. The intensification of airflow led to a shift in the location of maximum pollen deposition towards the anterior sections of the nose, with a simultaneous reduction in pollen penetration into the posterior segments.&lt;b&gt;Conclusions:&lt;/b&gt; The study confirms the role of inertial effects in the flow and deposition of aerosols in the nasal cavity, indicating that the large size of pollen grains and higher airflow rates promote pollen deposition mainly in the anterior regions of the lateral wall and nasal septum. However, it also shows that other deposition mechanis","PeriodicalId":520738,"journal":{"name":"Otolaryngologia polska = The Polish otolaryngology","volume":"79 5","pages":"1-20"},"PeriodicalIF":0.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of reoperation of cochlear implants.","authors":"Katarzyna Radomska, Michał Mielnik, Klaudia Górnostaj, Alicja Chańko, Patrycja Mickiewicz, Renata Twardowska","doi":"10.5604/01.3001.0055.2531","DOIUrl":"https://doi.org/10.5604/01.3001.0055.2531","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; At the Department of Otolaryngology, USK1 PUM in Szczecin, 205 cochlear implant surgeries were performed between 2008 and 2023 in patients with bilateral profound sensorineural hearing loss. Reimplantation was necessary in 8 cases, 3 of which were primarily operated on outside our clinic. The re-implantation rate at the local centre is 2.4%.&lt;b&gt;Aim:&lt;/b&gt; The aim of this study was to analyse the reasons for reimplantation and the surgical procedure at the Department of Otolaryngology in Szczecin. In addition, changes in electrophysiological parameters of electrode impedance, transimpedance measurement, and neural response telemetry (NRT) were assessed.&lt;b&gt;Materials and methods:&lt;/b&gt; Electrophysiological tests (impedance and NRT) were measured before and after the reimplantation procedure, followed by statistical analysis of the changes in the values of the collected measurements.&lt;b&gt;Results:&lt;/b&gt; Reasons for reimplantation comprised: tip fold-over n = 2, extrusion of the implant n = 2, recurrent mastoiditis n = 1, recurrent chronic otitis media with cholesteatoma n = 1, failure of the internal part of the device n = 2. Healing was normal in all patients. Analysis shows that reimplantation leads to a change in impedance. The variability between patients is very significant. In contrast, for NRT, all patients had a decrease in recorded values or no change, but the variation in effect between patients was not significant, allowing the general conclusion that reimplantation typically causes a decrease in NRT values.&lt;b&gt;Discussion:&lt;/b&gt; Given the observed changes in NRT and impedance values in patients after reimplantation surgery, each patient should be treated as newly implanted during the activation of the cochlear implant speech processor.&lt;b&gt;Conclusions:&lt;/b&gt; Surgical re-treatment was successful in all cases. Post-treatment follow-up has shown that reimplantation allows continued successful use of the cochlear implant system.</p>","PeriodicalId":520738,"journal":{"name":"Otolaryngologia polska = The Polish otolaryngology","volume":"79 5","pages":"1-8"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annual epidemiologic trends of 6000 ENT cases in the Emergency Department in the post-pandemic era: a cross-sectional study from Crete, Greece.","authors":"Nikolaos Papadopoulos, Emmanuel Prokopakis, Manolis Linardakis, Alexander Karatzanis, Evangelia Mourellou, Emmanouil Symvoulakis","doi":"10.5604/01.3001.0055.2374","DOIUrl":"https://doi.org/10.5604/01.3001.0055.2374","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; The COVID-19 pandemic significantly altered healthcare-seeking trends, leading to reduced emergency department (ED) visits and changes in referral patterns. By temporally distancing from the pandemic, healthcare utilization trends might be re-explored.&lt;b&gt;Aim:&lt;/b&gt; This study aims to analyze the epidemiologic trends of ear, nose, and throat (ENT) cases at the ED of a tertiary hospital in Crete, Greece, after the COVID-19 pandemic. It investigates changes in patient visit patterns, referral trends, and hospitalization rates.&lt;b&gt;Materials and methods:&lt;/b&gt; A prospective design data collection was conducted on all patients examined by an ENT specialist in the ED of the tertiary hospital of Crete during 2024. Data collected included patients' demographics, diagnosis (ICD-10 coded), referrals, and patient outcomes. Specific Hospitalization Index (SHI) was calculated as a rate of the total cases admitted for a specific ICD-10 by all visits recorded for that ICD-10.&lt;b&gt;Results:&lt;/b&gt; A total of 6,000 patients were examined. The most common diagnoses were acute otitis media (8.1%) and external otitis (7.0%). A total of 373 hospital admissions (6.2%) were recorded, with peritonsillar abscess (91 cases, SHI: 0.892) being the leading cause of in-hospital treatment, followed by vestibular neuronitis (29 cases, SHI: 0.617) and Bell's palsy (26 cases, SHI: 0.268). A total of 196 referrals (3.3%) were recorded, with 49.6% originating from public primary care. A decline was observed in referrals, from public primary care settings, to the same hospital, when compared with 2023 data (p = 0.013).&lt;b&gt;Conclusions:&lt;/b&gt; This study underscores the significant role of ENT emergencies for ED workload, indicating a return to pre-pandemic levels of ED overcrowding. The most common diagnoses recorded provided a low SHI, suggesting that they could be managed on an outpatient basis. Future research should focus on enhancing primary care in managing ENT cases to reduce unnecessary ED visits.</p>","PeriodicalId":520738,"journal":{"name":"Otolaryngologia polska = The Polish otolaryngology","volume":"79 5","pages":"1-8"},"PeriodicalIF":0.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and Genotypic Evaluation of the Bitter Taste Receptor T2R38 in Chronic Rhinosinusitis.","authors":"Anna Długosz-Karbowska, Aleksandra Auguściak-Duma, Jarosław Markowski, Monika Szymańska-Czerwińska, Krzysztof Niemczuk, Krzysztof Piotr Jasik, Jarosław Paluch","doi":"10.5604/01.3001.0055.2373","DOIUrl":"10.5604/01.3001.0055.2373","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Chronic rhinosinusitis (CRS) is a multifactorial disease in which genetic predisposition plays a significant role. The bitter taste receptor T2R38, expressed in nasal and sinus mucosa, supports innate immunity. Single nucleotide polymorphisms (SNPs) in the &lt;i&gt;TAS2R38&lt;/i&gt; gene affect individuals' ability to perceive its agonist - phenylthiocarbamide (PTC) - as bitter. Carriers of non-functional variants often experience more severe CRS.&lt;b&gt;Aim:&lt;/b&gt; To evaluate the accuracy of the PTC taste strip test in determining the T2R38 phenotype and its correlation with genotype confirmed by molecular analysis. We also assessed associations between T2R38 polymorphisms, surgical outcomes, and COVID-19 incidence.&lt;b&gt;Material and methods:&lt;/b&gt; A total of 50 patients with CRS and 37 controls underwent a PTC taste strip test and completed a clinical questionnaire. &lt;i&gt;TAS2R38&lt;/i&gt; genotyping was performed using DNA extracted from peripheral blood and mucosal samples.&lt;b&gt;Results:&lt;/b&gt; The functional PAV variant strongly correlated with the ability to perceive PTC as bitter. Identified genotypes included &lt;i&gt;PAV/PAV, PAV/AVI, AVI/AVI&lt;/i&gt;, and rarer forms (&lt;i&gt;AAV/AVI, PAV/AAV&lt;/i&gt;). The &lt;i&gt;AVI/AVI&lt;/i&gt; genotype was associated with more severe CRS on CT scans. No significant association was found between genotype and surgical outcomes or COVID-19 incidence.&lt;b&gt;Discussion:&lt;/b&gt; Phenotypic taste testing may help identify individuals with impaired T2R38 function and poorer innate immune responses, allowing for more tailored treatment.&lt;b&gt;Conclusions:&lt;/b&gt; The PTC taste strip test is a simple, non-invasive tool that correlates well with &lt;i&gt;TAS2R38&lt;/i&gt; genotype and may support clinical decision-making in CRS.</p>","PeriodicalId":520738,"journal":{"name":"Otolaryngologia polska = The Polish otolaryngology","volume":"79 5","pages":"1-8"},"PeriodicalIF":0.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous occurrence ofcholesteatoma and vestibularschwannoma - surgicalchallenges and analysis ofpotential solutions.","authors":"Monika Zaborek-Łyczba, Andrzej Kucharski, Radosław Rola, Marcin Szymański","doi":"10.5604/01.3001.0055.1955","DOIUrl":"10.5604/01.3001.0055.1955","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Vestibular schwannoma (VS) is the most common cerebellopontinetumor, causing sensorineural hearing loss, tinnitus, and vertigo. Chronic otitis mediawith cholesteatoma presents with recurrent ear discharge and hearing loss, typicallyrequiring surgical intervention. Although the coexistence of VS and cholesteatoma israre, it creates complex diagnostic and therapeutic challenges that necessitate individualized management approaches.&lt;b&gt;Aim:&lt;/b&gt; : Considering the rare coexistence of VS and cholesteatoma, we aimed to analyze diagnostic patterns and therapeutic outcomes in our patient cohort.&lt;b&gt;Materials and methods:&lt;/b&gt; We reviewed four patients with simultaneous VS and cholesteatoma. One patient presented with cholesteatoma in one ear and VS in the contralateral ear, and underwent middle ear cholesteatoma removal via an endaural approach, followed by translabyrinthine VS resection. The other three patients had ipsilateral lesions; two were managed with a transotic approach for the simultaneous removal of both lesions, while one underwent closed-cavity cholesteatoma surgery, with a cerebellopontine angle tumor subsequently detected and treated with gamma knife radiosurgery.&lt;b&gt;Results:&lt;/b&gt; During a follow-up period of two to four years, no residual or recurrent cholesteatoma or tumor was observed in all patients except the one treated with gammaknife, who remained stable post-treatment.&lt;b&gt;Conclusions:&lt;/b&gt; A tailored treatment strategy based on tumor stage, hearing status, patient age, and cholesteatoma characteristics resulted in favorable functional and anatomical outcomes. The coexistence of cholesteatoma and VS should be consideredin the differential diagnosis of hearing loss. Our findings underscore the importanceof a multidisciplinary approach in managing these rare concurrent conditions, ultimately optimizing hearing preservation and overall quality of life.</p>","PeriodicalId":520738,"journal":{"name":"Otolaryngologia polska = The Polish otolaryngology","volume":"79 4","pages":"40-47"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in the Absolute Distance of the Mandibular Condylar Processes after Orthognathic Surgery.","authors":"Jacek Rożko, Paweł Grab, Michał Szałwiński, Aldona Chloupek, Maria Sobol","doi":"10.5604/01.3001.0055.1536","DOIUrl":"https://doi.org/10.5604/01.3001.0055.1536","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Orthognathic surgery is a branch of maxillofacial surgery specializing in the correction of malocclusion, facial asymmetries, and other jaw and facial deformities that may be congenital, acquired, or trauma-related. Surgical treatment of skeletal deformities of the facial part of the skull may lead to changes in the distance between the mandibular condylar processes.&lt;b&gt;Aim:&lt;/b&gt; The aim of this study is to mathematically assess the impact of orthognathic procedures on the position of mandibular condylar processes based on measurements obtained from imaging studies.&lt;b&gt;Materials and methods:&lt;/b&gt; A group of 30 individuals with skeletal Class II or III underwent bimaxillary orthognathic surgery (BiMax). Preoperative diagnostics and postoperative outcomes (6 months after surgery) were evaluated using computed tomography. Statistical analysis was performed on the obtained measurements.&lt;b&gt;Results:&lt;/b&gt; The results showed that the absolute distance between mandibular condylar processes decreased following treatment. Statistically significant results were observed only in patients with skeletal Class III at a significance level of α=0.05.&lt;b&gt;Conclusions:&lt;/b&gt; Changes in the absolute distance between mandibular condylar processes indicate an indirect impact of orthognathic surgery on these structures. The presented results may serve as a basis for further consideration of the correlation between the discussed medical procedures and changes occurring in adjacent anatomical structures not directly affected by the surgery.</p>","PeriodicalId":520738,"journal":{"name":"Otolaryngologia polska = The Polish otolaryngology","volume":"79 4","pages":"29-33"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}