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Tumor heterogeneity and implications for clinical practice. 肿瘤异质性及其对临床实践的影响。
Oncology (Williston Park, N.Y.) Pub Date : 2014-09-01
Edward Chu
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引用次数: 0
Tumor heterogeneity: the Lernaean hydra of oncology? 肿瘤异质性:肿瘤学的勒纳水螅?
Oncology (Williston Park, N.Y.) Pub Date : 2014-09-01
Michalina Janiszewska, Francisco Beca, Kornelia Polyak
{"title":"Tumor heterogeneity: the Lernaean hydra of oncology?","authors":"Michalina Janiszewska, Francisco Beca, Kornelia Polyak","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520728,"journal":{"name":"Oncology (Williston Park, N.Y.)","volume":" ","pages":"781-2, 784"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32670965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroendocrine tumors: answers-and questions. 神经内分泌肿瘤:答案和问题。
Oncology (Williston Park, N.Y.) Pub Date : 2014-09-01
Matthew Kulke
{"title":"Neuroendocrine tumors: answers-and questions.","authors":"Matthew Kulke","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520728,"journal":{"name":"Oncology (Williston Park, N.Y.)","volume":" ","pages":"758, 760"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32670517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An update on gastroenteropancreatic neuroendocrine tumors. 胃肠胰神经内分泌肿瘤的最新进展。
Oncology (Williston Park, N.Y.) Pub Date : 2014-09-01
Mauro Cives, Jonathan Strosberg
{"title":"An update on gastroenteropancreatic neuroendocrine tumors.","authors":"Mauro Cives,&nbsp;Jonathan Strosberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of neoplasms arising from the diffuse neuroendocrine system. The incidence of GEP-NETs has increased markedly over the past 3 decades, probably as a result of trends in imaging and improvements in diagnosis. Advances in molecular biology have translated into an expansion of treatment options for patients with GEP-NETs. Somatostatin analogs, initially developed for control of hormonal syndromes, have recently been proven to inhibit tumor growth. Newer drugs, targeting angiogenesis and mammalian target of rapamycin (mTOR) pathways, have been approved for progressive pancreatic NETs; however, their role in nonpancreatic NETs remains controversial. Alkylating cytotoxic agents, such as streptozocin and temozolomide, play an important role in the treatment of pancreatic NETs, although estimated response rates vary widely and phase III data are lacking. During the next few years, randomized clinical trials are expected to provide more clarity regarding the role of radiolabeled somatostatin analogs. Predictive biomarkers that would allow for individualized selection of treatments are needed. </p>","PeriodicalId":520728,"journal":{"name":"Oncology (Williston Park, N.Y.)","volume":" ","pages":"749-56, 758"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32670516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Routine use of maintenance therapy in follicular lymphoma: the strategy is effective, raising the question, 'what is the most important measure of success in the current era?'. 滤泡性淋巴瘤常规使用维持治疗:该策略是有效的，提出了一个问题，“在当今时代，最重要的成功衡量标准是什么?”
Oncology (Williston Park, N.Y.) Pub Date : 2014-09-01
Loretta J Nastoupil
{"title":"Routine use of maintenance therapy in follicular lymphoma: the strategy is effective, raising the question, 'what is the most important measure of success in the current era?'.","authors":"Loretta J Nastoupil","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520728,"journal":{"name":"Oncology (Williston Park, N.Y.)","volume":" ","pages":"786, 793"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32670966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of the patient with postpartum breast cancer. 产后乳腺癌患者的处理。
Oncology (Williston Park, N.Y.) Pub Date : 2014-09-01
Virginia F Borges
{"title":"Management of the patient with postpartum breast cancer.","authors":"Virginia F Borges","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520728,"journal":{"name":"Oncology (Williston Park, N.Y.)","volume":" ","pages":"768-70"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32670962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Waiting for a miracle. 等待奇迹的出现。
Oncology (Williston Park, N.Y.) Pub Date : 2014-09-01
Paul R Helft
{"title":"Waiting for a miracle.","authors":"Paul R Helft","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520728,"journal":{"name":"Oncology (Williston Park, N.Y.)","volume":" ","pages":"811-2"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32670647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PET scanning: worth the cost in cancer? Not only worth the cost, but sometimes a cost-cutter! PET扫描:治疗癌症值得吗?不仅物有所值，有时还会降低成本!
Oncology (Williston Park, N.Y.) Pub Date : 2014-05-01
Eric M Rohren
{"title":"PET scanning: worth the cost in cancer? Not only worth the cost, but sometimes a cost-cutter!","authors":"Eric M Rohren","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520728,"journal":{"name":"Oncology (Williston Park, N.Y.)","volume":" ","pages":"390, 392"},"PeriodicalIF":0.0,"publicationDate":"2014-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32488020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The bifunctional role of steroid hormones: implications for therapy in prostate cancer. 类固醇激素的双重功能作用:前列腺癌治疗的意义。
Oncology (Williston Park, N.Y.) Pub Date : 2014-05-01
Paul Mathew
{"title":"The bifunctional role of steroid hormones: implications for therapy in prostate cancer.","authors":"Paul Mathew","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ablation of the androgen-signaling axis is currently a dominant theme in developmental therapeutics in prostate cancer. Highly potent inhibitors of androgen biosynthesis and androgen receptor (AR) function have formally improved survival in castration-resistant metastatic disease. Resistance to androgen-ablative strategies arises through diverse mechanisms. Strategies to preserve and extend the success of hormonal therapy while mitigating the emergence of resistance have long been of interest. In preclinical models, intermittent hormonal ablative strategies delay the emergence of resistant stem-cell-driven phenotypes, but clinical studies in hormone-naive disease have not observed more than noninferiority over continual androgen ablation. In castration-resistant disease, response and improvement in subjective quality of life with therapeutic testosterone has been observed, but so too has symptomatic and life-threatening disease acceleration. The multifunctional and paradoxical role of steroid hormones in regulating proliferation and differentiation, as well as cell death, requires deeper understanding. The lack of molecular biomarkers that predict the outcome of hormone supplementation in a particular clinical context remains an obstacle to individualized therapy. Biphasic patterns of response to hormones are identifiable in vitro, and endocrine-regulated neoplasms that proliferate after prolonged periods of hormone deprivation appear preferentially sex steroid-suppressible. This review examines the relevance of a translational framework for studying therapeutic androgens in prostate cancer.</p>","PeriodicalId":520728,"journal":{"name":"Oncology (Williston Park, N.Y.)","volume":" ","pages":"397-404"},"PeriodicalIF":0.0,"publicationDate":"2014-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32490137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The long road--and the high road--to successful implementation of OncoEMR. 成功实施OncoEMR的道路是漫长的，也是崇高的。
Oncology (Williston Park, N.Y.) Pub Date : 2014-05-01
Mark Rubin, Lucio Gordan, Tim Boozan
{"title":"The long road--and the high road--to successful implementation of OncoEMR.","authors":"Mark Rubin,&nbsp;Lucio Gordan,&nbsp;Tim Boozan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We believe that no matter where a practice currently is in the EMR process--vetting products or companies to determine what will best meet its needs, implementing the new product just selected, or trying to take maximum advantage of the product already in use--we hope these suggestions, based on our experience, will contribute to your anticipated success. It is not uncommon for practices to become overwhelmed in the choice, implementation, and utilization of their EMR. What distinguishes those practices that are successful in their use of the EMR is their commitment to the product and their recognition that it is the central element in the treatment of their patients. Consistently exploring better ways to use OncoEMR, staying educated about the changes that occur, and taking full advantage of its best features will keep it simple and actionable for your practice.</p>","PeriodicalId":520728,"journal":{"name":"Oncology (Williston Park, N.Y.)","volume":" ","pages":"361-2, 364"},"PeriodicalIF":0.0,"publicationDate":"2014-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32488015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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