Multiple sclerosis (Houndmills, Basingstoke, England)最新文献

{"title":"Longitudinal magnetic resonance spectroscopy study of metabolite changes over 2 years in relapsing and primary progressive multiple sclerosis treated with ocrelizumab.","authors":"Erin L MacMillan, Bretta Russell-Schulz, Glaynel Alejo, Christopher Harp, Briana Cameron, Ryan Winger, Sherman Jia, Ann Herman, Jasmyne Kassam, Michael Waine, Irene M Vavasour, Helen Cross, Roger Tam, Anthony L Traboulsee, Robert Carruthers, Shannon H Kolind","doi":"10.1177/13524585261456964","DOIUrl":"10.1177/13524585261456964","url":null,"abstract":"<p><strong>Background: </strong>Magnetic resonance spectroscopy (MRS) offers non-invasive assessments of neuron-oligodendrocyte coupling and neuroinflammation to monitor treatment response in multiple sclerosis (MS).</p><p><strong>Objective: </strong>To track changes in N-acetylaspartate and myo-inositol in relapsing MS (RMS) and primary progressive MS (PPMS) patients treated with ocrelizumab over 2 years.</p><p><strong>Methods: </strong>Single-voxel MRS at 3T was acquired at baseline in 10 healthy controls (HCs), and weeks 0, 12, 24, 52, and 96 in MS participants at a single center.</p><p><strong>Results: </strong>Baseline myo-inositol was higher in PPMS than RMS (<i>p</i> = 0.047) and HC (<i>p</i> = 0.001), and correlated with disability across both MS groups (<i>r</i> = 0.57, <i>p</i> = 0.0006). Following treatment with ocrelizumab, both RMS and PPMS demonstrated declines in myo-inositol over time, returning toward HC levels (RMS <i>p</i> = 0.016; PPMS <i>p</i> = 0.004). Conversely, N-acetylaspartate was not different between groups and remained stable over time.</p><p><strong>Conclusion: </strong>Ocrelizumab treatment is associated with declining myo-inositol levels measured by MRS in both RMS and PPMS. Myo-inositol offers a unique biomarker to track resolution of gliosis and reactive microglia with treatment. Furthermore, the relationship between a higher concentration of myo-inositol and greater disability across both MS subtypes at baseline supports the presence of \"smouldering inflammation\" as a disease process across the spectrum of MS.</p><p><strong>Clinical trial: </strong>Sub-study of the Ocrelizumab Biomarker Outcome Evaluation (OBOE; ML29966) trial: https://clinicaltrials.gov/study/NCT02688985.</p>","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1155-1167"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TSPO-PET-measurable neuroinflammation associates with information processing speed decline in multiple sclerosis.","authors":"Maija Saraste, Taru Nikkilä, Markus Matilainen, Päivi Hämäläinen, Saara Wahlroos, Johan Rajander, Anniina Snellman, Juha Rinne, Laura Airas","doi":"10.1177/13524585261446839","DOIUrl":"10.1177/13524585261446839","url":null,"abstract":"<p><strong>Background: </strong>Impaired information processing speed (IPS) is a common and disabling cognitive deficit in multiple sclerosis (MS).</p><p><strong>Objectives: </strong>To assess whether glial activation measured using translocator protein-positron emission tomography (TSPO-PET) predicts performance and long-term change on the Symbol Digit Modalities Test (SDMT).</p><p><strong>Methods: </strong>Forty-eight people with MS underwent [¹¹C]PK11195 TSPO-PET, magnetic resonance imaging (MRI), diffusion tensor imaging and SDMT at baseline; 34 repeated SDMT a median (first to third quartile) 4.9 (3.7-5.2) years later. Glial activation was quantified using the distribution volume ratio (DVR). Multivariable regression models were used to identify predictors of baseline SDMT and subsequent change.</p><p><strong>Results: </strong>Normal-appearing white matter (NAWM) radial diffusivity (estimate [95% confidence interval (CI)] -129 [-214, -44]), thalamic DVR (-52.5 [-94.8, -10.2]) and age (-0.57 [-1.07, -0.06]) explained 41% of baseline SDMT variance. NAWM DVR was the strongest predictor of SDMT change, explaining 53% of variance when adjusted for baseline SDMT (-6.23 [-8.55, -3.91]). A model including lesion rim DVR (odds ratio 1.36 [1.06, 1.73]) and baseline SDMT (1.18 [1.01, 1.37]) predicted SDMT decline with 73% sensitivity and 83% specificity (area under the curve [AUC] = 0.85).</p><p><strong>Conclusion: </strong>Diffuse neuroinflammation in the NAWM is associated with future SDMT change, suggesting a potential role for chronic glial activation in IPS deterioration in MS.</p>","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1193-1204"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148102505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteroviral infections with antiCD20 therapies-A class effect?","authors":"Jakob Stögbauer, Mathias Fousse","doi":"10.1177/13524585261444588","DOIUrl":"10.1177/13524585261444588","url":null,"abstract":"","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1342-1343"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal vessel diameters in multiple sclerosis: associations with disability, cardiovascular risk factors and retinal atrophy.","authors":"Kean Schoenholzer, Shaumiya Sellathurai, Federico Burguet Villena, Nuria Cerdá-Fuertes, Sveva Giulia Franchi, Lisa Hofer, Sabine Anna Schaedelin, Bettina Fischer-Barnicol, Vanny Phavanh, Pascal Benkert, Tobias Derfuss, Ludwig Kappos, Cristina Granziera, Jens Kuhle, Konstantin Gugleta, Christoph Hauser, Henner Hanssen, Athina Papadopoulou","doi":"10.1177/13524585261489425","DOIUrl":"10.1177/13524585261489425","url":null,"abstract":"<p><strong>Objective: </strong>To investigate if retinal vessel diameters on fundus imaging may be related to disability in people with multiple sclerosis and explore underlying mechanisms.</p><p><strong>Methods: </strong>People with multiple sclerosis received standardized static retinal vessel analysis to assess central retinal arteriolar and venular equivalents, neurological examination for the Expanded Disability Status Scale and optical coherence tomography for the macular ganglion cell-inner plexiform layer. Linear mixed-effect models and logistic regression were employed.</p><p><strong>Results: </strong>One hundred and seventy-nine people with multiple sclerosis (median age: 44 years, Expanded Disability Status Scale: 2.0, central retinal arteriolar equivalent: 184 µm, central retinal venular equivalent: 221 µm) were included. Retinal vessel diameters were related to age (central retinal arteriolar equivalent: <i>p</i> < 0.001, central retinal venular equivalent: <i>p</i> = 0.009), arterial hypertension (central retinal arteriolar equivalent: <i>p</i> = 0.008), higher body mass index (central retinal arteriolar equivalent: <i>p</i> = 0.042), and smoking (central retinal arteriolar equivalent: <i>p</i> = 0.028, central retinal venular equivalent: <i>p</i> < 0.001). A 5 μm decrease in vessel diameter increased the odds of being in the high (⩾4) Expanded Disability Status Scale group by 23.5% for central retinal arteriolar equivalent (<i>p</i> = 0.026) and 23.9% for central retinal venular equivalent (<i>p</i> = 0.018), after adjustment for age, treatment and cardiovascular risk factors. When additionally adjusting for macular ganglion cell-inner plexiform layer, the associations did not remain (central retinal arteriolar equivalent-Expanded Disability Status Scale: <i>p</i> = 0.355; central retinal venular equivalent-Expanded Disability Status Scale: <i>p</i> = 0.107). However, the area under the curve of these models was higher (0.883-0.896) compared to the models using only retinal vessels (0.836-0.837) or only macular ganglion cell-inner plexiform layer (0.858).</p><p><strong>Interpretation: </strong>Retinal vessel diameters show cross-sectional associations with cardiovascular risk factors, retinal atrophy and disability in people with multiple sclerosis, while longitudinal studies are warranted.</p>","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1266-1277"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Committees.","authors":"","doi":"10.1177/13524585261477850","DOIUrl":"https://doi.org/10.1177/13524585261477850","url":null,"abstract":"","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":"32 4_suppl","pages":"1-3"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affective reserve in older adults with and without multiple sclerosis: A residual-based approach.","authors":"Elizabeth S Gromisch, Frederick W Foley, Mark E Wagshul, Roee Holtzer","doi":"10.1177/13524585261480508","DOIUrl":"10.1177/13524585261480508","url":null,"abstract":"<p><strong>Background: </strong>The concept of affective reserve has been proposed, but not operationalized, as a buffer designed to regulate mood and behavior in response to adverse events. This study derived a residual-based metric of affective reserve and evaluated whether it mediated associations between having multiple sclerosis and subjective well-being in older adults.</p><p><strong>Methods: </strong>Sociodemographics and brain pathology metrics were regressed against a composite mood, extraversion, and consciousness variable to derive affective reserve in a sample of older adults with multiple sclerosis (<i>n</i> = 107) and without (<i>n</i> = 104). Linear regressions were run to examine the associations between affective reserve and well-being, measured with the Short Form-12 Mental Composite Summary and Physical Composite Summary. Hayes' PROCESS was used to evaluate affective reserve as a mediator between group status and well-being.</p><p><strong>Results: </strong>Affective reserve was positively associated with both Mental Composite Summary and Physical Composite Summary. After covariate adjustments, affective reserve fully mediated the relationship between having multiple sclerosis and Mental Composite Summary (<i>b</i> = 1.350, 95% confidence interval: 0.142-2.591) and partially mediated the association between multiple sclerosis and Physical Composite Summary (<i>b</i> = 0.915, 95% confidence interval: 0.073-1.906).</p><p><strong>Conclusion: </strong>This residual-based metric offers a novel approach for measuring affective reserve. Not only is it associated with both physical and mental well-being, but it explained the relationship between the latter and the presence of multiple sclerosis.</p>","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1214-1222"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility, validity, feasibility and acceptability of a clinician-administered depression, two-question screening tool for routine multiple sclerosis clinic administration.","authors":"Lisa Grech, Michelle Allan, David Skvarc, Ruby Hamer, Emily Friedel, Victor Chong, Andrew Giles, Jayashri Kulkarni, Jennifer Neil, Deepa Rajendran, Nevin John, Martin Short, Sally Shaw, Nigel Caswell, Vanessa Fanning, Ernest Butler","doi":"10.1177/13524585261435415","DOIUrl":"10.1177/13524585261435415","url":null,"abstract":"<p><strong>Background: </strong>Depression is prevalent among individuals with multiple sclerosis (MS) yet frequently goes undetected and untreated. Time constraints are a barrier to depression screening in MS clinics. We evaluated the clinical utility, diagnostic accuracy and feasibility of the Two-Question Screening tool (2QS) for routine, in-clinic depression screening.</p><p><strong>Objectives: </strong>A prospective cross-sectional study of 207 consecutively recruited adults with MS (M<i>age</i> = 47.3 ± 12.7, 77.3% female) was conducted at a metropolitan MS Clinic. Clinicians administered the 2QS during in-clinic or telehealth consultations. To assess the sensitivity and specificity of the 2QS in identifying depression, participants underwent a Structured Clinical Interview for <i>Diagnostic and Statistical Manual for Mental Disorders - Fifth Edition</i> (SCID-5) for major depressive disorder (MDD), Patient Health Questionnaire-9 (PHQ-9), and the Depression, Anxiety and Stress Scale-21 (DASS-21). Internal consistency, convergent validity and clinician feasibility were assessed.</p><p><strong>Results: </strong>The 2QS had 100% (95% CI: 71%-100%) sensitivity and 68% (95% CI: 60%-76%) specificity for detecting MDD. Clinician screening adherence was 76%. For the in-clinic subsample, clinician-administered 2QS correlations were SCID-5 MDD, <i>r</i> = 0.39 (<i>r</i> = 0.60 with subthreshold depression symptoms added); PHQ-9, <i>r</i> = 0.73; and DASS-D, <i>r</i> = 0.74.</p><p><strong>Conclusions: </strong>Clinician-administered 2QS is valid and feasible for routine depression screening at MS clinic appointments. With high sensitivity and acceptable specificity, the clinician-administered 2QS is suitable to improve depression detection in people with MS.</p>","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1205-1213"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional data on autologous hematopoietic stem cell transplantation in multiple sclerosis.","authors":"Guillermo J Ruiz-Argüelles","doi":"10.1177/13524585261472335","DOIUrl":"10.1177/13524585261472335","url":null,"abstract":"","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1223"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AHSCT versus high-efficacy DMTs in highly active MS: A perspective.","authors":"Antonio Bertolotto, Sabdi Valverde","doi":"10.1177/13524585261472338","DOIUrl":"10.1177/13524585261472338","url":null,"abstract":"","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1224-1225"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epiretinal membranes in multiple sclerosis: A window into glial pathobiology?","authors":"Stephanie Syc-Mazurek, John J Chen","doi":"10.1177/13524585261464504","DOIUrl":"10.1177/13524585261464504","url":null,"abstract":"","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1231-1232"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148393311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}