Journal of the renin-angiotensin-aldosterone system : JRAAS最新文献_第5页

The effects of the renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance in hypertensive families. 肾素-血管紧张素-醛固酮系统基因多态性对高血压家族胰岛素抵抗的影响。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2012-12-01 Epub Date: 2012-03-14 DOI: 10.1177/1470320312438790

Chin-Fu Hsiao, Wayne W H Sheu, Yi-Jen Hung, Ming-Wei Lin, David Curb, Koustubh Ranadex, Thomas Quertermous, Yue-Ming Chen, Ida Yi-Der Chen, Kwan-Dun Wu

{"title":"The effects of the renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance in hypertensive families.","authors":"Chin-Fu Hsiao, Wayne W H Sheu, Yi-Jen Hung, Ming-Wei Lin, David Curb, Koustubh Ranadex, Thomas Quertermous, Yue-Ming Chen, Ida Yi-Der Chen, Kwan-Dun Wu","doi":"10.1177/1470320312438790","DOIUrl":"https://doi.org/10.1177/1470320312438790","url":null,"abstract":"Introduction: The hereditability of insulin resistance has been demonstrated in both familial and twin studies. The effects of renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance remain inconclusive.Methods: This is a sibling-based association study. Polymorphisms of renin-angiotensin-aldosterone system genes were examined in 1113 hypertension and 676 normotension siblings from Chinese and Japanese hypertensive families. The generalized estimation equations method was used to compare the differences in metabolic variables between hypertension and normotensive siblings.Results: For the G-6A polymorphism of AGT, GG siblings had lower 2-h insulin than siblings carrying the A allele (p=0.006). Siblings with different variants of the angiotensin II type 1 receptor A1166C had no difference in metabolic variables. Siblings carrying the D allele of the angiotensin converting enzyme gene had higher levels of fasting glucose, fasting insulin, area under the curve of insulin levels and the homeostasis model assessment of insulin resistance than II siblings (all p<0.05). Lower levels of fasting glucose and 2-h glucose were observed in siblings with the T allele than their CC homozygotes for the C-344T polymorphism of CYP11B2 (p<0.05). Siblings carrying three high-risk genotypes of the angiotensin converting enzyme, angiotensinogen and CYP11B2 had higher fasting glucose level than siblings carrying no high-risk genotypes (p=0.011).Conclusion: Our comprehensive analysis of renin-angiotensin-aldosterone system gene polymorphisms demonstrates that the angiotensin converting enzyme and CYP11B2 gene polymorphisms are associated with insulin resistance in hypertensive families.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"446-54"},"PeriodicalIF":2.9,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320312438790","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40167203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Angiotensin-converting enzyme I/D polymorphism is not associated with type 2 diabetes in a Chinese population. 血管紧张素转换酶I/D多态性与中国人群2型糖尿病无关

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2012-09-01 Epub Date: 2012-03-05 DOI: 10.1177/1470320311435535

Donghao Zhou, Rikje Ruiter, Jingling Zhang, Ming'ai Zhou, Hongjun Liu, Weidong Liu, Shengxiang Wang

{"title":"Angiotensin-converting enzyme I/D polymorphism is not associated with type 2 diabetes in a Chinese population.","authors":"Donghao Zhou, Rikje Ruiter, Jingling Zhang, Ming'ai Zhou, Hongjun Liu, Weidong Liu, Shengxiang Wang","doi":"10.1177/1470320311435535","DOIUrl":"https://doi.org/10.1177/1470320311435535","url":null,"abstract":"Objective: A role for the angiotensin-converting enzyme (ACE) gene has been suggested in the aetiology of type 2 diabetes (T2DM). However, results have been inconsistent. In this study, we performed a meta-analysis to further clarify the association between ACE I/D polymorphism and T2DM risk in a Chinese population.Methods: PubMed, EMBASE, CNKI and Wan Fang Data were searched for eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a fixed-effects model or random-effects model.Results: : A total of 41 studies (4708 cases and 5368 controls) for the association between ACE I/D polymorphism and T2DM in a Chinese population were identified. The pooled ORs for the association between ACE I/D polymorphism and T2DM risk were not statistically significant under all genetic models (co-dominant model: DD vs. II: OR = 1.17, 95% CI 0.97-1.42 and ID vs. II: OR = 1.01, 95% CI 0.93-1.10; dominant model: OR = 1.06, 95% CI 0.94-1.19; multiplicative model: OR = 1.08, 95% CI 0.98-1.18). Although a marginally significant association was observed under a recessive model (OR = 1.17, 95% CI 1.00-1.36), robustness of this estimate could not be established under additional sensitivity analyses.Conclusions: : The meta-analysis presented in this study indicated that ACE I/D polymorphism may not be associated with the risk of T2DM in the Chinese population.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"372-8"},"PeriodicalIF":2.9,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320311435535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40143335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Diagnostics of primary aldosteronism: is obligatory use of confirmatory tests justified? 原发性醛固酮增多症的诊断:是否有必要进行确证性检查?

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2012-09-01 Epub Date: 2012-03-08 DOI: 10.1177/1470320312438791

Janusz Myśliwiec, Łukasz Zukowski, Anna Grodzka, Agata Piłaszewicz, Szymon Dragowski, Maria Górska

{"title":"Diagnostics of primary aldosteronism: is obligatory use of confirmatory tests justified?","authors":"Janusz Myśliwiec, Łukasz Zukowski, Anna Grodzka, Agata Piłaszewicz, Szymon Dragowski, Maria Górska","doi":"10.1177/1470320312438791","DOIUrl":"https://doi.org/10.1177/1470320312438791","url":null,"abstract":"Introduction: Assessment of the renin-angiotensin-aldosterone system has been recently granted a much greater role in the evaluation of patients with arterial hypertension. There is no single test efficient in selection of patients for second-step etiological investigation.Methods: Altogether, 198 consecutive patients--119 women (60%) and 79 men (40%)--hospitalized in years 2009-2011 at the Clinical Department of Endocrinology Medical University of Bialystok were diagnosed with primary aldosteronism. In each patient, plasma renin activity and plasma aldosterone concentration (basic and after 2 l NaCl infusion) were evaluated.Results: The percentage of patients with plasma aldosterone concentration ≥ 15 ng/ml was 53 and the percentage of patients with plasma renin activity ≤ 0.1 ng/ml/h was 20. The percentage of patients screened for primary aldosteronism in which the aldosterone:renin ratio exceeded consecutive cut-offs of 20, 30, 40 and 50 were respectively 57, 45, 34 and 29. Among 15 patients in which plasma aldosterone concentration after infusion of 2 l of saline was ≥ 6.5 ng/dl (8.6%), 13 (6.6%) were diagnosed with primary aldosteronism.Conclusion: The obligatory use of tests confirming autonomy of aldosterone secretion in patients screened for primary aldosteronism seems cost-effective in limiting the number of patients for further diagnosis.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"367-71"},"PeriodicalIF":2.9,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320312438791","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40154840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Renin and prorenin have no direct effect on aldosterone synthesis in the human adrenocortical cell lines H295R and HAC15. 肾素和前肾素对人肾上腺皮质细胞系H295R和HAC15的醛固酮合成无直接影响。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2012-09-01 Epub Date: 2012-03-06 DOI: 10.1177/1470320312438792

Pieter M Jansen, Johannes Hofland, Anton H van den Meiracker, Frank H de Jong, A H Jan Danser

{"title":"Renin and prorenin have no direct effect on aldosterone synthesis in the human adrenocortical cell lines H295R and HAC15.","authors":"Pieter M Jansen, Johannes Hofland, Anton H van den Meiracker, Frank H de Jong, A H Jan Danser","doi":"10.1177/1470320312438792","DOIUrl":"https://doi.org/10.1177/1470320312438792","url":null,"abstract":"Introduction: Transgenic rats expressing the human (pro)renin receptor (h(P)RR) have elevated plasma aldosterone levels despite unaltered levels, in plasma and adrenal, of renin and angiotensin II.Materials and methods: To investigate whether renin/prorenin-(P)RR interaction underlies these elevated aldosterone levels, the effect of (pro)renin on steroidogenesis was compared with that of angiotensin II in two (P)RR-expressing human adrenocortical cell lines, H295R and HAC15. Angiotensin II rapidly induced extracellular signal-regulated kinase (ERK) phosphorylation and increased the expression of STAR, CYP21A2, CYP11B2, and CYP17A1 at 6 and 24 hours, whereas the expression of CYP11A1 and HSD3B2 remained unaltered. Incubation with renin or prorenin at nanomolar concentrations had no effect on the expression of any of the steroidogenic enzymes tested, nor resulted in ERK phosphorylation. Angiotensin II, but not renin or prorenin, induced aldosterone production.Conclusion: Although the (P)RR is present in adrenocortical cells, renin and prorenin do not elicit ERK phosphorylation nor directly affect steroid production via this receptor at nanomolar concentrations. Thus, direct (pro)renin-(P)RR interaction is unlikely to contribute to the elevated aldosterone levels in human (P)RR transgenic rats. This conclusion also implies that the aldosterone rise that often occurs during prolonged renin-angiotensin system blockade is rather due to the angiotensin II 'escape' during such blockade.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"360-6"},"PeriodicalIF":2.9,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320312438792","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40145218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Ontogeny of angiotensin type 2 and type 1 receptor expression in mice. 小鼠血管紧张素2型和1型受体表达的个体发生。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2012-09-01 Epub Date: 2012-04-22 DOI: 10.1177/1470320312443720

Juan Gao, Jie Chao, Karma-Jaya K Parbhu, Li Yu, Liang Xiao, Fei Gao, Lie Gao

{"title":"Ontogeny of angiotensin type 2 and type 1 receptor expression in mice.","authors":"Juan Gao, Jie Chao, Karma-Jaya K Parbhu, Li Yu, Liang Xiao, Fei Gao, Lie Gao","doi":"10.1177/1470320312443720","DOIUrl":"https://doi.org/10.1177/1470320312443720","url":null,"abstract":"In the current experiment, we determined angiotensin type 2 receptor (AT2R) and angiotensin type 1 receptor (AT1R) protein expression by western blot analysis in developing normal mice. The results indicate that: (1) in all detected brain regions and in the spinal cord, adult mice exhibited significantly higher AT2R expression and lower AT1R expression in total protein extracts compared to fetuses and neonates; (2) other major organs, including heart, lung, liver and kidney, exhibited the same expression pattern as the brain and spinal cord; (3) reciprocal changes in AT2R and AT1R expression were found in the total protein extracts from the brainstems of mice from one-day prenatal to six weeks of age, and there was a negative correlation between AT2R and AT1R protein expression; (4) in both membrane and cytosolic fractions from the brainstem, adult mice exhibited higher AT2R and lower AT1R expression than did fetuses and neonates; and (5) in the brainstem, there were no significant differences in AT2R and AT1R messenger RNA (mRNA) levels among fetal, neonatal and adult mice. The above results reconfirmed our previous finding in rats that adult animals have higher AT2R and lower AT1R expression compared to fetuses and neonates. These data imply an involvement of AT1R in fetal development and of AT2R in adult function.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"341-52"},"PeriodicalIF":2.9,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320312443720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40176791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Influence of diabetes on efficacy of aliskiren, losartan or both on left ventricular mass regression. 糖尿病对阿利克伦、氯沙坦或两者治疗左心室肿块消退疗效的影响。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2012-06-01 Epub Date: 2012-03-13 DOI: 10.1177/1470320312437893

Orly Vardeny, Anne-Catherine Pouleur, Madoka Takeuchi, Evan Appelbaum, Anil Verma, Margaret Prescott, Beverly Smith, Bjorn Dahlof, Scott D Solomon

{"title":"Influence of diabetes on efficacy of aliskiren, losartan or both on left ventricular mass regression.","authors":"Orly Vardeny, Anne-Catherine Pouleur, Madoka Takeuchi, Evan Appelbaum, Anil Verma, Margaret Prescott, Beverly Smith, Bjorn Dahlof, Scott D Solomon","doi":"10.1177/1470320312437893","DOIUrl":"https://doi.org/10.1177/1470320312437893","url":null,"abstract":"Unlabelled: HYPOTHESIS/ INTRODUCTION: We investigated whether diabetes modified the effectiveness of renin-angiotensin-aldosterone system (RAAS) inhibition on left ventricular hypertrophy (LVH) regression in hypertensive patients in the Aliskiren in Left Ventricular Hypertrophy (ALLAY) trial.Materials and methods: Participants (n=465) with LVH and a BMI > 25 kg/m(2) were randomized to aliskiren 300mg, losartan 100mg or both daily for 36 weeks, and LVH regression was assessed by cardiac magnetic resonance imaging. Renin concentration, plasma renin activity and aldosterone were assessed in a subset of patients.Results: Patients with diabetes mellitus (DM) (n=111, 24%) were older (61±9 vs. 58±11 years, p=0.03), had higher BMI (32.2±4.2 vs. 30.7 ± 4 kg/m(2), p=0.004), higher systolic blood pressure (148±14 vs. 145±14mmHg, p=0.03) and lower eGFR (79±16 vs. 84±16ml/min, p=0.03) at baseline. Combination therapy with aliskiren plus losartan was associated with greater LVH reduction than losartan alone in patients with DM (p=0.01), but not in patients without DM (p=0.91; unadjusted interaction p=0.06; adjusted p = 0.038). In a subset of 138 participants, plasma aldosterone was reduced to a greater extent in patients with DM (p-interaction = 0.004).Conclusions: Patients with DM and LVH may derive differential benefit with dual RAAS inhibition with a combination of aliskiren and losartan compared with losartan alone with respect to LVH reduction. Whether these findings will result in improved outcomes will be further explored in larger studies.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"265-72"},"PeriodicalIF":2.9,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320312437893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40163321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Association of ACE I/D gene polymorphism with vesicoureteral reflux susceptibility in children: a meta-analysis. ACE I/D基因多态性与儿童膀胱输尿管反流易感性的关联:一项荟萃分析

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2012-06-01 Epub Date: 2012-03-06 DOI: 10.1177/1470320312437892

Tian-Biao Zhou, Na Lin, Yun-Guang Liu, Yuan-Han Qin, Ming-Bin Shao, Dan-Dan Peng

{"title":"Association of ACE I/D gene polymorphism with vesicoureteral reflux susceptibility in children: a meta-analysis.","authors":"Tian-Biao Zhou, Na Lin, Yun-Guang Liu, Yuan-Han Qin, Ming-Bin Shao, Dan-Dan Peng","doi":"10.1177/1470320312437892","DOIUrl":"https://doi.org/10.1177/1470320312437892","url":null,"abstract":"Background and objective: Many studies have been conducted to investigate the association between angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism and vesicoureteral reflux (VUR) susceptibility. However, the results from those studies are still conflicting. We performed a meta-analysis of studies relating the ACE I/D gene polymorphism to the risk of VUR.Method: We searched the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of 1 March 2011, and recruited the eligible investigations for this meta-analysis.Results: Ten investigations were identified for the analysis of association between ACE I/D gene polymorphism and VUR risk: six in Caucasians, three in East-Asians and one in a Turkish population. All the investigations were performed in children. There was no marked association between ACE I/D gene polymorphism and VUR susceptibility/renal scar for overall populations, Caucasians and East-Asians. In the Turkish population, D allele and DD genotype were associated with the VUR susceptibility/renal scar. Furthermore, ACE I/D gene polymorphism was not associated with VUR progression.Conclusions: D allele and DD genotype are risk factors for the VUR susceptibility/renal scar in Turkish children. However, more case-control association investigations on larger, stratified populations are required in the future.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"273-81"},"PeriodicalIF":2.9,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320312437892","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40145219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma. ACE2和Mas受体在人结肠腺癌中的表达及意义。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2012-03-01 Epub Date: 2011-11-02 DOI: 10.1177/1470320311426023

Stella Bernardi, Cristina Zennaro, Silvia Palmisano, Elena Velkoska, Nicoletta Sabato, Barbara Toffoli, Greta Giacomel, Luigi Buri, Fabrizio Zanconati, Giuseppe Bellini, Louise M Burrell, Nicolò De Manzini, Bruno Fabris

{"title":"Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma.","authors":"Stella Bernardi, Cristina Zennaro, Silvia Palmisano, Elena Velkoska, Nicoletta Sabato, Barbara Toffoli, Greta Giacomel, Luigi Buri, Fabrizio Zanconati, Giuseppe Bellini, Louise M Burrell, Nicolò De Manzini, Bruno Fabris","doi":"10.1177/1470320311426023","DOIUrl":"https://doi.org/10.1177/1470320311426023","url":null,"abstract":"Introduction: A new arm of the renin-angiotensin system (RAS) has been recently characterized; this includes angiotensin converting enzyme (ACE)2 and angiotensin (Ang)1-7, a heptapeptide acting through the Mas receptor (MasR). Recent studies show that Ang1-7 has an antiproliferative action on lung adenocarcinoma cells. The aim of this study was to characterize RAS expression in human colon adenocarcinoma and to investigate whether Ang1-7 exerts an antiproliferative effect on human colon adenocarcinoma cells.Materials and methods: Gene, protein expression and enzymatic activity of the main components of the RAS were determined on non-neoplastic colon mucosa as well as on the tumor mass and the mucosa taken 5 cm distant from it, both collected from patients with colon adenocarcinoma. Two different human colon cancer cell lines were treated with AngII and Ang1-7.Results: The novel finding of this study was that MasR was significantly upregulated in colon adenocarcinoma compared with non-neoplastic colon mucosa, which showed little or no expression of it. ACE gene expression and enzymatic activity were also increased in the tumors. However, AngII and Ang1-7 did not have any pro-/antiproliferative effects in the cell lines studied.Conclusions: The data suggest that upregulation of the MasR could be used as a diagnostic marker of colon adenocarcinoma.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"202-9"},"PeriodicalIF":2.9,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320311426023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40125264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

No association between ACE polymorphism and risk of nasopharyngeal carcinoma. ACE多态性与鼻咽癌风险无相关性。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2012-03-01 Epub Date: 2011-11-07 DOI: 10.1177/1470320311426168

Zhao-Hui Li, Xin-Min Pan, Bao-Wei Han, Hong-bin Han, Zhen Zhang, Lin-Bo Gao

{"title":"No association between ACE polymorphism and risk of nasopharyngeal carcinoma.","authors":"Zhao-Hui Li, Xin-Min Pan, Bao-Wei Han, Hong-bin Han, Zhen Zhang, Lin-Bo Gao","doi":"10.1177/1470320311426168","DOIUrl":"https://doi.org/10.1177/1470320311426168","url":null,"abstract":"Emerging evidence has shown that angiotensin I-converting enzyme (ACE) plays pivotal roles not only in the regulation of cardiovascular homeostasis but also in the process of tumorigenesis. A common ACE I/D polymorphism has been found to be functional, with the D allele displaying a higher plasma ACE level and ACE activity. The purpose of this study was to investigate whether the ACE I/D polymorphism was related to the risk of nasopharyngeal carcinoma (NPC). The study included 175 patients with NPC and 279 age- and sex-matched control subjects. The ACE I/D polymorphism was identified by a polymerase chain reaction analysis. No association was found between the ACE I/D polymorphism and risk of NPC (ID vs. II: odds ratio [OR] = 0.77, 95% confidence interval [CI] 0.51-1.17; DD vs. II: OR = 0.98, 95%CI 0.56-1.72, respectively). This finding indicates that the ACE I/D polymorphism may not play a role in susceptibility to NPC. Further studies are warranted to confirm this finding, especially in ethnically disparate populations.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"210-5"},"PeriodicalIF":2.9,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320311426168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40137663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Efficacy in angiotensin receptor blockade: a comparative review of data with olmesartan. 血管紧张素受体阻断的疗效:与奥美沙坦的比较回顾。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2009-09-01 Epub Date: 2009-08-03 DOI: 10.1177/1470320309342735

Josep Redon, Maria Jose Fabia

引用次数: 20