Journal of the renin-angiotensin-aldosterone system : JRAAS最新文献_第3页

Exploring the Mystery of Angiotensin-Converting Enzyme II (ACE2) in the Battle against SARS-CoV-2. 探索血管紧张素转换酶II (ACE2)在抗击SARS-CoV-2中的奥秘。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2021-06-04 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9939929

Divakar Sharma, Juhi Sharma, Amit Singh

{"title":"Exploring the Mystery of Angiotensin-Converting Enzyme II (ACE2) in the Battle against SARS-CoV-2.","authors":"Divakar Sharma, Juhi Sharma, Amit Singh","doi":"10.1155/2021/9939929","DOIUrl":"https://doi.org/10.1155/2021/9939929","url":null,"abstract":"COVID-19 is the newly born pandemic caused by the SARS-CoV-2 virus, which is the recently emerged betacoronavirus that crosses the species barrier. It predominantly infects pneumocytes of the respiratory tract, but due to the presence of angiotensin-converting enzyme II (ACE2) on other cells like surface enterocytes of the upper esophagus and colon, these are also considered as the primary sites of infection. ACE2 receptor served as a cellular entry point for SARS-CoV-2. The expression of the ACE2 receptors is regulated by several factors such as age, tobacco smoking, inflammatory signaling, ACE inhibitors, angiotensin receptor blockers, and comorbidities (chronic obstructive pulmonary disease (COPD), tuberculosis, cerebrovascular disease, coronary heart disease, hypertension, and diabetes). Therefore, scientists are trying to explore the in-depth knowledge of ACE2 and considered it as a potential indirect target for COVID-19 therapeutics. In this focused review, we discussed in detail ACE2 expressions and regulation by different factors in the primary or vulnerable sites of SARS-CoV-2 infections. Clinical trials of rhACE2 in COVID-19 patients are ongoing, and if the outcome of the trials proves positive, it will be a breakthrough for the management of COVID-19. Finally, we suggest that targeting the ACE2 (a master regulator) in a balanced way could serve as a potential option against the management of COVID-19.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"9939929"},"PeriodicalIF":2.9,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39204480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Assessment of Alamandine in Pulmonary Fibrosis and Respiratory Mechanics in Rodents. almanmanine对啮齿动物肺纤维化及呼吸力学的影响。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2021-05-18 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9975315

Renata Streck Fernandes, Henrique Bregolin Dias, Wynnie Amaral de Souza Jaques, Tiago Becker, Katya Rigatto

{"title":"Assessment of Alamandine in Pulmonary Fibrosis and Respiratory Mechanics in Rodents.","authors":"Renata Streck Fernandes, Henrique Bregolin Dias, Wynnie Amaral de Souza Jaques, Tiago Becker, Katya Rigatto","doi":"10.1155/2021/9975315","DOIUrl":"https://doi.org/10.1155/2021/9975315","url":null,"abstract":"Introduction: Pulmonary fibrosis (PF) is characterized by an accelerated decline in pulmonary function and has limited treatment options. Alamandine (ALA) is a recently described protective peptide of the renin-angiotensin system (RAS) with essential tasks in several conditions. Our group previously demonstrated that ALA is reduced by 365% in the plasma of patients with idiopathic PF, and thus, it is plausible to believe that stimulation of this peptide could represent an important therapeutic target. In this sense, this study investigates the effects of ALA in an experimental model of PF.Materials and methods: Bleomycin (BLM) was administrated in Wistar rats, and these fibrotic animals were treated with ALA for 14 days. Body weight, histology, respiratory, and hemodynamic parameters were analyzed to study the effects of ALA.Results: ALA treatment attenuated the development of fibrosis (P < 0.0001), reduced respiratory system elastance (P < 0.0001), and preserved weight gain (P < 0.0001) in fibrotic animals without affecting the autonomic control of blood pressure and heart rate.Conclusion: The data from this study demonstrate the potential of ALA to alleviate pulmonary fibrosis and improve respiratory system mechanics in vivo. The promising results encourage more detailed investigations of the potential of ALA as a future and efficient antifibrotic.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"9975315"},"PeriodicalIF":2.9,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39202999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Possible Benefit of Angiotensin II Receptor Blockers in COVID-19 Patients: A Case Series. 血管紧张素II受体阻滞剂对COVID-19患者可能的益处:一个病例系列

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2021-05-13 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9951540

Su Jin Lee, Taehwa Kim, Woo Hyun Cho, Doosoo Jeon, Seungjin Lim

{"title":"Possible Benefit of Angiotensin II Receptor Blockers in COVID-19 Patients: A Case Series.","authors":"Su Jin Lee, Taehwa Kim, Woo Hyun Cho, Doosoo Jeon, Seungjin Lim","doi":"10.1155/2021/9951540","DOIUrl":"https://doi.org/10.1155/2021/9951540","url":null,"abstract":"Introduction: Dysfunction in the renin-angiotensin-aldosterone system (RAAS) has been observed in patients with coronavirus disease 2019 (COVID-19). It is presumed that the effect of reducing interleukin-6 (IL-6) levels by angiotensin II receptor blockers (ARBs) by RAAS modulation. We investigated changes in angiotensin II and IL-6 levels in four COVID-19 patients treated with ARBs. Case Presentation. Cases 1 and 2 were who had not received ARBs before and were newly administered ARBs. Case 3 restarted ARBs after discontinuation for 7 days, and case 4 received an increased dose of ARBs. The mean in angiotensin II levels (607.5 pg/mL, range: 488-850 pg/mL, reference range < 100 pg/mL), C-reactive protein (CRP) (10.58 mg/dL, range 4.45-18.05 mg/dL), and IL-6 (55.78 pg/mL, range: 12.86-144.82 pg/mL, reference range < 7 pg/mL) was observed at the admission in all patients. Upon clinical improvement, the mean decrease in CRP (1.02 mg/dL, range 0.06-3.78 mg/dL) and IL-6 (5.63 pg/mL, range 0.17-20.87 pg/mL) was observed in all patients. Conversely, angiotensin II levels gradually increased.Conclusion: This report supports the potential benefit of ARBs to improve the clinical outcomes of COVID-19 patients by controlling RAAS dysfunction.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"9951540"},"PeriodicalIF":2.9,"publicationDate":"2021-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39202997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy. ACE基因的插入-删除多态性与妊娠末期女性血压升高有关。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2015-09-01 Epub Date: 2013-10-22 DOI: 10.1177/1470320313501217

Evgeny A Reshetnikov, Ludmila Y Akulova, Irina S Dobrodomova, Volodymyr Y Dvornyk, Alexey V Polonikov, Mikhail I Churnosov

{"title":"The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy.","authors":"Evgeny A Reshetnikov, Ludmila Y Akulova, Irina S Dobrodomova, Volodymyr Y Dvornyk, Alexey V Polonikov, Mikhail I Churnosov","doi":"10.1177/1470320313501217","DOIUrl":"https://doi.org/10.1177/1470320313501217","url":null,"abstract":"Introduction: Malfunctioning of the cardiovascular system during pregnancy may be responsible for adverse effects on the 'mother-fetus' system. The cardiovascular system of a pregnant woman develops adaptation to the increased load. Angiotensin-converting enzyme (ACE) is known to play an important role in the adaptation. The present study was designed to investigate whether the insertion-deletion (I/D) polymorphism of the ACE gene is associated with the level of arterial blood pressure in women before and during pregnancy.Materials and methods: The level of blood pressure was measured in 591 Russian women (Central Russia) before and during (37-40 weeks term) pregnancy. The women were divided into three groups which were hypertensive, hypotensive, and normotensive according to blood pressure level. Genotyping of the ACE I/D polymorphism was performed using polymerase chain reaction (PCR) and amplified fragment length polymorphism assay.Results: Women with genotype DD showed the highest blood pressure level both during and at the end of pregnancy (p<0.05). The highest frequencies of allele D and genotype DD were found in pregnant women in the hypertensive group.Conclusions: The deletion variant of the ACE gene is associated with high blood pressure level at the end of pregnancy.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"623-32"},"PeriodicalIF":2.9,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320313501217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40259525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

A meta-analysis of the association between angiotensin-converting enzyme insertion/ deletion gene polymorphism and the risk of overweight/obesity. 血管紧张素转换酶插入/缺失基因多态性与超重/肥胖风险相关性的荟萃分析

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2015-09-01 Epub Date: 2013-10-22 DOI: 10.1177/1470320313501218

Song Mao, Songming Huang

{"title":"A meta-analysis of the association between angiotensin-converting enzyme insertion/ deletion gene polymorphism and the risk of overweight/obesity.","authors":"Song Mao, Songming Huang","doi":"10.1177/1470320313501218","DOIUrl":"https://doi.org/10.1177/1470320313501218","url":null,"abstract":"Background and objective: The association between angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and the risk of overweight/obesity remains controversial. A meta-analysis was conducted to evaluate the association between ACE I/D gene polymorphism and overweight/obesity susceptibility.Method: All eligible studies were included in this meta-analysis by searching PubMed, Embase and Cochrane databases through April 2013 according to a predefined criteria.Results: Fourteen case-control studies including 3371 cases and 4490 controls were recruited for the analysis of the association between ACE I/D gene polymorphism and overweight/obesity susceptibility. A significant association was observed between DD genotype and overweight/obesity risk in overall populations and Africans (p=0.014 and 0.010, respectively). D allele was associated with the risk of overweight/ obesity in Africans (p=0.026). However, II genotype might not be a protective factor against overweight/obesity risk in overall populations, Africans, Caucasians and Asians.Conclusions: DD genotype is a risk factor for the overweight/obesity susceptibility in overall populations, particularly in Africans. D allele is a risk factor for the overweight/obesity susceptibility in Africans. Further larger studies are needed to confirm our findings.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"687-94"},"PeriodicalIF":2.9,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320313501218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40259524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Angiotensin II AT1 receptor blockade by telmisartan reduces impairment of spatial maze performance induced by both acute and chronic stress. 替米沙坦阻断血管紧张素II AT1受体可降低急性和慢性应激引起的空间迷宫表现障碍。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2015-09-01 Epub Date: 2014-03-12 DOI: 10.1177/1470320314526269

Dominik Wincewicz, Jan J Braszko

{"title":"Angiotensin II AT1 receptor blockade by telmisartan reduces impairment of spatial maze performance induced by both acute and chronic stress.","authors":"Dominik Wincewicz, Jan J Braszko","doi":"10.1177/1470320314526269","DOIUrl":"https://doi.org/10.1177/1470320314526269","url":null,"abstract":"Introduction: Despite recognition of stress as a causation of severe neuropsychological dysfunctions, no casual and clinically effective anti-stress therapeutic strategy has yet been found. We have previously shown that blockade of initial stress response by angiotensin receptor blockers alleviates the negative effect of prolonged stress on cognitive non-spatial functions of rats. Here we aimed to find whether telmisartan reduces stress-related memory decline in spatial hippocampal-dependent learning tasks conditioned upon differences in level of stress induced by aversive nature of memory tests.Methods: Male Wistar rats were exposed to chronic restraint stress for three weeks and daily treated with either vehicle or telmisartan (1 mg/kg). Afterwards rats were tested in three spatial learning and memory paradigms: Morris water maze (MWM), radial arm maze (RAM), and Barnes maze (BM).Results: Stressed animals demonstrated significantly impaired performance in all the tests, which was normalized in the animals stressed and treated with telmisartan. Interestingly, despite the fact that MWM and RAM are more stressful, which affects animal behavior, therefore considered less sensitive than BM, more significant effect of telmisartan was found in MWM and RAM than BM.Conclusions: AT1 angiotensin receptor blockade attenuates negative effect of both acute and chronic stress on spatial memory.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"495-505"},"PeriodicalIF":2.9,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320314526269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40303083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Increased circulatory RAS activity can be inhibited by statins in patients with hypercholesterolemia. 他汀类药物可抑制高胆固醇血症患者循环RAS活性的增加。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2015-03-01 Epub Date: 2013-03-28 DOI: 10.1177/1470320313483349

Huang Long, Ling Wang, Hai Su, Jinsong Xu, Juxiang Li, Qiang Peng, Yifei Dong, Xiaoshu Cheng

{"title":"Increased circulatory RAS activity can be inhibited by statins in patients with hypercholesterolemia.","authors":"Huang Long, Ling Wang, Hai Su, Jinsong Xu, Juxiang Li, Qiang Peng, Yifei Dong, Xiaoshu Cheng","doi":"10.1177/1470320313483349","DOIUrl":"https://doi.org/10.1177/1470320313483349","url":null,"abstract":"Objective: The objective of this paper is to investigate a profile on circulatory renin-angiotensin system (RAS) activity in hypercholesterolemic (HC) patients treated with statins.Methods: Eighteen primary HC patients and 18 sex- and age-matched healthy adults were included in this study as controls. Total cholesterol (TC), triglyceride (TG), LDL-C, blood glucose, angiotensin-converting enzyme (ACE) activity, and angiotensin II (Ang II) levels were measured before and four and eight weeks after beginning statin treatment in the HC group. Similar measurements were taken in the control group at baseline.Results: At baseline, TC, TG and LDL-C levels, as well as ACE activity and Ang II concentrations, were significantly higher in the HC group than in the control group. Based on the baseline data collection of 36 participants, there were significant positive correlations between ACE activity and TC (r = 0.54) or LDL-C (r = 0.51), and between Ang II level and TC (r = 0.34) or LDL-C (r = 0.27). TC, LDL-C, Ang II (35.46 ± 14.49 vs 71.10 ± 20.47 pg/ml, p < 0.05) levels and ACE activity (108.9 ± 51.9 vs 180.1 ± 71.3 U/L, p < 0.05) were decreased in HC patients eight weeks after starting statin treatment. In HC patients, RAS activity correlated positively with TC and LDL-C levels before and after treatment.Conclusions: In HC patients, lowering serum cholesterol with statins is associated with decreased circulatory RAS activity.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"126-30"},"PeriodicalIF":2.9,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320313483349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40235117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Importance of the time of initiation of mineralocorticoid receptor antagonists on risk of mortality in patients with heart failure. 矿皮质激素受体拮抗剂起始时间对心力衰竭患者死亡风险的重要性。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2015-03-01 Epub Date: 2013-03-28 DOI: 10.1177/1470320313482603

Rosario Rossi, Nicola Crupi, Francesca Coppi, Daniel Monopoli, Fabio Sgura

{"title":"Importance of the time of initiation of mineralocorticoid receptor antagonists on risk of mortality in patients with heart failure.","authors":"Rosario Rossi, Nicola Crupi, Francesca Coppi, Daniel Monopoli, Fabio Sgura","doi":"10.1177/1470320313482603","DOIUrl":"https://doi.org/10.1177/1470320313482603","url":null,"abstract":"Introduction: Several studies have definitively shown the benefit of mineralocorticoid receptor antagonists (MRAs) in patients with heart failure (HF). However, very few prior studies examined the relationship between the timing of initiation of MRAs and prognosis. In addition, on this topic, there is no information regarding the specific population of patients suffering a first episode of decompensated congestive HF.Methods: We studied a homogenous cohort of patients discharged alive from our hospital after a first episode of decompensated congestive HF, in order to clarify the association between time of aldosterone receptor antagonist (ARA) initiation (within the first 90 days after hospital discharge) and mortality. Our population was composed of a series of consecutive patients. All-cause mortality was compared between patients who initiated MRAs at discharge (early group) and those who initiated MRAs one month later and up to 90 days after discharge (delayed group). We used prescription time distribution matching to control for survival difference between groups.Results: The early and delayed groups consisted of 365 and 320 patients, respectively. During the one-year follow-up, a significant difference in mortality was demonstrated between groups. Adjusted hazard ratios (HRs) for early versus delayed initiation were 1.72 (95% confidence interval (CI) 0.96 to 2.84) at six months, and 1.93 (95% CI 1.18 to 3.14) at one year.Conclusions: Delay of MRA initiation up to 30 to 90 days after discharge implies a significant increase in mortality compared with MRA initiation at discharge, after a first episode of decompensate congestive HF.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"119-25"},"PeriodicalIF":2.9,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320313482603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40235116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Impact of electrocardiographic findings for diagnosis of left ventricular hypertrophy in patients with primary aldosteronism. 原发性醛固酮增多症患者左心室肥厚诊断的心电图结果的影响。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2015-03-01 Epub Date: 2013-03-27 DOI: 10.1177/1470320313482604

Satoshi Kurisu, Toshitaka Iwasaki, Naoya Mitsuba, Ken Ishibashi, Yoshihiro Dohi, Yasuki Kihara

{"title":"Impact of electrocardiographic findings for diagnosis of left ventricular hypertrophy in patients with primary aldosteronism.","authors":"Satoshi Kurisu, Toshitaka Iwasaki, Naoya Mitsuba, Ken Ishibashi, Yoshihiro Dohi, Yasuki Kihara","doi":"10.1177/1470320313482604","DOIUrl":"https://doi.org/10.1177/1470320313482604","url":null,"abstract":"Background: Compared to patients with similar levels of hypertension, patients with primary aldosteronism have a greater left ventricular hypertrophy (LVH). The presence of LVH should be detected as early as possible to prevent cardiovascular complications associated with the condition. We evaluated comparative diagnostic value of electrocardiographic (ECG) indexes for LVH in patients with primary aldosteronism.Methods: ECG and echocardiographic data were obtained in 88 patients with primary aldosteronism. We analyzed the four most commonly used ECG indexes, including Sokolow-Lyon index, Cornell voltage index, Cornell product index, and Gubner index.Results: Echocardiographic LVH was found in 35 patients (40%). Sensitivity ranged from 0% for Gubner index to 49% for Cornell product index. Specificity ranged from 81% for Sokolow-Lyon index to 100% for Gubner index. Sokolow-Lyon index (r=0.43, p<0.001), Cornell voltage index (r=0.55, p<0.001) and Cornell product index (r=0.52, p<0.001) correlated significantly with left ventricular mass (LVM) index. No significant correlation was found between Gubner index and LVM index.Conclusions: ECG indexes had a reasonably high specificity, but a low sensitivity for LVH in patients with primary aldosteronism. Cornell voltage index and Cornell product index had a better diagnostic value of LVH, and had a better correlation with LVM index in these patients.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"131-6"},"PeriodicalIF":2.9,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320313482604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40230904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2. 心肌细胞H9c2中ATIP及其变异的功能和表达。

IF 2.9

Journal of the renin-angiotensin-aldosterone system : JRAAS Pub Date : 2015-03-01 Epub Date: 2013-04-04 DOI: 10.1177/1470320313483845

Naghmeh Varghayee, Michael A Krezel, Linda Rezmann, Laurie Chow, Albert George Frauman, William J Louis, Simon N Louis

{"title":"Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2.","authors":"Naghmeh Varghayee, Michael A Krezel, Linda Rezmann, Laurie Chow, Albert George Frauman, William J Louis, Simon N Louis","doi":"10.1177/1470320313483845","DOIUrl":"https://doi.org/10.1177/1470320313483845","url":null,"abstract":"Hypothesis: Cardiac hypertrophy in myocytes is in part regulated by changes in expression of a novel Ang II type 2 receptor (AT2-receptor) interacting protein identified as ATIP.Introduction: The role of the AT2-receptor in cardiac hypertrophy is controversial, with some reports indicating that AT2-receptor activation has detrimental effects on disease progression, whereas others indicate that it has a beneficial role.Materials and methods: In an effort to unravel this paradox, we examined the expression and function of ATIP in cell-based models of cardiac hypertrophy using QPCR, immunohistochemistry, cell proliferation, morphological and transfection techniques in H9c2 cardio-myoblast and myotubules.Results: These studies indicate that in cultured cardio-myoblast and myotubules, Ang II mediates cellular hypertrophy and proliferation solely via the AT1-receptor, the ATIP variants are abundantly expressed and that ATIP3 may play an anti-proliferative/hypertrophic role in these cells in the absence of AT2-receptor expression or activation.Conclusions: Previously ATIP has been shown to inhibit growth factor signalling in cancerous cells via an interaction with the AT2-receptor. This is the first report to identify that ATIP may have a similar role in other disease states characterised by excessive growth and indicates that for ATIP3, at least, an interaction with the AT2-receptor may not be necessary.","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"79-91"},"PeriodicalIF":2.9,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1470320313483845","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40246765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1