Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation最新文献

{"title":"The Association of Serum Bicarbonate With Psychological and Physical Health-Related Quality of Life in Patients Receiving Maintenance Hemodialysis: A Secondary Analysis of the Frequent Hemodialysis Network Daily Trial.","authors":"Katherine Scovner Ravi, Enass Elsayed, Glenn M Chertow, Finnian R Mc Causland","doi":"10.1053/j.jrn.2025.05.007","DOIUrl":"10.1053/j.jrn.2025.05.007","url":null,"abstract":"<p><strong>Introduction: </strong>Serum bicarbonate (S_BIC) is a surrogate for acid-base. Although higher and lower S_BIC concentrations are associated with mortality in patients receiving maintenance hemodialysis (HD), the association of S_BIC with patient-reported outcomes is unclear.</p><p><strong>Methods: </strong>Using data from the Frequent Hemodialysis Network Daily Trial, we performed linear and repeated measures random effects regression to assess the association of pre-HD S_BIC with general well-being (feeling thermometer score), Beck Depression Inventory (BDI) score, and Physical Health Composite score.</p><p><strong>Results: </strong>Among the 244 subjects included in this study, mean age was 50 ± 14 years, 39% were women, and 42% were Black. Compared with S_BIC 25-<28 mEq/L, S_BIC <22 mEq/L and S_BIC ≥28 mEq/L were associated with lower feeling thermometer scores (-3.4; 95% confidence interval [CI] -10.3, +3.5 and -4.4; 95% CI -12.2, +3.4, respectively); S_BIC levels ≥28 mEq/L were associated with higher BDI scores (4.3; 95% CI + 0.5, +8.1). Compared with S_BIC 25-<28 mEq/L in the adjusted repeated measures analysis, S_BIC <22 mEq/L and S_BIC ≥28 mEq/L were associated with lower feeling thermometer scores (-5.1; 95% CI -9.1, -1.1 and -3.7; 95% CI -8.2, +0.7, respectively); S_BIC levels ≥28 mEq/L were associated with higher BDI scores (1.5; 95% CI -0.0, +3.1). There was no association of S_BIC with Physical Health Composite score.</p><p><strong>Conclusion: </strong>Higher and lower pre-HD S_BIC were associated with a lower sense of general well-being and higher S_BIC was associated with more pronounced depressive symptoms. Whether normalization of S_BIC could enhance the well-being of patients receiving maintenance dialysis is unclear.</p>","PeriodicalId":520689,"journal":{"name":"Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of protein supplementation on health-related quality of life in individuals with advanced chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.","authors":"Yasmin Iman, Krista Rossum, Amanda Krueger, Favian Co, Makan Pourmasoumi, Ruth Ewhrudjakpor, Nicole Askin, Rebecca C Mollard, Clara Bohm","doi":"10.1053/j.jrn.2025.08.003","DOIUrl":"https://doi.org/10.1053/j.jrn.2025.08.003","url":null,"abstract":"<p><strong>Objective: </strong>We performed a systematic review and meta-analysis to evaluate the effect of protein/amino acid supplementation on health-related quality of life (HRQOL) in advanced chronic kidney disease (CKD) including individuals on dialysis.</p><p><strong>Methods: </strong>Medline, Cochrane Central, Embase and CINAHL were searched from (establishment until August 2022) for randomized controlled trials evaluating the effect of protein or amino acid supplementation (> 5 g/day) in individuals with advanced CKD (eGFR < 30 ml/min and/or on dialysis). Primary outcome was change in HRQOL. Secondary outcomes included biochemical, anthropometric measures, and physical function. Two reviewers independently screened articles for inclusion based on pre-specified criteria, extracted data and assessed risk of bias. Meta-analysis was performed by pooling mean difference or standardized mean difference using a random effects model if at least 3 included studies reported our pre-specified outcomes.</p><p><strong>Results: </strong>Of 5699 articles, 17 were included for analysis. We found no improvement in HRQOL in qualitative synthesis of 4 studies. Protein and/or amino acid supplementation was associated with an improvement in serum albumin (MD = 1.76 g/L, 95% CI [0.67, 2.84], P=0.002, I² = 88%) and body mass index (MD = 0.29 kg/m², 95%CI [0.10, 0.49], P=0.004, I²=0%), as compared with controls.</p><p><strong>Conclusion: </strong>Small number of studies prevented meta-analysis for HRQOL. Statistically significant improvements in serum albumin and BMI were observed with protein supplementation compared to controls. Small number of studies, high risk of bias and heterogeneity of included studies support the need for rigorous clinical trials investigating the effect of protein supplementation on patient-relevant outcomes.</p>","PeriodicalId":520689,"journal":{"name":"Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Mitochondrial Targeting with Bioactive Compounds: Dietary Pattern Considerations for Patients with Chronic Kidney Disease.","authors":"Valeria Cecchini, Dario Troise, Alice Sabatino, Antonella Cicirelli, Greta Hallergård, Carla Maria Avesani, Peter Stenvinkel","doi":"10.1053/j.jrn.2025.08.002","DOIUrl":"https://doi.org/10.1053/j.jrn.2025.08.002","url":null,"abstract":"<p><p>Mitochondrial dysfunction plays a central role in chronic kidney disease (CKD) pathogenesis and progression. It is associated with inflammation, oxidative stress, and cellular senescence. In this regard, targeting the restoration of mitochondrial function could potentially delay disease progression and alleviate uremic symptoms. Notably, bioactive compounds, naturally present in food, have recently gained attention due to their potential to counteract mitochondrial dysfunction. These compounds include a diverse array of phytonutrients, such as antioxidants, vitamins and polyphenols, but also omega-3 fatty acids, that support cellular health, reduce the risk of chronic diseases, and help modulate metabolism. Considering that we do not consume isolated nutrients, translating the available evidence in favorable dietary patterns is of importance. In this context, a plant-based dietary pattern appears to offer the richest array of bioactive compounds and holds the greatest potential for providing benefits at the cellular level.</p>","PeriodicalId":520689,"journal":{"name":"Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vegetarian Diet and Kidney Function in Women and Men From Different Ethnic Groups: The Healthy Life in an Urban Setting (HELIUS) Study.","authors":"Robin L A Smits, Taryn G Vosters, Liffert Vogt, Henrike Galenkamp, Mary Nicolaou, Irene G M van Valkengoed","doi":"10.1053/j.jrn.2025.07.011","DOIUrl":"10.1053/j.jrn.2025.07.011","url":null,"abstract":"<p><strong>Objectives: </strong>A vegetarian diet may benefit kidney function. However, the sex-specific association of adherence to a vegetarian diet and change in kidney function, and its potential underlying mechanisms remain to be established.</p><p><strong>Methods: </strong>Our observational study included baseline and follow-up data on vegetarian diet adherence and estimated glomerular filtration rate (eGFR) from Dutch, South-Asian Surinamese, African Surinamese, Turkish, and Moroccan participants from Healthy Life in an Urban Setting, a multiethnic prospective cohort in Amsterdam. The median time between baseline and follow-up was 81 (70, 95) months. Vegetarian diet adherence was determined through a questionnaire and intake of dietary components was calculated using the food frequency questionnaire. The sex-specific association between vegetarian diet adherence and change in eGFR and albumin-creatinine ratio (ACR) was assessed with linear regression analysis. To explore whether associations were consistent by ethnic group, we stratified the groups of women and men by ethnicity.</p><p><strong>Results: </strong>Among 5,776 women and 4,443 men (median age: 48 [38, 55] and 48 [37, 56], respectively), the median eGFR was 102 (89, 112) and 101 (89, 111) at baseline and 92 (80, 104) and 93 (80, 103) at follow-up. We did not find an association between vegetarian diet adherence and eGFR or ACR change for both sexes. However, a 1 g/day higher fiber intake at baseline was associated with a lower decrease in eGFR of 0.10 (95% confidence interval [CI] 0.02, 0.17) in women and 0.07 (95% CI 0.00, 0.15) in men. Moreover, a 1 g/day higher intake of processed meat intake at baseline was associated with a 0.09 (95% CI 0.04, 0.14) higher increase in ACR in women.</p><p><strong>Conclusion: </strong>We found no evidence that vegetarian diet adherence was associated with a slower kidney function decline for both sexes across ethnic groups. Higher fiber intake and lower processed meat intake (women only) were associated with slower kidney function decline.</p>","PeriodicalId":520689,"journal":{"name":"Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amino Acid and Protein Losses in Adult Patients Receiving Maintenance Dialysis: A Literature Review.","authors":"Bruno Mafrici, Daniela Viramontes-Hörner, David S Gardner, Kenneth Smith, Maarten W Taal, Nicholas M Selby, Matt Hall","doi":"10.1053/j.jrn.2025.07.012","DOIUrl":"10.1053/j.jrn.2025.07.012","url":null,"abstract":"<p><strong>Background: </strong>A comprehensive, scoping review was initiated with the aim of providing an update regarding amino acid/protein losses in maintenance hemodialysis/hemodiafiltration (HD/HDF), peritoneal dialysis (PD), home HD (HHD), and nocturnal HD (NHD).</p><p><strong>Methods: </strong>From 2000 to 2024, all records that measured amino acid and peptide/protein losses in the dialysate effluent were included.</p><p><strong>Results: </strong>Twenty-nine eligible records were identified (14 HD/15 PD). Amino acid losses ranged from 9.3 ± 2.9 g to 12.0 ± 2.0 g per 4-hour HD session and 0.314 g to 0.522 g/day in PD. Albumin losses ranged from 0.448 g to 3.99 g per HD/HDF session and 4.23 g to 6.12 g/day in PD. Albumin losses were higher with postdilution HDF compared to HD. Total protein losses were not reported in HD studies. Daily protein losses in PD ranged from 4.37 ± 1.71 g to 10.0 ± 0.6 g. No studies in home HD or nocturnal HD populations were identified.</p><p><strong>Conclusion: </strong>Amino acid/protein losses differ between HD/HDF and PD. Since PD occurs daily, patients receiving PD have greater weekly amino acid/protein losses than HD. Whether individualized replacement of these losses is linked to better clinical outcomes needs to be further explored.</p>","PeriodicalId":520689,"journal":{"name":"Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eating Behavior Intervention of Overweight Women With Chronic Kidney Disease: A Qualitative Analysis.","authors":"Raíssa Antunes Pereira, Marle Dos Santos Alvarenga, Paula Costa Teixeira, Laila Santos de Andrade, Renata Rodrigues Teixeira, Elke Stedefeldt, Lilian Cuppari","doi":"10.1053/j.jrn.2025.07.009","DOIUrl":"10.1053/j.jrn.2025.07.009","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate a behavioral intervention conducted with nondialyzed overweight women with chronic kidney disease (CKD) by describing their eating behaviors.</p><p><strong>Design and methods: </strong>This prospective, mixed-method, noncontrolled clinical trial used a behavioral nondiet approach with 15 multisession group interventions for dietary management among 33 overweight women with CKD (age = 62.0 [54.0-67.5] years; body mass index = 32.8 [30.5-38.6] kg/m²; estimated glomerular filtration rate = 28.0 [20.0-31.5] mL/min/1.73 m³). Thematic content analysis was performed using qualitative data from focus groups conducted before and after the intervention. Combined quantitative and qualitative methods were triangulated using data from the Intuitive Eating Scale-2.</p><p><strong>Results: </strong>Eight categories emerged from the preintervention (factors that influence eating and living, diet culture, feelings of ambivalence and/or stagnation, and understanding one's limitations) and postintervention periods (appreciation for the different approach, awakening self-confidence, eating attunement, and discovering a new way to eat). The Intuitive Eating Scale-2 factors concur with the preintervention and postintervention categories, contributing to the transition from a less to more intuitive eating profile.</p><p><strong>Conclusion: </strong>Behavioral intervention raised positive eating experiences that aligned with a more intuitive way of eating. Patients felt more empowered to accept and manage the disease. These results may contribute to changes in the adherence paradigm in nondialysis CKD.</p>","PeriodicalId":520689,"journal":{"name":"Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Smoking in Dietary and Potassium Balance Among Hemodialysis Patients.","authors":"Syed Danial Kamal, Amir Reza Akbari, Benyamin Alam","doi":"10.1053/j.jrn.2025.05.008","DOIUrl":"10.1053/j.jrn.2025.05.008","url":null,"abstract":"","PeriodicalId":520689,"journal":{"name":"Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Effects of Ketoanalogue Supplements on Patients Receiving Continuous Ambulatory Peritoneal Dialysis: A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study.","authors":"Tingfei He","doi":"10.1053/j.jrn.2025.06.011","DOIUrl":"10.1053/j.jrn.2025.06.011","url":null,"abstract":"","PeriodicalId":520689,"journal":{"name":"Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: 'The Role of Smoking in Dietary and Potassium Balance Among Hemodialysis Patients'.","authors":"Manon de Geus, Wesley Visser, Anneke van Egmond-de Mik, Manouk Dam, Evelien de Cuyper, Marian de van der Schueren, Michael Tieland, Peter Weijs, Hinke Kruizenga, Karin Ipema","doi":"10.1053/j.jrn.2025.07.010","DOIUrl":"10.1053/j.jrn.2025.07.010","url":null,"abstract":"","PeriodicalId":520689,"journal":{"name":"Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's Response: Effects of Ketoanalogue Supplements on Patients Receiving Continuous Ambulatory Peritoneal Dialysis: A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study.","authors":"Sixiu Chen, Wei Chen, Xueqing Yu","doi":"10.1053/j.jrn.2025.07.013","DOIUrl":"10.1053/j.jrn.2025.07.013","url":null,"abstract":"","PeriodicalId":520689,"journal":{"name":"Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}