Journal of preventive medicine and public health = Yebang Uihakhoe chi最新文献

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Statin Intake and Gastric Cancer Risk: An Updated Subgroup Meta-analysis Considering Immortal Time Bias. 他汀类药物摄入与胃癌风险:考虑不朽时间偏差的最新亚组荟萃分析。
Journal of preventive medicine and public health = Yebang Uihakhoe chi Pub Date : 2022-09-01 Epub Date: 2022-08-18 DOI: 10.3961/jpmph.22.209
Jong-Myon Bae
{"title":"Statin Intake and Gastric Cancer Risk: An Updated Subgroup Meta-analysis Considering Immortal Time Bias.","authors":"Jong-Myon Bae","doi":"10.3961/jpmph.22.209","DOIUrl":"https://doi.org/10.3961/jpmph.22.209","url":null,"abstract":"<p><p>A retrospective record-linkage study (RLS) based on medical records containing drug prescription histories involves immortal time bias (ITB). Thus, it is necessary to control for this bias in the research planning and analysis stages. Furthermore, a summary of a metaanalysis including RLSs that did not control for ITB showed that specific drugs had a preventive effect on the occurrence of the disease. Previous meta-analytic results of three systematic reviews evaluating the association between statin intake and gastric cancer risk showed that the summary hazard ratio (sHR) of the RLSs was lower than 1 and was statistically significant. We should consider the possibility of ITB in the sHR of RLSs and interpret the results carefully.</p>","PeriodicalId":520687,"journal":{"name":"Journal of preventive medicine and public health = Yebang Uihakhoe chi","volume":" ","pages":"424-427"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/55/jpmph-22-209.PMC9561136.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33505903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Association Between Metabolic Syndrome and Colorectal Cancer Risk by Obesity Status in Korean Women: A Nationwide Cohort Study. 韩国女性肥胖状况与代谢综合征和结直肠癌风险之间的关系:一项全国性队列研究
Journal of preventive medicine and public health = Yebang Uihakhoe chi Pub Date : 2022-09-01 Epub Date: 2022-09-21 DOI: 10.3961/jpmph.22.286
Seong-Geun Moon, Boyoung Park
{"title":"The Association Between Metabolic Syndrome and Colorectal Cancer Risk by Obesity Status in Korean Women: A Nationwide Cohort Study.","authors":"Seong-Geun Moon,&nbsp;Boyoung Park","doi":"10.3961/jpmph.22.286","DOIUrl":"https://doi.org/10.3961/jpmph.22.286","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine the association between metabolic syndrome (MetS) and the incidence of colorectal cancer (CRC) in Korean women with obesity.</p><p><strong>Methods: </strong>Cancer-free women (n=6 142 486) aged 40-79 years, who underwent National Health Insurance Service health examinations in 2009 and 2010 were included. The incidence of CRC was followed until 2018. The hazard ratio (HR) of MetS for the incidence of colon and rectal cancer was analyzed according to body mass index (BMI) categories, adjusting for confounders such as women's reproductive factors. In addition, the heterogeneity of associations across BMI categories was assessed.</p><p><strong>Results: </strong>Women with MetS were at increased risk of colon and rectal cancer compared to women without MetS (HR, 1.20; 95% confidence interval [CI], 1.16 to 1.23 and HR,1.15; 95% CI, 1.11 to 1.20), respectively. The HR of MetS for colon cancer across BMI categories was 1.12 (95% CI, 1.06 to 1.19), 1.14 (95% CI, 1.08 to 1.20), and 1.16 (95% CI, 1.12 to 1.21) in women with BMIs &lt;23.0 kg/m2, 23.0-24.9 kg/m2, and ≥25.0 kg/m2, respectively. The HR of MetS for rectal cancer across corresponding BMI categories was 1.16 (95% CI, 1.06 to 1.26), 1.14 (95% CI, 1.05 to 1.23), and 1.13 (95% CI, 1.06 to 1.20). The heterogeneity of associations across BMI categories was not significant in either colon or rectal cancer (p=0.587 for colon cancer and p=0.927 for rectal cancer).</p><p><strong>Conclusions: </strong>Women with MetS were at increased risk of colon and rectal cancer. Clinical and public health strategies should be considered for primary CRC prevention with an emphasis on improving women's metabolic health across all BMI groups.</p>","PeriodicalId":520687,"journal":{"name":"Journal of preventive medicine and public health = Yebang Uihakhoe chi","volume":" ","pages":"475-484"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/df/jpmph-22-286.PMC9561145.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33504236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Primary Process and Key Concepts of Economic Evaluation in Healthcare. 医疗保健经济评价的主要过程和关键概念。
Journal of preventive medicine and public health = Yebang Uihakhoe chi Pub Date : 2022-09-01 Epub Date: 2022-08-24 DOI: 10.3961/jpmph.22.195
Younhee Kim, Yunjung Kim, Hyeon-Jeong Lee, Seulki Lee, Sun-Young Park, Sung-Hee Oh, Suhyun Jang, Taejin Lee, Jeonghoon Ahn, Sangjin Shin
{"title":"The Primary Process and Key Concepts of Economic Evaluation in Healthcare.","authors":"Younhee Kim,&nbsp;Yunjung Kim,&nbsp;Hyeon-Jeong Lee,&nbsp;Seulki Lee,&nbsp;Sun-Young Park,&nbsp;Sung-Hee Oh,&nbsp;Suhyun Jang,&nbsp;Taejin Lee,&nbsp;Jeonghoon Ahn,&nbsp;Sangjin Shin","doi":"10.3961/jpmph.22.195","DOIUrl":"https://doi.org/10.3961/jpmph.22.195","url":null,"abstract":"<p><p>Economic evaluations in the healthcare are used to assess economic efficiency of pharmaceuticals and medical interventions such as diagnoses and medical procedures. This study introduces the main concepts of economic evaluation across its key steps: planning, outcome and cost calculation, modeling, cost-effectiveness results, uncertainty analysis, and decision-making. When planning an economic evaluation, we determine the study population, intervention, comparators, perspectives, time horizon, discount rates, and type of economic evaluation. In healthcare economic evaluations, outcomes include changes in mortality, the survival rate, life years, and quality-adjusted life years, while costs include medical, non-medical, and productivity costs. Model-based economic evaluations, including decision tree and Markov models, are mainly used to calculate the total costs and total effects. In cost-effectiveness or costutility analyses, cost-effectiveness is evaluated using the incremental cost-effectiveness ratio, which is the additional cost per one additional unit of effectiveness gained by an intervention compared with a comparator. All outcomes have uncertainties owing to limited evidence, diverse methodologies, and unexplained variation. Thus, researchers should review these uncertainties and confirm their robustness. We hope to contribute to the establishment and dissemination of economic evaluation methodologies that reflect Korean clinical and research environment and ultimately improve the rationality of healthcare policies.</p>","PeriodicalId":520687,"journal":{"name":"Journal of preventive medicine and public health = Yebang Uihakhoe chi","volume":" ","pages":"415-423"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d7/c4/jpmph-22-195.PMC9561137.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33505902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigating the Relationship Between Accessibility of Green Space and Adult Obesity Rates: A Secondary Data Analysis in the United States. 研究绿地可达性与成人肥胖率的关系:美国的二次数据分析。
Journal of preventive medicine and public health = Yebang Uihakhoe chi Pub Date : 2021-05-01 Epub Date: 2021-05-18 DOI: 10.3961/jpmph.20.625
Junhyoung Kim, Sujung Lee, William Ramos
{"title":"Investigating the Relationship Between Accessibility of Green Space and Adult Obesity Rates: A Secondary Data Analysis in the United States.","authors":"Junhyoung Kim,&nbsp;Sujung Lee,&nbsp;William Ramos","doi":"10.3961/jpmph.20.625","DOIUrl":"https://doi.org/10.3961/jpmph.20.625","url":null,"abstract":"<p><strong>Objectives: </strong>In spite of the importance of green space for reducing obesity-related problems, there has been little exploration of whether access to green space (e.g., parks and recreational facilities) influences the obesity rate of adults in the United States. The purpose of the study was to investigate the relationships among accessibility of green space, obesity rates, and socioeconomic and demographic variables among adults living in the State of Indiana, United States.</p><p><strong>Methods: </strong>We conducted a secondary data analysis to investigate the relationships among accessibility to green space, obesity rates, and socio-demographic variables with employing Geographic Information System in order to measure the accessibility of green space.</p><p><strong>Results: </strong>This study found that accessibility of green space served as a strong predictor of reduced obesity rates among adults (β=-2.478; p<0.10). In addition, adults with higher education levels, as well as better access to green space, were found to have even lower obesity rates (β=-0.188; p<0.05). Other control variables such as unemployment rates, food security, and physical inactivity are additional factors that influence obesity rates among adults.</p><p><strong>Conclusions: </strong>Accessibility of green space may play an important role in facilitating physical activity participation and reducing obesity rates.</p>","PeriodicalId":520687,"journal":{"name":"Journal of preventive medicine and public health = Yebang Uihakhoe chi","volume":" ","pages":"208-217"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/7a/jpmph-20-625.PMC8190549.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39065345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
[Smoking and colorectal cancer risk in the Korean elderly]. [吸烟与韩国老年人患大肠癌的风险]。
Hwa Jung Kim, Seung-Mi Lee, Nam-Kyong Choi, Seon Ha Kim, Hong-Ji Song, Young Kyun Cho, Byung-Joo Park
{"title":"[Smoking and colorectal cancer risk in the Korean elderly].","authors":"Hwa Jung Kim,&nbsp;Seung-Mi Lee,&nbsp;Nam-Kyong Choi,&nbsp;Seon Ha Kim,&nbsp;Hong-Ji Song,&nbsp;Young Kyun Cho,&nbsp;Byung-Joo Park","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>The incidence of colorectal cancer increased greatly among the elderly in Korea, but the relationship between smoking and colon cancer remains controversial. Few studies have targeted Asian elderly people. We analyzed the smoking status, the amount smoked, and the smoking duration as risk factors of colorectal cancer to determine their association and causality.</p><p><strong>Methods: </strong>The cohort members (n = 14,103) consisted of 4,694 males and 9,409 females, and they were derived from the Korea Elderly Phamacepidemilogic Cohort (KEPEC), which was a population-based dynamic cohort. They were aged 65 years or more and they lived in Busan Metropolitan City between from 1993-1998; they were beneficiaries of the Korean Medical Insurance Corporation (KMIC). The baseline information was surveyed by a self-administered mailed questionnaire; after 8.7 person-years of mean follow up period, 100 cases of colorectal cancer occurred. The adjusted relative ratio (aRR) of smoking status, the smoking amount and the smoking duration were calculated from the Cox's proportional hazard model with the never-smokers as a reference group and the Cox model controlled for age, gender, precancerous lesions of CRC, medication history of NSAIDs and antibiotics, the alcohol drinking status and BMI.</p><p><strong>Results: </strong>Compared with the never smokers, the aRRs were 2.03 (95% CI = 1.02-4.03) and 1.36 (95% CI = 0.80-2.32) for the ex-smokers and current smokers, respectively. Statistical significant trends were not observed for the dose-relationship among the elderly, either for the mean daily amount smoked (p for trend = 0.28) or for the total amount (p for trend = 0.15). Still, the aRRs were 1.51 (95% Cl = 0.97-2.34) for the elderly who smoked less than 40 years and 2.35 (95% CI = 1.16-4.74) for the elderly who had 40 years or more of smoking (p for trend = 0.06). Smokers who started smoking before the age 20 had an increased aRR of 2.15 (95% CI = 1.17-3.93) compared to the never smokers.</p><p><strong>Conclusions: </strong>After controlling for age, gender, precancerous lesion of CRC, medication history of NSAIDs and antibiotics, the alcohol drinking status and BMI, smoking increases the risk of colorectal cancer among elderly people. The age when starting smoking is also important.</p>","PeriodicalId":520687,"journal":{"name":"Journal of preventive medicine and public health = Yebang Uihakhoe chi","volume":" ","pages":"123-9"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25974236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Reformation of residency trainingship for the future of preventive medicine in Korea]. [韩国预防医学未来的住院医师培训改革]。
Chang Yoon Kim
{"title":"[Reformation of residency trainingship for the future of preventive medicine in Korea].","authors":"Chang Yoon Kim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>From the start of the residency trainingship in 1963, the residency training programs have been contributed much on the establishment and development of preventive medicine in Korea. But these programs are now have several problems to update the changes in health service needs of the population that were caused by a rapid epidemiologic transition from the acute infectious diseases to chronic diseases in last a few decades. Strengthening in medical practice, not just in knowledge is urgently required. Must have more concentrate on preventive service for the individual, as in clinical preventive medicine. Training residents by the systematic and well scheduled programs, not just 'teacher's assistant' in the academic facilities. Trying the change in the system of Specilty of Preventive Medicine to the well established several subspecialty, so more specific competency can be gained through the training. These approach and reformation may not only contribute for the better future of the preventive medicine, but also improve in disease prevention and health promotion, which required by the society in Korea.</p>","PeriodicalId":520687,"journal":{"name":"Journal of preventive medicine and public health = Yebang Uihakhoe chi","volume":" ","pages":"110-4"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25974234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Estimating the cost savings due to the effect of Kremezin in delaying the initiation of dialysis treatments among patients with chronic renal failure]. [估计由于Kremezin延迟慢性肾衰竭患者开始透析治疗的效果而节省的成本]。
Hye-Young Kang, Woohyun Cho, Sunmi Lee, Hyung-Jong Kim, Ho Yong Lee, Tae-Wook Woo
{"title":"[Estimating the cost savings due to the effect of Kremezin in delaying the initiation of dialysis treatments among patients with chronic renal failure].","authors":"Hye-Young Kang,&nbsp;Woohyun Cho,&nbsp;Sunmi Lee,&nbsp;Hyung-Jong Kim,&nbsp;Ho Yong Lee,&nbsp;Tae-Wook Woo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>We wanted to evaluate the economic value of a pharmaceutical product, Kremezin, for treating patients with chronic renal failure (CRF) by estimating the amount of cost savings due to its effect for delaying the initiation of dialysis treatments.</p><p><strong>Methods: </strong>We defined a conventional treatment for CRF accompanied by Kremezin therapy as 'the treatment group' and only conventional treatment as 'the alternative group.' The types of costs included were direct medical and non-medical costs and costs of productivity loss. The information on the effect of Kremezin was obtained from the results of earlier clinical studies. Cost information was derived from the administrative data for 20 hemodialysis and 20 peritoneal dialysis patients from one tertiary care hospital, and also from the administrative data of 10 hemodialysis patients from one free-standing dialysis center. Per-capita cost savings resulting from Kremezin therapy were separately estimated for the cases with delay for the onset of hemodialysis and the cases with immediate performance of peritoneal dialysis. By computing the weighted average for the cases of hemodialysis and peritoneal dialysis, the expected per-capita cost savings of a patient with CRF was obtained. Using a discount rate of 5%, future cost savings were converted to the present value.</p><p><strong>Results: </strong>The present value of cumulative cost savings per patient with CRF from the societal perspective would be 18,555,000-29,410,000 Won or 72,104,000-112,523,000 Won if Kremezin delays the initiation of dialysis by 1 or 4 years.</p><p><strong>Conclusions: </strong>The estimated amount of cost savings resulting from treating CRF patients with Kremezin confirms that its effect for delaying the onset of dialysis treatments has a considerable economic value.</p>","PeriodicalId":520687,"journal":{"name":"Journal of preventive medicine and public health = Yebang Uihakhoe chi","volume":" ","pages":"149-58"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25974239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 polymorphisms and the risk of gastric cancer]. 谷胱甘肽s -转移酶(GSTM1, GSTT1和GSTP1)和n -乙酰转移酶2多态性与胃癌的风险[j]。
Su Hyung Hong, Jung Wan Kim, Ho Gak Kim, In Kyu Park, Jun Wook Ryoo, Chang Hyeong Lee, Yoon Kyung Sohn, Jong Young Lee
{"title":"[Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 polymorphisms and the risk of gastric cancer].","authors":"Su Hyung Hong,&nbsp;Jung Wan Kim,&nbsp;Ho Gak Kim,&nbsp;In Kyu Park,&nbsp;Jun Wook Ryoo,&nbsp;Chang Hyeong Lee,&nbsp;Yoon Kyung Sohn,&nbsp;Jong Young Lee","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Polymorphisms of genes from glutathione S-transferases (GSTs) and N-acetyltransferase 2 (NAT2) have been associated with increased susceptibility to various cancers. Previous results showed that East Asians such as Koreans, Japanese and Chinese have a much higher frequency of the GSTM1 and GSTT1 null genotypes and NAT2 rapid acetylator type. Therefore, we investigated the association between the polymorphic types of GSTs (GSTM1, GSTT1, GSTP1) and NAT2 and the incidence of gastric cancer which is one of the most prevalent cancers among the East Asians.</p><p><strong>Methods: </strong>It was performed in a case-control study consisting of 238 healthy subjects and 108 cancer patients (54 distal and 54 proximal carcinomas). We also evaluated the association between GSTs and NAT2 and the risk factors for gastric cancer such as alcohol consumption, smoking, H. pylori infection, family history of gastric cancer, and tumor location.</p><p><strong>Results: </strong>In our study, the percentage of cases whose hometown was rural was higher than those of controls (odds ratio (OR) = 2.88; 95% CI = 1.72-4.76), and the frequency of the lower socio-economic status increased significantly in patients (OR = 2.53; 95% Cl = 1.59-4.02). There was no significant difference in the GST polymorphic types between the cases and controls. However, NAT2 rapid or intermediate acetylator types were frequently detected in the cases with family history of gastric cancer (OR = 1.92; 95% CI = 1.79-26.0).</p><p><strong>Conclusions: </strong>These results suggest that the hometown and socio-economic status are important environmental factors for gastric carcinogenesis, and NAT2 polymorphic types could be associated with familial gastric carcinoma.</p>","PeriodicalId":520687,"journal":{"name":"Journal of preventive medicine and public health = Yebang Uihakhoe chi","volume":" ","pages":"135-40"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25974237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Association analysis of the essential hypertension susceptibility genes in adolescents: Kangwha study]. 青少年原发性高血压易感基因的关联分析:Kangwha研究。
Il Suh, Chung Mo Nam, Sung-Joo Kim, Dong-Jik Shin, Nam Wook Hur, Dae Ryong Kang
{"title":"[Association analysis of the essential hypertension susceptibility genes in adolescents: Kangwha study].","authors":"Il Suh,&nbsp;Chung Mo Nam,&nbsp;Sung-Joo Kim,&nbsp;Dong-Jik Shin,&nbsp;Nam Wook Hur,&nbsp;Dae Ryong Kang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>In this study we examined the association between the genetic markers ACE (A-240T, C-93T, I/D, A2350G), AGT (M235T), AT1R (A1166C), CYP11B2 (T-344C, V386A), REN (G2646A), ADRB2 (G46A, C79G, T-47C, T164I), GNB3 (C825T) and ADD1 (G460W) and the presence of essential hypertension in adolescents.</p><p><strong>Methods: </strong>The Kangwha Study is an 18-year prospective study that is aimed at elucidating the determinants of the blood pressure level from childhood to early adulthood. For this study, we constructed a case-control dataset of size of 277 and 40 family trios data from the Kangwha Study. For this purpose, we perform a single locus-based case-control association study and a single locus-based TDT (transmission/disequilibrium test) study.</p><p><strong>Results: </strong>In the case-control study, the single locus-based association study indicated that the ADD1 (G460W) (p = 0.0403), AGT (M235T) (p = 0.0002), and REN (G2646A) (p = 0.0101) markers were significantly associated with the risk of hypertension. These results were not confirmed on the TDT study. This study showed that genetic polymorphisms of the ADD1, AGT and REN genes might be related to the hypertension in Korean adolescents.</p><p><strong>Conclusions: </strong>This study provided useful information on genetics markers related to blood pressure. Further study will be needed to confirm the effect of the alpha adducin gene, the angiotensinogen gene and the renin gene on essential hypertension.</p>","PeriodicalId":520687,"journal":{"name":"Journal of preventive medicine and public health = Yebang Uihakhoe chi","volume":" ","pages":"177-83"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25973511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Relationship of socioeconomic factors with medical utilization for lower urinary tract symptoms and benign prostatic hyperplasia in a South Korean community]. [社会经济因素与韩国社区下尿路症状和良性前列腺增生的医疗利用的关系]。
Han-Hae Kim, Kyoung Ae Kong, Hun Jae Lee, Hana Yoon, Bo Eun Lee, Ok-Ryun Moon, Hyesook Park
{"title":"[Relationship of socioeconomic factors with medical utilization for lower urinary tract symptoms and benign prostatic hyperplasia in a South Korean community].","authors":"Han-Hae Kim,&nbsp;Kyoung Ae Kong,&nbsp;Hun Jae Lee,&nbsp;Hana Yoon,&nbsp;Bo Eun Lee,&nbsp;Ok-Ryun Moon,&nbsp;Hyesook Park","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>We wanted to evaluate the medical underutilization for benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) among Korean elderly men and we wanted to determine their associated factors.</p><p><strong>Methods: </strong>This study was conducted on 239 men with LUTS and 116 men with BPH who were compatible with the diagnostic criteria from a total of 641 participants. These participants were over 50 years old and they were randomly chosen in a community-based study for estimating the prevalence of BPH. Using a self-reported questionnaire, we surveyed the sociodemographics, health status, quality of life, lower urinary tract symptoms, medical utilization and reasons for not seeking treatment.</p><p><strong>Results: </strong>Only 27.6% of the men with LUTS and 31.0% of the men with BPH reported having visited a doctor for urinary symptoms. The reasons for not visiting a doctor were, in order of responses from the group with LUTS: 'considered the symptoms as a part of the normal ageing process', 'not enough time to visit a doctor', 'financial difficulty' and 'the symptoms were not severe or bothersome'. Regarding BPH, the responses were the same as those of the group with LUTS however, 'financial difficulty' placed second. Among the men with experience of visiting a doctor for urinary symptoms, 33.3% of those with LUTS and 28.1% of those with BPH were not treated. The most common reason in both groups was 'the symptoms were not severe to be treated'. On a multiple logistic regression analysis, the larger size household (odds ratio (OR) 3.03, 95% confidence interval (Cl) = 1.40-6.54) and an unsatisfactory quality of life related with urinary symptoms (OR 2.98, 95% CI = 1.23-7.21) were associated with medical utilization in the group of LUTS. For BPH, the current employment status was related with the medical utilization (OR 2.80, 95% CI = 1.10-7.11), in addition to the larger size household (OR 3.24, 95% CI = 1.14-9.21).</p><p><strong>Conclusions: </strong>Many men with urinary symptoms do not visit a doctor. This medical underutilization for people with LUTS and BPH may be associated with economic status in Korea.</p>","PeriodicalId":520687,"journal":{"name":"Journal of preventive medicine and public health = Yebang Uihakhoe chi","volume":" ","pages":"141-8"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25974238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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