Journal of clinical and experimental hematopathology : JCEH最新文献_第3页

Donor-derived diffuse large B-cell lymphoma after haploidentical stem cell transplantation for acute myeloid leukemia. 单倍体干细胞移植治疗急性髓系白血病后供体源性弥漫性大b细胞淋巴瘤。

IF 1.5

Journal of clinical and experimental hematopathology : JCEH Pub Date : 2022-01-01 DOI: 10.3960/jslrt.22014

Anna Kawashiri, Shun-Ichiro Nakagawa, Chisato Ishiguro, Kanako Mochizuki, Yoshinobu Maeda, Toshiro Kurokawa

{"title":"Donor-derived diffuse large B-cell lymphoma after haploidentical stem cell transplantation for acute myeloid leukemia.","authors":"Anna Kawashiri, Shun-Ichiro Nakagawa, Chisato Ishiguro, Kanako Mochizuki, Yoshinobu Maeda, Toshiro Kurokawa","doi":"10.3960/jslrt.22014","DOIUrl":"https://doi.org/10.3960/jslrt.22014","url":null,"abstract":"We report a case of donor-derived diffuse large B-cell lymphoma (DLBCL), which developed 5 years after stem cell transplantation from a human leukocyte antigen (HLA)-haploidentical donor for acute myeloid leukemia (AML). A 51-year-old male was diagnosed with AML with variant KMT2A translocation involving t(6;11)(q13;q23). After 12 cycles of azacitidine treatment, fluorescence in situ hybridization (FISH) for KMT2A split signal indicated that 94% of his bone marrow (BM) cells were positive. He underwent peripheral blood stem cell transplantation (PBSCT) from his HLA-haploidentical son. The preconditioning regimen consisted of fludarabine, busulfan, melphalan, and antithymocyte globulin (ATG). The graft-versus-host disease (GVHD) prophylaxis consisted of tacrolimus and short-term methotrexate. On day 28, KMT2A FISH analysis indicated that he had achieved a complete response (CR). He continued to receive tacrolimus for the limited type of cutaneous chronic GVHD. Five years after the transplantation, positron emission tomography/computed tomography (PET/CT) showed an abdominal tumor. The tumor was diagnosed as DLBCL without Epstein-Barr virus. BM aspiration revealed the infiltration of lymphoma cells with t(8;14)(q24;q32). Chimerism analysis showed that both the peripheral blood (PB) and abdominal lymphoma cells were of donor origin. After 4 cycles of salvage chemotherapy, PET/CT showed that a CR had been achieved. He underwent a second PBSCT from an HLA-identical unrelated donor. The preconditioning regimen and GVHD prophylaxis were the same as those for the first PBSCT without ATG. The patient's PB revealed complete second donor-type chimerism, and the patient has maintained a CR since the second transplantation.","PeriodicalId":520662,"journal":{"name":"Journal of clinical and experimental hematopathology : JCEH","volume":" ","pages":"175-180"},"PeriodicalIF":1.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/3e/jslrt-62-175.PMC9635034.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40381597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Retrospective study of the utility of FLIPI/FLIPI-2 for follicular lymphoma patients treated with R-CHOP. FLIPI/FLIPI-2在R-CHOP治疗滤泡性淋巴瘤患者中的应用回顾性研究。

IF 1.5

Journal of clinical and experimental hematopathology : JCEH Pub Date : 2012-01-01 DOI: 10.3960/jslrt.52.77

Ayumi Numata, Naoto Tomita, Katsumichi Fujimaki, Masatsugu Tanaka, Chizuko Hashimoto, Rika Oshima, Kenji Matsumoto, Shiro Matsuura, Wataru Yamamoto, Shigeki Motomura, Yoshiaki Ishigatsubo

引用次数: 8

Hepatitis B reactivation in a multiple myeloma patient with resolved hepatitis B infection during bortezomib therapy : case report. 在硼替佐米治疗期间，解决乙型肝炎感染的多发性骨髓瘤患者乙型肝炎再激活:病例报告。

IF 1.5

Journal of clinical and experimental hematopathology : JCEH Pub Date : 2012-01-01 DOI: 10.3960/jslrt.52.67

Hiroaki Tanaka, Ikuo Sakuma, Shinichiro Hashimoto, Yusuke Takeda, Shio Sakai, Toshiyuki Takagi, Takanori Shimura, Chiaki Nakaseko

引用次数: 27

Lymph node infarction in classical Hodgkin's lymphoma. 经典霍奇金淋巴瘤的淋巴结梗死。

IF 1.5

Journal of clinical and experimental hematopathology : JCEH Pub Date : 2012-01-01 DOI: 10.3960/jslrt.52.35

Eiichiro Mori, Yasunori Enomoto, Hirokazu Nakamine, Takahiko Kasai, Maiko Takeda, Masato Takano, Kouhei Morita, Toshizo Koizumi, Akitaka Nonomura

{"title":"Lymph node infarction in classical Hodgkin's lymphoma.","authors":"Eiichiro Mori, Yasunori Enomoto, Hirokazu Nakamine, Takahiko Kasai, Maiko Takeda, Masato Takano, Kouhei Morita, Toshizo Koizumi, Akitaka Nonomura","doi":"10.3960/jslrt.52.35","DOIUrl":"https://doi.org/10.3960/jslrt.52.35","url":null,"abstract":"Among lymphoproliferative disorders, lymph node infarction appears to be most frequently seen in diffuse large B-cell lymphoma, followed by follicular lymphoma, with other types being rare. We experienced one such case, classical Hodgkin's lymphoma (cHL) associated with lymph node infarction, in which Reed-Sternberg (RS) cells were positive for CD15, CD30, fascin, PAX-5, p53, latent membrane protein-1 (LMP-1), Bcl-2, and EBV-encoded small non-polyadenylated RNAs. Furthermore, RS cells in the infarcted area were still positive for CD30, fascin, p53, and Bcl-2. For definitive diagnosis of nodal lymphomas including Hodgkin's lymphoma, identification of the effacement of normal nodal architecture is essential. Although this could not be evaluated in our case because of predominant reactive follicular hyperplasia with interfollicular distribution of RS cells, the presence of large cells with RS cell-related molecules together with the distorted distribution of cCD3-positive cells and CD20-positive cells led us to make a definitive diagnosis of cHL. It is, therefore, considered that immunohistochemical evaluation of the infarcted lymph node is, at least on some occasions, still informative for more accurate diagnosis of lymphoid neoplasia. Hodgkin's lymphoma should also be considered when one encounters lymph node infarction.","PeriodicalId":520662,"journal":{"name":"Journal of clinical and experimental hematopathology : JCEH","volume":" ","pages":"35-9"},"PeriodicalIF":1.5,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3960/jslrt.52.35","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30697004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Epstein-Barr virus-negative classical Hodgkin's lymphoma in a patient with T-cell prolymphocytic leukemia treated with fludarabine. 用氟达拉滨治疗t细胞前淋巴细胞白血病患者的Epstein-Barr病毒阴性经典霍奇金淋巴瘤

IF 1.5

Journal of clinical and experimental hematopathology : JCEH Pub Date : 2012-01-01 DOI: 10.3960/jslrt.52.71

Takahiro Tsuji, Hiroshi Yamasaki, Nobuyuki Arima, Daisuke Niino, Koichi Ohshima, Hiroyuki Tsuda

引用次数: 0

Rheumatoid lymphadenopathy with abundant IgG4(+) plasma cells : a case mimicking IgG4-related disease. 类风湿性淋巴结病伴大量IgG4(+)浆细胞:一例模拟IgG4相关疾病

IF 1.5

Journal of clinical and experimental hematopathology : JCEH Pub Date : 2012-01-01 DOI: 10.3960/jslrt.52.57

Naoko Asano, Yasuharu Sato

{"title":"Rheumatoid lymphadenopathy with abundant IgG4(+) plasma cells : a case mimicking IgG4-related disease.","authors":"Naoko Asano, Yasuharu Sato","doi":"10.3960/jslrt.52.57","DOIUrl":"https://doi.org/10.3960/jslrt.52.57","url":null,"abstract":"Immunoglobulin (Ig) G4-related disease is a recently confirmed clinical entity with several unique clinicopathological features. Here we report a case of rheumatoid lymphadenopathy mimicking IgG4-related disease. The patient was a 63-year-old woman who had been treated for rheumatoid arthritis (RA) for six years. The patient noted cervical lymphadenopathy. Upon radiological examination, systemic lymphadenopathy was detected, and enlarged right brachial lymph node biopsy was performed. Histologically, the lymph node showed marked follicular hyperplasia and interfollicular plasmacytosis without eosinophil infiltration. Although the histological findings were compatible with rheumatoid lymphadenopathy, numerous plasma cells were IgG4(+) (IgG4(+)/IgG(+) plasma cell ratio > 50%). However, laboratory findings revealed elevation of C-reactive protein level, polyclonal hyper-γ-globulinemia, anemia, and hypoalbuminemia. These findings were compatible with hyper-interleukin (IL)-6 syndrome, namely, RA. It is known that hyper-IL-6 syndromes, such as multicentric Castleman's disease, RA, and other autoimmune diseases, fulfill the histological diagnostic criteria for IgG4-related disease. Therefore, hyper-IL-6 syndromes and IgG4-related disease cannot be differentially diagnosed by immunohistochemical staining alone. In conclusion, rheumatoid lymphadenopathy sometimes occurs with abundant IgG4(+) plasma cells, which is required for the differential diagnosis of IgG4-related disease.","PeriodicalId":520662,"journal":{"name":"Journal of clinical and experimental hematopathology : JCEH","volume":" ","pages":"57-61"},"PeriodicalIF":1.5,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3960/jslrt.52.57","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30697006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Granulomatous lymphadenitis. 肉芽肿性淋巴结炎。

IF 1.5

Journal of clinical and experimental hematopathology : JCEH Pub Date : 2012-01-01 DOI: 10.3960/jslrt.52.1

Shigeyuki Asano

{"title":"Granulomatous lymphadenitis.","authors":"Shigeyuki Asano","doi":"10.3960/jslrt.52.1","DOIUrl":"https://doi.org/10.3960/jslrt.52.1","url":null,"abstract":"In this review, representative types of granulomatous lymphadenitis (GLA) are described. GLA can be classified as noninfectious GLA and infectious GLA. Noninfectious GLA includes sarcoidosis and sarcoid-like reaction. The cause of sarcoidosis remains unknown, but it has good prognosis. Sarcoid-like reaction, which is considered to be a biological defense mechanism, is observed in regional lymph nodes with many underlying diseases. Infectious GLA can be classified as suppurative lymphadenitis (LA) and nonsuppurative LA. Suppurative LA generally shows follicular hyperplasia and sinus histiocytosis in the early phase. In tularemia and cat scratch disease, monocytoid B lymphocytes (MBLs) with T cells and macrophages contribute to the formation of granuloma. However, none of the epithelioid cell granulomas of Yersinia LA contains MBLs like in cat scratch disease. In addition, almost all have a central abscess in granulomas induced by Gram-negative bacteria. In terms of the lymph nodes, tularemia and cat scratch disease are apt to affect the axillary and cervical regions while Yersinia LA affects the mesenteric lymph node. Nonsuppurative LA includes tuberculosis and BCG-histiocytosis. These are induced by delayed allergic reaction of M. tuberculosis. Tuberculosis LA mainly appears in the cervical lymph node. Organisms are histologically detected by Ziehl-Neelsen staining in the necrotic area. Toxoplasmosis is also a nonsuppurative protozoan infection (Toxoplasma gondii). In toxoplasma LA, MBLs can also be seen, but round and organized, well-formed granulomas are not found in this disease. Furthermore, necrosis is not induced and there are no accompanying neutrophils, eosinophils and fibrosis. GLA described above is associated with characteristic histological findings. An accurate pathological diagnosis using the above findings can lead to precise treatment.","PeriodicalId":520662,"journal":{"name":"Journal of clinical and experimental hematopathology : JCEH","volume":" ","pages":"1-16"},"PeriodicalIF":1.5,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3960/jslrt.52.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30698661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 109

Orbital MALT lymphoma, abdominal hodgkin lymphoma, and systemic diffuse large B-cell lymphoma develop sequentially in one patient. 眼眶MALT淋巴瘤、腹部霍奇金淋巴瘤和全身性弥漫性大b细胞淋巴瘤先后发生于1例患者。

IF 1.5

Journal of clinical and experimental hematopathology : JCEH Pub Date : 2012-01-01 DOI: 10.3960/jslrt.52.41

Toshihiko Matsuo, Kouichi Ichimura, Katsuji Shinagawa

{"title":"Orbital MALT lymphoma, abdominal hodgkin lymphoma, and systemic diffuse large B-cell lymphoma develop sequentially in one patient.","authors":"Toshihiko Matsuo, Kouichi Ichimura, Katsuji Shinagawa","doi":"10.3960/jslrt.52.41","DOIUrl":"https://doi.org/10.3960/jslrt.52.41","url":null,"abstract":"In February 2002, a 42-year-old woman developed ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), MALT lymphoma, in the bilateral orbits involving lacrimal glands. She underwent 30 Gy external beam irradiation to the orbital lesions on both sides. She was well until November 2008 when she developed abdominal lymphadenopathy and transabdominal excisional biopsy showed mixed cellularity classical Hodgkin lymphoma at stage II. She underwent standard combination chemotherapy. In July 2010, she developed systemic lymphadenopathy and was diagnosed with diffuse large B-cell lymphoma (DLBCL) by cervical lymph node biopsy. She underwent rituximab monotherapy and finally allogeneic hematopoietic stem cell transplantation in October 2010, but died of renal failure in February 2011. Amplification by polymerase chain reaction of the immunoglobulin heavy chain gene gave rise to dominant discrete fragments of the same size between the orbital lesion with MALT lymphoma in 2002 and the cervical lymph node lesion with DLBCL in 2010. The sequential development of MALT lymphoma, Hodgkin lymphoma, and DLBCL in the long-term course of this patient suggests the common origin of the neoplastic cells, changing their pathological faces in response to irradiation and combination chemotherapy.","PeriodicalId":520662,"journal":{"name":"Journal of clinical and experimental hematopathology : JCEH","volume":" ","pages":"41-9"},"PeriodicalIF":1.5,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3960/jslrt.52.41","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30697005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Tuberculous meningoencephalitis in a patient with hairy cell leukemia in complete remission. 毛细胞白血病完全缓解的结核性脑膜脑炎1例。

IF 1.5

Journal of clinical and experimental hematopathology : JCEH Pub Date : 2012-01-01 DOI: 10.3960/jslrt.52.31

K Girardi, A Paviglianiti, M Cirillo, A Bianchi, G Gherardi, O Annibali, E Cerchiara, F Marchesi, V Tomarchio, C Miglio, Mc Tirindelli, A Onetti Muda, G Avvisati

引用次数: 5

Prediction of progression from refractory cytopenia with unilineage dysplasia by analysis of bone marrow blast cell composition. 通过分析骨髓母细胞组成预测难治性细胞减少症合并单株发育不良的进展。

IF 1.5

Journal of clinical and experimental hematopathology : JCEH Pub Date : 2012-01-01 DOI: 10.3960/jslrt.52.63

Satoko Oka, Kazuo Muroi, Shin-Ichiro Fujiwara, Iekuni Oh, Tomohiro Matsuyama, Ken Ohmine, Takahiro Suzuki, Katsutoshi Ozaki, Masaki Mori, Tadashi Nagai, Keiya Ozawa, Toshiaki Hanafusa

{"title":"Prediction of progression from refractory cytopenia with unilineage dysplasia by analysis of bone marrow blast cell composition.","authors":"Satoko Oka, Kazuo Muroi, Shin-Ichiro Fujiwara, Iekuni Oh, Tomohiro Matsuyama, Ken Ohmine, Takahiro Suzuki, Katsutoshi Ozaki, Masaki Mori, Tadashi Nagai, Keiya Ozawa, Toshiaki Hanafusa","doi":"10.3960/jslrt.52.63","DOIUrl":"https://doi.org/10.3960/jslrt.52.63","url":null,"abstract":"A retrospective analysis of 71 patients newly diagnosed with refractory cytopenia with unilineage dysplasia (RCUD) revealed that 12 developed refractory anemia with an excess of blasts or acute myeloblastic leukemia. Before the diagnosis of RCUD was made, phenotypes of cells in the bone marrow (BM) blast region were analyzed using flow cytometry. Patients with RCUD were divided into two groups ; those with no progression (Group A) and those with disease progression later on (Group B). The cell composition in the BM blast region differed significantly between the groups : Group A showed higher percentages of B lymphoid cells but lower percentages of myeloid cells. A cut-off value of 20 for the CD33/CD10 ratio in the BM blast region clearly separated Group A from Group B. These results suggest that cell composition in the BM blast region evaluated by flow cytometry may indicate the progression of RCUD.","PeriodicalId":520662,"journal":{"name":"Journal of clinical and experimental hematopathology : JCEH","volume":" ","pages":"63-6"},"PeriodicalIF":1.5,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30697007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3