Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism最新文献_第9页

Repeated hypoxia exposure induces cognitive dysfunction, brain inflammation, and amyloidβ/p-Tau accumulation through reduced brain O-GlcNAcylation in zebrafish. 反复缺氧暴露可通过减少斑马鱼脑o - glcn酰化诱导认知功能障碍、脑炎症和β -淀粉样蛋白/p-Tau积累。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-11-01 Epub Date: 2021-06-26 DOI: 10.1177/0271678X211027381

Jiwon Park, Sunhee Jung, Sang-Min Kim, In Young Park, Ngan An Bui, Geum-Sook Hwang, Inn-Oc Han

{"title":"Repeated hypoxia exposure induces cognitive dysfunction, brain inflammation, and amyloidβ/p-Tau accumulation through reduced brain O-GlcNAcylation in zebrafish.","authors":"Jiwon Park, Sunhee Jung, Sang-Min Kim, In Young Park, Ngan An Bui, Geum-Sook Hwang, Inn-Oc Han","doi":"10.1177/0271678X211027381","DOIUrl":"https://doi.org/10.1177/0271678X211027381","url":null,"abstract":"Repetitive hypoxia (RH) exposure affects the initiation and progression of cognitive dysfunction, but little is known about the mechanisms of hypoxic brain damage. In this study, we show that sublethal RH increased anxiety, impaired learning and memory (L/M), and triggered downregulation of brain levels of glucose and several glucose metabolites in zebrafish, and that supplementation of glucose or glucosamine (GlcN) restored RH-induced L/M impairment. Fear conditioning (FC)-induced brain activation of and PKA/CREB signaling was abrogated by RH, and this effect was reversed by GlcN supplementation. RH was associated with decreased brain O-GlcNAcylation and an increased O-GlcNAcase (OGA) level. RH increased brain inflammation and p-Tau and amyloid β accumulation, and these effects were suppressed by GlcN. Our observations collectively suggest that changes in O-GlcNAc flux during hypoxic exposure could be an important causal factor for neurodegeneration, and that supplementation of the HBP/O-GlcNAc flux may be a potential novel therapeutic or preventive target for addressing hypoxic brain damage.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3111-3126"},"PeriodicalIF":6.3,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211027381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39112403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Integrative analysis of the human brain mural cell transcriptome. 人脑壁细胞转录组的整合分析。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-11-01 Epub Date: 2021-05-22 DOI: 10.1177/0271678X211013700

Benjamin D Gastfriend, Koji L Foreman, Moriah E Katt, Sean P Palecek, Eric V Shusta

{"title":"Integrative analysis of the human brain mural cell transcriptome.","authors":"Benjamin D Gastfriend, Koji L Foreman, Moriah E Katt, Sean P Palecek, Eric V Shusta","doi":"10.1177/0271678X211013700","DOIUrl":"https://doi.org/10.1177/0271678X211013700","url":null,"abstract":"Brain mural cells, including pericytes and vascular smooth muscle cells, are important for vascular development, blood-brain barrier function, and neurovascular coupling, but the molecular characteristics of human brain mural cells are incompletely characterized. Single cell RNA-sequencing (scRNA-seq) is increasingly being applied to assess cellular diversity in the human brain, but the scarcity of mural cells in whole brain samples has limited their molecular profiling. Here, we leverage the combined power of multiple independent human brain scRNA-seq datasets to build a transcriptomic database of human brain mural cells. We use this combined dataset to determine human-mouse species differences in mural cell transcriptomes, culture-induced dedifferentiation of human brain pericytes, and human mural cell organotypicity, with several key findings validated by RNA fluorescence in situ hybridization. Together, this work improves knowledge regarding the molecular constituents of human brain mural cells, serves as a resource for hypothesis generation in understanding brain mural cell function, and will facilitate comparative evaluation of animal and in vitro models.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3052-3068"},"PeriodicalIF":6.3,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211013700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38942372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Association between pre-treatment perfusion profile and cerebral edema after reperfusion therapies in ischemic stroke. 缺血性脑卒中再灌注治疗后治疗前灌注情况与脑水肿的关系。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-11-01 Epub Date: 2021-05-17 DOI: 10.1177/0271678X211017696

Felix C Ng, Leonid Churilov, Nawaf Yassi, Timothy J Kleinig, Vincent Thijs, Teddy Y Wu, Darshan Shah, Helen M Dewey, Gagan Sharma, Patricia M Desmond, Bernard Yan, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis, Peter J Mitchell, Bruce Cv Campbell

{"title":"Association between pre-treatment perfusion profile and cerebral edema after reperfusion therapies in ischemic stroke.","authors":"Felix C Ng, Leonid Churilov, Nawaf Yassi, Timothy J Kleinig, Vincent Thijs, Teddy Y Wu, Darshan Shah, Helen M Dewey, Gagan Sharma, Patricia M Desmond, Bernard Yan, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis, Peter J Mitchell, Bruce Cv Campbell","doi":"10.1177/0271678X211017696","DOIUrl":"https://doi.org/10.1177/0271678X211017696","url":null,"abstract":"The relationship between reperfusion and edema is unclear, with experimental and clinical data yielding conflicting results. We investigated whether the extent of salvageable and irreversibly-injured tissue at baseline influenced the effect of therapeutic reperfusion on cerebral edema. In a pooled analysis of 415 patients with anterior circulation large vessel occlusion from the Tenecteplase-versus-Alteplase-before-Endovascular-Therapy-for-Ischemic-Stroke (EXTEND-IA TNK) part 1 and 2 trials, associations between core and mismatch volume on pre-treatment CT-Perfusion with cerebral edema at 24-hours, and their interactions with reperfusion were tested. Core volume was associated with increased edema (p < 0.001) with no significant interaction with reperfusion (p = 0.82). In comparison, a significant interaction between reperfusion and mismatch volume (p = 0.03) was observed: Mismatch volume was associated with increased edema in the absence of reperfusion (p = 0.009) but not with reperfusion (p = 0.27). When mismatch volume was dichotomized at the median (102 ml), reperfusion was associated with reduced edema in patients with large mismatch volume (p < 0.001) but not with smaller mismatch volume (p = 0.35). The effect of reperfusion on edema may be variable and dependent on the physiological state of the cerebral tissue. In patients with small to moderate ischemic core volume, the benefit of reperfusion in reducing edema is related to penumbral salvage.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"2887-2896"},"PeriodicalIF":6.3,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211017696","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38986311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model. 流诱导屏障和糖萼相关基因和负表面电荷在实验室芯片上的人血脑屏障模型。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-09-01 Epub Date: 2021-02-09 DOI: 10.1177/0271678X21992638

Ana R Santa-Maria, Fruzsina R Walter, Ricardo Figueiredo, András Kincses, Judit P Vigh, Marjolein Heymans, Maxime Culot, Peter Winter, Fabien Gosselet, András Dér, Mária A Deli

{"title":"Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model.","authors":"Ana R Santa-Maria, Fruzsina R Walter, Ricardo Figueiredo, András Kincses, Judit P Vigh, Marjolein Heymans, Maxime Culot, Peter Winter, Fabien Gosselet, András Dér, Mária A Deli","doi":"10.1177/0271678X21992638","DOIUrl":"https://doi.org/10.1177/0271678X21992638","url":null,"abstract":"Microfluidic lab-on-a-chip (LOC) devices allow the study of blood-brain barrier (BBB) properties in dynamic conditions. We studied a BBB model, consisting of human endothelial cells derived from hematopoietic stem cells in co-culture with brain pericytes, in an LOC device to study fluid flow in the regulation of endothelial, BBB and glycocalyx-related genes and surface charge. The highly negatively charged endothelial surface glycocalyx functions as mechano-sensor detecting shear forces generated by blood flow on the luminal side of brain endothelial cells and contributes to the physical barrier of the BBB. Despite the importance of glycocalyx in the regulation of BBB permeability in physiological conditions and in diseases, the underlying mechanisms remained unclear. The MACE-seq gene expression profiling analysis showed differentially expressed endothelial, BBB and glycocalyx core protein genes after fluid flow, as well as enriched pathways for the extracellular matrix molecules. We observed increased barrier properties, a higher intensity glycocalyx staining and a more negative surface charge of human brain-like endothelial cells (BLECs) in dynamic conditions. Our work is the first study to provide data on BBB properties and glycocalyx of BLECs in an LOC device under dynamic conditions and confirms the importance of fluid flow for BBB culture models.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"2201-2215"},"PeriodicalIF":6.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X21992638","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25350250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Effects of mild hypoxia on oxygen extraction fraction responses to brain stimulation. 轻度缺氧对脑刺激下氧提取部分反应的影响。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-09-01 Epub Date: 2021-02-09 DOI: 10.1177/0271678X21992896

Yayan Yin, Su Shu, Lang Qin, Yi Shan, Jia-Hong Gao, Jie Lu

{"title":"Effects of mild hypoxia on oxygen extraction fraction responses to brain stimulation.","authors":"Yayan Yin, Su Shu, Lang Qin, Yi Shan, Jia-Hong Gao, Jie Lu","doi":"10.1177/0271678X21992896","DOIUrl":"https://doi.org/10.1177/0271678X21992896","url":null,"abstract":"Characterizing the effect of limited oxygen availability on brain metabolism during brain activation is an essential step towards a better understanding of brain homeostasis and has obvious clinical implications. However, how the cerebral oxygen extraction fraction (OEF) depends on oxygen availability during brain activation remains unclear, which is mostly attributable to the scarcity and safety of measurement techniques. Recently, a magnetic resonance imaging (MRI) method that enables noninvasive and dynamic measurement of the OEF has been developed and confirmed to be applicable to functional MRI studies. Using this novel method, the present study investigated the motor-evoked OEF response in both normoxia (21% O2) and hypoxia (12% O2). Our results showed that OEF activation decreased in the brain areas involved in motor task execution. Decreases in the motor-evoked OEF response were greater under hypoxia (-21.7% ± 5.5%) than under normoxia (-11.8% ± 3.7%) and showed a substantial decrease as a function of arterial oxygen saturation. These findings suggest a different relationship between oxygen delivery and consumption during hypoxia compared to normoxia. This methodology may provide a new perspective on the effects of mild hypoxia on brain function.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"2216-2228"},"PeriodicalIF":6.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X21992896","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25350177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Acute micro-thrombosis after subarachnoid hemorrhage: A new therapeutic target? 蛛网膜下腔出血后急性微血栓形成:新的治疗靶点?

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-09-01 Epub Date: 2021-05-17 DOI: 10.1177/0271678X211013595

Fenghui Ye, Richard F Keep, Ya Hua, Hugh Jl Garton, Guohua Xi

引用次数: 11

ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood brain barrier modulation. ErbB3是脑微血管内皮细胞细胞骨架动力学的关键调节因子:血管重塑和血脑屏障调节的意义。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-09-01 Epub Date: 2021-02-14 DOI: 10.1177/0271678X20984976

Limin Wu, Mohammad R Islam, Janice Lee, Hajime Takase, Shuzhen Guo, Allison M Andrews, Tetyana P Buzhdygan, Justin Mathew, Wenlu Li, Ken Arai, Eng H Lo, Servio H Ramirez, Josephine Lok

{"title":"ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood brain barrier modulation.","authors":"Limin Wu, Mohammad R Islam, Janice Lee, Hajime Takase, Shuzhen Guo, Allison M Andrews, Tetyana P Buzhdygan, Justin Mathew, Wenlu Li, Ken Arai, Eng H Lo, Servio H Ramirez, Josephine Lok","doi":"10.1177/0271678X20984976","DOIUrl":"https://doi.org/10.1177/0271678X20984976","url":null,"abstract":"Neuregulin (NRG)1 - ErbB receptor signaling has been shown to play an important role in the biological function of peripheral microvascular endothelial cells. However, little is known about how NRG1/ErbB signaling impacts brain endothelial function and blood-brain barrier (BBB) properties. NRG1/ErbB pathways are affected by brain injury; when brain trauma was induced in mice in a controlled cortical impact model, endothelial ErbB3 gene expression was reduced to a greater extent than that of other NRG1 receptors. This finding suggests that ErbB3-mediated processes may be significantly compromised after injury, and that an understanding of ErbB3 function would be important in the of study of endothelial biology in the healthy and injured brain. Towards this goal, cultured brain microvascular endothelial cells were transfected with siRNA to ErbB3, resulting in alterations in F-actin organization and microtubule assembly, cell morphology, migration and angiogenic processes. Importantly, a significant increase in barrier permeability was observed when ErbB3 was downregulated, suggesting ErbB3 involvement in BBB regulation. Overall, these results indicate that neuregulin-1/ErbB3 signaling is intricately connected with the cytoskeletal processes of the brain endothelium and contributes to morphological and angiogenic changes as well as to BBB integrity.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"2242-2255"},"PeriodicalIF":6.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X20984976","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25370394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Brain energy metabolism in intracerebroventricularly administered streptozotocin mouse model of Alzheimer's disease: A ¹H-[¹³C]-NMR study. 脑室内给药链脲佐菌素小鼠阿尔茨海默病模型的脑能代谢:1H-[13C]- nmr研究

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-09-01 Epub Date: 2021-03-03 DOI: 10.1177/0271678X21996176

Narayan D Soni, Akila Ramesh, Dipak Roy, Anant B Patel

{"title":"Brain energy metabolism in intracerebroventricularly administered streptozotocin mouse model of Alzheimer's disease: A 1H-[13C]-NMR study.","authors":"Narayan D Soni, Akila Ramesh, Dipak Roy, Anant B Patel","doi":"10.1177/0271678X21996176","DOIUrl":"https://doi.org/10.1177/0271678X21996176","url":null,"abstract":"Alzheimer's disease (AD) is a very common neurodegenerative disorder. Although a majority of the AD cases are sporadic, most of the studies are conducted using transgenic models. Intracerebroventricular (ICV) administered streptozotocin (STZ) animals have been used to explore mechanisms in sporadic AD. In this study, we have investigated memory and neurometabolism of ICV-STZ-administered C57BL6/J mice. The neuronal and astroglial metabolic activity was measured in 1H-[13C]-NMR spectrum of cortical and hippocampal tissue extracts of mice infused with [1,6-13C2]glucose and [2-13C]acetate, respectively. STZ-administered mice exhibited reduced (p = 0.00002) recognition index for memory. The levels of creatine, GABA, glutamate and NAA were reduced (p ≤ 0.04), while that of myo-inositol was increased (p < 0.05) in STZ-treated mice. There was a significant (p ≤ 0.014) reduction in aspartate-C3, glutamate-C4/C3, GABA-C2 and glutamine-C4 labeling from [1,6-13C2]glucose. This resulted in decreased rate of glucose oxidation in the cerebral cortex (0.64 ± 0.05 vs. 0.77 ± 0.05 µmol/g/min, p = 0.0008) and hippocampus (0.60 ± 0.04 vs. 0.73 ± 0.07 µmol/g/min, p = 0.001) of STZ-treated mice, due to similar reductions of glucose oxidation in glutamatergic and GABAergic neurons. Additionally, reduced glutamine-C4 labeling points towards compromised synaptic neurotransmission in STZ-treated mice. These data suggest that the ICV-STZ model exhibits neurometabolic deficits typically observed in AD, and its utility in understanding the mechanism of sporadic AD.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"2344-2355"},"PeriodicalIF":6.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X21996176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25433339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture. 星形胶质细胞CB1R的激活介导电针诱导的脑缺血耐受。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-09-01 Epub Date: 2021-03-04 DOI: 10.1177/0271678X21994395

Cen Yang, Jingjing Liu, Jingyi Wang, Anqi Yin, Zhenhua Jiang, Shuwei Ye, Xue Liu, Xia Zhang, Feng Wang, Lize Xiong

{"title":"Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture.","authors":"Cen Yang, Jingjing Liu, Jingyi Wang, Anqi Yin, Zhenhua Jiang, Shuwei Ye, Xue Liu, Xia Zhang, Feng Wang, Lize Xiong","doi":"10.1177/0271678X21994395","DOIUrl":"https://doi.org/10.1177/0271678X21994395","url":null,"abstract":"There are no effective treatments for stroke. The activation of endogenous protective mechanisms is a promising therapeutic approach, which evokes the intrinsic ability of the brain to protect itself. Accumulated evidence strongly suggests that electroacupuncture (EA) pretreatment induces rapid tolerance to cerebral ischemia. With regard to mechanisms underlying ischemic tolerance induced by EA, many molecules and signaling pathways are involved, such as the endocannabinoid system, although the exact mechanisms have not been fully elucidated. In the current study, we employed mutant mice, neuropharmacology, microdialysis, and virus transfection techniques in a middle cerebral artery occlusion (MCAO) model to explore the cell-specific and brain region-specific mechanisms of EA-induced neuroprotection. EA pretreatment resulted in increased ambient endocannabinoid (eCB) levels and subsequent activation of ischemic penumbral astroglial cannabinoid type 1 receptors (CB1R) which led to moderate upregulation of extracellular glutamate that protected neurons from cerebral ischemic injury. These findings provide a novel cellular mechanism of EA and a potential therapeutic target for ischemic stroke.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"2295-2310"},"PeriodicalIF":6.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X21994395","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25437836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Targeting neutrophils as a novel therapeutic strategy after stroke. 靶向中性粒细胞作为脑卒中后治疗的新策略。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-09-01 Epub Date: 2021-03-10 DOI: 10.1177/0271678X211000137

Chen Chen, Tingting Huang, Xiaozhu Zhai, Yezhi Ma, Lv Xie, Bingwei Lu, Yueman Zhang, Yan Li, Zengai Chen, Jiemin Yin, Peiying Li

{"title":"Targeting neutrophils as a novel therapeutic strategy after stroke.","authors":"Chen Chen, Tingting Huang, Xiaozhu Zhai, Yezhi Ma, Lv Xie, Bingwei Lu, Yueman Zhang, Yan Li, Zengai Chen, Jiemin Yin, Peiying Li","doi":"10.1177/0271678X211000137","DOIUrl":"https://doi.org/10.1177/0271678X211000137","url":null,"abstract":"Stroke is followed by an intricate immune interaction involving the engagement of multiple immune cells, including neutrophils. As one of the first responders recruited to the brain, the crucial roles of neutrophils in the ischemic brain damage are receiving increasing attention in recent years. Notably, neutrophils are not homogenous, and yet there is still a lack of full knowledge about the extent and impact of neutrophil heterogeneity. The biological understanding of the neutrophil response to both innate and pathological conditions is rapidly evolving as single-cell-RNA sequencing uncovers overall neutrophil profiling across maturation and differentiation contexts. In this review, we scrutinize the latest research that points to the multifaceted role of neutrophils in different conditions and summarize the regulatory signals that may determine neutrophil diversity. In addition, we list several potential targets or therapeutic strategies targeting neutrophils to limit brain damage following ischemic stroke.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"2150-2161"},"PeriodicalIF":6.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211000137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25453941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19