Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism最新文献

{"title":"Corrigendum to \"Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/YAP pathway in a neonatal rat model of germinal matrix hemorrhage\".","authors":"","doi":"10.1177/0271678X251357166","DOIUrl":"https://doi.org/10.1177/0271678X251357166","url":null,"abstract":"","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251357166"},"PeriodicalIF":4.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of relaxation-exchange magnetic resonance imaging (REXI) for measuring water exchange across the blood-CSF barrier in the human choroid plexus.","authors":"Xuetao Wu, Shuyuan Tan, Yifan Zhang, Yu Yin, Yi-Cheng Hsu, Rong Xue, Ruiliang Bai","doi":"10.1177/0271678X251369218","DOIUrl":"https://doi.org/10.1177/0271678X251369218","url":null,"abstract":"<p><p>The choroid plexus (CP) is important for cerebrospinal fluid (CSF) secretion and forms the blood-CSF barrier (BCSFB), which is essential for brain homeostasis. However, noninvasive methods for evaluating BCSFB function remain limited. Previously, we introduced a novel magnetic resonance imaging (MRI) technique, relaxation-exchange MRI (REXI), to quantify water exchange between CP and CSF in rats by leveraging the substantial difference in transverse relaxation times between CP tissue and CSF. Here, we adapted REXI to human applications by implementing segmented echo-planar imaging readout for enhanced acquisition speed, optimizing key parameters based on the Cramér-Rao lower bound, and refining the analysis methodology. We conducted simulations and phantom experiments for methodological validation. Subsequently, we performed a scan-rescan experiment in healthy volunteers (n = 6, mean-age ∼22 years), revealing relatively good repeatability in measurements of the apparent water exchange rate <i>k</i>_BCSFB (intraclass correlation coefficient = 0.84). REXI detected a 34% decrease in <i>k</i>_BCSFB among middle-aged healthy adults (n = 6, mean-age ∼55 years) compared with young healthy adults (n = 9, mean-age ∼23 years, <i>p = </i>0.0048). These results demonstrate the feasibility of REXI in quantifying water exchange in human CP in vivo, providing a promising tool for future investigations of BCSFB function.</p>","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251369218"},"PeriodicalIF":4.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small vessel dysfunction at 7T MRI locally predicts white matter damage progression in CADASIL.","authors":"Stanley Dt Pham, Hilde van den Brink, Anna Kopczak, Naomi Vlegels, Alberto De Luca, Benno Gesierich, Michael S Stringer, Michael J Thrippleton, Joanna M Wardlaw, Alex A Bhogal, Nikki Dieleman, Jacobus Jm Zwanenburg, Marco Duering, Geert Jan Biessels, Jeroen Cw Siero","doi":"10.1177/0271678X251369257","DOIUrl":"https://doi.org/10.1177/0271678X251369257","url":null,"abstract":"<p><p>Cerebral small vessel diseases (cSVDs) contribute significantly to stroke and dementia. Advanced 7 T MRI techniques have revealed small vessel dysfunction in cSVD patients, linked to global white matter damage cross-sectionally. However, it remains unclear whether these vascular deficits predict progressive tissue damage. This longitudinal study examined the spatial relationship between local vascular function and white matter damage progression in patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). Twenty-two patients underwent baseline small vessel function assessment using 7 T MRI. Voxelwise blood-oxygenation level-dependent cerebrovascular reactivity (BOLD-CVR) to a hypercapnic was evaluated. White matter changes were assessed on 3 T MRI over two years, analyzing mean diffusivity changes and conversion of normal-appearing white matter to white matter hyperintensities (WMH). Results showed significant global increases in white matter damage over time. Voxelwise analysis revealed that lower baseline BOLD-CVR magnitude and higher dispersion were associated with increased white matter damage and WMH progression at specific locations at follow-up. However, whole-brain vascular function measures did not predict white matter changes at a global level. These findings suggest that local vascular function plays a key role in white matter damage progression in CADASIL, highlighting the importance of regional vascular health in cSVDs.</p>","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251369257"},"PeriodicalIF":4.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted proteomic analysis identifies ACVRL1 as a marker of cerebral edema in aneurysmal subarachnoid hemorrhage.","authors":"Bosco Seong Kyu Yang, Lena O'Keefe, Sarah Hinds, Hua Chen, Athziry Paz, Jude Savarraj, Han-Gil Jeong, Moon-Ku Han, Aaron Gusdon, Xuefang Sophie Ren, Spiros Blackburn, Huimahn Alex Choi","doi":"10.1177/0271678X251361250","DOIUrl":"https://doi.org/10.1177/0271678X251361250","url":null,"abstract":"<p><p>Cerebral edema (CE) is a major component of early brain injury from aneurysmal subarachnoid hemorrhage (SAH). Despite the utility of blood-based protein markers, biomarkers targeting cerebral edema have yet to be developed. We performed a targeted proteomic search analyzing 141 proteins in plasma samples taken from 80 adult patients within 48 hours after aneurysmal rupture to identify plasma biomarkers of cerebral edema. The protein expression profiles were analyzed for associations with a higher level of the subarachnoid hemorrhage early brain edema score measured in admission computed tomography scans. Five differentially expressed proteins-brorin, ectodysplasin A2 receptor, layilin, scavenger receptor class A member 5, and activin A receptor like type 1 (ACVRL1)-were identified. To confirm our findings, in a separate cohort of 75 adult patients with SAH, these biomarker candidates was analyzed using a different confirmatory analytic method-enzyme-linked immunosorbent assay-based on the plasma samples collected within 48 hours after aneurysmal rupture. ACVRL1 levels consistently showed a decrease expression levels as the severity of edema increased. The association between CE and ACVRL1 was significant before and after adjusting for patient factors.</p>","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251361250"},"PeriodicalIF":4.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome analyses of brain arteries and microvessels in male and female mice reveal prominent olfactory receptor gene and protein expression.","authors":"David W Busija, Melody C Baddoo, Erik K Flemington, Mary E Schulz, Jorge A Castorena-Gonzalez, Partha K Chandra, Ibolya Rutkai-Green","doi":"10.1177/0271678X251359753","DOIUrl":"10.1177/0271678X251359753","url":null,"abstract":"<p><p>We studied sex differences of large arteries (LAs: Circle of Willis, middle cerebral and basilar arteries) and microvessels (MVs: end arterioles, capillaries, and venules) in the brain circulation of young male/female C57Bl6/J mice and evaluated results using KEGG enrichment plots. Most surprising was the discovery of gene expression in <i>KEGG olfactory transduction</i> (olfactory receptors [ORs] and signaling pathways) which was predominant in LAs compared with MVs for both sexes, although expression was greater in males for most, but not all, ORs. Western blots demonstrated substantial protein levels of several ORs in both sexes. Immunofluorescence showed the prominent expression of ORs in the adventitia in a pattern resembling perivascular innervation. Female LAs manifested <i>KEGG ribosome</i> enrichment compared with male LAs. Also prominent in female LAs was upregulation of mitochondrial related genes as seen in <i>KEGG Parkinson's disease</i>. Male MVs showed enhanced expression of <i>KEGG neuroactive ligand receptor interaction</i> whereas female MVs showed enhanced expression of <i>KEGG intestinal immune network for IGA production</i>. Male KEGG pathway MVs included numerous neurotransmitter receptor expression genes, whereas female MVs KEGG pathway promoted anti-inflammatory products. Our findings provide for further explorations of sex and segmental differences especially ORs affecting cerebral vascular function during health and disease.</p>","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251359753"},"PeriodicalIF":4.5,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal perinidal cerebral metabolism is associated with symptoms in brain arteriovenous malformation: New insights by a novel approach using oxygen-15 labelled tracers and PET.","authors":"Atsushi Hashio, Taichi Ikedo, Hisae Mori, Hidehiro Iida, Daisuke Maruyama, Masayuki Yamagishi, Yoshiaki Kitazawa, Etsuko Yamamoto Hattori, Koji Shimonaga, Eika Hamano, Kiyofumi Yamada, Hirotoshi Imamura, Koji Iihara, Hiroharu Kataoka","doi":"10.1177/0271678X251369258","DOIUrl":"10.1177/0271678X251369258","url":null,"abstract":"<p><p>The mechanisms underlying neurological symptoms, including epilepsy, in unruptured brain arteriovenous malformations (bAVM) remain to be elucidated. The dual-tracer basis function method (DBFM) with single-scan dual-tracer (¹⁵O₂ and C¹⁵O₂) approach is a novel PET imaging technique that can evaluate the hemodynamics and metabolism of brain tissue adjacent to the nidus without the influence of abundant vascular radioactivity. We aimed to clarify the relationship between neurological symptoms and hemodynamic and metabolic abnormalities using the DBFM. Cerebral blood volume (CBV), cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO₂), and oxygen extraction fraction (OEF) were compared between symptomatic and asymptomatic bAVMs and before and after treatment. Among 46 patients with unruptured bAVMs who underwent DBFM, 26 cases were included. While CBV and OEF increased in the perinidus (p < 0.01), CBF and CMRO₂ decreased (p < 0.01). Symptoms were significantly associated with higher OEF (symptomatic vs. asymptomatic, ratio of perinidal to contralateral, n = 13 vs. n = 13, 1.07 ± 0.030 vs. 1.01 ± 0.080, p = 0.017). All elevated OEFs in symptomatic bAVMs with therapeutic symptom resolved in post-therapeutic PET imaging. DBFM revealed a higher OEF was associated with symptomatic bAVM. The DBFM potentially aids in predicting post-therapeutic symptom improvement.</p>","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251369258"},"PeriodicalIF":4.5,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model.","authors":"Vanessa O Torres, Michelle E Pizzo, Darren Chan, Jason C Dugas, David Huynh, David Joy, Eric K Liang, Lily Sarrafha, Isabel Becerra, Roni Chau, Kylie S Chew, Johann Chow, Claire B Discenza, Timothy K Earr, Laura Furaso, Nathalie Khoury, Kendra J Lechtenberg, Amy W Leung, Hoang N Nguyen, Emmanuel S Ojo, Elysia Roche, Matthew J Simon, Hilda Solanoy, Mabel Tong, Raymond K Tong, Kirk Henne, Joseph W Lewcock, Ryan J Watts, Meredith E Calvert, Robert G Thorne, Y Joy Yu Zuchero","doi":"10.1177/0271678X251361997","DOIUrl":"10.1177/0271678X251361997","url":null,"abstract":"<p><p>Transferrin receptor (TfR)-targeting of biologics has emerged as a promising strategy to improve drug delivery across the blood-brain barrier (BBB). However, most preclinical studies evaluating TfR-enabled drugs have been conducted in young adult animals. It remains unclear whether age and aging-related diseases impact TfR protein levels and/or BBB transport capacity. Here, we utilized a previously described TfR-targeting antibody transport vehicle (ATV^TfR) to investigate how healthy aging and disease progression in the 5xFAD mouse model of Alzheimer's disease (AD) impact TfR protein and TfR-mediated brain delivery. ATV^TfR transport capacity remained stable across 3- to 24-month-old healthy mice and 5xFAD progression did not impair ATV^TfR brain transport up to 10.5 months, despite significant amyloid burden. Interestingly, neonates exhibited significantly elevated levels of vascular TfR protein and ATV^TfR brain exposure compared to adult mice. Furthermore, vascular TfR in AD patient brains was similar to age-matched controls, suggesting conserved TfR transport is also likely in human AD. Overall, our data demonstrates broad functional utility for TfR-based brain delivery in both healthy aging and in an AD mouse model. Additionally, elevated TfR-mediated brain delivery during early mouse development highlights the potential of added efficacy in utilizing such platforms in disease treatment of infants and children.</p>","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251361997"},"PeriodicalIF":4.5,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse traumatic brain injury in mice is associated with a transient mismatch of cerebral blood flow and energy metabolism.","authors":"Sertan Arkan, Michael Gottschalk, Saema Ansar, Jesper Peter Bömers, Johannes Ehinger, Eskil Elmér, Imen Chamkha, Michael Karlsson, Niklas Marklund","doi":"10.1177/0271678X251364136","DOIUrl":"10.1177/0271678X251364136","url":null,"abstract":"<p><p>Axonal injuries commonly contribute to poor functional outcomes following traumatic brain injury (TBI). To assess cerebral blood flow (CBF) and energy metabolic disturbances in a TBI model of widespread axonal injury, we exposed 105 adult mice to the central (midline) fluid percussion injury (cFPI) diffuse TBI model, or sham injury, and used 9.4 T magnetic resonance (MR) arterial spin labeling (ASL), cortical and hippocampal mitochondrial respiration, and hippocampal MR spectroscopy at 1- and 7-days post-injury (dpi). Widespread, bilateral CBF reductions were observed at day 1 dpi, changes that were normalized by 7 dpi. However, cortical and hippocampal mitochondrial respiration and reactive oxygen species (ROS) production was not significantly altered at 1 and 7 dpi. Moreover, hippocampal volumes, evaluated by MRI, were not altered by cFPI, and by immunohistochemistry only a few apoptotic hippocampal cells were observed. By MRS, evidence of delayed (7 dpi) membrane disruption (phosphocholine and glycerophosphocholine) and glutamate/glutamine increase were observed. While widespread traumatic axonal pathology associated with functional impairments is observed in this TBI model, early CBF alterations were transient and did not translate into significant energy metabolic disturbances. Instead, the delayed hippocampal metabolite changes observed by MRS may contribute to the functional impairment observed in this diffuse TBI model.</p>","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251364136"},"PeriodicalIF":4.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic expression of type III collagen in the lesion core of post-ischemic brain colocalizing with angiogenesis and lipid droplets during fibrotic scar formation.","authors":"Tohru Mutoh, Keiko Kitajo, Atsushi Yamaguchi","doi":"10.1177/0271678X251366820","DOIUrl":"10.1177/0271678X251366820","url":null,"abstract":"<p><p>Two distinct types of scars are formed in the brain after ischemic stroke: glial scar and fibrotic scar. Dynamic collagen expression has been well-studied in peripheral tissue wound healing. However, it is less understood in the post-ischemic brain. This study investigated the spatiotemporal dynamics of type III collagen (Col III) in the lesion core of mouse photothrombotic stroke model. First, RNA-seq analysis was performed to examine the transcriptional profiling of the lesion core at 14 days post-injury (dpi). <i>Collagen 3a1</i>, encoding Col III, was one of the most induced genes. Gene ontology (GO) enrichment analysis revealed that inflammatory responses are primarily activated, as well as phagosome, extracellular matrix (ECM) organization, and vasculature development pathways. In the subacute stage (at 3-14 dpi), Col III immunoreactivity was higher than Col I, which surrounded the penetrating vasculatures from the meninges. Late (14-28 dpi), the fibrillar mesh of Col III was prominent in which Iba1-positive phagocytes stored lipid droplets (LDs). <i>In vivo</i> injection of collagen synthesis inhibitor reduced penetrating vasculatures, decreased LD accumulation, and increased the infarcted area. Collectively, these results suggest that Col III is dynamically expressed in the lesion core during fibrotic scar formation colocalizing with angiogenesis and LDs.</p>","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251366820"},"PeriodicalIF":4.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional and post-transcriptional responses to amyloid-<b>β</b> in cerebral amyloid angiopathy.","authors":"Barend W Florijn, Niek A Verwey, Ellis S van Etten, Helga E de Vries, Marieke Jh Wermer","doi":"10.1177/0271678X251366082","DOIUrl":"10.1177/0271678X251366082","url":null,"abstract":"<p><p>Cerebral amyloid angiopathy (CAA) is a common age-related small vessel disease characterized by amyloid-beta (Aβ) accumulation in cortical and leptomeningeal blood vessel walls. Reduced Aβ clearance in the vasculature elevates the risk of CAA, while increasing evidence indicates that enhanced Aβ production in neurons also contributes. The impact of Aβ on the diverse cell types of the neurovascular unit (NVU)-including endothelial cells (ECs), pericytes, neurons, vascular smooth muscle cells (VSMCs), and astrocytes-remains unclear. This narrative review proposes that Aβ accumulation in NVUs during CAA drives a transcriptional response that reduces Aβ clearance while activating a neuron-specific post- transcriptional response that enhances Aβ production. Specifically, Aβ in NVUs was found to initiate a transcriptional cascade that destabilizes endothelial cells, increases blood-brain barrier permeability, and damages pericytes, ultimately inducing inflammatory and dysfunctional changes in VSMCs. These changes cause mitochondrial dysfunction and TGFβ deregulation in neurons, activating profibrotic mechanisms. Post-transcriptional regulation by microRNA networks in neurons affects Aβ processing by controlling the balance between amyloidogenic and non-amyloidogenic pathways through BACE1 and ADAM10 expression respectively. This review improves our understanding of Aβ accumulation in neurovascular units in CAA, potentially leading to better diagnostics, early biomarkers, and tools for prognosis and treatment.</p>","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251366082"},"PeriodicalIF":4.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}