Journal of alternative and complementary medicine (New York, N.Y.)最新文献

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Effects of physical therapy on pain and mood in patients with terminal cancer: a pilot randomized clinical trial. 物理治疗对晚期癌症患者疼痛和情绪的影响:一项试点随机临床试验。
IF 2.6
Journal of alternative and complementary medicine (New York, N.Y.) Pub Date : 2012-05-01 Epub Date: 2012-04-27 DOI: 10.1089/acm.2011.0277
Nuria López-Sendín, Francisco Alburquerque-Sendín, Joshua A Cleland, César Fernández-de-las-Peñas
{"title":"Effects of physical therapy on pain and mood in patients with terminal cancer: a pilot randomized clinical trial.","authors":"Nuria López-Sendín,&nbsp;Francisco Alburquerque-Sendín,&nbsp;Joshua A Cleland,&nbsp;César Fernández-de-las-Peñas","doi":"10.1089/acm.2011.0277","DOIUrl":"https://doi.org/10.1089/acm.2011.0277","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to determine the effects of physical therapy, including massage and exercise, on pain and mood in patients with advanced terminal cancer.</p><p><strong>Design: </strong>The design was a randomized controlled pilot study.</p><p><strong>Subjects: </strong>Twenty-four (24) patients with terminal cancer were randomly assigned to one of two treatment groups.</p><p><strong>Interventions: </strong>Group A received a physiotherapy intervention consisting of several massage techniques, mobilizations, and local and global exercises. Group B received a simple hand contact/touch to areas of pain (cervical area, shoulder, interscapular area, heels, and gastrocnemius), which was maintained for the same period of time as the intervention group. All patients received six sessions of 30-35 minutes in duration over a 2-week period.</p><p><strong>Outcomes: </strong>Outcomes were collected at baseline, at 1 week, and at a 2-week follow-up (after treatment completion) by an assessor blinded to the treatment allocation of the participants. Outcomes included the Brief Pain Inventory (BPI, 0-10 scale), Memorial Pain Assessment Card (0-10 scale), and Memorial Symptom Assessment Scale (MSAS Physical, Psychological, 0-4 scale). Baseline between-group differences were assessed with an independent t-test. A two-way repeated-measures analysis of variance was used to examine the effects of the intervention.</p><p><strong>Results: </strong>There were no significant between-group baseline differences (p>0.2). A significant group × time interaction with greater improvements in group A was found for BPI worst pain (F=3.5, p=0.036), BPI pain right now (F=3.94, p=0.027), and BPI index (F=13.2, p<0.001), for MSAS Psychological (F=8.480, p=0.001).</p><p><strong>Conclusions: </strong>The combination of massage and exercises can reduce pain and improve mood in patients with terminal cancer. A sustained effect on pain and psychologic distress existed; however, parameters such as physical distress and the least pain were no greater in the intervention group as compared to the sham.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"480-6"},"PeriodicalIF":2.6,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2011.0277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40188689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 60
A case of unilateral pleural effusion secondary to congestive heart failure successfully treated with traditional Chinese herbal formulas. 中药方剂治疗充血性心力衰竭单侧胸腔积液1例。
IF 2.6
Journal of alternative and complementary medicine (New York, N.Y.) Pub Date : 2012-05-01 Epub Date: 2012-04-26 DOI: 10.1089/acm.2011.0292
Han-Dao Lee, Hsien-Hsueh Elley Chiu
{"title":"A case of unilateral pleural effusion secondary to congestive heart failure successfully treated with traditional Chinese herbal formulas.","authors":"Han-Dao Lee,&nbsp;Hsien-Hsueh Elley Chiu","doi":"10.1089/acm.2011.0292","DOIUrl":"https://doi.org/10.1089/acm.2011.0292","url":null,"abstract":"<p><strong>Objectives: </strong>A case is presented that illustrates the potential effect of traditional Chinese medicine (TCM) herbal formulas on treatment for unilateral pleural effusion secondary to congestive heart failure (CHF).</p><p><strong>Subject: </strong>A 79-year-old woman experienced episodic dyspnea with unilateral pleural effusion for 2 years. Thoracocentesis with pleural fluid analysis revealed no infection, tuberculosis, or malignancy. She had received conventional treatment for CHF but the symptoms persisted. Therefore, she visited the authors' TCM clinic for help.</p><p><strong>Interventions and outcome: </strong>This patient was treated with TCM herbal granules including Shengmaisan, Xiebaisan, and Tinglizi, 3 times a day for 4 weeks. The daily dosage was adjusted on the basis of the patient's clinical response and her follow-up chest x-ray studies. After 8 months of treatment, her symptoms improved and the pleural effusion showed significant regression.</p><p><strong>Conclusions: </strong>It is suggested that TCM herbal formulas could play an important role in preventing the progression of unilateral pleural effusion secondary to CHF, in case of poor response to conservative treatment. Additional studies about the mechanism of action of the medication involved are warranted.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"509-12"},"PeriodicalIF":2.6,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2011.0292","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40186916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A comparative pilot study of litholytic properties of Celosia argental (Sitivaraka) versus potassium citrate in renal calculus disease. 阿根廷芹与柠檬酸钾在肾结石治疗中的溶石特性比较初步研究。
IF 2.6
Journal of alternative and complementary medicine (New York, N.Y.) Pub Date : 2012-05-01 Epub Date: 2012-04-26 DOI: 10.1089/acm.2011.0431
Rana G Singh, Takhellambam Brojen Singh, Rakesh Kumar, Udal S Dwivedi, Kanupuri N Moorthy, Neeraj Kumar
{"title":"A comparative pilot study of litholytic properties of Celosia argental (Sitivaraka) versus potassium citrate in renal calculus disease.","authors":"Rana G Singh,&nbsp;Takhellambam Brojen Singh,&nbsp;Rakesh Kumar,&nbsp;Udal S Dwivedi,&nbsp;Kanupuri N Moorthy,&nbsp;Neeraj Kumar","doi":"10.1089/acm.2011.0431","DOIUrl":"https://doi.org/10.1089/acm.2011.0431","url":null,"abstract":"Dear Editor: Nephrolithiasis is a global problem from ancient times and many remedies have been used over the ages. Its incidence varies in different parts of world, and many factors are contributory, such as high intake of animal proteins, wheat diets, and hot and dry climate, which might augment the risk of stone formation. In industrialized nations, it affects about 10% of the population with an annual incidence of 0.5%–1.9%. In India, the incidence of renal stone is still high (30 of 1000 population). It is more common in Northern India compared to the southern state. Calcium oxalate urolithiasis accounts for approximately 75% of urinary stone disease in the United States. In Ayurvedic literature, a number of drugs have been described that are very effective against nephrolithiasis. Kulattha, Sitivaraka, Varun, and Sighru are among them. We conducted a study to compare the efficacy of herbal medicine, Sitivaraka (Celosia argental) with potassium citrate as litholytic agent in urinary stone diseases. The ethical committee of the university had approved the study. In this randomized, controlled, open-label trial, we selected 44 patients with renal stones and randomly divided them into two groups to receive the drugs. Group I received Sitivaraka seed preparation (dose: 10 mg/kg body weight 3 times daily) and group II received potassium citrate (dose: 0.25 mL/kg body weight every 6 hours). A total of 21 cases were in group I and 23 cases were in group II. Inclusion criteria were the following:","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"427-8"},"PeriodicalIF":2.6,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2011.0431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40186917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Effects of an integrated approach of hatha yoga therapy on functional disability, pain, and flexibility in osteoarthritis of the knee joint: a randomized controlled study. 哈达瑜伽综合疗法对膝关节骨关节炎功能障碍、疼痛和柔韧性的影响:一项随机对照研究。
IF 2.6
Journal of alternative and complementary medicine (New York, N.Y.) Pub Date : 2012-05-01 Epub Date: 2012-04-26 DOI: 10.1089/acm.2010.0320
John Ebnezar, Raghuram Nagarathna, Bali Yogitha, Hongasandra Ramarao Nagendra
{"title":"Effects of an integrated approach of hatha yoga therapy on functional disability, pain, and flexibility in osteoarthritis of the knee joint: a randomized controlled study.","authors":"John Ebnezar,&nbsp;Raghuram Nagarathna,&nbsp;Bali Yogitha,&nbsp;Hongasandra Ramarao Nagendra","doi":"10.1089/acm.2010.0320","DOIUrl":"https://doi.org/10.1089/acm.2010.0320","url":null,"abstract":"<p><strong>Objectives: </strong>The study objectives were to evaluate the efficacy of integrating hatha yoga therapy with therapeutic exercises for osteoarthritis (OA) of the knee joints.</p><p><strong>Design: </strong>This was a prospective, randomized, active controlled trial. Two hundred and fifty (250) participants who had OA knees and who were between 35 and 80 years (yoga 59.56±9.54) and (control 59.42±10.66) from the outpatient department of Ebnezar Orthopedic Center, Bengaluru, were randomly assigned to receive hatha yoga therapy or therapeutic exercises after transcutaneous electrical stimulation and ultrasound treatment (20 minutes per day). Both of the groups practiced supervised interventions (40 minutes per day) for 3 months. One hundred and eighteen (118) (yoga) and 117 (control) subjects were available for the final analysis.</p><p><strong>Results: </strong>There were significant differences within (Wilcoxon's, p<0.001) and between the groups (Mann-Whitney U, p<0.001) on all the variables, with better improvements in the yoga than the control groups. Walking pain in the yoga (37.3%, 64.9%) and control (24.9%, 42%), knee disability in the yoga (59.7%, 83%) and control (32.7%, 53.6%), range of knee flexion in yoga (12.7%, 26.5% right, 13.5%, 28% left) and control (6.9%, 13.3% right, 5.6%, 11.5% left), joint tenderness in yoga (52.3%, 86.1%) and control (28%, 57.1%), swelling in yoga (55.4%, 85.9%) and control (32.1%, 60%), crepitus in yoga (44.0%, 79.9%) and control (27.0%, 47.8%) and walking time in yoga (26.6%, 52.8%) and control (9.3%, 21.6%), all improved more in the yoga than the control groups on the 15th and 90th day, respectively.</p><p><strong>Conclusions: </strong>An integrated approach of hatha yoga therapy is better than therapeutic exercises as an adjunct to transcutaneous electrical stimulation and ultrasound treatment in improving walking pain, range of knee flexion, walking time, tenderness, swelling, crepitus, and knee disability in patients with OA knees.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"463-72"},"PeriodicalIF":2.6,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2010.0320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40185748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 74
The pulse spectrum analysis at three stages of pregnancy. 妊娠三个阶段的脉搏谱分析。
IF 2.6
Journal of alternative and complementary medicine (New York, N.Y.) Pub Date : 2012-04-01 Epub Date: 2012-03-15 DOI: 10.1089/acm.2010.0575
Yin-Tzu Liao, Huey-Yi Chen, Chin-Ming Huang, Ming Ho, Jaung-Geng Lin, Chun-Chien Chiu, Hong-Song Wang, Fun-jou Chen
{"title":"The pulse spectrum analysis at three stages of pregnancy.","authors":"Yin-Tzu Liao,&nbsp;Huey-Yi Chen,&nbsp;Chin-Ming Huang,&nbsp;Ming Ho,&nbsp;Jaung-Geng Lin,&nbsp;Chun-Chien Chiu,&nbsp;Hong-Song Wang,&nbsp;Fun-jou Chen","doi":"10.1089/acm.2010.0575","DOIUrl":"https://doi.org/10.1089/acm.2010.0575","url":null,"abstract":"<p><strong>Objectives: </strong>This study is the first to detect the radial pulses of the three diagnosis positions (inch, bar, and cubit) in both wrists (six positions) by pulse spectrum analysis. The purpose of this study was to identify the difference among pulses of the six positions at three stages of pregnancy and to examine whether the results of this study agree with the theory of Traditional Chinese Medicine (TCM), which states that the cubit pulse shows unique changes for an expectant woman and that the pulse changes coincide with the progression of gestation.</p><p><strong>Subjects and methods: </strong>One hundred and fifty (150) healthy pregnant women were divided into three groups according to gestational age (9-14 weeks, 20-28 weeks, and 32-37 weeks of gestation) and 50 healthy nonpregnant women were used as controls. A pulse analyzer was used to detect the six positions of the radial pulses and to calculate the 10 relative energy values of the spectrum's harmonics of the six positions.</p><p><strong>Results: </strong>Results show that most of the 10 relative spectral energy values of the right and left cubits are statistically (p<0.01) higher than those of the inch for the pregnant women as compared with the nonpregnant women. In addition, the 10 relative spectral energy values of the six positions are not identical at the three stages of pregnancy.</p><p><strong>Conclusions: </strong>The cubit pulse is unique for pregnant women, which is consistent with the theory of TCM. In addition, the pulse conditions at the three stages of pregnancy are dissimilar.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"382-6"},"PeriodicalIF":2.6,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2010.0575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40167108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Urut Melayu, the traditional Malay massage, as a complementary rehabilitative care in postpartum stroke. Urut Melayu,传统马来按摩,作为产后中风的补充康复护理。
IF 2.6
Journal of alternative and complementary medicine (New York, N.Y.) Pub Date : 2012-04-01 Epub Date: 2012-03-08 DOI: 10.1089/acm.2010.0802
Fariza Fadzil, Haniza Mohd Anuar, Suhaila Ismail, Norsuria Abd Ghani, Norlaili Ahmad
{"title":"Urut Melayu, the traditional Malay massage, as a complementary rehabilitative care in postpartum stroke.","authors":"Fariza Fadzil,&nbsp;Haniza Mohd Anuar,&nbsp;Suhaila Ismail,&nbsp;Norsuria Abd Ghani,&nbsp;Norlaili Ahmad","doi":"10.1089/acm.2010.0802","DOIUrl":"https://doi.org/10.1089/acm.2010.0802","url":null,"abstract":"<p><strong>Background: </strong>The case of a 32-year-old Malay woman who developed postpartum stroke is reported.</p><p><strong>Methods: </strong>The patient received a series of urut Melayu, the traditional Malay massage, sessions at one of the newly established integrated hospitals in the country.</p><p><strong>Results: </strong>After 14 urut Melayu sessions, she improved tremendously in her speech and fine motor skills and regained her activities of daily living.</p><p><strong>Conclusions: </strong>This use of urut Melayu to complement rehabilitation care in patients poststroke is promising.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"415-9"},"PeriodicalIF":2.6,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2010.0802","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40149551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Earthing the human organism influences bioelectrical processes. 人体组织的接地会影响生物电过程。
IF 2.6
Journal of alternative and complementary medicine (New York, N.Y.) Pub Date : 2012-03-01 DOI: 10.1089/acm.2010.0683
Karol Sokal, Pawel Sokal
{"title":"Earthing the human organism influences bioelectrical processes.","authors":"Karol Sokal,&nbsp;Pawel Sokal","doi":"10.1089/acm.2010.0683","DOIUrl":"https://doi.org/10.1089/acm.2010.0683","url":null,"abstract":"<p><strong>Objectives: </strong>This article describes interaction of the Earth's mass-electrolytic conductor on the electrical environment of human organism-aqueous environment and skeleton. In this environment, bioelectrical and bioenergetical processes take place.</p><p><strong>Methods and subjects: </strong>Measurements of electric potential on tongue, teeth, nails, and in venous blood in subjects earthed and unearthed were conducted in Faraday's cage with the use of an electrometer placed outside the cage. Measurements were performed in subjects in lying position and in movements of standing up and lying down.</p><p><strong>Results: </strong>In the unearthed human organism in the lying position, electric potential measured in examined points is around 0  mV. Contact of the Earth by a copper conductor with a moistened surface of the human body evokes a rapid decrease of electrostatic potential on the body and in venous blood to the value of approximately -200  mV. This effect is immediate and general. Interruption of contact with the Earth causes a rapid return of the potential to its initial values in examined points. Changes in electric potential measured in venous blood and on mucosal membrane of the tongue reflect alterations in electric potential of the aqueous, electrical environment. Up-and-down movement of the insulated human organism causes transient changes in potential in the human electrical environment. During the same movement, values of potential in the electrical environment of an earthed human body remain constant.</p><p><strong>Conclusions: </strong>These results indicate that up-and-down movement and the elimination of potentials in the electrical environment of the human organism by the Earth's mass may play a fundamental role in regulation of bioelectrical and bioenergetical processes. The Earth's electromagnetohydrodynamic potential is responsible for this phenomenon.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"229-34"},"PeriodicalIF":2.6,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2010.0683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40167996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Use of complementary therapies for cancer symptom management: results of the 2007 National Health Interview Survey. 使用辅助疗法治疗癌症症状:2007年全国健康访谈调查的结果。
IF 2.6
Journal of alternative and complementary medicine (New York, N.Y.) Pub Date : 2012-03-01 DOI: 10.1089/acm.2011.0022
Joel G Anderson, Ann Gill Taylor
{"title":"Use of complementary therapies for cancer symptom management: results of the 2007 National Health Interview Survey.","authors":"Joel G Anderson,&nbsp;Ann Gill Taylor","doi":"10.1089/acm.2011.0022","DOIUrl":"https://doi.org/10.1089/acm.2011.0022","url":null,"abstract":"<p><strong>Objectives: </strong>Complementary therapies are often used as adjuncts to conventional treatment by individuals with cancer. Patterns of use of these practices and products represent important data for health care providers in delivering adequate patient care.</p><p><strong>Design: </strong>This study compared use of complementary therapies between the cancer and noncancer populations in the United States through secondary analyses of the 2007 National Health Interview Survey data. The analysis compared use by cancer survivors (those individuals self-reporting a diagnosis of cancer; n=1785) and individuals without cancer (n=21,585), as well as self-report of symptoms affecting health-related quality of life (HQoL).</p><p><strong>Results: </strong>Data suggest similar patterns of use between cancer survivors and the general population; however, a greater percentage of cancer survivors use complementary modalities. Individuals with cancer reported a greater percentage of use of complementary therapies overall, with cancer status significantly associated with ever having used complementary and alternative medicine (p<0.001). The five most common complementary practices and products used by individuals with cancer and controls were vitamin/mineral supplements, prayer for self, intercessory prayer, chiropractic/osteopathic manipulation, and herbal therapies. Additionally, as might be expected, individuals with cancer experience greater frequency of deleterious symptoms associated with decreased HQoL. Individuals with cancer were more likely to sleep fewer than 7 hours (p=0.0108) or greater than 9 hours (p=0.0108), and have increased insomnia (p<0.001), excessive sleepiness (p<0.001), depression (p<0.001), and anxiety (p<0.001) versus those without cancer.</p><p><strong>Conclusions: </strong>The current findings may inform health care providers about the use of complementary and integrative practices and products by patients with cancer in an effort to manage symptoms of the disease. Additionally, these results may also be used to promote research to define the merits of the use of such complementary and integrative practices and products.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"235-41"},"PeriodicalIF":2.6,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2011.0022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40167997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 89
Genome-wide association analysis of Sasang constitution in the Korean population. 韩国人群Sasang体质的全基因组关联分析。
IF 2.6
Journal of alternative and complementary medicine (New York, N.Y.) Pub Date : 2012-03-01 Epub Date: 2012-03-06 DOI: 10.1089/acm.2010.0764
Bu-Yeo Kim, Hee-Jeong Jin, Jong Yeol Kim
{"title":"Genome-wide association analysis of Sasang constitution in the Korean population.","authors":"Bu-Yeo Kim,&nbsp;Hee-Jeong Jin,&nbsp;Jong Yeol Kim","doi":"10.1089/acm.2010.0764","DOIUrl":"https://doi.org/10.1089/acm.2010.0764","url":null,"abstract":"<p><strong>Objectives: </strong>Sasang constitutional medicine is a traditional Korean medicine in which an individual is classified into one of four types of constitution: Taeum (TE), Soeum (SE) Soyang (SY), and Taeyang (TY). These constitution types are determined with biologic and physiologic characteristics, so it has been assumed that genetic factors are associated with each constitution type. Identifying the genetic elements underlying each constitution is necessary for the elucidation of the molecular mechanism of Sasang constitutional medicine.</p><p><strong>Design: </strong>A total of 341,998 genetic loci across the whole genome were genotyped for 1222 subjects of defined constitution type. The genetic loci associated with each constitution type were identified and the functional connectivity of genes within these loci was analyzed using statistical text mining.</p><p><strong>Results: </strong>From the difference in allele frequencies between constitution types, significant genetic loci associated with each type were identified. Chromosomes 3q27.3 (rs10937331, p=2.71×10(-6)), 15q22.2 (rs7180547, p=1.58×10(-6)), and 14q22.3 (rs12431592, p=1.31×10(-6)) were most significantly associated with TE, SE, and SY constitution types, respectively. From the functional relationship analysis using all loci with a p-value≤10(-4), genes associated with each constitution type were identified. Fifteen (15) genes, including GPM6A, SYT4, and GRIK1, were significantly associated with the TE constitution type (p<0.05); 12 genes, including DRGX and AKAP11, were significantly associated with the SE constitution type (p<0.05); and 17 genes, including ZFP42, CDH22, ALDH1A2, OTX2, and EN2, were significantly associated with the SY constitution type (p<0.05).</p><p><strong>Conclusions: </strong>Genetic loci and genes associated with Sasang constitution types were systematically identified from a genome-wide association study using a large number of subjects.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"262-9"},"PeriodicalIF":2.6,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2010.0764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40144286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Traditional plant-based therapies for respiratory diseases found in North Jeolla Province, Korea. 在全北发现了以植物为基础治疗呼吸系统疾病的传统疗法。
IF 2.6
Journal of alternative and complementary medicine (New York, N.Y.) Pub Date : 2012-03-01 Epub Date: 2012-03-06 DOI: 10.1089/acm.2010.0848
Hyun Kim, Mi-Jang Song
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引用次数: 21
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