Journal of alternative and complementary medicine (New York, N.Y.)最新文献

{"title":"Protocol for The International Cohort on Lifestyle Determinants of Health Study: A Longitudinal Investigation of Complementary and Integrative Health Utilization in Postsecondary Education Students.","authors":"Ryan Bradley,&nbsp;Courtney K Pickworth,&nbsp;Ryan S Wexler,&nbsp;Adam Sadowski,&nbsp;Lita Buttolph,&nbsp;Hadil Sarrar,&nbsp;Jillian Moehle,&nbsp;M Tediana Torrens,&nbsp;Joanna Harnett,&nbsp;Erica McIntyre,&nbsp;Janet Schloss,&nbsp;Amie Steel,&nbsp;Jon Adams","doi":"10.1089/acm.2020.0419","DOIUrl":"https://doi.org/10.1089/acm.2020.0419","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> The specific aims are: 1) To characterize the health, wellness, and lifestyle of graduate and undergraduate students, and how these characteristics change over time; 2) To evaluate associations between lifestyle factors and gut microbiota populations and diversity; and 3) To evaluate associations between stress and stress management practices with sleep habits, quality of life, and overall health. <b><i>Design:</i></b> The International Cohort on Lifestyle Determinants of Health (INCLD Health) longitudinal cohort study is designed to assess health behaviors and lifestyle practices amongst adults studying complementary and integrative health (CIH) and higher-education students more generally after at least one to six years of exposure to CIH education. INCLD Health will adhere to the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines. <b><i>Settings/Location:</i></b> Colleges and universities with a CIH focus or interest with the flagship site being the National University of Natural Medicine. <b><i>Participants:</i></b> Adults currently enrolled in a college or university with a CIH focus or interest. <b><i>Outcome Measures:</i></b> Study visits will be conducted at baseline, 6 months, then every 12 months until the end of each participants' degree program. Measures include anthropometrics; serum and salivary biomarkers of cardiovascular risk, reproductive hormones, and cortisol; nutritional intake measured by a digital food frequency questionnaire; sequencing of fecal microbiota; plus validated questionnaires investigating mood, perceived stress, stress management practices, physical activity, sleep, and wellness. <b><i>Conclusions:</i></b> The INCLD Health Study, approved by the NUNM IRB in late 2018, will enroll a unique cohort of adults to characterize the use of CIH practices in relation to short- and long-term health. Our study design provides a breadth of information that could be implemented at multiple sites internationally allowing for comparisons across diverse student cohorts with relatively low cost and personnel.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"184-191"},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2020.0419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38384165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative Treatment Approaches to Small Intestinal Bacterial Overgrowth: A Systematic Review.","authors":"Melissa A Nickles,&nbsp;Aliza Hasan,&nbsp;Anastasia Shakhbazova,&nbsp;Sarah Wright,&nbsp;Cynthia J Chambers,&nbsp;Raja K Sivamani","doi":"10.1089/acm.2020.0275","DOIUrl":"https://doi.org/10.1089/acm.2020.0275","url":null,"abstract":"<p><p><b><i>Background:</i></b> Broad-spectrum antibiotics are the first-line treatment for small intestinal bacterial overgrowth (SIBO). However, many antibiotics have a considerable side-effect profile and SIBO commonly reoccurs after successful eradication with antibiotics. Alternative therapies such as probiotics, therapeutic diets, and herbal medicines have been used to individualize SIBO management, particularly in recalcitrant cases. <b><i>Objectives:</i></b> The objective of this review is to evaluate the role of alternative therapies in SIBO treatment. <b><i>Data Sources:</i></b> EMBASE, MEDLINE, and the Cochrane Central Register were systematically searched for clinical studies evaluating alternative therapies in the management of SIBO. <b><i>Study Eligibility Criteria:</i></b> Human studies in which an alternative intervention was used to treat SIBO were included. Alternative interventions were defined as an intervention that included a probiotic supplement, herbal preparation, or a dietary change. Randomized controlled trials (RCTs), nonrandomized clinical trials with or without a control, and crossover studies were included. <b><i>Study Appraisal:</i></b> The following information was extracted from the selected studies: study type, study participants, SIBO subtype, intervention, comparison, outcome measures, relevant results, relevant side effects, and Jadad score. <b><i>Results:</i></b> Eight studies met inclusion criteria. The studies evaluated probiotics (<i>n</i> = 5), therapeutic diet (<i>n</i> = 1), and herbal medicines (<i>n</i> = 2). Among these studies, there were four RCTs, two open-label single-arm studies, one randomized, double-blind crossover study, and one two-arm open-label study with crossover. Main results are summarized. <b><i>Limitations:</i></b> There may be studies not captured by the defined search criteria. Additionally, studies used different methodologies in both breath testing and measurement of clinical symptoms, making it difficult to draw conclusions on SIBO eradication and symptom improvement across studies. <b><i>Conclusions and Implications:</i></b> Our findings suggest preliminary evidence for a role of alternative therapies in the treatment of SIBO. However, robust clinical trials are generally lacking. Existing studies tend to be small and lack standardized formulations of treatment. Breath testing protocols and clinical symptom measurement greatly varied between studies. Large-scale, randomized, placebo-controlled trials are needed to further evaluate the best way to utilize alternative therapies in the treatment of SIBO.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"108-119"},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2020.0275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38606890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Control with Lavender Oil in Premature Infants: A Double-Blind Randomized Controlled Study.","authors":"Ceren Usta,&nbsp;Bilge Tanyeri-Bayraktar,&nbsp;Süleyman Bayraktar","doi":"10.1089/acm.2020.0327","DOIUrl":"https://doi.org/10.1089/acm.2020.0327","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> Aromatherapy has become popular in pain control in recent years compared with other complementary methods. Lavender (<i>Lavandula angustifolia</i> Miller) is a fragrant essential oil used in aromatherapy for its antibacterial, antifungal, muscle-relaxing, and analgesic effects. The smell of lavender oil, known for its soothing effect on adults, has not been adequately investigated in regards to pain control in premature infants. The purpose of our study was to assign the effect of the scent of lavender oil on pain in preterm infants during heel lancing. <b><i>Design:</i></b> A double-blind randomized controlled clinical study. <b><i>Settings/Location:</i></b> The study was conducted in a third-level neonatal intensive care unit of Bezmialem Vakif University Hospital from March 2019 to November 2019. It consisted of two groups. <b><i>Subjects:</i></b> Sixty-one premature babies (24-37 weeks of gestation) were enrolled in the study. <b><i>Interventions:</i></b> Heel stick sampling for metabolic screening was used for both study groups. The interventions were performed by two experienced nurses. Heart rate, oxygen saturation, and the baby's facial expression were recorded by a camera 3 min before the intervention, during the sampling, and 3 min after the procedure. After collecting the data, the head researcher and the assistant researcher separately watched the videos and scored them by using the Premature Infant Pain Profile-Revised (PIPP-R). <b><i>Outcome measures:</i></b> The difference of pain scores (PIIP-R) between two groups. <b><i>Results:</i></b> There was a statistically significant difference between the two groups in terms of PIPP-R scores during and after the sampling (<i>p</i> = 0.008 and <i>p</i> = 0.03 respectively). The PIPP-R scores at the beginning of the procedure were not found to be significantly different between the groups (<i>p</i> > 0.05). <b><i>Conclusions:</i></b> Inhalation of lavender scent is effective in pain control in premature infants. It is safe and low cost; it does not interfere with medical care.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"136-141"},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2020.0327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38660827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal or Dietary Supplement Use and Hypertensive Medications: Does the Combination Relate to Medication Adherence and Blood Pressure Control?","authors":"Catherine S Nagawa,&nbsp;Jessica A Palakshappa,&nbsp;Rajani S Sadasivam,&nbsp;Thomas K Houston","doi":"10.1089/acm.2020.0254","DOIUrl":"https://doi.org/10.1089/acm.2020.0254","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Medication nonadherence contributes to poor blood pressure control and increases cardiovascular disease risk in patients with hypertension. Identifying modifiable risk factors for low or nonadherence to antihypertensive medication is needed. Studies that have examined the relationship between herbal or dietary supplement (HDS) use and antihypertensive medication nonadherence provide inconsistent findings. Data from the National Health and Nutrition Examination Survey were used to examine the association between HDS use, current use of prescribed antihypertensive medication, and blood pressure status. <b><i>Methods:</i></b> The study sample included hypertensive adults (<i>n</i> = 5,478) who have been told by a health professional to take prescribed medication for their health condition. Respondents were classified as either HDS users or HDS nonusers. Depending on the kind of supplement used, HDS users were further divided into three mutually exclusive groups: hypertension HDS users, nonhypertension HDS users, and those who used both kinds of supplements. Supplements groupings were based on reports in the literature. Blood pressure status definition was based on Eighth Joint National Committee (JNC 8) recommendations. Adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were obtained from logistic models. <b><i>Results:</i></b> Overall HDS use prevalence was 62%. Current medication use did not significantly differ between patients reporting no HDS use and those reporting HDS use (aOR: 1.45; 95% CI: 0.78-2.69). No observable differences were found in current medication use between patients reporting no HDS use and those taking nonhypertension HDS or both kinds of supplements. Use of hypertension HDS was associated with improved blood pressure (aOR: 1.90; 95% CI: 1.07-3.36) compared with no HDS use. <b><i>Conclusion:</i></b> In a nationally representative U.S. sample, HDS use did not compromise current use of prescribed medication and was associated with improved blood pressure control. More research is needed to better understand why HDS use is associated with better blood pressure control.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"168-175"},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020560/pdf/acm.2020.0254.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38691382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness and Acceptance Interventions for Parents of Children and Adolescents Diagnosed with Chronic Medical Conditions: A Systematic Review.","authors":"Danielle Ruskin,&nbsp;Melissa Young,&nbsp;Carly Sugar,&nbsp;Jaclyn Nofech-Mozes","doi":"10.1089/acm.2020.0191","DOIUrl":"https://doi.org/10.1089/acm.2020.0191","url":null,"abstract":"<p><p><b><i>Background:</i></b> Mindfulness and acceptance interventions (MAIs) have been identified as potentially beneficial for parents of children and adolescents diagnosed with chronic medical conditions. <b><i>Objective:</i></b> The objective of this review was to provide a descriptive summary of the existing literature on MAIs delivered to parents of children and adolescents diagnosed with chronic medical conditions. <b><i>Data sources:</i></b> Electronic searches were conducted by a Library Information Specialist familiar with the field by using EMBASE, MEDLINE, PsycINFO, EBM Reviews Databases, and Cochrane Database of Systematic Reviews. <b><i>Study eligibility, participants, and interventions:</i></b> Peer-reviewed journal articles of MAIs delivered to parents of children and adolescents (birth to 18 years of age) diagnosed with a chronic medical condition were eligible for inclusion. <b><i>Study appraisal and synthesis methods:</i></b> A total of 18 studies involving 793 parents met inclusion criteria and thus were included in this review. The majority of studies were either pre/post design (<i>n</i> = 8) or randomized controlled trials (<i>n</i> = 6). Most interventions were delivered within a group (<i>n</i> = 6) or individually (<i>n</i> = 5). Nearly all studies (<i>n</i> = 14) reported statistically significant outcomes following the MAI intervention. <b><i>Conclusions and implications of key findings:</i></b> Descriptive information yielded from this review provides promising evidence that MAIs are being delivered to parents across the world and many researchers are using similar outcome measures when assessing the psychological flexibility, acceptance, and mindfulness skills following participation in MAIs among this population of parents.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"120-135"},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2020.0191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38577095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could Dietary Factors Reduce COVID-19 Mortality Rates? Moderating the Inflammatory State.","authors":"Arnold R Eiser","doi":"10.1089/acm.2020.0441","DOIUrl":"https://doi.org/10.1089/acm.2020.0441","url":null,"abstract":"It has become well known that the severity of illness and lethality in corona virus disease 2019 (COVID-19) infection is strongly associated with exuberant inflammatory cytokine activation. Many factors may go into determining one’s preinfection inflammatory status including genetic constitution, presence of obesity, air pollution, exercise, and even the sauna usage. None is probably more important than the role of nutrition in determining one’s inflammatory status. This hypothesis, based on the evidence presented below, indicates that the baseline inflammatory state of an individual in the absence of disease is significantly influenced by the content of one’s diet, specifically whether it contains proinflammatory or anti-inflammatory foodstuffs. Furthermore, the hypothesis suggests that the severity of illness that develops when one contracts COVID-19, that is, whether it be a mild-to-moderate upper respiratory viral illness or a fatal acute respiratory distress syndrome (ARDS) or myocarditis death is dependent on that inflammatory state. I will contrast the Japanese diet and the Mediterranean diet both known for its anti-inflammatory qualities with the Western diet, known for its proinflammatory properties as well as refer to laboratory studies addressing lethal viral infections and COVID-19 risk factors. The Mediterranean diet containing specific polyphenols, lipids, and peptides with anti-inflammatory, antithrombotic, and antioxidant properties has been suggested as offering benefit regarding COVID-19 infectious severity as well through similar mechanisms.","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"176-178"},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38357890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Call to Action: Adoption of Trauma Informed Care in Complementary and Integrative Health Services.","authors":"Kathryn A Hansen,&nbsp;Elizabeth G Walsh,&nbsp;Cynthia Price","doi":"10.1089/acm.2021.0018","DOIUrl":"https://doi.org/10.1089/acm.2021.0018","url":null,"abstract":"","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"103-107"},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25384362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness Training for Adults with Attention-Deficit/Hyperactivity Disorder: Implementation of Mindful Awareness Practices in a French-Speaking Attention-Deficit/Hyperactivity Disorder Unit.","authors":"Rosetta Nicastro,&nbsp;Françoise Jermann,&nbsp;Sophie Bluteau Blin,&nbsp;Caroline Waeber,&nbsp;Nader Perroud","doi":"10.1089/acm.2020.0216","DOIUrl":"https://doi.org/10.1089/acm.2020.0216","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Mindfulness-based programs are a promising option for patients with attention-deficit/hyperactivity disorder (ADHD), who face attention, hyperactivity, and emotion dysregulation issues in their daily life. <b><i>Objective:</i></b> To examine the implementation and impact of specific mindfulness training for adults with ADHD in a French-speaking unit. <b><i>Methods:</i></b> Thirty-eight adults with ADHD were included in an 8-week Mindful Awareness Practices (MAPs) program. Patients were assessed for ADHD symptoms, anxiety, depression, and mindfulness skills, before (T1) and after (T2) the eight sessions, and then 2 months later (T3). <b><i>Results:</i></b> The patients adhered to the program as the majority of them completed it. A significant decrease in ADHD, depression, and anxiety symptoms was found between T1 and T2. Regarding mindfulness skills, a significant increase was observed between T1 and T2 in Observing, Describing and Nonreactivity to inner experience cores, but not Acting with awareness and Nonjudging of inner experience scores. There was no significant change between T2 and T3. <b><i>Conclusion:</i></b> The MAPs program was successfully implemented and showed promising effects on ADHD symptomatology and related symptoms.</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"179-183"},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2020.0216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38699307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Yugengtongyu Granules in Patients with Stable Coronary Artery Disease on Reducing Adverse Cardiovascular Events: A Double-Blind Controlled Trial.","authors":"Dayang Wang,&nbsp;Chunyan Li,&nbsp;Xiaoqing Xu,&nbsp;Hui Xu,&nbsp;Congcong Guo,&nbsp;Jinping Wang,&nbsp;Jingyin Guo,&nbsp;Li Huang","doi":"10.1089/acm.2020.0361","DOIUrl":"https://doi.org/10.1089/acm.2020.0361","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> To evaluate the effect of Yugengtongyu granules on reducing the incidence of adverse cardiovascular events and improving quality of life (QOL) in patients with stable coronary artery disease (SCAD). <b><i>Methods:</i></b> A double-blind randomized controlled trial was conducted among SCAD population. One hundred fourteen patients were randomly assigned to experimental group (<i>n</i> = 57) and control group (<i>n</i> = 57) following randomized block design. Combined with the basis of standard treatment of SCAD, the experimental group and control group received Yugengtongyu granules or placebo, respectively, twice daily for 6 months and were followed for another 1 year (18 months in total from enrollment). Major outcomes (any occurrence of cardiovascular death, nonfatal myocardial infarction, or coronary revascularization), minor outcomes (any occurrence of all-cause death, ischemic stroke, readmission due to unstable angina, heart failure, or malignant arrhythmia), and composite outcomes (union of major and minor outcomes) were used to evaluate prognosis; Seattle Angina Questionnaire (SAQ) was applied to evaluate QOL, and levels of low density lipoprotein-cholesterol (LDL-C) and high sensitive C reacting protein (HS-CRP) in serum were tested. <b><i>Results:</i></b> The incidence of composite outcomes in the experimental group was significantly lower than that in the control group (3 [5.2%] vs. 11 [19.2%], hazard ratio: 0.273, 95% confidence interval: 0.080-0.926, <i>p</i> = 0.022); major outcomes, minor outcomes, and independent events such as nonfatal myocardial infarction showed lowering trend in experimental group. Experimental group scored significantly higher than control group in four dimensions of SAQ: physical limitation, angina frequency, treatment satisfaction, and disease perception at the third- and sixth-month follow-up; there was no significant difference in serum level of LDL or HS-CRP at all scheduled timepoints. <b><i>Conclusion:</i></b> The addition of Yugengtongyu granules based on current standard treatment reduced the incidence of composite outcomes and improved QOL in patients with SCAD. The trial was registered in the Chinese Clinical Trial Registry (ChiCTR-TRC-13004370).</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"142-149"},"PeriodicalIF":2.6,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2020.0361","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38658738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Fufang Banmao</i> Capsule, a Traditional Chinese Medicinal Formulation, Enhances the Survival of Patients with Hepatocellular Carcinoma and Vp3-4 Portal Vein Tumor Thrombosis Undergoing Supportive Treatment.","authors":"Yao Liu,&nbsp;Yuxin Li,&nbsp;Xiaojing Wang,&nbsp;Yunyi Huang,&nbsp;Qun Zhang,&nbsp;Ke Shi,&nbsp;Chongping Ran,&nbsp;Jie Hou,&nbsp;Xianbo Wang","doi":"10.1089/acm.2019.0334","DOIUrl":"https://doi.org/10.1089/acm.2019.0334","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> <i>Fufang Banmao</i> (FFBM) capsule, a type of Chinese medicinal formulation, has decades of history in treating hepatocellular carcinoma (HCC). This retrospective study aimed to observe the effect of FFBM capsules on the 6-month survival of patients with advanced HCC and Vp3-4 portal vein tumor thrombosis (PVTT) who received supportive therapy alone. <b><i>Design:</i></b> In total, 320 HCC/Vp3-4 PVTT patients underwent treatment with supportive therapy, of whom 95 took FFBM capsules and were treated with supportive therapy (FFBM group) and 225 received supportive therapy alone (control group). Comparisons of the 6-month overall survival (OS) rate of the two groups were performed. Propensity score matching (PSM) was used to match the characteristics between individuals in the two groups. A nomogram was built based on independent predictive factors for OS. <b><i>Results:</i></b> Cox multivariate analysis revealed that hepatic encephalopathy, aspartate transaminase (AST) and γ-glutamyl transpeptidase levels, Child-Pugh class, prothrombin time, α-fetoprotein level, largest tumor diameter, and use of FFBM capsules were independent predictive factors of OS. Variceal bleeding, alanine transaminase, AST, total bilirubin, and Barcelona Clinic for Liver Cancer stage were different at baseline in the FFBM and control groups. Analysis revealed no significant adverse effects or toxicities relevant to the medications. After PSM (1:1), 95 patient pairs were analyzed as FFBM versus control. The OS probability was remarkably higher for patients in the FFBM group than in those in the control group at 6 months (<i>p</i> < 0.0001). The median survival time was 4 months in the FFBM group and 2.2 months in the control group. Kaplan-Meier analysis showed significant statistical differences in the 6-month OS rates in the patients with total nomogram scores ≥84 (<i>p</i> < 0.0001). <b><i>Conclusions:</i></b> Given the satisfying survival outcomes, the results suggested that FFBM capsules should be administered to patients with HCC/Vp3-4 PVTT in the high-risk group (score ≥84). FFBM capsules have the potential for improving patient survival time in those with advanced HCC and Vp3-4 PVTT who receive supportive therapy alone, especially those in the high-risk group (score ≥84).</p>","PeriodicalId":520659,"journal":{"name":"Journal of alternative and complementary medicine (New York, N.Y.)","volume":" ","pages":"956-965"},"PeriodicalIF":2.6,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/acm.2019.0334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38110015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}