Internal medicine (Tokyo, Japan)最新文献_第6页

Gastric Adenocarcinoma Mimicking Foveolar-type Presenting with a Whitish Elevation. 模拟小窝型胃腺癌表现为白色抬高。

IF 1.1

Internal medicine (Tokyo, Japan) Pub Date : 2026-10-15 DOI: 10.2169/internalmedicine.8103-26

Naoya Osuki, Sota Nakagami, Takaaki Yoshikawa, Gen Honjo, Shujiro Yazumi

引用次数: 0

Bullous Pemphigoid in Patients with Amyotrophic Lateral Sclerosis: A Retrospective Study of 1,067 Cases. 1067例肌萎缩侧索硬化症患者的大疱性类天疱疮回顾性研究。

IF 1.1

Internal medicine (Tokyo, Japan) Pub Date : 2026-10-15 DOI: 10.2169/internalmedicine.7919-26

Kentaro Kawama, Kota Bokuda, Hideki Kimura, Kentaro Hayashi, Tomoya Kawazoe, Keigo Totani, Yoshiyuki Matsuki, Keisuke Ishizawa, Juri Sawada, Yumi Itagaki, Michiko Haraguchi, Chiharu Matsuda, Yuki Nakayama, Miyuki Yabuki, Kazushi Takahashi, Toshio Shimizu

{"title":"Bullous Pemphigoid in Patients with Amyotrophic Lateral Sclerosis: A Retrospective Study of 1,067 Cases.","authors":"Kentaro Kawama, Kota Bokuda, Hideki Kimura, Kentaro Hayashi, Tomoya Kawazoe, Keigo Totani, Yoshiyuki Matsuki, Keisuke Ishizawa, Juri Sawada, Yumi Itagaki, Michiko Haraguchi, Chiharu Matsuda, Yuki Nakayama, Miyuki Yabuki, Kazushi Takahashi, Toshio Shimizu","doi":"10.2169/internalmedicine.7919-26","DOIUrl":"https://doi.org/10.2169/internalmedicine.7919-26","url":null,"abstract":"Background　Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that affects motor neurons. Bullous pemphigoid (BP) is an autoimmune blistering disease associated with autoantibodies against BP180 and BP230. Previous studies have suggested an increased incidence of BP in patients with ALS. However, the neurological status and disease severity of patients with ALS at the time of BP onset remain insufficiently characterized. This study aimed to investigate the frequency and clinical characteristics of BP in patients with ALS.Methods　In this retrospective study, we reviewed the medical records of 1,067 patients with ALS who were admitted to our institution between April 2010 and May 2025. Patients who developed BP after the onset of ALS were identified. BP was diagnosed by dermatologists based on clinical findings and, when available, by immunological or histopathological examinations. Disease severity at BP onset was assessed based on the ambulatory status and ventilatory support requirements.Results　Seven of the 1,067 patients (0.66%) developed BP after ALS onset. The median interval between ALS and BP onset was 8.0 years (IQR 5.0-16.5). At BP onset, four patients (57.1%) were bedridden, four (57.1%) required tracheostomy and invasive ventilation, and two (28.6%) required non-invasive ventilation. Five patients (71.4%) required enteral feeding. The median age at BP onset was 68.0 years (IQR, 64.0-72.5). BP180 antibody testing was positive in three of the six patients. The lesions most commonly involved both the extremities and the trunk.Conclusion　BP may occur more frequently in ALS patients than in the general population. Clinicians should consider BP when evaluating cutaneous lesions in patients with ALS.","PeriodicalId":520650,"journal":{"name":"Internal medicine (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Venetoclax and Azacitidine in Induction-Refractory Adult Acute Myeloid Leukemia with UBTF Tandem Duplication and Associated Aberrant Splicing: A Case Report. Venetoclax和阿扎胞苷对诱导难治性成人急性髓系白血病UBTF串联复制和相关异常剪接的应答：1例报告。

IF 1.1

Internal medicine (Tokyo, Japan) Pub Date : 2026-10-15 DOI: 10.2169/internalmedicine.8128-26

Seigi Oshima, Kazuhisa Chonabayashi, Takashi Sakamoto, Junya Kanda, Yuki Oku, Hiroyuki Matsui, Tadahiko Matsumoto, June Takeda, Chisaki Mizumoto, Kouhei Yamashita, Daichi Inoue, Yasuhito Nannya, Seishi Ogawa, Akifumi Takaori-Kondo

引用次数: 0

Calcified Pleural Dissemination and Malignant Pleural Effusion in Dedifferentiated Chondrosarcoma: A Case Report with an Institutional Review. 去分化软骨肉瘤的钙化胸膜播散和恶性胸腔积液：1例报告并机构回顾。

IF 1.1

Internal medicine (Tokyo, Japan) Pub Date : 2026-10-15 DOI: 10.2169/internalmedicine.8150-26

Takeru Ichikawa, Miho Fujiwara, Hiromi Watanabe, Akiko Sato, Tetsuya Isoda, Yoshiyuki Ayada, Takahiro Kitayama, Yosuke Togashi, Yoshinobu Maeda, Go Makimoto

引用次数: 0

Phlegmonous Gastritis in Chemotherapy-related Neutropenia with Endoscopic Findings that Prompted Early Therapeutic Intervention. 痰性胃炎伴化疗相关中性粒细胞减少，内镜检查提示早期治疗干预。

IF 1.1

Internal medicine (Tokyo, Japan) Pub Date : 2026-10-15 Epub Date: 2026-02-24 DOI: 10.2169/internalmedicine.7028-25

Kazuhiro Ota, Sayaka Tsuji, Masatoshi Kaizuka, Kazuki Takayama, Shun Sasaki, Akitoshi Hakoda, Noriaki Sugawara, Taro Iwatsubo, Yoshitaka Kurisu, Hiroki Nishikawa

引用次数: 0

Response to the Letter Regarding "If Becker Muscular Dystrophy Initially Manifests with Heart Disease and Rhabdomyolysis, Neurological Work-up Is Imperative". 对“如果贝克肌萎缩症最初表现为心脏病和横纹肌溶解，神经系统检查是必要的”的回复。

IF 1.1

Internal medicine (Tokyo, Japan) Pub Date : 2026-10-15 Epub Date: 2026-03-03 DOI: 10.2169/internalmedicine.7138-26

Kento Kumai, Hiroki Mochizuki, Takuya Watanabe, Keiko Ohta-Ogo, Taisuke Ishikawa, Makoto Araki, Chisato Ota, Katsuki Nagatomo, Gaku Narita, Hirotaka Kawauchi, Reiko Shiomura, Terufumi Iwanaga, Takuma Sato, Osamu Seguchi, Yoshihiko Ikeda, Kinta Hatakeyama, Naomasa Makita, Satsuki Fukushima, Yasumasa Tsukamoto

引用次数: 0

Pleural Mesothelioma with Net-like Structures. 网状结构胸膜间皮瘤。

IF 1.1

Internal medicine (Tokyo, Japan) Pub Date : 2026-10-15 Epub Date: 2026-03-10 DOI: 10.2169/internalmedicine.6505-25

Mika Horie, Daisuke Niino, Tamio Okimoto

引用次数: 0

The Safety and Efficacy of a Transbronchial Lung Cryobiopsy Using a 1.7-mm Cryoprobe in Older Adult Patients with Suspected Interstitial Lung Disease: A Single-center, Retrospective, Observational Study. 使用1.7 mm低温探针经支气管肺低温活检治疗疑似间质性肺病的老年患者的安全性和有效性：一项单中心、回顾性、观察性研究

IF 1.1

Internal medicine (Tokyo, Japan) Pub Date : 2026-10-15 Epub Date: 2026-03-03 DOI: 10.2169/internalmedicine.6521-25

Miho Fujiwara, Yuki Takigawa, Ken Sato, Tomoyoshi Inoue, Suzuka Matsuoka, Hiromi Watanabe, Kenichiro Kudo, Akiko Sato, Keiichi Fujiwara, Takuo Shibayama

{"title":"The Safety and Efficacy of a Transbronchial Lung Cryobiopsy Using a 1.7-mm Cryoprobe in Older Adult Patients with Suspected Interstitial Lung Disease: A Single-center, Retrospective, Observational Study.","authors":"Miho Fujiwara, Yuki Takigawa, Ken Sato, Tomoyoshi Inoue, Suzuka Matsuoka, Hiromi Watanabe, Kenichiro Kudo, Akiko Sato, Keiichi Fujiwara, Takuo Shibayama","doi":"10.2169/internalmedicine.6521-25","DOIUrl":"10.2169/internalmedicine.6521-25","url":null,"abstract":"Objective The safety and efficacy of a transbronchial lung cryobiopsy (TBLC) in older adult patients have not yet been fully established. We assessed the safety and clinical utility of TBLC in older adult Japanese patients with suspected interstitial lung disease (ILD). Methods We retrospectively reviewed the medical data of patients who underwent TBLC with a 1.7-mm cryoprobe for suspected ILD at the National Hospital Organization Okayama Medical Center between June 2022 and August 2024. Data on complications, diagnostic yield, and treatment after TBLC were collected and analyzed. Patients The patients were divided into two groups: an older adult group (OA group; age ≥70 years; n=31) and a non-older adult group (NOA group; age <70 years; n=19). Results The median age of the patients in the OA group was 72 years. Pneumothorax occurred only in the NOA group (p=0.017), whereas the frequencies of other complications did not differ significantly. No severe complications were noted. The severity of bleeding did not differ significantly between the groups, regardless of the hemostatic method used (p=0.690). The overall diagnostic yield was 82% (OA group: 84%; NOA group: 79%; p=0.715). Idiopathic pulmonary fibrosis was significantly more common in the OA group than in the NOA group (p=0.035), whereas hypersensitivity pneumonitis was significantly more common in the NOA group than in the OA group (p=0.013). Conclusion TBLC may help diagnose ILD in older adult patients, particularly in those with a preserved respiratory function and no apparent contraindications.","PeriodicalId":520650,"journal":{"name":"Internal medicine (Tokyo, Japan)","volume":" ","pages":"2671-2679"},"PeriodicalIF":1.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Septic Arthritis of the Knee Caused by Neisseria meningitidis Serogroup Y. Y型脑膜炎奈瑟菌所致脓毒性膝关节炎。

IF 1.1

Internal medicine (Tokyo, Japan) Pub Date : 2026-10-15 DOI: 10.2169/internalmedicine.7610-26

Takahiro Maruyama, Takahiro Yonemoto, Haruki Imura

引用次数: 0

Long COVID and Sex Differences: A Narrative Review. 长冠状病毒与性别差异：叙述性回顾。

IF 1.1

Internal medicine (Tokyo, Japan) Pub Date : 2026-10-15 Epub Date: 2026-03-03 DOI: 10.2169/internalmedicine.6969-25

Norifumi Kudeken

{"title":"Long COVID and Sex Differences: A Narrative Review.","authors":"Norifumi Kudeken","doi":"10.2169/internalmedicine.6969-25","DOIUrl":"10.2169/internalmedicine.6969-25","url":null,"abstract":"Long COVID (post-COVID-19 condition) is a heterogeneous syndrome of persistent or new symptoms after severe acute respiratory syndrome coronavirus 2 infection. While men have higher risks of severe acute COVID-19 and mortality, epidemiological studies consistently show a female predominance in Long COVID, especially among middle-aged women. Interpretation is complicated by variable case definitions (World Health Organization, Centers for Disease Control and Prevention, National Institute for Health and Care Excellence) and variant-era differences; however, sex disparities persist across both pre-Omicron and Omicron periods. We review evidence on sex differences in epidemiology, symptom clusters, and longitudinal trajectories, incorporating recent RECOVER findings and emerging data from Japanese cohorts. Potential mechanisms include sexually dimorphic antiviral immunity, hormonal and X-chromosome-linked immunoregulation, autoimmunity, autonomic dysfunction, and gender-related social exposures and health-care access. Recognizing sex- and gender-related determinants can improve differential diagnosis, risk stratification, and individualized management, and should be embedded as core variables in future mechanistic studies and clinical trials.","PeriodicalId":520650,"journal":{"name":"Internal medicine (Tokyo, Japan)","volume":" ","pages":"2652-2657"},"PeriodicalIF":1.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0