Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment最新文献

Mercury speciation and nanoparticle analysis in foods from the Danish market.

IF 2.2

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Pub Date : 2026-10-20 DOI: 10.1080/19440049.2026.2739981

Doaa Abouelenein, Heidi Amlund, Yuka Omura Lund, Lene Duedahl-Olesen, Jens J Sloth, Katrin Loeschner

{"title":"Mercury speciation and nanoparticle analysis in foods from the Danish market.","authors":"Doaa Abouelenein, Heidi Amlund, Yuka Omura Lund, Lene Duedahl-Olesen, Jens J Sloth, Katrin Loeschner","doi":"10.1080/19440049.2026.2739981","DOIUrl":"https://doi.org/10.1080/19440049.2026.2739981","url":null,"abstract":"Mercury toxicity depends strongly on chemical form, yet dietary exposure assessments and regulatory monitoring are typically based on total mercury (THg). This study evaluated inorganic mercury (iHg), methylmercury (MeHg), THg, selenium (Se), and Hg- and Se-containing nanoparticles (NPs) in 44 seafood and 10 non-seafood products from the Danish market. A rapid reversed-phase HPLC-ICP-MS method was validated in-house and applied for Hg speciation, providing baseline separation of iHg and MeHg within 3.5 min. MeHg recoveries in certified reference materials were 94-101%, within-laboratory reproducibility was ≤12.3%, and the limit of quantification (LOQ) for fresh seafood samples was 0.29 µg kg-1 wet weight. The sum of speciated Hg (∑Hg = iHg + MeHg) agreed with acid-digestion THg within 80-105% across seafood samples. In fish and crustaceans, MeHg was the predominant Hg species, accounting for approximately 90-94% of THg, supporting the use of THg as a practical proxy for MeHg exposure in these categories. In contrast, MeHg accounted for only 22.6-44.5% of THg in mussels and was below the LOQ in all non-seafood matrices except one pig liver sample, demonstrating that fixed species-proportion assumptions may overestimate MeHg exposure in some food categories. The highest THg concentration was observed in common dab (Limanda limanda) at 0.33 mg kg-1 wet weight, slightly above the 0.30 mg kg-1 EU maximum level applicable to this species group under Commission Regulation (EU) 2023/915. Hg-containing NPs represented approximately 1% of the iHg fraction within the detectable particle size range across analysed samples, indicating a minor contribution to the measured iHg pool.","PeriodicalId":520628,"journal":{"name":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","volume":" ","pages":"1-15"},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a novel compound, 1-carboxy-7-bromo-6-hydroxy-2,3,4,5-tetrachloroxanthone, as an impurity in the colour additives D&C red nos. 27 and 28 (phloxine B). 1-羧基-7-溴-6-羟基-2,3,4,5-四氯杂蒽酮在D&C红27号和28号（苯氧辛B）中作为杂质的新化合物的鉴定。

IF 2.2

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Pub Date : 2026-10-17 DOI: 10.1080/19440049.2026.2747039

Adrian Weisz, Clark D Ridge, Yoichiro Ito

{"title":"Identification of a novel compound, 1-carboxy-7-bromo-6-hydroxy-2,3,4,5-tetrachloroxanthone, as an impurity in the colour additives D&C red nos. 27 and 28 (phloxine B).","authors":"Adrian Weisz, Clark D Ridge, Yoichiro Ito","doi":"10.1080/19440049.2026.2747039","DOIUrl":"https://doi.org/10.1080/19440049.2026.2747039","url":null,"abstract":"The focus of this work was the characterisation of an impurity sometimes found in batches of the hydroxyxanthene colour additives D&C Red No. 27 (R27) and D&C Red No. 28 (R28, phloxine B). Countercurrent chromatography (CCC) was used to separate and concentrate the impurity (named here pHXCA) to ∼48% from a dye sample that contained ∼0.74% pHXCA. Pure pHXCA was obtained by collecting analytical HPLC-separated fractions from multiple injections of the CCC-concentrated sample. Various NMR and mass spectral techniques were used to determine the structure of pHXCA. In particular, the presence of a 35/37Cl isotope shift in the 13C NMR spectrum pointed to the location of the C-Cl bond specific to pHXCA and facilitated identification of its structure as 1-carboxy-7-bromo-6-hydroxy-2,3,4,5-tetrachloroxanthone. Significantly, that structure was different from the one erroneously reported by other researchers. A rapid screening of 18 dye batches (R27, n = 13; R28, n = 5) representing nine manufacturers, revealed that 12 batches contained pHXCA, with levels that ranged from 0.0009 to 0.182%. A side reaction during the manufacture of R27/28 in which a bromine atom is replaced with a chlorine atom in a closely related contaminant is suggested as the potential basis of pHXCA formation.","PeriodicalId":520628,"journal":{"name":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety evaluation of a β-fructofuranosidase enzyme preparation from Aspergillus fijiensis SYG-K1 for the production of 1-kestose-enriched short-chain fructooligosaccharides. 斐济曲霉SYG-K1 β-果糖呋喃糖苷酶制剂生产富含1-酮糖短链低聚果糖的安全性评价

IF 2.2

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Pub Date : 2026-10-13 DOI: 10.1080/19440049.2026.2747799

Sanghee Lee, Sinhye Ahn, Jeongmin Kim, Sangyi Lim, Bu-Soo Park, Dong-Il Kim

{"title":"Safety evaluation of a β-fructofuranosidase enzyme preparation from Aspergillus fijiensis SYG-K1 for the production of 1-kestose-enriched short-chain fructooligosaccharides.","authors":"Sanghee Lee, Sinhye Ahn, Jeongmin Kim, Sangyi Lim, Bu-Soo Park, Dong-Il Kim","doi":"10.1080/19440049.2026.2747799","DOIUrl":"https://doi.org/10.1080/19440049.2026.2747799","url":null,"abstract":"Short-chain fructooligosaccharides (scFOS) are prebiotic food ingredients, and 1-kestose-enriched preparations are of interest because of their defined short-chain composition. This study evaluated a β-fructofuranosidase preparation from Aspergillus fijiensis SYG-K1 developed for 1-kestose-enriched scFOS production. Fermented food-derived microbial isolates were screened for FOS-producing activity, and the selected parental strain was improved by ultraviolet/N-methyl-N'-nitro-N-nitrosoguanidine-induced random mutagenesis. The resulting SYG-K1 strain showed increased β-fructofuranosidase activity and produced a favourable FOS profile with high GF2 formation, limited GF3 formation, and no detectable GF4 formation under the tested conditions. A GLP-compliant toxicological safety package was applied according to appropriate OECD test guidelines, including acute oral toxicity, repeated-dose oral toxicity, and genotoxicity studies. A single oral dose of 2,000 mg/kg produced no toxicity. Repeated oral dose administration of up to 1,643.9 mg total organic solids (TOS)/kg bw/day produced no treatment-related adverse effects or delayed toxicity. The enzyme preparation was negative in bacterial reverse mutation, in vitro chromosomal aberration, in vitro micronucleus, and in vivo micronucleus assays. The NOAEL was established at 1,643.9 mg TOS/kg bw/day, supporting the toxicological safety of this enzyme preparation.","PeriodicalId":520628,"journal":{"name":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary exposure to five highly polar pesticides of the Hong Kong population through a total diet study. 香港人口从饮食中摄取五种高极性农药的研究

IF 2.2

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Pub Date : 2026-10-13 DOI: 10.1080/19440049.2026.2741930

Stephen W C Chung, Margaret C L Yeung, Waiky W K Wong, W K Chu, Joey L Y Kwok, K H Kung, Terence Y Y Cheung

{"title":"Dietary exposure to five highly polar pesticides of the Hong Kong population through a total diet study.","authors":"Stephen W C Chung, Margaret C L Yeung, Waiky W K Wong, W K Chu, Joey L Y Kwok, K H Kung, Terence Y Y Cheung","doi":"10.1080/19440049.2026.2741930","DOIUrl":"https://doi.org/10.1080/19440049.2026.2741930","url":null,"abstract":"Dietary exposure assessment of the Hong Kong adult and younger populations to five highly polar pesticides, namely ethephon, fosetyl aluminium, glyphosate, glufosinate ammonium and maleic hydrazide, was included in the second Hong Kong Total Diet Study (TDS). A total of 187 commonly consumed food items were collected and prepared \"as consumed\". A total of 374 composite food samples were analysed for these five highly polar pesticides by modified Quick Polar Pesticides (QuPPe) method combined with LC-MS/MS. Related dietary exposure was estimated based on the analytical results and the food consumption data of the local residents. The results showed that 283 out of 374 composite samples were tested positive for these five highly polar pesticides, with a detection rate of 76%. The most commonly detected residue of these five highly polar pesticides was fosetyl aluminium (75%), while the remaining four were detected in less than 10% of composite samples. Fosetyl aluminium was found in a wide variety of food across all the food groups while the other highly polar pesticides were mainly found in the foods of plant origin, such as vegetables and cereals. In terms of contribution to the acceptable daily intakes (ADIs), glufosinate ammonium represented the highest upper-bound exposure for high consumers of both adult and younger populations, accounting for 4.2% and 6.6% of its ADI value, respectively. The findings of this study indicated that dietary exposure estimates to these five highly polar pesticides were unlikely to pose significant health risk to both average and high consumers of the Hong Kong adult and younger populations.","PeriodicalId":520628,"journal":{"name":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A modified DNA-barcoding method to identify jumbo squid (Dosidicus gigas) substitution in canned octopus products. 改良的dna条形码法鉴定章鱼罐头产品中巨型鱿鱼的替代。

IF 2.2

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Pub Date : 2026-10-12 DOI: 10.1080/19440049.2026.2693109

Sarah R Stadig, Amanda M Windsor, Christopher J Kim, Jonathan R Deeds

{"title":"A modified DNA-barcoding method to identify jumbo squid (Dosidicus gigas) substitution in canned octopus products.","authors":"Sarah R Stadig, Amanda M Windsor, Christopher J Kim, Jonathan R Deeds","doi":"10.1080/19440049.2026.2693109","DOIUrl":"https://doi.org/10.1080/19440049.2026.2693109","url":null,"abstract":"In recent years, the United States Food and Drug Administration (US FDA) has documented several instances where more abundant, and lower priced, jumbo squid (Dosidicus gigas) has been substituted for octopus (family Octopodidae) in a variety of products (e.g. frozen, canned) resulting in the products being misbranded and/or adulterated. FDA typically utilises a short (approx. 655 base pair) fragment of the cytochrome c oxidase subunit 1 (COI) mitochondrial gene (a.k.a. DNA barcoding) for the identification of seafood products. However, this method is not applicable for the identification of canned products due to DNA fragmentation that occurs during the retort process. Described herein is a modified DNA barcoding method using standard DNA marine invertebrate barcoding primers in combination with degenerate forward and reverse internal primers to create two smaller (313-316 base pair) fragments. The fragments are sequenced separately then assembled to form a nearly full-length DNA barcode fragment. Using this method, 11 of the 12 canned jumbo squid and octopus products tested, in a variety of forms (i.e. in hot sauce, in garlic sauce, smoked, etc.), were successfully identified. This method is fit for the purpose of ad hoc regulatory identification of canned squid and octopus products to confirm product labelling or to be used as a screening tool to prevent species substitution, economic adulteration, and fraud.","PeriodicalId":520628,"journal":{"name":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary exposure and health risk assessment of perchlorate and chlorate in Shenzhen: a Monte Carlo simulation study. 深圳市高氯酸盐和氯酸盐饮食暴露与健康风险评估：蒙特卡罗模拟研究

IF 2.2

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Pub Date : 2026-10-12 DOI: 10.1080/19440049.2026.2743167

Jingwei Wu, Jing Liang, Kun Guan, Tian Du, Sirou Xie, Fengna Li, Fen Qiu

{"title":"Dietary exposure and health risk assessment of perchlorate and chlorate in Shenzhen: a Monte Carlo simulation study.","authors":"Jingwei Wu, Jing Liang, Kun Guan, Tian Du, Sirou Xie, Fengna Li, Fen Qiu","doi":"10.1080/19440049.2026.2743167","DOIUrl":"https://doi.org/10.1080/19440049.2026.2743167","url":null,"abstract":"Perchlorate and chlorate are environmental contaminants that competitively inhibit thyroidal iodide uptake, posing health risks particularly for vulnerable populations. This study developed an isotope dilution UPLC-MS/MS method to determine perchlorate and chlorate levels in 346 samples (vegetables, fruits, eggs, and drinking water) collected from Shenzhen. Probabilistic dietary exposure assessment was conducted across 11 age-gender groups using Monte Carlo simulation (10,000 iterations) with local consumption data (n = 853). Perchlorate was detected in 94% of samples (mean = 16.1 μg/kg), with leafy vegetables (78.5 μg/kg) and eggs (32.0 μg/kg) showing the highest mean levels; chlorate was detected in 45% of samples, whilst drinking water had a 100% detection rate and the highest concentrations (mean = 53.5 μg/L). Males aged 4-14 years had the highest 95th percentile perchlorate estimated daily intake (EDI) (1.19 μg/kg bw/day), with 4.0% exceeding the EFSA tolerable daily intake (TDI). For chlorate, the highest 95th percentile EDI was observed in the 0-3 years old group (14.8 μg/kg bw/day), with 55.2% exceeding the TDI under the lower bound scenario. Sensitivity analysis identified perchlorate concentration in leafy vegetables and drinking water intake as the key drivers of perchlorate and chlorate exposure, respectively. These findings indicate widespread contamination and notable health risks for children, supporting the need for regulatory measures to reduce chlorate in drinking water and monitor perchlorate in leafy vegetables and eggs.","PeriodicalId":520628,"journal":{"name":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggregate risk assessment of bisphenols A, S, and F among the general Korean population. 韩国普通人群中双酚A、S和F的总体风险评估。

IF 2.2

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Pub Date : 2026-10-06 DOI: 10.1080/19440049.2026.2701456

Seungyoung Park, Selim Bak, Yong-Kook Kwon, Da-In Kim, Dokyeong Yong, Ryun Kyung Lee, Ju Hee Kim, Yeong Min Shin, Hye-Young Lee

{"title":"Aggregate risk assessment of bisphenols A, S, and F among the general Korean population.","authors":"Seungyoung Park, Selim Bak, Yong-Kook Kwon, Da-In Kim, Dokyeong Yong, Ryun Kyung Lee, Ju Hee Kim, Yeong Min Shin, Hye-Young Lee","doi":"10.1080/19440049.2026.2701456","DOIUrl":"https://doi.org/10.1080/19440049.2026.2701456","url":null,"abstract":"Bisphenol A (BPA) and its substitutes Bisphenol S (BPS) and Bisphenol F (BPF) have been identified as endocrine-disrupting chemicals that affects reproductive functions. In Korea, BPA use has been restricted, resulting in increased utilisation of BPS and BPF as alternatives. However, risk assessment and exposure management of these alternatives remain limited. Therefore, we conducted a risk assessment of BPA, BPS, and BPF prioritising human-use products while considering additional environmental exposure pathways. Product concentration data, usage amounts, and frequency factors were studied for products considered in the National Institute of Food and Drug Safety Evaluation between 2023 and 2024. Based on the data, the estimated daily exposure levels of the general Korean population indicated that food is the primary source of bisphenol exposure. The age-specific exposure levels corresponded to 0.02-0.12% of the health-based guidance value. Risk characterisation based on the hazard index for BPA and the margin of exposure approach for BPS and BPF revealed that current regulatory measures have managed BPA, BPS, and BPF exposures effectively. Reassessment should be considered if new evidence of unrecognised toxicities becomes available. These findings highlight the need for continuous monitoring of alternative bisphenols to ensure public health protection.","PeriodicalId":520628,"journal":{"name":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trifluoroacetic acid (TFA) in grain products from the US supermarkets. 美国超市谷物产品中的三氟乙酸（TFA）。

IF 2.2

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Pub Date : 2026-10-06 DOI: 10.1080/19440049.2026.2739979

Yelena Sapozhnikova, Jonathan Antle

{"title":"Trifluoroacetic acid (TFA) in grain products from the US supermarkets.","authors":"Yelena Sapozhnikova, Jonathan Antle","doi":"10.1080/19440049.2026.2739979","DOIUrl":"https://doi.org/10.1080/19440049.2026.2739979","url":null,"abstract":"A targeted analytical method for seven short- and ultra-short chain per- and polyfluoroalkyl substances (PFAS) was developed and validated in grain products using LC-MS/MS. The method is simple and robust, with validation results demonstrating acceptable recoveries and reproducibility. The validated method was applied to a variety of grain products commonly consumed in the United States, including flour, rice, corn, oats, and pasta, with both conventional and organic products represented. Trifluoroacetic acid (TFA) was detected in 92 out of 95 samples with concentrations ranging from not detectable to 356 ng/g. To evaluate the impact of cooking, selected grains were prepared according to typical household practices and analysed alongside the corresponding cooking water. TFA concentrations generally decreased after cooking, accompanied by transfer into the cooking water. Among all tested grain products, flour contained the highest TFA levels (range: 36.6-356 ng/g), followed by oats (27.5-292 ng/g), pasta (13.6-265 ng/g), and rice (8.52-77.8 ng/g). Historical grain samples collected between 2016 and 2019 were also analysed, providing a retrospective view of TFA occurrence, and analysis of identical products purchased in 2026 indicated an overall upward trend in TFA levels. Estimated dietary intake of TFA from cooked grains was below the European Food Safety Authority's (EFSA) acceptable daily intake of 0.014 mg/kg body weight.","PeriodicalId":520628,"journal":{"name":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to polycyclic aromatic hydrocarbons (PAHs) for the Danish population based on 20 years of food control. 基于20年食品控制的丹麦人口暴露于多环芳烃（PAHs）。

IF 2.2

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Pub Date : 2026-10-05 DOI: 10.1080/19440049.2026.2741629

Lene Duedahl-Olesen, Karsten Steen Jensen, Tue Christensen, Kirsten H Lund, Annette Petersen

{"title":"Exposure to polycyclic aromatic hydrocarbons (PAHs) for the Danish population based on 20 years of food control.","authors":"Lene Duedahl-Olesen, Karsten Steen Jensen, Tue Christensen, Kirsten H Lund, Annette Petersen","doi":"10.1080/19440049.2026.2741629","DOIUrl":"https://doi.org/10.1080/19440049.2026.2741629","url":null,"abstract":"Food can be contaminated with polycyclic aromatic hydrocarbons (PAHs) from environmental and food processing sources. Carcinogenic properties of some of these compounds have resulted in EU food control of both benzo[a]pyrene (BaP) and four PAHs (PAH4). The last twenty years Danish food surveillance program has included analysis of PAHs. Results from these programs including 1315 food samples of fish and fish products, meat and sausages, vegetable oils, fruit and beverages and miscellaneous samples, were used to estimate the total exposure to benzo[a]pyrene and PAH4 for the Danish population. Exposure values for both children (4-15 years) and adults (15-70 years) were used for calculation of margin of exposure (MOE) values for estimation of the consumer risk. Our results showed that for PAH4 MOE will be less than 10,000 only if concentration data between the 90th percentile and the maximum values were used. The conclusion was therefore that there is low risk for the Danish population in relation to PAH4 exposure. In general, processed meat was the major contributor to the total exposure. Future consumption patterns and changes in food preparation should however still be under surveillance.","PeriodicalId":520628,"journal":{"name":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Residue depletion and withdrawal time estimation of moxidectin and triclabendazole in cattle following pour-on administration. 莫西丁和三氯苄唑灌胃后在牛体内的残留损耗及停药时间估计。

IF 2.2

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Pub Date : 2026-10-01 Epub Date: 2026-08-27 DOI: 10.1080/19440049.2026.2704198

Yufeng Wu, Mengdi Zhang, Tingting Chen, Xiaosong Zhang, Zhuo Chen, Fengting Lang, Zhihui Hao

{"title":"Residue depletion and withdrawal time estimation of moxidectin and triclabendazole in cattle following pour-on administration.","authors":"Yufeng Wu, Mengdi Zhang, Tingting Chen, Xiaosong Zhang, Zhuo Chen, Fengting Lang, Zhihui Hao","doi":"10.1080/19440049.2026.2704198","DOIUrl":"10.1080/19440049.2026.2704198","url":null,"abstract":"Moxidectin-triclabendazole pour-on solution is a broad-spectrum antiparasitic formulation used to control both ectoparasites and endoparasites in livestock. This study evaluated the residue depletion of moxidectin (MOX) and triclabendazole ketone (keto-TCB), the major metabolite of triclabendazole, in edible bovine tissues following pour-on administration at a dose of 0.1 mL/kg body weight. A validated LC-MS/MS method was employed for residue quantification. The method demonstrated tissue-specific limits of detection (LOD) and limits of quantification (LOQ) for MOX and keto-TCB. For MOX, LODs were 2, 10, 5, and 50 μg/kg, and LOQs were 5, 20, 10, and 100 μg/kg in muscle, liver, kidney, and fat, respectively. For keto-TCB, LODs were 10, 100, 50, and 10 μg/kg, and LOQs were 50, 200, 100, and 20 μg/kg in muscle, liver, kidney, and fat, respectively. Tissue samples from muscle, liver, kidney, and fat were collected up to 180 days after administration. MOX showed prolonged persistence in fat, which was identified as the critical tissue for withdrawal period evaluation, whereas keto-TCB depleted more rapidly overall. Based on the corresponding maximum residue limits, the withdrawal intervals were estimated to be at least 121 days for MOX and at least 53 days for keto-TCB. These findings provide residue depletion data to support withdrawal period evaluation and food safety assessment of this formulation in cattle.","PeriodicalId":520628,"journal":{"name":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","volume":" ","pages":"1561-1575"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0