Experimental biology and medicine (Maywood, N.J.)最新文献

{"title":"Association between serum placental growth factor and vascular endothelial function in hyprtensive disorders complicating pregnancy.","authors":"Weiling Li,&nbsp;Shasha Liu,&nbsp;Yuan Li,&nbsp;Weijing Wang,&nbsp;Yiming Dong,&nbsp;Lin Qi,&nbsp;Jie Ren,&nbsp;Jiefang Zhang","doi":"10.1177/15353702211063833","DOIUrl":"https://doi.org/10.1177/15353702211063833","url":null,"abstract":"<p><p>Hypertensive disorders complicating pregnancy (HDCP) is a systemic disease among pregnant women. Therefore, the prevention and prediction of hypertension during pregnancy are critical. This study aimed to clarify whether the vascular endothelial function of women with gestational hypertension was linked to placental growth factor. A total of 200 pregnant women were enrolled in our study and subsequently divided into two groups: the HDCP group and the normal pregnancy controls. The levels of serum placental growth factor, as well as plasma endothelin-1 and nitric oxide, between the two groups were measured. In addition, the endothelial function indexes, including pressure-strain elasticity coefficient (EP), the common carotid stiffness index (β), arterial compliance, single-point pulsed-wave velocity, and augment index (AI) of bilateral common carotid arteries, were compared between the HDCP and control groups using the echo tracking technique. In our study, the level of placental growth factor in the HDCP group was significantly lower than the control group. Furthermore, our results clarified that endothelin-1 increased while nitric oxide decreased in the HDCP group compared with the control group. On the other hand, we found that EP, β, pulsed-wave velocity and augment index values were significantly higher in the HDCP group than in the control group (P < 0.001). However, the value of arterial compliance was significantly decreased in patients of the HDCP group compared with the control group (P < 0.001). In conclusion, the association between serum placental growth factor and vascular endothelial function in HDCP could serve as a more accurate predictive factor of pregnant hypertension.</p>","PeriodicalId":520623,"journal":{"name":"Experimental biology and medicine (Maywood, N.J.)","volume":" ","pages":"480-487"},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943328/pdf/10.1177_15353702211063833.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39724059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial microbiota in upper respiratory tract of COVID-19 and influenza patients.","authors":"Somruthai Rattanaburi,&nbsp;Vorthon Sawaswong,&nbsp;Suwalak Chitcharoen,&nbsp;Pavaret Sivapornnukul,&nbsp;Pattaraporn Nimsamer,&nbsp;Nungruthai Suntronwong,&nbsp;Jiratchaya Puenpa,&nbsp;Yong Poovorawan,&nbsp;Sunchai Payungporn","doi":"10.1177/15353702211057473","DOIUrl":"https://doi.org/10.1177/15353702211057473","url":null,"abstract":"<p><p>The upper respiratory tract is inhabited by diverse range of commensal microbiota which plays a role in protecting the mucosal surface from pathogens. Alterations of the bacterial community from respiratory viral infections could increase the susceptibility to secondary infections and disease severities. We compared the upper respiratory bacterial profiles among Thai patients with influenza or COVID-19 by using 16S rDNA high-throughput sequencing based on MiSeq platform. The Chao1 richness was not significantly different among groups, whereas the Shannon diversity of Flu A and Flu B groups were significantly lower than Non-Flu & COVID-19 group. The beta diversity revealed that the microbial communities of influenza (Flu A and Flu B), COVID-19, and Non-Flu & COVID-19 were significantly different; however, the comparison of the community structure was similar between Flu A and Flu B groups. The bacterial classification revealed that Enterobacteriaceae was predominant in influenza patients, while <i>Staphylococcus</i> and <i>Pseudomonas</i> were significantly enriched in the COVID-19 patients. These implied that respiratory viral infections might be related to alteration of upper respiratory bacterial community and susceptibility to secondary bacterial infections. Moreover, the bacteria that observed in Non-Flu & COVID-19 patients had high abundance of <i>Streptococcus</i>, <i>Prevotella</i>, <i>Veillonella</i>, and <i>Fusobacterium</i>. This study provides the basic knowledge for further investigation of the relationship between upper respiratory microbiota and respiratory disease which might be useful for better understanding the mechanism of viral infectious diseases.</p>","PeriodicalId":520623,"journal":{"name":"Experimental biology and medicine (Maywood, N.J.)","volume":" ","pages":"409-415"},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919321/pdf/10.1177_15353702211057473.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39622485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal serum-derived exosomal lactoferrin as a marker in detecting and predicting ventricular septal defect in fetuses.","authors":"Suping Li,&nbsp;Yuxia Jin,&nbsp;Ping Tang,&nbsp;Xiaodan Liu,&nbsp;Xiaojun Chai,&nbsp;Jinhua Dong,&nbsp;Xuan Che,&nbsp;Qinqin Zhou,&nbsp;Meidi Ni,&nbsp;Fan Jin","doi":"10.1177/15353702211060517","DOIUrl":"https://doi.org/10.1177/15353702211060517","url":null,"abstract":"Among different types of congenital heart diseases, ventricular septal defect is the most frequently diagnosed type and is frequently missed in early prenatal screening programs. Herein, we explored the role of maternal serum-derived exosomes in detecting and predicting ventricular septal defect in fetuses in the early stage of pregnancy. A total of 104 pregnant women consisting of 52 ventricular septal defect cases and 52 healthy controls were recruited. TMT/iTRAQ proteomic analysis uncovered 15 maternal serum exosomal proteins, which showed differential expression between ventricular septal defect and control groups. Among these, four down-regulated proteins, lactoferrin, SBSN, DCD, and MBD3, were validated by Western blot. The protein lactoferrin was additionally verified by ELISA which was able to distinguish ventricular septal defects from controls with area under the ROC curve (AUC) 0.804 (p < 0.001). Our findings reveal that lactoferrin in maternal serum-derived exosomes may be a potential biomarker for non-invasive prenatal diagnosis of fetal ventricular septal defects.","PeriodicalId":520623,"journal":{"name":"Experimental biology and medicine (Maywood, N.J.)","volume":" ","pages":"488-497"},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943331/pdf/10.1177_15353702211060517.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39696893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>CCNB1</i> promotes the development of hepatocellular carcinoma by mediating DNA replication in the cell cycle.","authors":"Min-Hua Rong,&nbsp;Jian-Di Li,&nbsp;Lu-Yang Zhong,&nbsp;Yu-Zhen Huang,&nbsp;Juan Chen,&nbsp;Li-Yuan Xie,&nbsp;Rong-Xing Qin,&nbsp;Xiao-Lian He,&nbsp;Zhan-Hui Zhu,&nbsp;Su-Ning Huang,&nbsp;Xian-Guo Zhou","doi":"10.1177/15353702211049149","DOIUrl":"https://doi.org/10.1177/15353702211049149","url":null,"abstract":"<p><p>In our studies, cyclin B1 (<i>CCNB1</i>) mRNA and protein were overexpressed in hepatocellular carcinoma (HCC) tissues compared with non-HCC tissues. Moreover, <i>CCNB1</i> was overexpressed in the serum of HCC patients. The expression of <i>CCNB1</i> was associated with several crucial clinicopathologic characteristics, and the HCC patients with overexpressed <i>CCNB1</i> had worse overall survival outcomes. In the screening of interactional genes, a total of 266 upregulated co-expression genes, which were positively associated with <i>CCNB1</i>, were selected from the datasets, and 67 downregulated co-expression genes, which were negatively associated with <i>CCNB1</i>, were identified. The key genes might be functionally enriched in DNA replication and the cell cycle pathways. <i>CDC20</i>, <i>CCNA2</i>, <i>PLK1</i>, and <i>FTCD</i> were selected for further research because they were highly connected in the protein-protein interaction networks. Upregulated <i>CDC20</i>, <i>CCNA2</i>, and <i>PLK1</i> and downregulated <i>FTCD</i> might result in undesirable overall survival outcomes for HCC patients. The univariate Cox analysis results showed that <i>CDC20</i> and <i>PLK1</i> might be two independent risk factors, while <i>FTCD</i> might be protective in HCC. Therefore, <i>CCNB1</i> may participate in the cell cycle of HCC by regulating DNA replication, and <i>CCNB1</i> may provide a direction for the diagnosis of early-stage HCC and targeted HCC therapy.</p>","PeriodicalId":520623,"journal":{"name":"Experimental biology and medicine (Maywood, N.J.)","volume":" ","pages":"395-408"},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919315/pdf/10.1177_15353702211049149.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern approaches on stem cells and scaffolding technology for osteogenic differentiation and regeneration.","authors":"Shivaani Kirankumar,&nbsp;Narasimman Gurusamy,&nbsp;Sheeja Rajasingh,&nbsp;Vinoth Sigamani,&nbsp;Jayavardini Vasanthan,&nbsp;Selene G Perales,&nbsp;Johnson Rajasingh","doi":"10.1177/15353702211052927","DOIUrl":"https://doi.org/10.1177/15353702211052927","url":null,"abstract":"<p><p>The process of bone repair has always been a natural mystery. Although bones do repair themselves, supplemental treatment is required for the initiation of the self-regeneration process. Predominantly, surgical procedures are employed for bone regeneration. Recently, cell-based therapy for bone regeneration has proven to be more effective than traditional methods, as it eliminates the immune risk and painful surgeries. In clinical trials, various stem cells, especially mesenchymal stem cells, have shown to be more efficient for the treatment of several bone-related diseases, such as non-union fracture, osteogenesis imperfecta, osteosarcoma, and osteoporosis. Furthermore, the stem cells grown in a suitable three-dimensional scaffold support were found to be more efficient for osteogenesis. It has been shown that the three-dimensional bioscaffolds support and simulate an <i>in vivo</i> environment, which helps in differentiation of stem cells into bone cells. Bone regeneration in patients with bone disorders can be improved through modification of stem cells with several osteogenic factors or using stem cells as carriers for osteogenic factors. In this review, we focused on the various types of stem cells and scaffolds that are being used for bone regeneration. In addition, the molecular mechanisms of various transcription factors, signaling pathways that support bone regeneration and the senescence of the stem cells, which limits bone regeneration, have been discussed.</p>","PeriodicalId":520623,"journal":{"name":"Experimental biology and medicine (Maywood, N.J.)","volume":" ","pages":"433-445"},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919323/pdf/10.1177_15353702211052927.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39517052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expressing <i>MLH1</i> in HCT116 cells increases cellular resistance to radiation by activating the PRKAC.","authors":"Yuling Huang,&nbsp;Liu Feng,&nbsp;Yongqiang Bao,&nbsp;Yun Zhang,&nbsp;Jinghui Liang,&nbsp;Qingfeng Mao,&nbsp;Jingao Li,&nbsp;Chunling Jiang","doi":"10.1177/15353702211059829","DOIUrl":"https://doi.org/10.1177/15353702211059829","url":null,"abstract":"<p><p>Mut L homolog-1 (MLH1) is a key DNA mismatch repair protein which participates in the sensitivity to DNA damaging agents. However, its role in the radiosensitivity of tumor cells is less well characterized. In this study, we investigated the role of MLH1 in cellular responses to ionizing radiation (IR) and explored the signaling molecules involved. The isogenic pair of MLH1 proficient (MLH1⁺) and deficient (MLH1^-) human colorectal cancer HCT116 cells was exposed to IR for 24 h at the dose of 3 cGy. The clonogenic survival was examined by the colony formation assay. Cell cycle distribution was analyzed with flow cytometry. Changes in the protein level of MLH1, DNA damage marker γH2AX, and protein kinase A catalytic subunit (PRKAC), a common target for anti-tumor drugs, were examined with Western blotting. The results showed that the HCT116 (MLH1⁺) cells demonstrated increased radio-resistance with increased S population, decreased G2 population, a low level of γH2AX, a reduced ratio of phosphorylated PRKACαβ to total PRKAC, and an elevated level of total PRKAC and phosphorylated PRKACβII following IR compared with the HCT116 (MLH1^-) cells. Importantly, silencing <i>PRKAC</i> in HCT116 (MLH1⁺) cells increased the cellular radiosensitivity. In conclusion, MLH1 may increase cellular resistance to IR by activating PRKAC. Our finding is the first to demonstrate the important role of PRKAC in MLH1-mediated radiosensitivity, suggesting that PRKAC has potential as a biomarker and a therapeutic target for increasing radio-sensitization.</p>","PeriodicalId":520623,"journal":{"name":"Experimental biology and medicine (Maywood, N.J.)","volume":" ","pages":"426-432"},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919320/pdf/10.1177_15353702211059829.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39630701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild hypobaric hypoxia influences splenic proliferation during the later phase of stress erythropoiesis.","authors":"Liyuan Zhang,&nbsp;Shailey Patel,&nbsp;Julia N Soulakova,&nbsp;Charles C Caldwell,&nbsp;Barbara St Pierre Schneider","doi":"10.1177/15353702211060775","DOIUrl":"https://doi.org/10.1177/15353702211060775","url":null,"abstract":"<p><p>Tissue trauma and hemorrhagic shock are common battlefield injuries that can induce hypoxia, inflammation, and/or anemia. Inflammation and hypoxia can initiate adaptive mechanisms, such as stress erythropoiesis in the spleen, to produce red blood cells and restore the oxygen supply. In a military context, mild hypobaric hypoxia-part of the environmental milieu during aeromedical evacuation or en route care-may influence adaptive mechanisms, such as stress erythropoiesis, and host defense. In the present study, healthy (control), muscle trauma, and polytrauma (muscle trauma and hemorrhagic shock) mice were exposed to normobaric normoxia or hypobaric hypoxia for ∼17.5 h to test the hypothesis that hypobaric hypoxia exposure influences splenic erythropoiesis and splenic inflammation after polytrauma. This hypothesis was partially supported. The polytrauma + hypobaric hypoxia group exhibited more splenic neutrophils, fewer total spleen cells, and fewer splenic proliferating cells than the polytrauma+normobaric normoxia group; however, no splenic erythroid cell differences were detected between the two polytrauma groups. We also compared splenic erythropoiesis and myeloid cell numbers among control, muscle trauma, and polytrauma groups. More reticulocytes at 1.7 days (40 h) post-trauma (dpt) and neutrophils at 4 dpt were produced in the muscle trauma mice than corresponding control mice. In contrast to muscle trauma, polytrauma led to a reduced red blood cell count and elevated serum erythropoietin levels at 1.7 dpt. There were more erythroid subsets and apoptotic reticulocytes in the polytrauma mice than muscle trauma mice at 4 and 8 dpt. At 14 dpt, the red blood cell count of the polytrauma + normobaric normoxia mice was 12% lower than that of the control + normobaric normoxia mice; however, no difference was observed between polytrauma + hypobaric hypoxia and control + hypobaric hypoxia mice. Our findings suggest muscle trauma alone induces stress erythropoiesis; in a polytrauma model, hypobaric hypoxia exposure may result in the dysregulation of splenic cells, requiring a treatment plan to ensure adequate immune functioning.</p>","PeriodicalId":520623,"journal":{"name":"Experimental biology and medicine (Maywood, N.J.)","volume":" ","pages":"509-518"},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943327/pdf/10.1177_15353702211060775.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39724026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum.","authors":"","doi":"10.1177/15353702221074862","DOIUrl":"https://doi.org/10.1177/15353702221074862","url":null,"abstract":"Figure 1 (corrected). Numerical solution of the averaged equations for the source–sink vortex. (a) The assumed azimuthal velocity v0, (b) the radial velocity u0, (c) the vertical velocity w0, and (d) the boundary layer thickness δ all computed at a central Rossby number of 1. The solid curves show the linear theory, the dashed curves the result obtained with the self-similar profile, and the dotted curves the result obtained with the non-self-similar profile. In (b) the solid and the dotted curves are identical by assumption and thus only the solid curve is shown.","PeriodicalId":520623,"journal":{"name":"Experimental biology and medicine (Maywood, N.J.)","volume":" ","pages":"NP1"},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919318/pdf/10.1177_15353702221074862.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39652102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal administration of mitochondria improves spatial memory in olfactory bulbectomized mice.","authors":"Natalia V Bobkova,&nbsp;Daria Y Zhdanova,&nbsp;Natalia V Belosludtseva,&nbsp;Nikita V Penkov,&nbsp;Galina D Mironova","doi":"10.1177/15353702211056866","DOIUrl":"https://doi.org/10.1177/15353702211056866","url":null,"abstract":"<p><p>Here, we found that functionally active mitochondria isolated from the brain of NMRI donor mice and administrated intranasally to recipient mice penetrated the brain structures in a dose-dependent manner. The injected mitochondria labeled with the MitoTracker Red localized in different brain regions, including the neocortex and hippocampus, which are responsible for memory and affected by degeneration in patients with Alzheimer's disease. In behavioral experiments, intranasal microinjections of brain mitochondria of native NMRI mice improved spatial memory in the olfactory bulbectomized (OBX) mice with Alzheimer's type degeneration. Control OBX mice demonstrated loss of spatial memory tested in the Morris water maze. Immunocytochemical analysis revealed that allogeneic mitochondria colocalized with the markers of astrocytes and neurons in hippocampal cell culture. The results suggest that a non-invasive route intranasal administration of mitochondria may be a promising approach to the treatment of neurodegenerative diseases characterized, like Alzheimer's disease, by mitochondrial dysfunction.</p>","PeriodicalId":520623,"journal":{"name":"Experimental biology and medicine (Maywood, N.J.)","volume":" ","pages":"416-425"},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919317/pdf/10.1177_15353702211056866.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39584763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive overview of PPM1A: From structure to disease.","authors":"Mao Li,&nbsp;Xingfeng Xu,&nbsp;Yan Su,&nbsp;Xiaoyun Shao,&nbsp;Yali Zhou,&nbsp;Jianguo Yan","doi":"10.1177/15353702211061883","DOIUrl":"https://doi.org/10.1177/15353702211061883","url":null,"abstract":"<p><p>PPM1A (magnesium-dependent phosphatase 1 A, also known as PP2Cα) is a member of the Ser/Thr protein phosphatase family. Protein phosphatases catalyze the removal of phosphate groups from proteins via hydrolysis, thus opposing the role of protein kinases. The PP2C family is generally considered a negative regulator in the eukaryotic stress response pathway. PPM1A can bind and dephosphorylate various proteins and is therefore involved in the regulation of a wide range of physiological processes. It plays a crucial role in transcriptional regulation, cell proliferation, and apoptosis and has been suggested to be closely related to the occurrence and development of cancers of the lung, bladder, and breast, amongst others. Moreover, it is closely related to certain autoimmune diseases and neurodegenerative diseases. In this review, we provide an insight into currently available knowledge of PPM1A, including its structure, biological function, involvement in signaling pathways, and association with diseases. Lastly, we discuss whether PPM1A could be targeted for therapy of certain human conditions.</p>","PeriodicalId":520623,"journal":{"name":"Experimental biology and medicine (Maywood, N.J.)","volume":" ","pages":"453-461"},"PeriodicalIF":3.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943326/pdf/10.1177_15353702211061883.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39688900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}