Drug discoveries & therapeutics最新文献_第4页

Agents that induce pseudo-allergic reaction. 诱发假性过敏反应的药剂。

IF 3.1

Drug discoveries & therapeutics Pub Date : 2011-10-01 DOI: 10.5582/ddt.2011.v5.5.211

H Wang, H S Wang, Z P Liu

{"title":"Agents that induce pseudo-allergic reaction.","authors":"H Wang, H S Wang, Z P Liu","doi":"10.5582/ddt.2011.v5.5.211","DOIUrl":"https://doi.org/10.5582/ddt.2011.v5.5.211","url":null,"abstract":"Pseudo-allergic reactions may result from the activation of inflammatory or anaphylactic mechanisms independent of antigen-specific immune responses. Recent statistics show that pseudo-allergic reactions may represent as high as two thirds of all immediate hypersensitivity reactions, implying a great amount of morbidity and numerous health care costs. In this review, we concentrate on agents mediating pseudo-allergic reactions and evaluate accurately the available information on their modes of action. The agents discussed here are divided into three types: (i) Direct mast cell activators, which may activate mast cells in an IgE-independent manner, such as opioid drugs, basic secretagogues and calcium ionophore A23187; (ii) Complement activators, including liposomes, radiocontrast media and Cremophor EL, which may activate the complement system by different pathways: the classical pathway, the mannose-binding lectin pathway or the alternative pathway; (iii) Nonsteroidal anti-inflammatory drugs, which may inhibit the function of cyclooxygenase-1, resulting in the occurrence of adverse reactions. In addition, nonclinical detection methods of pseudo-allergic reactions are also reviewed in order to supply valuable information for clinical diagnosis.","PeriodicalId":520606,"journal":{"name":"Drug discoveries & therapeutics","volume":" ","pages":"211-9"},"PeriodicalIF":3.1,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5582/ddt.2011.v5.5.211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30545244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis. 厚朴树皮活性成分厚朴酚和厚朴酚靶向肿瘤细胞凋亡途径的研究。

IF 3.1

Drug discoveries & therapeutics Pub Date : 2011-10-01 DOI: 10.5582/ddt.2011.v5.5.202

H L Xu, W Tang, G H Du, N Kokudo

引用次数: 44

Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae. 生姜精油、油树脂与姜科其它植物精油抗念珠菌及自由基清除活性的研究。

IF 3.1

Drug discoveries & therapeutics Pub Date : 2011-10-01 DOI: 10.5582/ddt.2011.v5.5.238

M Takahashi, S Inouye, S Abe

引用次数: 26

Initial characterization of D-cycloserine for future formulation development for anxiety disorders. d -环丝氨酸的初步表征，用于未来焦虑症的配方开发。

IF 3.1

Drug discoveries & therapeutics Pub Date : 2011-10-01 DOI: 10.5582/ddt.2011.v5.5.253

G Kaushal, R Ramirez, D Alambo, W Taupradist, K Choksi, C Sirbu

{"title":"Initial characterization of D-cycloserine for future formulation development for anxiety disorders.","authors":"G Kaushal, R Ramirez, D Alambo, W Taupradist, K Choksi, C Sirbu","doi":"10.5582/ddt.2011.v5.5.253","DOIUrl":"https://doi.org/10.5582/ddt.2011.v5.5.253","url":null,"abstract":"The purpose of this study is to characterize D-cycloserine (DCS) physicochemical properties to facilitate future formulation development of DCS for anxiety disorders. A stability-indicating HPLC assay method for the quantitation of DCS was developed and calibrated to be used for this study. The partition coefficient was determined and compared with the predicted value. The solution stability of DCS was studied under various pH (2.0-11.5) and ionic strengths of 10 and 20 mM at physiological temperature of 37°C. The 250 mg capsule was compounded to the nominal strength of 50 mg used for anxiety disorders. These capsules were then put under stability. The in vitro dissolution was also carried out at 37°C as per the United States Pharmacopeia (USP) guidelines. The partition coefficient value (Kp) determined for the DCS was log Kp = -2.89 ± 0.06 (n = 6). The pH-solution stability profile shows that DCS has maximum stability under alkaline conditions. The maximum rate of degradation was seen at pH of 4.7. The mean percent recovery of DCS from the capsules compounded to strength of 50 mg was 100.3 ± 1.4. The stability study of the reformulated capsules concluded that reformulated DCS is stable for at least one year at room temperature. The in vitro dissolution illustrates that all the DCS is released from the capsules in 10 min. The present characterization of DCS study will serve as guidance for the future directions regarding the reformulation of DCS in order to be used in anxiety disorders.","PeriodicalId":520606,"journal":{"name":"Drug discoveries & therapeutics","volume":" ","pages":"253-60"},"PeriodicalIF":3.1,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5582/ddt.2011.v5.5.253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30544150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Development of microemulsion of a potent anti-tyrosinase essential oil of an edible plant. 食用植物强效抗酪氨酸酶精油微乳剂的研制。

IF 3.1

Drug discoveries & therapeutics Pub Date : 2011-10-01 DOI: 10.5582/ddt.2011.v5.5.246

K Saeio, S Yotsawimonwat, S Anuchapreeda, S Okonogi

引用次数: 7

Matrix type transdermal therapeutic systems of glibenclamide: Formulation, ex vivo and in vivo characterization. 格列本脲基质型透皮治疗系统:配方、体外和体内表征。

IF 3.1

Drug discoveries & therapeutics Pub Date : 2011-02-01 DOI: 10.5582/ddt.v5.1.53

A Ali, A Trehan, Z Ullah, M Aqil, Y Sultana

{"title":"Matrix type transdermal therapeutic systems of glibenclamide: Formulation, ex vivo and in vivo characterization.","authors":"A Ali, A Trehan, Z Ullah, M Aqil, Y Sultana","doi":"10.5582/ddt.v5.1.53","DOIUrl":"https://doi.org/10.5582/ddt.v5.1.53","url":null,"abstract":"Matrix type transdermal therapeutic systems (TTS) of glibenclamide were formulated using polymers Eudragit RL 100, ethyl cellulose, PVP K-30, and polyvinyl acetate, and citral was used as the penetration enhancer. The polymer films were formulated with Eudragit RL 100 and PVP K-30 in different ratios and subsequently subjected to ex vivo studies (drug permeation through rat skin) followed by interaction studies, skin irritation studies, accelerated stability analysis, and in vivo studies (determination of blood glucose level in rabbits). The drug content of the formulations was found to be 99.1-99.2%. The cumulative percentages of drug permeated through rat skin from the three selected formulations in 48 h were 95.3%, 98.8%, and 99%, respectively. A plot between cumulative percent of drug permeated and square root of time exhibited linear curves, which suggests the Higuchian matrix mechanism of drug release. The formulation containing Eudragit RL 100 and PVP K-30 showed better improvement in hypoglycemic activity in rabbits (56.2-60.8% reduction in blood glucose level, p < 0.05). There were fewer fluctuations in blood glucose level as compared to oral therapy due to controlled release of the active pharmaceutical ingredient, and no interaction was found between the drug and excipients of the formulation. Accelerated stability analysis showed that the formulation was stable up to 5.5 years, with negligible skin irritation. The formulation precluded severe hypoglycemic reactions (side effect of sulfonylureas) and was effective for management of diabetes mellitus up to 48 h, with a single TTS.","PeriodicalId":520606,"journal":{"name":"Drug discoveries & therapeutics","volume":" ","pages":"53-9"},"PeriodicalIF":3.1,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5582/ddt.v5.1.53","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30543384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Antibacterial activities of Sesbania grandiflora extracts. 大田菁提取物的抑菌活性研究。

IF 3.1

Drug discoveries & therapeutics Pub Date : 2011-02-01 DOI: 10.5582/ddt.v5.1.12

P Anantaworasakul, S Klayraung, S Okonogi

引用次数: 25

Drug Discoveries & Therapeutics: A platform for promoting pharmaceutical sciences and clinical therapeutics. 药物发现与治疗:促进药物科学和临床治疗的平台。

IF 3.1

Drug discoveries & therapeutics Pub Date : 2011-02-01

Y Yen

引用次数: 0

c-Met: A potential therapeutic target for hepatocellular carcinoma. c-Met:肝细胞癌的潜在治疗靶点

IF 3.1

Drug discoveries & therapeutics Pub Date : 2011-02-01 DOI: 10.5582/ddt.2011.v5.1.2

J J Gao, Y Inagaki, X Xue, X J Qu, W Tang

引用次数: 27

A comparative study of protective mechanisms of glycine and L-arginine against cisplatin-induced nephrotoxicity in rat renal cortical slices. 甘氨酸和l -精氨酸对顺铂所致大鼠肾皮质片肾毒性保护机制的比较研究。

IF 3.1

Drug discoveries & therapeutics Pub Date : 2011-02-01 DOI: 10.5582/ddt.v5.1.32

Y Fk Mahran, A E Khalifa, E El-Demerdash

{"title":"A comparative study of protective mechanisms of glycine and L-arginine against cisplatin-induced nephrotoxicity in rat renal cortical slices.","authors":"Y Fk Mahran, A E Khalifa, E El-Demerdash","doi":"10.5582/ddt.v5.1.32","DOIUrl":"https://doi.org/10.5582/ddt.v5.1.32","url":null,"abstract":"Amino acids exert nephroprotective effects in various forms of acute renal injury depending on their renal hemodynamic effects. The present study was designed to elucidate and compare the role of non hemodynamic mechanisms in protective actions afforded by glycine and L-arginine against cisplatin (CDDP)-induced nephrotoxicity using rat renal cortical slices (RCS). We have investigated the possible modulatory effect of glycine and L-arginine on oxidative stress and necrosis induced by CDDP as well as on CDDP uptake by kidney. After 4 h of incubation with 2 mM CDDP, nephrotoxicity was demonstrated by significant increased lactate dehydrogenase leakage, decreased ability of the slices to reduce 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, increased lipid peroxides and depleted reduced glutathione. Also, CDDP significantly inhibited pyruvate-stimulated gluconeogenesis. Histopathological examination of RCS confirmed the occurrence of tubular coagulative necrosis in cortex and corticomedullary regions. Preincubation of RCS with 1 mM glycine or L-arginine 1 h before CDDP addition significantly attenuated the oxidative stress and tubular necrotic effects of CDDP. L-Arginine showed greater antioxidant properties while glycine showed a greater antinecrotic effect. Moreover, the nephroprotective effect was mediated through lowering the platinum uptake by RCS. However, they could not counteract the inhibition of gluconeogenesis induced by CDDP. In conclusion, the present study sheds light on the mechanisms involved in glycine and L-arginine nephroprotection.","PeriodicalId":520606,"journal":{"name":"Drug discoveries & therapeutics","volume":" ","pages":"32-40"},"PeriodicalIF":3.1,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5582/ddt.v5.1.32","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30543383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11