Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis最新文献

{"title":"Significance of D-Dimer Levels in the Evaluation of Postoperative Muscular Calf Vein Thrombosis: A Restricted Cubic Spline Analysis.","authors":"Honghui Zhang, Mengmeng Liu, Qi Qin, Aiqin Chu, Lingyun Tian","doi":"10.1177/10760296261437064","DOIUrl":"10.1177/10760296261437064","url":null,"abstract":"<p><p>BackgroundD-dimer have been frequently used to assess the preliminary risk of muscular calf vein thrombosis (MCVT) after knee arthroplasty. However, D-dimer is usually higher than the clinical reference range in clinical settings, the relationship between D-dimer and postoperative MCVT remains to be explored.ObjectiveTo investigate the association between postoperative MCVT and D-dimer after knee arthroplasty.MethodsA retrospective case-control study was conducted on patients who received knee arthroplasty in the Department of Orthopaedics from September 1, 2022, to December 31, 2022.We collected basic demographic information, disease history, surgical and anesthesia information, blood examination results on admission and the first day of postoperative, and postoperative MCVT from patients. A multivariate logistic regression model was adopted to evaluate the association between D-dimer and postoperative MCVT, and the restricted cubic spline was used to analyze the dose-response relationship between D-dimer and postoperative MCVT.ResultsPostoperative MCVT was diagnosed in 103 out of 401 patients, with a prevalence of 25.69%. The median of preoperative and postoperative D-dimer was 0.47 ug/mL and 3.80 ug/mL in patients with postoperative MCVT, compared with 0.42 ug/mL and 2.42 ug/mL in patients without postoperative MCVT. After adjustment for the covariates, postoperative D-dimer was statistically significantly associated with an increased risk of postoperative MCVT. Restricted cubic spline regression showed a nonlinear dose-response relationship between postoperative D-dimer and postoperative MCVT and an increased risk of postoperative MCVT overall with higher D-dimer levels when D-dimer was over 2.62 ug/mL. There was no interaction between D-dimer and postoperative MCVT for the subgroups of age, sex, lacunar cerebral infarction, nerve block anesthesia, and surgery duration in the subgroup analyses.ConclusionsWith the high incidence of postoperative MCVT in patients with knee arthroplasty and the positive dose-response relationship between postoperative D-dimer and the risk of postoperative MCVT, risk stratification strategies should be developed for postoperative D-dimer to reduce the incidence of postoperative MCVT in patients with knee arthroplasty.</p>","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"32 ","pages":"10760296261437064"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do We Need A CML-Specific Bleeding Tool? Concerns About The Proposed BAT-CML.","authors":"Fatoş Dilan Köseoğlu, Ufuk Demirci, Mehmet Baysal","doi":"10.1177/10760296261459343","DOIUrl":"10.1177/10760296261459343","url":null,"abstract":"","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"32 ","pages":"10760296261459343"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Fibrinogen Levels on Thromboelastography-Derived Clot Strength in Pregnant Women With or Without Immune Thrombocytopenia.","authors":"Shujuan Xu, Zhenzhen Xu, Yu Zhou, Baihua Yang, Zhenshu Xu, Meijuan Huang","doi":"10.1177/10760296251410930","DOIUrl":"10.1177/10760296251410930","url":null,"abstract":"<p><p>ObjectivesPlatelet-fibrin interactions are critical for hemostasis. Thromboelastography (TEG) assesses these dynamics globally. We investigated the role of fibrinogen on TEG-derived clot strength in pregnant women with and without thrombocytopenia, integrating transcriptomic analysis of public datasets to molecularly corroborate our functional findings.MethodsA retrospective study was conducted on 140 third-trimester pregnancies (70 with normal platelet counts and 70 with thrombocytopenia) enrolled between 2015 and 2020. TEG parameters, platelet indices, and fibrinogen concentrations were analyzed. In parallel, public transcriptomic datasets were reanalyzed to explore coagulation- and fibrinogen-related pathways during pregnancy.ResultsMean platelet volume (MPV), platelet count, fibrinogen, and TEG parameters [R-time, K-time, alpha angle, and maximum amplitude (MA)] differed significantly between groups (p < .05). MA positively correlated with platelet count (r = 0.873, p < .001) and fibrinogen concentration (r = 0.410, p < .01). In thrombocytopenic women, MA correlated with platelet count (r = 0.736, p < .0001), MPV (r = 0.447, p < .01), and fibrinogen (r = 0.361, p < .01). Multivariate regression confirmed platelet count and fibrinogen as independent predictors of MA (p < .05). Transcriptomic analysis further demonstrated upregulation of fibrinogen subunits (FGB, F13A1) and enrichment of coagulation pathways in pregnancy, consistent with the functional TEG findings.ConclusionsElevated fibrinogen is associated with and may compensate for preserved clot strength in late pregnancy, particularly in thrombocytopenia. Our integrative analysis provides functional and molecular insights into a potential compensatory mechanism, which forms a rationale for future research to evaluate the therapeutic utility of fibrinogen supplementation. These hypothesis-generating findings warrant prospective interventional validation before clinical application.</p>","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"32 ","pages":"10760296251410930"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Time in Therapeutic Range Among Thai Patients with Non-valvular Atrial Fibrillation Taking Warfarin: Development of AHfHDP Score.","authors":"Pitchapong Kositchaiwat, Ubonwan Sapoo, Nutthada Areepium, Krittin Bunditanukul","doi":"10.1177/10760296261480894","DOIUrl":"https://doi.org/10.1177/10760296261480894","url":null,"abstract":"<p><p>BackgroundIn Thai patients with non-valvular atrial fibrillation (NVAF), anticoagulation quality with warfarin remains suboptimal. Existing prediction tools for poor international normalized ratio (INR) control, such as the SAMe-TT₂R₂ score, perform poorly in this population. Identifying population-specific determinants of time in therapeutic range (TTR) may improve risk stratification and inform clinical decision-making.MethodsWe conducted a single-center, retrospective cohort study of adult patients with NVAF taking warfarin between 2016 and 2019. TTR was calculated using the Rosendaal method, with a target INR range of 2.0-3.0. Logistic regression analysis was performed to identify independent predictors of suboptimal anticoagulation control (TTR <65%). A novel risk score was derived from the regression coefficients and evaluated using receiver operating characteristic (ROC) curve analysis.ResultsAmong 1,322 patients (median age 68 years; 57% female), median TTR was 50.5% (IQR 29.8-69.0), and 70% had TTR <65%. Independent predictors of suboptimal TTR included age ≥65 years, heart failure, hypertension, and drug-drug interactions with warfarin, while prior warfarin use ≥1 year was protective (all P<0.05). These variables were incorporated into the AHfHDP score (range, -2 to 4). The AHfHDP score showed modest discrimination (C-statistic 0.64; 95% CI 0.61-0.67), outperforming SAMe-TT₂R₂ (C-statistic, 0.53).ConclusionsWarfarin anticoagulation control in Thai patients with NVAF remains suboptimal. The AHfHDP score demonstrated modest predictive performance and superior discrimination compared to the SAMe-TT₂R₂ score. However, its overall predictive ability remained limited, and external validation is required before clinical application.</p>","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"32 ","pages":"10760296261480894"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13490818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148805035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Causal Association Between Biological Aging Indicators and Vascular Disease Through Two-Sample Mendelian Randomization Analysis.","authors":"Hao Yan, Wei Shan, Hui Hui, Qian Xia","doi":"10.1177/10760296261486120","DOIUrl":"10.1177/10760296261486120","url":null,"abstract":"<p><p>ObjectiveThis study used two-sample Mendelian Randomization to investigate the causal link between multiple biological aging indicators and vascular disease.MethodsSummary genetic data was obtained from genome-wide association studies (GWAS) focusing on aging-related exposures and various vascular disease outcomes. The exposures included granulocyte proportions, PAI-1 (plasminogen activator inhibitor-1), telomere lengths, and the Frailty Index. The primary analysis employed the Inverse Variance Weighted (IVW) method to estimate causal relationships, supported by MR-Egger, weighted median, and weighted mode methods. Sensitivity analyses, including Cochran's Q test, MR-Egger regression, leave-one-out test, and the MR Pleiotropy Residual Sum and Outlier (MR-PRESSO) test, were conducted to evaluate heterogeneity and pleiotropy.ResultsThe analysis revealed distinct pathways after sensitivity adjustments. A higher genetically predicted Frailty Index was associated with an increased risk of abdominal aortic aneurysm (OR=2.5935, 95% CI: 1.3936-4.8268, <i>P</i>=0.0026, false discovery rate (FDR)=0.0475), atherosclerosis excluding cerebral and coronary sclerosis (OR=2.0262, 95% CI:1.5179-2.705, <i>P</i>=1.66×10^-6, FDR=1×10^-4), and arterial thromboembolic events (OR = 4.0306, 95% CI: 1.7133-9.4818, <i>P</i> = 0.0014, FDR = 0.0337). Conversely, longer telomere length demonstrated a strong, specific protective effect against abdominal aortic aneurysm (OR=0.5008, 95% CI:0.4111-0.6100, <i>P</i>=6.42×10^-12, FDR=9.25×10^-10), indicating that shorter telomere length is associated with an increased risk of AAA. Furthermore, a lower granulocyte proportion was causally linked to an increased risk of thoracic aortic aneurysm (OR=0.0181, 95% CI: 0.0014-0.2376, <i>P</i>=0.0023, FDR=0.0465).ConclusionThis study identifies three genetic pathways linking biological aging to vascular disease, offering new molecular targets for its prevention and treatment.</p>","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"32 ","pages":"10760296261486120"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of Clot Waveform Analysis-Activated Thromboplastin Time (APTT) for Diagnosing Thrombotic Diseases.","authors":"Hiyori Ikeda, Hideo Wada, Nobuo Arai, Masafumi Kimura, Jun Masuda, Nobuo Ito, Nozomi Ikeda, Yuhuko Ichikawa, Motoko Tanaka, Kaoru Azuma, Minoru Ezaki, Katsuya Shiraki, Motomu Shimaoka, Hideto Shimpo","doi":"10.1177/10760296261459261","DOIUrl":"10.1177/10760296261459261","url":null,"abstract":"<p><p>ObjectiveClot waveform analysis (CWA)-activated partial thromboplastin time (APTT) has been used for the diagnosis of bleeding disorders. In addition to previous parameters such as Min 1, Min 2, and Max 2, we analyzed the area under the curve (AUC) of CWA (CWA-AUC) to examine its usefulness in the diagnosis of thrombosis.Materials and MethodsHypercoagulability in patients with acute myocardial infarction (AMI), acute cerebral infarction (ACI), chronic liver disease (CLD), and cancer and in healthy volunteers (HVs) was examined using CWA-APTT.ResultsMin 1 and Min 2 times were significantly shorter in patients with CLD, cancer, ACI, and AMI than in HVs. Min 1, Min 2, Max 2 and CWA-AUC were significantly higher in patients with cancer, ACI, and AMI than in HVs and patients with CLD and were significantly higher in individuals with thrombotic diseases (AMI and ACI) than in non-thrombotic individuals. ROC analyses for thrombosis vs. HVs or non-thrombotic individuals, Min 1, Min 2, Max 2, and CWA-AUC were useful for the diagnosis of thrombosis.In conclusionCWA-APTT was suggested to be potentially useful in diagnosing the risk of thrombosis, including AMI and ACI. Min1, Min2, and CWA-AUC are useful for diagnosing thrombosis, with CWA-AUC being the most effective.</p>","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"32 ","pages":"10760296261459261"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Therapy vs. Single Anticoagulation After Acute Deep Vein Thrombosis Iliac Stenting: A Doubly Robust Multicenter Study.","authors":"Pengyu Ji, Yong Wang","doi":"10.1177/10760296261480932","DOIUrl":"10.1177/10760296261480932","url":null,"abstract":"<p><p>BackgroundThe optimal antithrombotic strategy after iliac vein stenting for acute iliofemoral deep vein thrombosis (IFDVT) remains uncertain. We compared dual antithrombotic therapy (DAT) with single anticoagulation (SAC) in patients with May-Thurner syndrome-related IFDVT.MethodsThis multicenter retrospective cohort included 450 patients undergoing successful iliac vein stenting between 2018 and 2022. At discharge, 186 received DAT and 264 received SAC. Inverse probability of treatment weighting, doubly robust estimation, and time-varying exposure modeling were used. The primary outcome was primary stent patency. Secondary outcomes included primary-assisted and secondary patency, chronic post-thrombotic symptoms requiring treatment, recurrent ipsilateral DVT, and bleeding.ResultsDuring a median follow-up of 46 months, DAT was associated with a lower risk of primary patency loss than SAC (sHR, 0.58; 95% CI, 0.41-0.82; p = 0.002); estimated 5-year primary patency was 81.8% versus 67.5%. Similar associations were observed for primary-assisted (sHR, 0.52; 95% CI, 0.35-0.78; p = 0.001) and secondary patency loss (sHR, 0.45; 95% CI, 0.28-0.71; p < 0.001). DAT was also associated with fewer chronic post-thrombotic symptoms requiring treatment (sHR, 0.61; p = 0.005) and recurrent DVT (sHR, 0.48; p = 0.019). Major bleeding did not differ significantly (HR, 1.28; p = 0.624), whereas clinically relevant non-major bleeding was more frequent with DAT (HR, 2.35; p < 0.001).ConclusionsDuring anticoagulant-treated follow-up, DAT exposure was associated with higher long-term stent patency and fewer clinically treated chronic post-thrombotic symptoms and recurrent DVT than SAC exposure, but with more clinically relevant non-major bleeding. The study does not determine the optimal duration of anticoagulation or the effectiveness of subsequent antiplatelet monotherapy.</p>","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"32 ","pages":"10760296261480932"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Hemoglobin-To-Red Cell Distribution Width Ratio and Mortality Risk in Sepsis-Induced Coagulopathy: A Retrospective Study Based on MIMIC-IV Database.","authors":"Xiner Qiu, Yue Hou, Shiman Lin, Wenqin Xie, Weixia Wu, Zhu Wu","doi":"10.1177/10760296261479849","DOIUrl":"10.1177/10760296261479849","url":null,"abstract":"<p><p>BackgroundSepsis-induced coagulopathy (SIC) is an early stage of disseminated intravascular coagulation (DIC) and is associated with adverse clinical outcomes. The hemoglobin-to-red cell distribution width ratio (HRR) is a novel biomarker that has been found to have predictive value in various diseases. However, its prognostic significance in patients with SIC remains unclear.MethodsThis retrospective cohort study used the MIMIC-IV database and included ICU patients meeting the Sepsis-3 and SIC criteria. Clinical data within 24 hours of ICU admission were collected to calculate HRR, and patients were categorized into quartiles according to it (Q1: <0.56; Q2: 0.56-0.69; Q3: 0.69-0.82; Q4: ≥0.82). Associations between HRR and 28-, 90- and 365-day all-cause mortality were evaluated using restricted cubic splines, Kaplan-Meier curves, Cox proportional hazards models, and receiver operating characteristic curves. Subgroup and interaction analyses were performed to assess robustness and potential effect modification.ResultsA total of 5,279 patients with SIC were included in the study. After multivariate adjustment, the lowest HRR quartile was significantly associated with elevated 28-day mortality risk (HR = 1.36, 95% CI: 1.18-1.53, P < 0.001), suggesting that lower HRR levels were linked to higher mortality. This association remained consistent across different time points and was robust in subgroup analyses.ConclusionsHRR demonstrated a significant non-linear association with all-cause mortality in patients with SIC, with lower levels indicating a higher risk of death. As a readily available hematological marker, HRR may serve as a practical tool for the early risk assessment in this population.</p>","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"32 ","pages":"10760296261479849"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Atrial Appendage Occlusion in Cancer-Associated Atrial Fibrillation: Who, When, and How to Manage Antithrombotic Therapy.","authors":"Ameer Awashra, Ahmed Emara, Mohammed AbuBaha, Kareem Istetieh, Shahd Aldarak, Mays Nasser Shaheen, Nouran Alwisi, Bayan Mahafdah, Bara AbuBaha, Hamza A Abdul-Hafez, Mohamed S Elgendy, Abdalhakim Shubietah, Muath Baniowda","doi":"10.1177/10760296261429249","DOIUrl":"10.1177/10760296261429249","url":null,"abstract":"<p><p>BackgroundCancer-associated atrial fibrillation (AF) is increasingly common, posing dual risks of thrombosis and bleeding. Long-term oral anticoagulation is often limited in these patients due to drug interactions, thrombocytopenia, and treatment-related bleeding. Left atrial appendage occlusion (LAAO) offers a non-pharmacological alternative for stroke prevention, yet its optimal use in cancer remains uncertain.MethodsWe conducted a narrative review of studies from 2009 to October 2025 across PubMed, Embase, and Google Scholar, including randomized trials, observational studies, registries, clinical guidelines, and expert statements addressing LAAO in AF patients, with emphasis on cancer and cardio-oncology populations. Case reports, non-English studies, abstracts without full text, and non-oncologic studies were excluded.ResultsRecent evidence suggests LAAO achieves high procedural success in selected cancer patients and reduces long-term bleeding compared with oral anticoagulants. Post-procedure management typically involves individualized anticoagulant or antiplatelet regimens adjusted for bleeding risk and hematologic status. However, short-term complications may be more frequent, likely reflecting cytopenias and patient frailty.ConclusionLAAO represents a promising stroke-prevention strategy for cancer-related AF when anticoagulation is unsafe or ineffective. Optimal outcomes require multidisciplinary evaluation, timing aligned with cancer status, and tailored post-implant antithrombotic therapy. Prospective studies are still needed to define patient selection, procedural timing, and post-procedural management in this high-risk population.</p>","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"32 ","pages":"10760296261429249"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrelationship of Tissue Factor With Thromboinflammatory Biomarkers in ESRD and CKD 5 Patients.","authors":"Luke Rohde, Fakiha Siddiqui, Katherine Konczak, Ella Kaufmann, Debra Hoppensteadt, Jeanine Walenga, Vinod Bansal, Hamzah Hussain, Jawed Fareed, Kavitha Vellanki","doi":"10.1177/10760296261496960","DOIUrl":"https://doi.org/10.1177/10760296261496960","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) affects hundreds of millions worldwide and contributes to significant morbidity and mortality. Understanding its pathophysiology may help identify plasma biomarkers that reflect disease severity and treatment response. This study compared plasma tissue factor (TF) concentrations between end-stage renal disease (ESRD) patients and healthy controls using combined 2022 and 2023 retrospective cohorts (142 ESRD, 22 controls). Mean TF levels were calculated, and percent change for each ESRD patient was determined relative to the healthy control mean. In 2022, normal human plasma (NHP) TF averaged 96.37 ± 12.72 pg/mL versus 305.19 ± 11.57 pg/mL in ESRD patients, a 216.68% increase. In 2023, NHP TF was 60.19 ± 12.12 pg/mL compared with 341.93 ± 20.40 pg/mL in ESRD patients, a 468.11% increase. Across both cohorts, ESRD patients showed markedly elevated TF levels, supporting a pronounced pro-thrombotic state driven by inflammation and endothelial dysfunction from chronic uremic metabolite accumulation.</p>","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"32 ","pages":"10760296261496960"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}