Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery最新文献

{"title":"Clinical outcomes and bony restenosis after foramen magnum decompression for achondroplasia patients.","authors":"Sung Hyun Kang, Jung Min Ko, Youngbo Shim, Tae-Joon Cho, Seung-Ki Kim, Ji Hoon Phi","doi":"10.1007/s00381-026-07404-8","DOIUrl":"10.1007/s00381-026-07404-8","url":null,"abstract":"<p><strong>Purpose: </strong>Achondroplasia is a genetic syndrome characterized by short stature and rhizomelic shortening of the limbs. Many patients also exhibit craniocervical junction stenosis, which often progresses to spinal cord compression or hydrocephalus. Foramen magnum decompression (FMD) is performed to relieve stenosis at the craniovertebral junction. The purpose of this study was to analyze the clinical outcomes of FMD in achondroplasia patients and to discuss restenosis due to bone regrowth (bony restenosis), an important cause of postoperative worsening.</p><p><strong>Methods: </strong>Medical records and brain imaging data of 89 pediatric achondroplasia patients who visited our institution between January 2012 and April 2022 were retrospectively analyzed.</p><p><strong>Results: </strong>Among 89 achondroplasia patients, FMD was performed in 38 patients. During the median 60 months of follow-up after FMD, eleven patients developed warning changes at MRI. Warning changes consisted of four types: restenosis due to bone regrowth (bony restenosis), restenosis due to soft tissue thickening, de novo T2 HSI of the cervical spinal cord, and progression of ventriculomegaly. Patients with bony restenosis (3 of 38; 7.9%) required reoperation of FMD. The age of restenosis was 46, 48, and 98 months old, and the time interval after FMD was 38, 34, and 87 months, respectively. Removal of bony spur was performed and no recurrence of bony restenosis was found until the most recent follow-up.</p><p><strong>Conclusion: </strong>Bony restenosis was observed in 3 of 38 patients (7.9%) after FMD during the follow-up. Regular imaging studies and close observation until late childhood may be reasonable for early detection and management of bony restenosis.</p>","PeriodicalId":520587,"journal":{"name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","volume":"42 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148972945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: pediatric meningioma and seizures: a single center cohort study.","authors":"Mahara Muhammad Saleem, Hamza Yousuf Ibrahim","doi":"10.1007/s00381-026-07459-7","DOIUrl":"10.1007/s00381-026-07459-7","url":null,"abstract":"","PeriodicalId":520587,"journal":{"name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","volume":"42 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle cranial fossa Sylvian fissure arachnoid cysts in infants younger than 1 year: clinical characteristics, preoperative growth patterns, and outcomes of endoscopic fenestration.","authors":"Wenjing Wu, Feng Mo, Genrui Guo, Zhixuan Sun, Hongbin Cao","doi":"10.1007/s00381-026-07462-y","DOIUrl":"10.1007/s00381-026-07462-y","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and purpose: &lt;/strong&gt;Middle cranial fossa Sylvian fissure arachnoid cysts represent the most common type of intracranial arachnoid cysts in children, yet their natural history and optimal management strategies remain controversial. In infants younger than 1 year, the number of reported cases is limited, and these patients are often analyzed together with older children, limiting our understanding of cyst growth patterns and treatment responses during infancy. This study was aimed at characterizing the clinical features and preoperative growth patterns of middle cranial fossa Sylvian fissure arachnoid cysts in infants younger than 12 months and at evaluating the radiological outcomes and complications associated with neuroendoscopic cyst fenestration.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We retrospectively reviewed infants with middle cranial fossa Sylvian fissure arachnoid cysts who underwent neuroendoscopic cyst fenestration at the Department of Neurosurgery, Hebei Children's Hospital, between January 2016 and December 2024. Inclusion criteria were age younger than 12 months at the time of surgery. Five patients met the inclusion criteria. Demographic data, clinical and radiological characteristics, surgical details, postoperative radiological outcomes, and procedure-related complications were systematically analyzed. Because clinical symptoms were absent or nonspecific, radiological change was used as the primary outcome measure. Imaging outcomes were semi-quantitatively graded according to the estimated overall cyst reduction as Excellent (more than three quarters), Good (more than one half and up to three quarters), Fair (more than one quarter and up to one half), or Poor (one quarter or less). The duration of follow-up ranged from 4 to 9 years.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Five infants (age range, 3-10 months; median age, 6 months) were included. All patients had Galassi type III cysts on preoperative imaging. Three cysts were located on the left side and two on the right. Progressive cyst enlargement before surgery was documented in three patients, including one patient with complete serial imaging demonstrating marked enlargement. Postoperative radiological improvement was graded as Excellent in three patients, Good in one, and Fair in one. All patients developed postoperative subdural effusion; four had bilateral effusions, whereas one had a persistent ipsilateral effusion. In most patients, the effusions gradually regressed during follow-up. Two patients developed subdural hemorrhage, including one with recurrent bilateral hemorrhage requiring two burr-hole drainage procedures. No patient ultimately required shunt placement.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In this small series of surgically treated infants, progressive cyst enlargement before surgery was observed in selected patients, suggesting that cyst growth may remain active during infancy in some cases. Neuroendoscopic cyst fenestration was associated with s","PeriodicalId":520587,"journal":{"name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","volume":"42 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Go digital! The surgeon's finger as a digital shield for dura in cranial defects in repeat craniofacial surgery.","authors":"Vikram P Sharma, Richard Hayward, Adikarige Haritha Dulanka Silva, Greg James, Noor Ul Owase Jeelani","doi":"10.1007/s00381-026-07453-z","DOIUrl":"10.1007/s00381-026-07453-z","url":null,"abstract":"<p><p>Calvarial bone gaps are commonly encountered in craniofacial surgery, particularly in syndromic craniosynostosis and secondary bone pathology, with exposed or adherent dura increasing the risk of injury during subperiosteal dissection. We describe a simple, reproducible technique-digital shielding-using the surgeon's gloved finger as a dynamic protective interface for the dura while enabling controlled circumferential dissection around calvarial bone defects. We present a 4-year-old child with syndromic craniosynostosis, raised intracranial pressure and multiple calvarial defects with dural adherence encountered during posterior cranial vault remodelling. The technique enabled safe delineation of calvarial bone margins to facilitate osteotomies. The patient was discharged 3 days postoperatively and remains well at 10 weeks. Digital shielding is a simple, no-cost adjunct used safely in our unit for over 30 years.</p>","PeriodicalId":520587,"journal":{"name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","volume":"42 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous complete regression of congenital brain tumors - a systematic literature review and case report.","authors":"Natalia Kardas, Karolina Sztuba, Natalia Wyroba, Monika Putz, Wieslawa Grajkowska, Joanna Trubicka, Marek Mandera, Ryszard Sordyl","doi":"10.1007/s00381-026-07458-8","DOIUrl":"10.1007/s00381-026-07458-8","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to review the available literature on spontaneous complete regression of congenital brain tumors and report an institutional case with a posterior fossa tumor that involuted at the age of 3 months.</p><p><strong>Methods: </strong>A systematic review was conducted in accordance with PRISMA guidelines. The study protocol was registered with INPLASY. A systematic review of the articles published from inception to 5 April 2026 in Web of Science, Scopus, PubMed (MEDLINE), and Embase was conducted. Six eligible case reports were identified and included in the analysis.</p><p><strong>Results: </strong>Initial clinical presentation varied, with neurological deficits observed in 2/7 patients, signs of intracranial hypertension in 4/7 patients, and no neurological symptoms in one neonate. Tumors were most commonly located within deep brain structures (3/7), followed by cortical regions (2/7) and extracerebral locations (1/7). Histopathological grading revealed high-grade tumors in 3/7 patients and low-grade tumors in 2/7 individuals. Tumor resection was not pursued because of risky tumor topography (2/7), presumed benign tumor biology with a wait-and-see strategy (1/7), or parental decision to pursue hospice care (1/7). In three individuals, tumor surgery had been initially planned after gaining a greater body weight. Complete spontaneous regression was achieved between 3 and 33 months of age.</p><p><strong>Conclusion: </strong>Spontaneous complete regression of congenital brain tumors is a rare and incompletely understood phenomenon. Our study highlights the heterogeneity of histopathological findings, lesion localization, and the subtle clinical presentation in this age group.</p>","PeriodicalId":520587,"journal":{"name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","volume":"42 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of trametinib use in pediatric brain tumors in a low- to middle-income country.","authors":"Roula Farah, Robin Farah, Elie Charro, Joe Bedran, Romy Daccache, Eric Bouffet","doi":"10.1007/s00381-026-07464-w","DOIUrl":"10.1007/s00381-026-07464-w","url":null,"abstract":"<p><strong>Purpose: </strong>Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, is a promising targeted therapy for children with progressive, unresectable low-grade gliomas (LGGs) who have failed standard chemotherapy regimens. There are limited data on the use of targeted therapy in Low-Middle-Income Countries (LMIC), and specifically, there are no published data from Lebanon on the use, efficacy, and safety of these agents.</p><p><strong>Methods: </strong>A retrospective review of the medical records of pediatric patients with brain tumors who received trametinib at the LAU Medical Center Rizk Hospital was undertaken, along with a detailed data collection and a family interview to evaluate the quality of life of the patients while administering this agent.</p><p><strong>Results: </strong>Four pediatric patients diagnosed with progressive LGGs, harboring distinct molecular drivers (KIAA1549-BRAF, NF1 Loss, and BRAF V600E), were identified. Age range at diagnosis was 11 months to 10 years. Trametinib was obtained on a compassionate basis through an international Managed Access Program. The median duration of trametinib use was 30.2 months (range 22 to 35.5 months). Clinical improvement was observed in all patients along with partial radiographic response in one patient. The most common side effects were skin reactions and gastrointestinal complaints, with few therapy interruptions required. Quality-of-life assessment using the Pediatric Quality of Life Inventory™ 4.0 Generic Core Scales revealed significant heterogeneity, with physical and school function being the most affected.</p><p><strong>Conclusion: </strong>Despite few manageable side effects, the favorable outcomes on tumor response and quality of life of trametinib-based therapy in Lebanese pediatric LGG patients suggest that MEK inhibitors may be a feasible option in selected LMIC settings, when appropriate diagnostic and monitoring infrastructure is available.</p>","PeriodicalId":520587,"journal":{"name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","volume":"42 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric low-grade glial, glioneuronal and neuronal tumors: a retrospective study of 85 cases.","authors":"Meriem Boubekri, Nadia Cherradi","doi":"10.1007/s00381-026-07457-9","DOIUrl":"10.1007/s00381-026-07457-9","url":null,"abstract":"<p><strong>Purpose: </strong>Pediatric low-grade glial, glioneuronal, and neuronal tumors are the most prevalent solid tumors in children, accounting for more than one-third of all pediatric brain tumors. These tumors exhibit a wide range of clinicopathological characteristics. This study aimed to define the epidemiological and clinicopathological profile of these tumors based on the experience of the Pathology Department of the Specialties Hospital of Ibn Sina University Hospital in Rabat.</p><p><strong>Methods: </strong>A retrospective descriptive study was conducted on 85 cases of low-grade glial, glioneuronal, and neuronal tumors in patients aged ≤ 18 years at the Pathology Department of the Specialties Hospital of Ibn Sina University Hospital in Rabat over a period of 10 years (2016-2025).</p><p><strong>Results: </strong>The mean age of the patients was 10 years, and there was a slight male predominance. The most common clinical presentation was intracranial hypertension, observed in 59 cases (69%). Supratentorial locations were identified in 49 cases (57.6%). Neuroimaging using MRI identified both cystic and solid components in 61 cases. Histopathological examination identified pilocytic astrocytoma as the most common tumour entity (61/85 cases, 71.7%), followed by ganglioglioma (10/85 cases, 11.7%) and dysembryoplastic neuroepithelial tumour (5/85 cases, 6%). Subependymal giant cell astrocytoma and pleomorphic xanthoastrocytoma were each diagnosed in two cases (2.3%). Angiocentric glioma, polymorphous low-grade neuroepithelial tumor of the young, central neurocytoma, extraventricular neurocytoma, and pilomyxoid astrocytoma were each identified in one case (1.2%).</p><p><strong>Conclusion: </strong>Pediatric low-grade glial, glioneuronal, and neuronal tumors are a heterogeneous group with distinct clinicopathological features. This study defines their profile at our institution and supports the need for larger multicenter studies.</p>","PeriodicalId":520587,"journal":{"name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","volume":"42 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent C19MC-altered embryonal tumors with multilayered rosettes: outcomes of stereotactic radiosurgery.","authors":"Paul M Harary, Yusuke S Hori, Sze Kiat Tan, Kelly Mahaney, Susan M Hiniker, Iris C Gibbs, David J Park, Steven D Chang","doi":"10.1007/s00381-026-07447-x","DOIUrl":"10.1007/s00381-026-07447-x","url":null,"abstract":"<p><strong>Purpose: </strong>Embryonal tumors with multilayered rosettes (ETMR) are aggressive grade IV brain tumors primarily affecting children under age 3. Despite intensive multimodal therapy, prognosis remains poor, and salvage protocols for localized recurrence are not standardized. Traditional radiotherapy is frequently deferred in young children to protect neurocognitive function. Herein, we evaluate the efficacy of stereotactic radiosurgery (SRS) as focal treatment for recurrent ETMR.</p><p><strong>Methods: </strong>We retrospectively reviewed three pediatric patients with molecularly confirmed C19MC-altered ETMR, treated with mask-based SRS for localized recurrence. Data regarding molecular profiles, prior treatments, SRS dosimetry, and longitudinal clinical outcomes were analyzed.</p><p><strong>Results: </strong>All patients underwent initial gross total resection and adjuvant chemoradiotherapy before experiencing localized recurrence. In case 1, a 3-year-old female received multiple SRS courses for serial recurrences and remains stable 22 months post-diagnosis. Case 2, a 4-year-old female, achieved local control at the primary recurrence site following SRS but developed diffuse spinal leptomeningeal spread 10 months later and succumbed to the disease 20.5 months post-diagnosis. In case 3, a 3-year-old female received SRS for a nodular recurrence and remains disease-free 16 years after initial diagnosis. Across all cases, SRS was well-tolerated without acute neurotoxicity.</p><p><strong>Conclusion: </strong>SRS demonstrates promise as a salvage strategy for localized ETMR recurrence. It may extend survival and, in select cases, facilitate long-term local control while minimizing neurocognitive burden typically associated with large-field re-irradiation. Notably, the efficacy of SRS cannot be separated from concurrent salvage therapies in this highly multimodal treatment context. Further investigation is needed to define the role of SRS within multimodal protocols for ETMR.</p>","PeriodicalId":520587,"journal":{"name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","volume":"42 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148915013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of \"Should children with a ventriculo-peritoneal shunt play rugby: a survey of UK and Ireland paediatric neurosurgeons\".","authors":"Tasbehullah Khan","doi":"10.1007/s00381-026-07454-y","DOIUrl":"10.1007/s00381-026-07454-y","url":null,"abstract":"","PeriodicalId":520587,"journal":{"name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","volume":"42 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Same-day discharge after pediatric neurosurgical procedures: a single-institution experience.","authors":"Kishore Balasubramanian, Holden Husbands, Giancarlo Mignucci, Beste Gulsuna, Andrew Jea","doi":"10.1007/s00381-026-07450-2","DOIUrl":"10.1007/s00381-026-07450-2","url":null,"abstract":"<p><strong>Background and objectives: </strong>Same-day discharge (SDD) after neurosurgical procedures in children remains underexplored. To our knowledge, this represents one of the first modern North American single-institution series to include SDD after major pediatric spinal instrumentation and procedures performed on children of elevated anesthetic risk.</p><p><strong>Methods: </strong>A retrospective review of all neurosurgical procedures performed at an academic, tertiary referral center was conducted. Patients were identified as those who underwent surgery and were discharged on the same calendar day (length of stay [LOS] = 0 days). Patient demographics, procedural details, operative times, ASA classification, intraoperative complications, postoperative outcomes, and symptom status at follow-up were recorded.</p><p><strong>Results: </strong>Of 976 neurosurgical encounters, 87 (8.9%) had a 0-day LOS, of which 75 were in patients younger than 18 years. Sixteen encounters in 16 unique pediatric patients met all inclusion criteria and were analyzed. Median age at surgery was 14.7 years (interquartile range [IQR] 7.1-16.1; range 0.1-17.4), with equal distribution by sex (8 males, 8 females). Procedures were classified as major in 14 encounters (87.5%) and minor in 2 (12.5%). Median operative time was 103 min (IQR 65-111; range 43-188). There were no intraoperative complications (0%), no surgical site infections (0%), no 7-day reoperations (0%), and no operative failures at first follow-up imaging (0%). No patient was readmitted within 30 days (0%), and 2 (12.5%) returned to the emergency department within 30 days, both managed without admission. At follow-up, symptoms were stable or improved in 14 of 16 encounters (87.5%). Fifteen patients were discharged on the operative calendar day; 1 was observed overnight and discharged the following morning.</p><p><strong>Conclusions: </strong>In this small, heterogeneous retrospective series, a diverse range of pediatric neurosurgical procedures, including major spinal and intracranial operations, were managed with SDD without serious complications. These preliminary observations are hypothesis-generating; careful patient selection remains paramount, and larger prospective studies are needed before broader adoption.</p>","PeriodicalId":520587,"journal":{"name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","volume":"42 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}