Blood transfusion = Trasfusione del sangue最新文献

{"title":"Cold platelets, redefined: pathogen reduction without surrendering hemostatic intent.","authors":"Fabrice Cognasse, Hind Hamzeh Cognasse, Jose Maria Garcia-Gala, Konstanze Aurich","doi":"10.2450/BloodTransfus.1351","DOIUrl":"10.2450/BloodTransfus.1351","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":"24 4","pages":"261-264"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen delivery, hemodilution and transfusion in critical illness: an underrecognized safety signal in albumin randomized trials.","authors":"Raffaele Mandarano, Stefano Romagnoli, Mayurathan Balachandran, Yahya Shehabi","doi":"10.2450/BloodTransfus.1367","DOIUrl":"10.2450/BloodTransfus.1367","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"345-346"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehospital whole blood after SWiFT and TOWAR: not superior, not settled.","authors":"Daniele Prati, Luca Barcella, Chiara Novelli, Irene Cuppari","doi":"10.2450/BloodTransfus.1418","DOIUrl":"10.2450/BloodTransfus.1418","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"291-293"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets.","authors":"Teresa Jimenez-Marco, Natalia Torres-Reverte, Miguel Quetglas-Oliver, Daniel Morell-Garcia, Carme Ballester-Servera","doi":"10.2450/BloodTransfus.1268","DOIUrl":"10.2450/BloodTransfus.1268","url":null,"abstract":"<p><strong>Background: </strong>Riboflavin and UV light-based pathogen reduction technology (PRT) and cold-stored platelets (CSP) have a significant impact on platelet (PLT) function. The aim of this study is to determine whether the use of both methods is beneficial.</p><p><strong>Materials and methods: </strong>Twenty buffy coat (BC) PLT concentrates were grouped into 10 type-matched pairs, which were pooled and split into 10 non-PRT-treated PLTs and 10 PRT-treated PLTs, diluted in platelet additive solution (PAS-E) and leukoreduced. Both groups were cold-stored at 2-6ºC without agitation for 14 days (non-PRT CSP and PRT CSP). Hemostatic function and metabolic parameters were monitored on day 1 pre-refrigeration and on days 3, 7 and 14 of cold storage.</p><p><strong>Results: </strong>No swirling and no aggregates were observed at any time in either group after cold storage for 14 days. PRT CSP were less metabolically active (with better pH, lower lactate, lower pCO₂ and higher pO₂) than non-PRT CSP (p<0.001) after 14 days of cold storage. PRT CSP and non-PRT CSP resulted in faster clot formation over storage (p<0.001). Clot strength was reduced under optimal levels on day 14 in the PRT CSP (p<0.001).</p><p><strong>Discussion: </strong>The enhanced hemostatic PLT function achieved by CSP, i.e., faster clot formation, is also maintained by riboflavin and UV light treatment. The combination of riboflavin and UV light-based PRT and CSP has the added benefit of reducing platelet metabolism, which may have a positive effect on PLT viability. Further research is required to assess whether the in vitro benefits of combining PRT and CSP are confirmed in clinical trials.</p>","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"325-333"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effective use of platelet-rich plasma (PRP) in treating a severe traumatic knee injury in a child with hemophilia A.","authors":"Samantha Pasca, Federica Fati, Clara Revetria, Stella Poda, Sonia Secchi","doi":"10.2450/BloodTransfus.1275","DOIUrl":"10.2450/BloodTransfus.1275","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"347-348"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rh_null phenotype caused by a novel RHAG allele, RHAG*c.640+1G>C, in a Chinese individual.","authors":"Min Wang, Shuangshuang Jia, Shanshan Zhou, Shihui Li, Qian Liu","doi":"10.2450/BloodTransfus.1235","DOIUrl":"10.2450/BloodTransfus.1235","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"286-288"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived risk explains aversion to blood donation by men who have sex with men.","authors":"June S Kam, Lisa A Williams","doi":"10.2450/BloodTransfus.1265","DOIUrl":"https://doi.org/10.2450/BloodTransfus.1265","url":null,"abstract":"<p><strong>Background: </strong>With advances in HIV testing and waning prevalence of the disease, policies restricting men who have sex with men (MSM) from donating blood have been eased. However, aversion towards the notion of receiving a transfusion of blood donated by MSM relative to heterosexual donors is documented. This research tested the role of perceived risk in driving such aversion.</p><p><strong>Materials and methods: </strong>In online experiments, 460 (Study 1) and 863 (Study 2) heterosexual participants read an article about transfusion policies and rated perceived risk of transfusions, willingness to receive a transfusion, and willingness to donate blood. In Study 1, the articles detailed eased MSM deferral policies or other transfusion policies. In Study 2, the MSM article was adapted to highlight low risk or high benefit of policy changes in an attempt to mitigate aversion.</p><p><strong>Results: </strong>In Study 1, participants who read the MSM article reported significantly higher perceived risk relative to those who read about general eligibility. Perceived risk explained downstream impacts on willingness to receive a transfusion. In Study 2, neither highlighting low risk nor high benefit of MSM deferral policy changes reduced perceived risk of transfusions.</p><p><strong>Discussion: </strong>This research highlights that perceived risk may drive aversion toward the notion of receiving a transfusion of blood donated by MSM. Interventions that aim to reduce perceived risk by emphasizing high benefits or low risks of easing deferral policies may not be effective. Research into other routes to mitigate negativity towards donation of blood by MSM is warranted.</p>","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148538023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a high-resolution melting assay for detection of GYP*Mur allele zygosity.","authors":"Onruedee Khantisitthiporn, Oytip Nathalang, Kamphon Intharanut, Tanaporn Choychimplee","doi":"10.2450/BloodTransfus.1293","DOIUrl":"https://doi.org/10.2450/BloodTransfus.1293","url":null,"abstract":"<p><strong>Background: </strong>The antigens in the MNS blood group system, presented on glycophorin (GP), are regulated by the GYPA, GYPB, and GYPE genes. Some hybrid GP can express Mi^a antigen, the most common being GP.Mur. Of potential clinical significance in transfusion practice, GYP*Mur homozygotes can produce anti-JENU because they lack expression of the high-frequency JENU antigen. Although serological typing using anti-Mi^a is very likely to identify GP.Mur, this method cannot reliably distinguish the underlying GP or confirm the zygosity of GP.Mur, which is relevant for transfusion safety. We, therefore, developed and validated a polymerase chain reaction with high-resolution melting (PCR-HRM) assay for distinguishing homozygous GYP*Mur from heterozygous GYP*Mur/GYPB and homozygous GYPB genotypes.</p><p><strong>Materials and methods: </strong>An HRM assay targeting exon 3 of GYP(B-A-B) hybrid genes was designed and validated using 186 Mi(a+) samples with known sequencing data. This assay was subsequently applied to 211 DNA samples from Thai blood donors, including Mi(a+) and Mi(a-) samples.</p><p><strong>Results: </strong>HRM analysis showed high concordance with sequencing data in 184 of 186 validated samples. Discrepant cases were attributable to rare sequence variations that altered melting profiles. Among Mi(a+) samples not previously sequenced, 81.45% were classified as GYP*Mur/GYPB, 3.97% as GYP*Mur/GYP*Mur, 12.58% as GYP*Thai/GYPB, and 2% as other clusters, which were identified as rare variants by sequencing. All Mi(a-) samples were consistently classified as homozygous GYPB.</p><p><strong>Discussion: </strong>Our PCR-HRM assay can rapidly and reliably discriminate homozygous GYP*Mur from heterozygous GYP*Mur/GYPB and homozygous GYPB genotypes. Rare or unexpected variants can be identified when DNA quality is well controlled, and appropriate quality controls are applied. Accordingly, this method may serve as a practical first-line screening tool to support transfusion safety, particularly in populations with a high prevalence of hybrid GP.</p>","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"35° Congreso de la Sociedad Española de Transfusión Sanguínea y Terapia Celular - SETS Madrid, 4-6 Junio 2026.","authors":"Luis Larrea-González, Luisa Barea, Ana Arruga Manzano, Gemma Moreno Jimenez, Isabel Antolin Denizot, Laura Biritxinaga Rodríguez, Manuel Albors Ferreiro, María Angustias Jiménez, Mercedes López, Paz Martín, Eva Alonso Nogués","doi":"10.2450/BloodTransfus.2026.Suppl2","DOIUrl":"https://doi.org/10.2450/BloodTransfus.2026.Suppl2","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure of red blood cell concentrates to temperatures below 0°C for a short period does not alter in vitro quality.","authors":"Natascha Roser, Mohamed Benbrika, Mauro Borri, Agathe Martin, David Crettaz, Jeremy Touati, Simon Hänni, Stefano Fontana, Michel Prudent","doi":"10.2450/BloodTransfus.1161","DOIUrl":"10.2450/BloodTransfus.1161","url":null,"abstract":"<p><strong>Background: </strong>To guarantee the quality of red blood cell (RBC) transfusion, RBC concentrates (RCCs) are stored at 4±2°C. Deviations from this specification can alter the RBCs. Although the exposure to higher temperatures is well documented, the exposure to subzero temperatures has been less investigated.</p><p><strong>Materials and methods: </strong>RCCs (prepared from top-bottom kits and stored in saline-adenine-glucose-mannitol - SAGM) accidentally exposed to temperatures below 0°C were investigated in two regional blood services in Switzerland; Case 1: 1 h 52 min below 0°C (minimum of -5.7°C), and Case 2: 3 h 19 min below 0°C (minimum of -0.9°C). In case 1, 5 exposed and 5 unexposed RCCs were visually inspected for hemolysis or other alterations. Hemolysis was quantified in the 5 exposed RCCs and one control. In Case 2, 71 RCCs were analyzed at the time of the incident and at day 42 for hematological parameters and hemolysis. Ten RCCs were followed weekly for glucose, lactate, potassium levels and deformability.</p><p><strong>Results: </strong>Under these conditions no signs of out-of-specification hemolysis or RBC damages were observed. Nevertheless, a higher hemolysis was reported in 4-day-old RCCs exposed to subzero temperature compared to existing and age-matched controls. Storage lesions were equivalent to those of unexposed RCCs and to values reported in the literature.</p><p><strong>Discussion: </strong>The two present real cases of RCCs exposure to temperatures below 0°C did not show damage to RBCs over storage. Even though the present work did not investigate the limits of RBCs sensitivity to cold temperature, it provides indications on the capability of RCCs to resist such type of storage deviation.</p>","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"221-231"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}