Blood transfusion = Trasfusione del sangue最新文献

{"title":"Navigating boundaries of autoimmunity in rare anemias: anti-erythropoietin antibody-mediated pure red cell aplasia in a patient with cold agglutinin disease.","authors":"Giacinto Luca Pedone, Marta Bortolotti, Giorgio Alberto Croci, Bruno Fattizzo","doi":"10.2450/BloodTransfus.1295","DOIUrl":"https://doi.org/10.2450/BloodTransfus.1295","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148538007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and analysis of a novel ABO allele with c.959insC variant in a Chinese blood donor.","authors":"Jian-Cheng Liu, Wei Zhang, Feng Shao","doi":"10.2450/BloodTransfus.1242","DOIUrl":"10.2450/BloodTransfus.1242","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"289-290"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood donation Word-of-Mouth behavior among Chinese and Indian donors: an exploration with Australian donors.","authors":"Faiza El-Higzi, Kathleen Chell, Barbara Masser, Michael Polonsky, Hrishikesh Arvikar, Sabrina Wong, David O Irving","doi":"10.2450/BloodTransfus.1253","DOIUrl":"10.2450/BloodTransfus.1253","url":null,"abstract":"<p><strong>Background: </strong>Cultural diversity in a blood donor panel is vital for healthcare, especially in countries where multiple cultural groups are growing in representation and have unique phenotypes. Word-of-mouth (WOM) is considered a potentially powerful way to recruit diverse donors; however, donors seldom talk about blood donation. This study explores factors influencing positive WOM about blood donation among people within Chinese and Indian communities in Australia.</p><p><strong>Materials and methods: </strong>Six online focus groups were conducted with 35 donors (20 Chinese and 15 Indian) aged 18-57 who had donated in the past 12 months. Using thematic analysis, the factors that contributed and inhibited sharing WOM about blood donation were identified. Participants shared their WOM experiences, motivations, perceived barriers, and supports needed to enhance their WOM activities.</p><p><strong>Results: </strong>Donors from both cultural groups recognized the benefits of discussing blood donation, however their engagement varied. Most were reactive, responding to inquiries rather than initiating conversations. Their WOM behaviors were influenced by personal experiences, conversational context, and social connections. The main concern was being perceived as bragging, while motivators included altruism and professional links to healthcare. Significant cultural differences emerged: Indian participants were cautious about WOM to avoid personal health disclosures from recipients, while Chinese donors highlighted cultural perceptions of loss of vitality from donating, especially among older individuals, as a barrier to discussing donation. A proposed model of willingness to share WOM was developed based on individuals' goals for sharing WOM and perceived agency to do so.</p><p><strong>Discussion: </strong>Strategies are needed to help donors view their role as including active support for blood donation. Tools and resources that give donors a \"license\" to initiate WOM discussions about blood donation, while addressing cultural misconceptions, may strengthen their confidence and agency to discuss blood donation.</p>","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"268-277"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of early pregnancy pulmonary embolism following mifepristone administration: a call for increased pharmacovigilance and research.","authors":"Elena Dasti, Maria Lombardi, Aderville Cabassi, Michele Riva, Elisa Avantaggiato, Gaetano Carolla, Francesco Greco, Veronica Rendo, Pietro Rossetti, Pasquale Rubino, Elena Scardina, Adriano Stella, Elvira Grandone","doi":"10.2450/BloodTransfus.1267","DOIUrl":"10.2450/BloodTransfus.1267","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"334-336"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing operational readiness for plasma fractionation within Indonesia's National Transfusion Medicine System: a cross-sectional mixed-methods study.","authors":"Mas Rahman Roestan, Tsania Mahira, Indri Widuri Yani, Ikhsan Rambia, Aristo Fajar Nugroho, Evi Sylvia Nurrasjid, Angga Prawira Kautsar","doi":"10.2450/BloodTransfus.1243","DOIUrl":"10.2450/BloodTransfus.1243","url":null,"abstract":"<p><strong>Background: </strong>Plasma-derived medicinal products (PDMPs) such as albumin, immunoglobulins, and clotting factors are essential in treating life-threatening conditions. Indonesia lacks local plasma fractionation capacity and relies heavily on imports, leading to high costs and financial strain on the National Health Insurance. Developing national plasma production capacity is vital for pharmaceutical independence and health system resilience. This study assessed the readiness of regional blood centers and hospital blood center in Indonesia as potential suppliers of plasma raw material for domestic PDMP production and identified logistical and governance challenges in the existing system.</p><p><strong>Materials and methods: </strong>A cross-sectional mixed-methods study was conducted in five institutions -four regional blood centers and one hospital blood center- across Java. Readiness was evaluated across three domains: preparation, inventory, and transportation. Instruments were adapted from WHO, LIAT, and LSAT guidelines, with expert-validated content. Content validity was ensured through expert panel review involving WHO and national regulatory representatives, and reliability was measured using the Kuder-Richardson Formula 20 (KR-20). Quantitative data were analyzed descriptively using Kruskal-Wallis and Dunn's tests, while qualitative data were thematically analyzed.</p><p><strong>Results: </strong>The overall KR-20 was 0.821, indicating strong reliability (Preparation=0.801; Inventory=1.00; Transportation=0.856). No significant inter-institutional differences were observed (p=0.406), suggesting uniformly high readiness. Bias testing confirmed consistent scoring patterns.</p><p><strong>Discussion: </strong>This study provides a structured baseline assessment of Indonesia's readiness to support domestic PDMP production, revealing strong preparedness across key operational domains. While readiness does not yet translate to full production capacity, these findings establish an evidence-based foundation for future implementation, investment planning, and governance reforms toward a sustainable and transparent plasma supply chain.</p>","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"337-344"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipidomic and metabolomic analysis of human erythrocytes during storage for transfusion applications.","authors":"Husam B R Alabed, Francesco Arcioni, Roberto M Pellegrino, Martina Nicolini, Sandra Buratta, Lorena Urbanelli, Mauro Marchesi, Laura Berchicci, Anair G Lema Fernandez, Carlotta Nardelli, Cristina Mecucci, Carla Emiliani, Paolo Gorello","doi":"10.2450/BloodTransfus.1187","DOIUrl":"10.2450/BloodTransfus.1187","url":null,"abstract":"<p><strong>Background: </strong>The preservation of concentrated red blood cells (RBCs) is crucial for their vitality and functionality. During storage, various metabolic changes occur, such as the loss of ATP, diphosphoglycerate, and potassium, as well as oxidative damage to proteins, lipids, and carbohydrates. Lipids, the most abundant class of metabolites in cells, are essential for maintaining the integrity and function of the red blood cell membrane. This study aims to evaluate molecular changes and identify potential biomarkers to optimise RBC transfusion by analysing metabolic and lipid profiles of preserved RBC at different time points.</p><p><strong>Materials and methods: </strong>Thirty samples from 10 freshly collected RBC units from 10 donors, were collected at three time points: collection, after 20 days, and after 40 days, and stored properly. The RBCs were then centrifugated, and the pellet was stored at -80°C for the metabolomic and lipidomic analyses using liquid chromatography coupled with mass spectrometry.</p><p><strong>Results: </strong>Lipidomic analysis revealed a progressive reduction in major membrane phospholipid classes, including phosphatidylcholines, phosphatidylethanolamines, sphingomyelins, and phosphatidic acids. At increased resolution, molecular-species-level analysis identified selective depletion of arachidonate-containing phosphatidic acid species alongside a concomitant increase in free arachidonic acid, indicating active phospholipid remodeling during storage. Metabolomic profiling confirmed previously described alterations in glycolysis, energy metabolism, and redox-related pathways and revealed coordinated changes in metabolites linked to phospholipid synthesis and turnover.</p><p><strong>Discussion: </strong>These findings confirm established features of RBC storage lesions while providing refined insight into membrane lipid remodeling at the molecular species and fatty acid building block levels. The integrated lipidomic and metabolomic approach highlights specific lipid signatures associated with RBC membrane aging, which may complement existing frameworks for studying storage-associated cellular changes and support future investigations linking molecular remodelling to functional RBC quality metrics.</p>","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"313-324"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma pathways for Low and Middle Income Countries - needed more than ever.","authors":"Albert Farrugia, Leni von Bonsdorff","doi":"10.2450/BloodTransfus.1320","DOIUrl":"10.2450/BloodTransfus.1320","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":"24 4","pages":"265-267"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion practice in elderly patients across surgical disciplines in Germany - a secondary data analysis of over 21 million patients.","authors":"Lea Valeska Blum, Christian Friedrich Weber, Florian Wöhling, Thomas Jasny, Benjamin Friedrichson, Vanessa Neef, Kai Zacharowski, Jan Andreas Kloka","doi":"10.2450/BloodTransfus.1233","DOIUrl":"10.2450/BloodTransfus.1233","url":null,"abstract":"<p><strong>Background: </strong>Clinicians are increasingly confronted with elderly patients across nearly all surgical disciplines. Advanced age is an independent risk factor for complications, prolonged hospitalization, and particularly for red blood cell (RBC) transfusion. The elderly suffer more frequently from anemia, which is associated with higher perioperative transfusion requirements, increased complication rates, and mortality Surgical disciplines differ not only in primary diagnoses but also in the demographics of their typical patient population.</p><p><strong>Material and methods: </strong>Hospitalized surgical patients in Germany between January 1^st, 2013, and December 31^st 2022, were analyzed.</p><p><strong>Inclusion criteria: </strong>Age ≥65 years, surgical disciplines: General surgery, Gynecology, Cardiac surgery, Thoracic surgery, Oral and Maxillofacial surgery, Neurosurgery, Trauma and Orthopedic surgery, Urology or Vascular surgery. Exclusion criteria included unknown or overlapping surgical procedures. Risk factors, comorbidities, transfusion rates, bleeding, complications, and blood product use were assessed using ICD and OPS (the German national procedure coding system) codes. The primary endpoint was RBC transfusion rate; the secondary endpoint was preoperative transfusion rate.</p><p><strong>Results: </strong>A total of 21,143,317 patients were analyzed of which 2,640,608 (12%) received RBC transfusion. The highest transfusion rate was seen in Trauma and Orthopedic surgery (17.2% - No.=1,116,082). Trauma and Orthopedic surgery also had the highest risk (Odds Ratio [OR]) for RBC Transfusion (1.36 [1.35-1.36]). The highest preoperative transfusion rate was noted in general surgery, where 48.2% (No.=384,553) of the transfused patients received at least one RBC transfusion prior to surgery.</p><p><strong>Discussion: </strong>Our study revealed that the highest transfusion rate in elderly patients is in Trauma and Orthopedic surgery, while the highest rate of preoperative transfusion was seen in General surgery. It would seem worthwhile to reduce these rates wherever possible, and these are the disciplines which offer the most room for improvement and would thus benefit most from consistent establishment of PBM programs.</p>","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"299-312"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serology and molecular genetic analysis of weakened expression of ABO blood group antigens in Chinese pediatric population.","authors":"Qian Ren, Jinfeng Li, Chunmiao Li, Xingli Liu, Xiaolin Ma","doi":"10.2450/BloodTransfus.1237","DOIUrl":"10.2450/BloodTransfus.1237","url":null,"abstract":"<p><strong>Background: </strong>The ABO blood group system is vital for red blood cell antigens. Weakened expression of ABO antigens often leads to misidentification of blood types, challenging transfusion safety.</p><p><strong>Materials and methods: </strong>Blood samples from 44 cases underwent serological analysis using microcolumn agglutination and tube tests. To investigate genetic variations, we sequenced the promoter region and exons 1-7 of the ABO gene. We also examined the relationship between ABO haplotypes and the presence of rare alleles. We used PolyPhen-2 to predict the structure and function of glycosyltransferase B (GTB) and classify missense variants. We also conducted pedigree analysis on 4 selected cases to further understand the inheritance patterns.</p><p><strong>Results: </strong>We detected 18 different ABO subgroup alleles in 44 cases of weakened ABO antigen expression. We found 7 subtype A (predominantly A2), 7 subtype B (which included Bw and B3), one cisAB, and 3 group B(A). The complete phenotypes we observed included A2, Bw, B3, A2B, ABw, AB3, cisAB, and B(A). Notably, we discovered a rare B allele characterized by the c.538C>T variant, which alters residue 180 to p.Arg180Cys. This variant received a PolyPhen-2 score of 1.00, suggesting a high likelihood of damaging effects. Furthermore, pedigree analysis supported an autosomal inheritance pattern for this allele.</p><p><strong>Discussion: </strong>The weakened expression of ABO antigens in young children may result from their immature immune systems or subtyping. ABO genotyping is essential to accurately identify blood groups and ensure transfusion safety.</p>","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"278-285"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passenger lymphocyte syndrome after living-donor kidney transplantation with minor ABO incompatibility: a case report.","authors":"Alessandra Sandini, Teresa G Da Molin, Gabriella Errigo, Barbara Sartori, Cinzia Ongaro, Monica Castelli, Manuela Rigno, Davide Facchinelli, Fiorella Gastaldon, Francesco Fiorin","doi":"10.2450/BloodTransfus.1244","DOIUrl":"10.2450/BloodTransfus.1244","url":null,"abstract":"","PeriodicalId":520572,"journal":{"name":"Blood transfusion = Trasfusione del sangue","volume":" ","pages":"294-298"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}