Acta endocrinologica (Bucharest, Romania : 2005)最新文献

{"title":"18F-FLUORODEOXYGLUCOSE PET/CT CAN BE AN ALTERNATIVE METHOD TO ASSESSMENT OF INSULIN RESISTANCE.","authors":"S Altun Tuzcu,&nbsp;F A Cetin,&nbsp;Z Pekkolay,&nbsp;A K Tuzcu","doi":"10.4183/aeb.2019.539","DOIUrl":"https://doi.org/10.4183/aeb.2019.539","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance is routinely measured by homeostasis model assessment of insulin resistance (HOMA-IR).Positron emission tomography of 18F-fluorodeoxyglucose combined with computed tomography (18F-FDG PET/CT) is a valuable assessment tool for patients with cancer or staging tumors. 18F-FDG PET/CT imaging can also be utilised to detect the metabolic activity of glucose in the adipose tissue, liver and muscles. The aim of this study was to determine insulin sensitivity in the liver, muscle visceral adipose and subcutaneous adipose tissue separately via18F-FDG PET/CT.</p><p><strong>Materials and method: </strong>Sixty three adult patients who underwent whole body 18F-FDG PET/CT scanning for clinical purposes (diagnosis or staging of cancer) between July and August of 2016 were included in the study. Patients were divided into two groups according to their BMI (Group 1: BMI<25kg/m², Group 2: BMI>25kg/m²). HOMA-IR,fasting glucose,insulin, triglycerides, total cholesterol, HDL levels were measured. We calculated SUV as the tissue activity of the ROI (MBq/g)/(injected dose [MBq]/ body weight [g]) on PET images and measured the maximum SUVs (SUVmax) of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT),liver and rectus muscle ROIs (2 cm). SUV corrected by blood glucose level (SUVgluc) was calculated as SUVmax×blood glucose level/100. Student-t test, Chi-square test and Pearson correlation test were used for statistical analysis.</p><p><strong>Results: </strong>Mean glucose,insulin,HOMA-IR levels of the group-2 were statistically higher than of group-1. Muscle SUVmax and liver SUVmax of group-1 were statistically higher than of group-2. Muscle SUVgluc of group-1 was statistically higher than of group-2. HOMA-IR was negatively correlated with both SUVmax(r=-0.340, p=0.01) and muscle SUVmax(r=-0.373, p=0.005).</p><p><strong>Conclusion: </strong>18F-FDG PET/CT has shown that the muscle tissue maximum FDG uptake was lower in the insulin resistance group. Therefore, 18-FDG PET/CT could be a valuable tool for diagnosing insulin resistance.</p>","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"539-543"},"PeriodicalIF":1.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200103/pdf/aeb.2019.539.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37909581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADRENAL INCIDENTALOMA, BREAST CANCER AND UNRECOGNIZED MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.","authors":"S H Kim,&nbsp;J H Park","doi":"10.4183/aeb.2019.513","DOIUrl":"https://doi.org/10.4183/aeb.2019.513","url":null,"abstract":"Background\u0000The incidence of adrenal incidentaloma has been increasing proportional to the use of radiologic examination. Multiple endocrine neoplasia1 (MEN1) syndrome may present with various tumors. The present study reports a case of adrenal incidentaloma with unrecognised MEN1 syndrome associated with breast cancer.\u0000\u0000\u0000Clinical case\u0000A 48-year-old woman presented with a 2.4cm left adrenal incidentaloma on abdominal computed tomography. Her history revealed primary amenorrhea, recurrent peptic ulcer and nephrolithiasis. Laboratory and radiologic examination revealed two pancreatic tail mass lesions with markedly elevated gastrin levels (1462 pg/mL), hypercalcemia with increased parathyroid hormone levels (72 pg/mL), a 1.5cm pituitary mass with hyperprolactinemia (234 ng/mL), a 1.0cm meningioma and a nonfunctional left adrenal mass. During this image work up, a 0.6cm nodule in the right breast was incidentally detected. Surgeries (laparoscopic distal pancreatectomy, parathyroidectomy and wide local excision of breast) and pathologic findings confirmed pancreatic neuroendocrine tumors, parathyroid gland hyperplasia, and breast cancer. Carbergoline treatment for 12 months decreased prolactin levels to 27 ng/mL. Genetic testing using peripheral blood revealed a pathogenic variant in MEN1 on chr11q13 (NM_000244.3:c.1365+1_1365+11 del, GTGAGGGACAG, heterozygous).\u0000\u0000\u0000Conclusion\u0000Considering the increasing incidence of adrenal incidentaloma and 20% prevalence of adrenal tumors in patients with MEN1, it is important to rule out MEN1 association in patients with adrenal incidentaloma. Additionally, breast cancer was detected during MEN1 work-up in this case. Female patients with MEN1 are at increased risk for breast cancer. Therefore, intensified breast cancer screening at a relatively young age should be considered in female MEN1 patients.","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"513-517"},"PeriodicalIF":1.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200108/pdf/aeb.2019.513.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37909692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IRISIN AND CHEMERIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.","authors":"Y Akgul Balaban,&nbsp;N Yilmaz,&nbsp;M Kalayci,&nbsp;M Unal,&nbsp;T Turhan","doi":"10.4183/aeb.2019.442","DOIUrl":"https://doi.org/10.4183/aeb.2019.442","url":null,"abstract":"<p><strong>Context: </strong>Changes in the secretion of signaling molecules that originates from adipose tissue and inflammation draw attention in the pathogenesis of type 2 DM. Chemerin, one of the signaling molecules of adipose origin, and irisin, defined as the Renaissance of the metabolism, are among these molecules.</p><p><strong>Objectives: </strong>This cross-sectional study was planned in order to compare the values of serum irisin and chemerin levels in patients newly diagnosed with T2DM and in healthy subjects.</p><p><strong>Subjects and methods: </strong>The study included 41 patients newly diagnosed with T2DM and 49 healthy individuals. The chemistry parameters were analyzed with a biochemistry autoanalyzer, and hormonal parameters were analyzed with an immunoassay analyzer. Plasma irisin and chemerin levels were measured using the enzyme-linked immunosorbent assay method.</p><p><strong>Results: </strong>There was a significant difference between the groups in terms of glucose, HbA1C, Insulin, HOMA-IR and lipid panel results. Irisin levels in the group of patients newly diagnosed with T2DM were lower than in the control group. Chemerin levels in the group of patients newly diagnosed with T2DM were higher than in the control group.</p><p><strong>Conclusion: </strong>Consequently, diabetes-dependent changes in chemerin and irisin concentrations suggest that these two hormones have a role in the pathophysiology of DM. Further studies are required to understand the complex structure of the signaling pathways of chemerin and irisin molecules as well as the physiological importance of these molecules as metabolism regulators especially in humans.</p>","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"442-446"},"PeriodicalIF":1.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200117/pdf/aeb.2019.442.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37908129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GASTROINTESTINAL MOTILITY DISORDERS IN OBESITY.","authors":"I Miron,&nbsp;D L Dumitrascu","doi":"10.4183/aeb.2019.497","DOIUrl":"https://doi.org/10.4183/aeb.2019.497","url":null,"abstract":"<p><p>The gastrointestinal (GI) motility, which is important for the digestion and absorption, may be altered in obesity. The aim of this review is to present the GI motility changes occurring in obesity, as well as their underlying mechanisms. We have conducted a systematic review of the published literature concerning GI motility and obesity and have described recent published data on the changes throughout the entire GI tract. Most recent discoveries include evidence supporting the increase of gastroesophageal reflux disease in obesity and inhibition of gastric motility. Intestinal transit of the distal small bowel generally slows down, ensuring enough time for digestion and absorption. Constipation is more frequent in obese patients than in those with a normal weight. The gut-brain axis plays an important role in the pathophysiology of GI motility disorders in obesity. This bidirectional communication is achieved by way of neurons, hormones, metabolites derived from intestinal microbiota and cytokines. The molecular mechanisms of GI motility changes in obesity are complex. Current data offer a starting point for further research needed to clarify the association of obesity with GI motility disorders.</p>","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"497-504"},"PeriodicalIF":1.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200119/pdf/aeb.2019.497.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37910122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOT JUST HASHIMOTO'S THYROIDITIS.","authors":"A A Gheorghisan-Galateanu,&nbsp;D Terzea,&nbsp;D Ioachim,&nbsp;M Carsote","doi":"10.4183/aeb.2019.537","DOIUrl":"https://doi.org/10.4183/aeb.2019.537","url":null,"abstract":"A 50-year old woman known for several years with autoimmune thyroiditis and normal function experienced symptoms of hypothyroidism in association with thyroid enlargement within months (Fig. 1). TSH of 30 (Normal: 0.5-4.5) μUI/ mL and with ATPO > 2000 (Normal <34) UI/ mL required levothyroxine substitution. Despite the therapy, the goiter increased while the level of haemoglobin decreased from 7.8 to 6.9 (normal: 12-15.5) g/ dL [an erythrocyte s e d i m e n t a t i o n rate of 65 (normal <25) mm/1 hour] requiring 2 units of erythrocyte mass transfusion. Thyroid ultrasound: Right lobe of 3/2.8/5.5 cm, left lobe of 4.1/3/3.7 cm with two nodules, one of 2.4/0.8 cm, and a larger one of 4.5 / 4.4 cm, with hypoechoic pattern and normal blood flow in Color flow Doppler, and left laterocervical conglomerate of 3.6/ 1.5 cm (Figs 2, 3). CT: A 4.4 cm mass in the left lobe and isthmus with longitudinal extension, multiple lymph nodes at laterocervical and mediastinal level, and the smallest tracheal diameter of 1.5/1.6 cm (Figs 4, 5). FNA: chronic thyroiditis background, hyperplasia of germinal centers, blast-like elements (BETHESDA 5)(Fig. 6). Cell block: CD20 + (Fig. 7), CD10 + (Fig. 8), BCL2 negative and high Ki67 suggest lymphoid hyperplasia with phenotype of reactive germinative centers due to autoimmune thyroiditis. The patient refused lymph node biopsy or core biopsy. The bone marrow aspiration result was irrelevant. Based on these, the diagnosis of primary thyroid lymphoma and its type could not be established so total thyroidectomy with lymph nodes resection was done. Pathological and immunohistochemical analysis revealed a diffuse lymphoma with large B-cell requiring further chemotherapy. 1300","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"537-538"},"PeriodicalIF":1.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200110/pdf/aeb.2019.537.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37910124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BONE QUALITY IN A YOUNG COHORT OF HIV-POSITIVE PATIENTS.","authors":"A R Negru,&nbsp;C Tiliscan,&nbsp;A M Tudor,&nbsp;D I Munteanu,&nbsp;C Popescu,&nbsp;M Lazar,&nbsp;A Streinu-Cercel,&nbsp;V Arama,&nbsp;S S Arama","doi":"10.4183/aeb.2019.447","DOIUrl":"https://doi.org/10.4183/aeb.2019.447","url":null,"abstract":"Context\u0000In HIV+ patients, several factors related to patient and antiretroviral therapy (ART) could determine early onset of bone mineral density (BMD) disturbances.\u0000\u0000\u0000Objective\u0000Evaluation of bone quality according to gender in patients from the HIV Romanian cohort.\u0000\u0000\u0000Design\u0000A cross-sectional study in \"Prof. Dr. Matei Balş\" National Institute for Infectious Diseases, Bucharest between 2016-2018.\u0000\u0000\u0000Subject and Methods\u0000We collected data regarding HIV infection, ART history, viral hepatitis co-infections and we calculated patients body mass index (BMI). CD4 cell count, HIV viral load (VL), vitamin-D levels were determined. Dual-energy X-ray absorptiometry (DXA) scans were used to evaluate BMD.\u0000\u0000\u0000Results\u0000We enrolled 97 patients with the median age of 26 years. According to the DXA T-scores, 10 males and 8 females had osteopenia and 4 males and 4 females had osteoporosis. According to Z-scores 2 males and 1 female had osteoporosis. Hip DXA T-scores revealed osteopenia in 6 males and 9 females, whereas T and Z-scores showed osteoporosis in 2 males and 3 females. Lumbar spine (LS) T-score diagnosed osteopenia in 9 males and 6 females, while T and Z-scores revealed osteoporosis in 3 males and females. In males, low T-scores were associated with decreased BMI; low LS DXA Z-scores with low vitamin-D levels; low T and Z-scores and LS-BMD with high VL.\u0000\u0000\u0000Conclusions\u0000Evaluating bone quality in patients with a long history of HIV infection, multiple factors should be taken into account.","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"447-453"},"PeriodicalIF":1.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200100/pdf/aeb.2019.447.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37908128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN A PAEDIATRIC INTENSIVE CARE UNIT.","authors":"M Demiral,&nbsp;E Kiral,&nbsp;E C Dinleyici,&nbsp;E Simsek","doi":"10.4183/aeb.2019.466","DOIUrl":"https://doi.org/10.4183/aeb.2019.466","url":null,"abstract":"<p><strong>Background: </strong>Relative adrenal insufficiency (RAI) is the inadequate production of cortisol due to dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis during a severe illness. We evaluated the HPA axis and RAI in a tertiary pediatric intensive care unit (PICU).</p><p><strong>Methods: </strong>A total of 100 PICU patients were included in this prospective cohort study. Basal serum levels of adrenocorticotropic hormone (ACTH), cortisol values were compared with those in the control group. A low-dose ACTH stimulation test was performed in patients with basal cortisol levels below 18 µg/dL.</p><p><strong>Results: </strong>The basal cortisol levels of the PICU patients were significantly higher than those of the control group (P < 0.05). All tested patients (n= 24) had delta cortisol levels > 9 µg/dL and a peak cortisol response > 18 µg/dL. Basal cortisol levels were positively correlated with Pediatric Risk of Mortality (PRISM) III scores (P < 0.05; r = 0.363). The basal or stimulated cortisol levels of the patients who received glucocorticoid treatment were higher than the cut-off levels.</p><p><strong>Conclusions: </strong>High basal or stimulated cortisol levels are indicative of disease severity in the acute phase of stress. Patients with very high cortisol levels should be particularly carefully monitored because of the high mortality risk.</p>","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"466-471"},"PeriodicalIF":1.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200109/pdf/aeb.2019.466.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37908130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NON-FUNCTIONAL PITUITARY TUMORS: A MISLEADING PRESENTATION OF AN INTRASELLAR PLASMACYTOMA.","authors":"R Pujia,&nbsp;D Russo,&nbsp;E Guadagno,&nbsp;L Bartone,&nbsp;R Trapasso,&nbsp;E Piro,&nbsp;D Foti,&nbsp;A Brunetti","doi":"10.4183/aeb.2019.518","DOIUrl":"https://doi.org/10.4183/aeb.2019.518","url":null,"abstract":"<p><p>Intrasellar plasmacytoma is a rare pituitary tumor, which originates from monoclonal plasma cells in a single lesion. Knowledge of its features comes from case reports only. Here, we present an interesting case of a 77-year-old woman with a presumptive diagnosis of non-functioning pituitary adenoma, as based on both clinical and radiological examinations. Following endoscopic endonasal transsphenoidal surgery, the definitive diagnosis of intrasellar plasmacytoma was made by immunohistochemical analysis of the sellar mass. Intrasellar plasmacytoma is rare, but it should be evaluated in the differential diagnosis of a pituitary mass due to its different therapeutic approach and prognosis, since it can frequently progress to multiple myeloma.</p>","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"518-521"},"PeriodicalIF":1.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200105/pdf/aeb.2019.518.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37910121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHICH FACTORS ARE ASSOCIATED WITH MALIGNANCY IN THYROID NODULES CLASSIFIED AS BETHESDA CATEGORY 3 (AUS/FLUS) AND HOW DO THEY INFLUENCE THE PATIENT'S MANAGEMENT?","authors":"C Kaya,&nbsp;E Bozkurt,&nbsp;D Türkyılmaz Mut,&nbsp;M Mihmanli,&nbsp;M Uludağ","doi":"10.4183/aeb.2019.491","DOIUrl":"https://doi.org/10.4183/aeb.2019.491","url":null,"abstract":"<p><strong>Background: </strong>Thyroid nodules are a common pathology worldwide. Fine needle aspiration biopsy (FNAB) is an important diagnostic method for the investigation of malignancy in thyroid nodules. However, according to the Bethesda System used to classify the results, patients with atypia of undetermined significance/follicular lesion of undetermined significance (AUS / FLUS) may not be classified as benign or malignant. Therefore, it may be necessary to determine some clinical risk factors to apply the best treatment in these patients.</p><p><strong>Aim: </strong>To determine the factors that increase the risk of malignancy in this patient group.</p><p><strong>Methods: </strong>A retrospective study including 138 patients with an FNAB categorized as AUS/FLUS and operated between June 2015-September 2018. Demographical, Laboratory (TSH) and Ultrasound variables (number, size and characteristics of nodules) of the patients were compared among postoperative histopathological results.</p><p><strong>Results: </strong>Hypo-echoic structure, microcalcification and irregular margin of the nodules were detected to be associated with malignancy in patients with FNAB results of AUS/FLUS (p <0.001).</p><p><strong>Conclusion: </strong>We suggest that surgical treatment should be considered if the patients have nodules with the hypo-echoic structure, microcalcification and irregular margin with an FNAB histopathological result of AUS / FLUS.</p>","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"491-496"},"PeriodicalIF":1.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200114/pdf/aeb.2019.491.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37909690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ASSOCIATION BETWEEN PRO AND ANTI-INFLAMMATORY MARKERS WITH THE COMPONENTS OF METABOLIC SYNDROME.","authors":"S Kir,&nbsp;K Ekiz,&nbsp;H Alacam,&nbsp;R Turkel,&nbsp;E Koroglu,&nbsp;B L Altintop","doi":"10.4183/aeb.2019.430","DOIUrl":"https://doi.org/10.4183/aeb.2019.430","url":null,"abstract":"<p><strong>Objectives: </strong>Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that is linked with increased circulating markers of oxidative stress and low-grade inflammation. The link between inflammation and MetS is not yet fully understood. We aim to evaluate the relationship between the levels of pro and anti-inflammatory markers such as apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B), interleukin (IL) 6, tumor necrosis factor alpha (TNF-α), fibrinogen and complement component 3 (C3) and adiponectin and MetS/MetS components.</p><p><strong>Methods: </strong>This study was a case-control study conducted in an outpatient internal medicine clinic of the Ondokuz Mayıs University Internal Medicine Department. A total of 108 subjects (59 female, 49 male) who were not under any dietary restrictions and older than 17 years were selected and divided into two groups (54 with MetS and 54 healthy controls).</p><p><strong>Results: </strong>Increased levels of IL-6, C3 and Apo-B/Apo-A1 ratios and decreased levels of Apo-A1 and TNF-α (except in patients with hypertriglyceridemia) were detected in the MetS group. Apo-A1 and TNF-α exhibited decreased levels, and IL-6, fibrinogen, C3 and Apo-B levels and Apo-B/Apo-A1 ratios increased as higher numbers of MetS criteria were met in the total study group.</p><p><strong>Conclusions: </strong>We found that inflammatory marker levels were not affected by an increased number of MetS criteria met in the MetS group although these levels increased in the control group with higher numbers of MetS components. The presence of a high number of MetS components does not have an additive pro-inflammatory contribution for subjects already diagnosed with MetS.</p>","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"430-435"},"PeriodicalIF":1.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200101/pdf/aeb.2019.430.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37908125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}