WHICH FACTORS ARE ASSOCIATED WITH MALIGNANCY IN THYROID NODULES CLASSIFIED AS BETHESDA CATEGORY 3 (AUS/FLUS) AND HOW DO THEY INFLUENCE THE PATIENT'S MANAGEMENT?

Acta endocrinologica (Bucharest, Romania : 2005) Pub Date : 2019-10-01 DOI:10.4183/aeb.2019.491

C Kaya, E Bozkurt, D Türkyılmaz Mut, M Mihmanli, M Uludağ

{"title":"WHICH FACTORS ARE ASSOCIATED WITH MALIGNANCY IN THYROID NODULES CLASSIFIED AS BETHESDA CATEGORY 3 (AUS/FLUS) AND HOW DO THEY INFLUENCE THE PATIENT'S MANAGEMENT?","authors":"C Kaya, E Bozkurt, D Türkyılmaz Mut, M Mihmanli, M Uludağ","doi":"10.4183/aeb.2019.491","DOIUrl":null,"url":null,"abstract":"Background: Thyroid nodules are a common pathology worldwide. Fine needle aspiration biopsy (FNAB) is an important diagnostic method for the investigation of malignancy in thyroid nodules. However, according to the Bethesda System used to classify the results, patients with atypia of undetermined significance/follicular lesion of undetermined significance (AUS / FLUS) may not be classified as benign or malignant. Therefore, it may be necessary to determine some clinical risk factors to apply the best treatment in these patients.Aim: To determine the factors that increase the risk of malignancy in this patient group.Methods: A retrospective study including 138 patients with an FNAB categorized as AUS/FLUS and operated between June 2015-September 2018. Demographical, Laboratory (TSH) and Ultrasound variables (number, size and characteristics of nodules) of the patients were compared among postoperative histopathological results.Results: Hypo-echoic structure, microcalcification and irregular margin of the nodules were detected to be associated with malignancy in patients with FNAB results of AUS/FLUS (p <0.001).Conclusion: We suggest that surgical treatment should be considered if the patients have nodules with the hypo-echoic structure, microcalcification and irregular margin with an FNAB histopathological result of AUS / FLUS.","PeriodicalId":520542,"journal":{"name":"Acta endocrinologica (Bucharest, Romania : 2005)","volume":" ","pages":"491-496"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200114/pdf/aeb.2019.491.pdf","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta endocrinologica (Bucharest, Romania : 2005)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4183/aeb.2019.491","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 7

Abstract

Background: Thyroid nodules are a common pathology worldwide. Fine needle aspiration biopsy (FNAB) is an important diagnostic method for the investigation of malignancy in thyroid nodules. However, according to the Bethesda System used to classify the results, patients with atypia of undetermined significance/follicular lesion of undetermined significance (AUS / FLUS) may not be classified as benign or malignant. Therefore, it may be necessary to determine some clinical risk factors to apply the best treatment in these patients.

Aim: To determine the factors that increase the risk of malignancy in this patient group.

Methods: A retrospective study including 138 patients with an FNAB categorized as AUS/FLUS and operated between June 2015-September 2018. Demographical, Laboratory (TSH) and Ultrasound variables (number, size and characteristics of nodules) of the patients were compared among postoperative histopathological results.

Results: Hypo-echoic structure, microcalcification and irregular margin of the nodules were detected to be associated with malignancy in patients with FNAB results of AUS/FLUS (p <0.001).

Conclusion: We suggest that surgical treatment should be considered if the patients have nodules with the hypo-echoic structure, microcalcification and irregular margin with an FNAB histopathological result of AUS / FLUS.

查看原文本刊更多论文

哪些因素与归类为bethesda 3类(aus /流感)的甲状腺结节的恶性相关?它们如何影响患者的治疗?

背景:甲状腺结节是世界范围内常见的病理。细针穿刺活检(FNAB)是诊断甲状腺结节恶性肿瘤的重要方法。然而，根据用于分类结果的Bethesda系统，未确定意义的异型性/未确定意义的滤泡性病变(AUS / FLUS)患者可能无法分类为良性或恶性。因此，可能有必要确定一些临床危险因素，以便对这些患者进行最佳治疗。目的:探讨增加本组患者恶性肿瘤发生风险的因素。方法:对2015年6月至2018年9月期间手术的138例归类为AUS/FLUS的FNAB患者进行回顾性研究。比较患者的人口学、实验室(TSH)和超声变量(结节数量、大小和特征)与术后组织病理学结果。结果:AUS/FLUS的FNAB检查结果显示结节的低回声结构、微钙化、边缘不规则与恶性有关(p)结论:如果伴有AUS/FLUS的FNAB病理检查结果为低回声结构、微钙化、边缘不规则的结节，建议考虑手术治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta endocrinologica (Bucharest, Romania : 2005)

自引率

0.00%

发文量