Abdominal radiology (New York)最新文献

{"title":"CT-derived visceral adiposity and paraspinal muscle depletion associated with severe acute pancreatitis according to the Revised Atlanta Classification.","authors":"Halil Tekdemir, Asiye Sözeri, Bilal Egemen Çifçi","doi":"10.1007/s00261-026-05782-w","DOIUrl":"https://doi.org/10.1007/s00261-026-05782-w","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether CT-derived visceral adiposity and skeletal muscle metrics are associated with severe acute pancreatitis (AP), as defined by the Revised Atlanta Classification, in a selected cohort of CT-imaged patients.</p><p><strong>Methods: </strong>This retrospective study included 254 adults with AP who underwent abdominal CT and had follow-up imaging. Mild and moderately severe AP were combined as the non-severe group and compared with severe AP. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), bilateral erector spinae and psoas muscle areas, and muscle attenuation were measured at L3 on the earliest available unenhanced CT series. ROC analysis with exploratory Youden cutoffs, DeLong tests, bootstrap internal validation, and age- and sex-adjusted logistic regression were performed.</p><p><strong>Results: </strong>The cohort included 198 non-severe and 56 severe AP cases. Severe AP was associated with higher VAT and SAT areas and lower muscle area and attenuation. VAT outperformed SAT (AUC 0.810 vs. 0.645; p = 0.00048), and erector spinae area outperformed psoas area (AUC 0.923 vs. 0.870; p = 0.0086). VAT (OR 4.88 per 5,000 mm² increase; p < 0.001) and erector spinae area (OR 2.71 per 1,000 mm² decrease; p < 0.001) remained independently associated with severe AP.</p><p><strong>Conclusion: </strong>CT-derived VAT and erector spinae muscle area were independently associated with Revised Atlanta-defined severe AP. These opportunistic imaging biomarkers may complement, rather than replace, clinical risk stratification, and the proposed thresholds require external validation.</p>","PeriodicalId":520541,"journal":{"name":"Abdominal radiology (New York)","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative assessment of postoperative urinary jet dynamics after unilateral ureteral stricture reconstruction using non-contrast cine MR urography.","authors":"Zheng Li, Tengxin Wang, Deying Wen, Xinyu Tang, Jiayu Wei, Jingran Peng, Qianlan Wan, Jiayu Sun, Yu Liu","doi":"10.1007/s00261-026-05776-8","DOIUrl":"https://doi.org/10.1007/s00261-026-05776-8","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate non-contrast cine magnetic resonance urography (MRU) for quantifying postoperative urinary jet dynamics in unilateral ureteral stricture disease (USD) and explore their relevance to ureteral functional recovery.</p><p><strong>Methods: </strong>This prospective single-center study included 53 patients examined within 1 week before and 3 months after surgery. Five 60-s cine acquisitions were obtained per examination. Two radiologists assessed image quality and measured urinary jet frequency and injection duration. Intraclass correlation coefficients (ICCs) assessed interobserver agreement. Jet parameters were compared between affected and contralateral ureters before and after surgery, and their correlations were analyzed.</p><p><strong>Results: </strong>Image quality and quantitative measurements showed excellent interobserver agreement (ICC = 0.895 and 0.910, respectively; both P < 0.001). Jet frequency and injection duration were lower in the affected than contralateral ureter before and after surgery (all P < 0.001) and increased in the affected ureter postoperatively (both P < 0.001). Contralateral jet frequency decreased modestly (P = 0.007), whereas injection duration did not change (P = 0.443). Frequency and duration were positively correlated under all conditions, most strongly in the preoperative affected ureter (r = 0.974, P < 0.001).</p><p><strong>Conclusion: </strong>Non-contrast cine MRU enabled quantitative assessment of postoperative urinary jet changes. Increased affected-side jet activity was consistent with improved ureteral urine transport and may provide indirect, complementary functional information during follow-up. Urinary jet parameters should not be considered standalone measures of complete recovery of ureteral function, and cine MRU should not replace CTU for anatomical evaluation.</p>","PeriodicalId":520541,"journal":{"name":"Abdominal radiology (New York)","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148922534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiology considerations for the PREMIUM study: a multicenter randomized controlled trial of abbreviated MRI versus ultrasound for liver cancer screening in cirrhosis.","authors":"Dell P Dunn, Genta Dani, Ashu Sharma, George N Ioannou, Tamar H Taddei, Stephanie T Chang, Ifeyinwa Y Onyiuke, Beata M Planeta, Grant D Huang, Noel S Weiss, Timothy R Morgan, Jason A Dominitz, Ghassan K Abou-Alfa, Mustafa R Bashir, Michael V Beheshti, Amit G Singal, Cynthia A Moylan, Robin J Boland, Rajni L Mehta, Lynn F Buchwalder, Rafael B Fricks, Alexey Kotlik, Nhan V Do, Luis E Selva, Shari S Rogal, David E Kaplan, Jihane N Benhammou, Grace L Su, Linda M Mcdonald, Tassos C Kyriakides","doi":"10.1007/s00261-026-05720-w","DOIUrl":"https://doi.org/10.1007/s00261-026-05720-w","url":null,"abstract":"<p><p>This paper describes the rationale and radiology considerations in the implementation of the Preventing Liver Cancer Mortality through Imaging with Ultrasound versus MRI (PREMIUM) study. PREMIUM is a multicenter, randomized controlled trial sponsored by the Department of Veterans Affairs comparing dynamic contrast-enhanced (DCE) abbreviated MRI (aMRI) plus serum AFP versus ultrasound (US) plus serum AFP for hepatocellular carcinoma (HCC) screening in patients with cirrhosis. PREMIUM aims to randomize 4,700 participants across over 47 Veterans Affairs Medical Centers to semiannual surveillance for up to eight years, with HCC-related mortality as the primary endpoint. To date, 35 sites have been activated with 1,085 patients randomized. To ensure uniform implementation and reporting of per-protocol screening, the PREMIUM Radiology Workgroup developed standardized imaging protocols, structured LI-RADS-based reporting templates, and a centralized training program for radiologists and technologists. They also perform ongoing quality control on both scans and reports. The aMRI protocols utilize multiphasic post-contrast imaging to allow LI-RADS scoring. A non-contrast-enhanced aMRI protocol is available for participants who develop renal impairment or contrast allergy during the study. US protocols conform to US LI-RADS standards. Structured reporting promotes consistency in documentation of findings, visualization scores, and follow-up recommendations. A centralized Image Repository was established, incorporating advanced de-identification methods to remove metadata and pixel-embedded protected health information from imaging files. More than 20,000 curated liver MRI and US exams are anticipated, supporting both trial outcomes and future radiomics and artificial intelligence research. PREMIUM aims to determine whether screening for HCC with a DCE aMRI protocol reduces HCC-related mortality and also facilitates ancillary studies utilizing the Image Repository.</p>","PeriodicalId":520541,"journal":{"name":"Abdominal radiology (New York)","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T1 Mapping-Derived Extracellular Volume Fraction for Non-Invasive Assessment of Tumor-Stroma Ratio in Rectal Cancer.","authors":"Jie Yuan, Yiqun Sun, Hao Zhou, Yu Cao, Mengxiao Liu, Kun Liu, Mingrong Yao, Wenli Tan","doi":"10.1007/s00261-026-05769-7","DOIUrl":"https://doi.org/10.1007/s00261-026-05769-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the value of extracellular volume fraction (ECV) derived from T1 mapping and apparent diffusion coefficient (ADC) for non-invasive assessment of tumor stroma percentage (TSP) in rectal cancer.</p><p><strong>Methods: </strong>This prospective study enrolled 158 patients (104 men, 54 women; mean age 65.96 ± 10.87 years) with rectal adenocarcinoma. All patients underwent 3.0T MRI including pre- and post-contrast T1 mapping and diffusion-weighted imaging. ECV was calculated from native and post-contrast T1 values. TSP was histopathologically assessed on surgical specimens. Interobserver reproducibility, correlations with TSP, diagnostic performance for stroma-rich tumors (TSP > 50%), and associations with clinicopathological features were evaluated.</p><p><strong>Results: </strong>The pre- and post-contrast T1 measurements used to calculate ECV showed excellent interobserver reproducibility (ICC = 0.978 and 0.964, respectively). ECV showed a moderate positive correlation with TSP (ρ = 0.520, P < 0.001), whereas ADC showed no significant correlation (ρ = 0.070, P > 0.05). ECV demonstrated good discrimination of stroma-rich tumors (AUC, 0.819; 95% CI 0.742-0.897), whereas ADC derived from the two-b-value DWI protocol did not discriminate between stroma-rich and stroma-poor tumors (AUC, 0.495; 95% CI: 0.398-0.592; P < 0.001 vs. ECV). Adding ADC to ECV did not significantly improve diagnostic performance compared with ECV alone (AUC = 0.845, P > 0.05; DeLong P > 0.05). ECV differed across tumor differentiation grades after correction (P < 0.05), but not according to LVI status (P > 0.05).</p><p><strong>Conclusion: </strong>T1 mapping-derived ECV was reproducible and showed a moderate association with histological TSP, with good performance for distinguishing stroma-rich from stroma-poor tumors.</p>","PeriodicalId":520541,"journal":{"name":"Abdominal radiology (New York)","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of magnetic resonance-guided high-intensity focused ultrasound surgery (MRgFUS) in adenomyosis with dysmenorrhea.","authors":"Qi Zhang, Haicheng Li, Haoxiong Li, Linghui Xu, Yujia Shen, Wai Yan Ryana Fok, Mao Lai, Xiongrui Guo, Yiting Wang, Jamie Jiangmin Hou, Woo Yuan Xin, Junhai Zhang, Xiaohong Ruan","doi":"10.1007/s00261-026-05772-y","DOIUrl":"https://doi.org/10.1007/s00261-026-05772-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the safety and short-term efficacy of magnetic resonance-guided high-intensity focused ultrasound surgery (MRgFUS) for adenomyosis-associated dysmenorrhea.</p><p><strong>Materials and methods: </strong>This retrospective single-center cohort included 62 patients with MRI-confirmed adenomyosis and dysmenorrhea who underwent MRgFUS between October 2018 and March 2021. Uterine volume, adenomyosis lesion volume, and non-perfused volume (NPV) were measured on MRI. The non-perfused volume ratio (NPVR) was calculated as NPV divided by lesion volume. Dysmenorrhea severity was assessed using the visual analogue scale (VAS). Follow-up data were analyzed as available cases at 3, 6, and 12 months.</p><p><strong>Results: </strong>All 62 patients completed MRgFUS. The mean immediate NPVR was 69.12% ± 17.64%. MRI follow-up was available in 53/62 patients (85.5%) at 3 months, 38/62 (61.3%) at 6 months, and 13/62 (21.0%) at 12 months. Mean uterine volume decreased from 201.38 ± 126.17 cm³ at baseline to 174.97 ± 108.32 cm³ at 3 months and 164.86 ± 108.58 cm³ at 6 months, but was 205.45 ± 125.76 cm³ in the small 12-month subgroup. Mean adenomyosis lesion volume decreased from 83.72 ± 84.02 cm³ at baseline to 62.66 ± 66.31 cm³, 56.09 ± 66.67 cm³, and 68.53 ± 87.04 cm³ at 3, 6, and 12 months, respectively. Mean VAS score decreased from 6.68 ± 2.13 at baseline to 3.69 ± 1.95 at 3 months, 2.72 ± 1.40 at 6 months, and 3.38 ± 1.45 at 12 months. No serious procedure-related complications occurred.</p><p><strong>Conclusion: </strong>MRgFUS was technically feasible and appeared safe in this retrospective cohort, with encouraging short-term improvement in dysmenorrhea and early reduction in adenomyosis lesion volume. Because 12-month follow-up was available for only 21.0% of patients and no control group was included, long-term efficacy should be interpreted cautiously and confirmed in prospective controlled studies.</p>","PeriodicalId":520541,"journal":{"name":"Abdominal radiology (New York)","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The typical and atypical CT features of pancreatic schwannoma: pearls and pitfalls.","authors":"Zahra F Rahmatullah, Mohammad Salimian, Ralph H Hruban, Satomi Kawamoto, Linda C Chu, Elliot K Fishman","doi":"10.1007/s00261-026-05779-5","DOIUrl":"https://doi.org/10.1007/s00261-026-05779-5","url":null,"abstract":"<p><p>Pancreatic schwannomas (PSs) are rare, benign nerve sheath tumors that can be encountered as incidental findings on imaging, and their imaging features overlap with other solid and cystic pancreatic lesions. This often leads to preoperative misdiagnosis. On computed tomography (CT), which is often the first modality to detect these tumors, PS classically appears as a well-defined, round or oval, encapsulated mass without pancreatic ductal dilation when small. Degenerative changes in larger lesions can produce cystic change, septations, calcification, and hemorrhage. In this pictorial essay, we present the CT spectrum of PS through a series of illustrative cases, spanning typical and atypical appearances, to help radiologists recognize this rare tumor and include it as a benign differential diagnosis for pancreatic masses.</p>","PeriodicalId":520541,"journal":{"name":"Abdominal radiology (New York)","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT-guided percutaneous gastrostomy using needle puncture sequential coaxial dilation for high-risk patients with contraindications to conventional approaches.","authors":"Keyu Tang, Guiyuan Zhang, Xianhong Xiang, Run Lin, Haitao Dai, Tiansheng He, Yonghui Huang, Bin Chen","doi":"10.1007/s00261-026-05767-9","DOIUrl":"https://doi.org/10.1007/s00261-026-05767-9","url":null,"abstract":"<p><strong>Objective: </strong>Evaluates the safety, efficacy, and nutritional outcomes of needle puncture sequential coaxial dilation technique in high-risk patients requiring long-term enteral nutrition.</p><p><strong>Methods: </strong>This retrospective single-center study included 127 consecutive patients (mean age 67.4 ± 12.3 years; mean ASA 3.2 ± 0.7) who underwent CT-guided percutaneous gastrostomy using the needle puncture sequential coaxial dilation technique between January 2020 and December 2025. Notably, 89 patients (70.1%) had contraindications to PEG and 103 patients (81.1%) were unsuitable for surgical gastrostomy. Nutritional parameters including serum albumin, prealbumin, and body mass index (BMI) were assessed at baseline, 3 months, and 6 months post-procedure.</p><p><strong>Results: </strong>Technical success was achieved in 126 of 127 patients (99.2%). Major complications occurred in 0 patients (0%), and minor complications in 16 patients (12.6%). Nutritional outcomes demonstrated significant improvement: serum albumin increased from 2.8 ± 0.6 g/dL to 3.4 ± 0.5 g/dL at 3 months (p<0.001); prealbumin increased from 14.2 ± 3.8 mg/dL to 22.7 ± 4.2 mg/dL at 3 months (p<0.001); BMI increased from 18.7 ± 3.2 kg/m² to 20.1 ± 3.1 kg/m² at 6 months (p<0.01). Mean duration of enteral nutrition support was 147.3 ± 42.6 days.</p><p><strong>Conclusions: </strong>CT-guided percutaneous gastrostomy using needle puncture sequential coaxial dilation is a safe and effective enteral access technique for high-risk patients with contraindications to conventional PEG/PRG approaches. The technique demonstrates excellent technical success (99.2%), minimal complications (0% major), and significant nutritional improvement, providing a viable nutritional support solution for patients who would otherwise be excluded from enteral feeding access.</p>","PeriodicalId":520541,"journal":{"name":"Abdominal radiology (New York)","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging for visualization, segmentation and 3D reconstruction of surgical meshes in the lower abdomen: a systematic review.","authors":"Alireza Teymouri, Jonas P Rops, Cedric Vanmarcke, Diederik Meylemans, Axel Geysels, Willem Mestdagh, Ahmed M Chaoui, Nathalie Noppe, Fernando Crema Garcia, Hermen C van Beek, Gerrit D Slooter, Willem A R Zwaans, Marc Miserez","doi":"10.1007/s00261-026-05759-9","DOIUrl":"https://doi.org/10.1007/s00261-026-05759-9","url":null,"abstract":"<p><strong>Background: </strong>We aimed to provide a comprehensive review on magnetic resonance imaging (MRI) and its utility to postoperatively assess visibility and deformation of surgical mesh in patients with groin hernia or pelvic organ prolapse (POP).</p><p><strong>Method: </strong>PubMed, Web of Science and Embase were searched on July 7th, 2026 using the keywords \"surgical mesh\" AND (\"groin hernia\" OR \"POP\") AND \"MRI\". Observational studies were considered eligible if they included patients with an implanted mesh, performed static MRI, and reported mesh features, visibility, or provided information on its segmentation in groin hernia or POP patients. Results were narratively synthesized, and the quality of studies was assessed via the appropriate JBI tool.</p><p><strong>Results: </strong>Of 3,090 retrieved articles, 18 original studies fulfilled the eligibility criteria. Mesh for groin hernia was assessed in eight studies (796 groins in 592 patients) and mesh for POP in 10 studies (300 patients). Conventional meshes were used in seven studies, in which the mesh recognition rate by the reader ranged from 68.1% to 100%. Eleven studies assessed iron-loaded meshes with 100% visibility. Five studies reported results on mesh segmentation in iron-loaded meshes and successfully delineated its contours.</p><p><strong>Conclusion: </strong>MRI enables visualization of surgical meshes in the lower abdomen, particularly iron-loaded meshes, which provide more consistent visualization than conventional meshes. However, because conventional meshes remain the most widely used and are often less visible on MRI, standardized imaging protocols and prospective validation studies are warranted to improve mesh assessment.</p>","PeriodicalId":520541,"journal":{"name":"Abdominal radiology (New York)","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging features of TSC2/PKD1 contiguous gene deletion syndrome in adults.","authors":"Julien Bitton, Idris Boudhabhay, Charles Dariane, Marie Essig, Jerome Tourret, Marie-Pierre Audrezet, Aurélie Hummel, Bertrand Knebelmann, Jean-Michel Correas, Olivier Hélénon, Sylvain Bodard","doi":"10.1007/s00261-026-05768-8","DOIUrl":"https://doi.org/10.1007/s00261-026-05768-8","url":null,"abstract":"<p><strong>Objectives: </strong>To report the first detailed description of the radiological features of tuberous sclerosis complex 2/polycystic kidney disease 1 (TSC2/PKD1) contiguous gene deletion syndrome (CGS), a rare and poorly reported or described syndrome.</p><p><strong>Methods: </strong>This multicenter retrospective study included 9 adult patients (6 women, 3 men; mean age, 29±8 years) with genetically confirmed TSC2/PKD1 CGS. Clinical data and imaging studies (MRI, CT, ultrasound) were reviewed independently by two radiologists. Radiological features assessed included kidney length, total kidney volume (TKV), height-adjusted TKV (hTKV), cyst burden, angiomyolipomas (AMLs), and extrarenal manifestations.</p><p><strong>Results: </strong>All patients presented with enlarged polycystic kidneys (mean TKV: 2134 ± 904 mL; mean hTKV: 1260 ± 471 mL/m) and a high cyst burden (median 45 cysts per kidney); 7 of 8 classifiable patients (88%) were assigned to Mayo imaging class 1E, a classification validated in ADPKD whose prognostic value cannot be directly transposed to CGS, where renal volume also reflects solid angiomyolipomatous tissue. AMLs were observed in 78% of cases, with both fat-rich and fat-poor subtypes. One patient developed a hemorrhagic AML requiring embolization and underwent nephrectomy for a growing fat-poor lesion, ultimately diagnosed as AML. End-stage renal disease occurred in 67% of patients at a median age of 25 years. Extrarenal findings included cerebral cortical tubers and subependymal nodules in all patients, hepatic cysts (56%), hepatic AMLs (33%), pulmonary lymphangioleiomyomatosis (22%), and cardiac rhabdomyomas (22%).</p><p><strong>Conclusion: </strong>Adult patients with TSC2/PKD1 CGS exhibit a distinct imaging phenotype characterized by features of both ADPKD and TSC. The identification of AML in the context of ADPKD-like cystic disease should prompt consideration of CGS. Early diagnosis is crucial for guiding appropriate follow-up, therapeutic interventions, and genetic counseling.</p>","PeriodicalId":520541,"journal":{"name":"Abdominal radiology (New York)","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated model of MRI biomarkers and clinical factors for predicting pathologic response after neoadjuvant chemoradiotherapy in locally advanced rectal cancer.","authors":"Zijie Lin, Muzhen He, Weixiong Xiao, Wei Zhang, Jie Zhou, Xiaoyun Liang, Huijian Chen, Yining Ou, Mingping Ma","doi":"10.1007/s00261-026-05740-6","DOIUrl":"https://doi.org/10.1007/s00261-026-05740-6","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the utility of multiparametric MRI combined with clinical and laboratory biomarkers in predicting pathologic response to neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC).</p><p><strong>Methods: </strong>This retrospective study included 88 LARC patients who received nCRT followed by total mesorectal excision (TME). Based on pathological tumor regression grade (pTRG), patients were categorized into a good response group (GR, pTRG 0-1, n = 30) and a non-good response group (nGR, pTRG 2-3, n = 58). Independent predictors of GR were identified through univariable and multivariable logistic regression analyses. A combined predictive model was developed, and its predictive performance and calibration were evaluated using receiver operating characteristic curve (ROC) analysis and a calibration curve, with internal validation performed using 1000 bootstrap resamples.</p><p><strong>Results: </strong>Compared with the nGR group, the GR group had a higher proportion of female patients, a lower rate of carcinoembryonic antigen positivity, a higher proportion of patients with good magnetic resonance tumor regression grade (mrTRG-good), lower ADCₚᵣₑ, higher ADCₚₒₛₜ, and greater ΔADC% (all p < 0.05). Multivariable analysis identified gender, mrTRG, and ΔADC% as independent predictors of GR. The combined model integrating these three independent predictors achieved an apparent area under the curve (AUC) of 0.958, which was significantly higher than that of any individual predictor (all p < 0.05). Bootstrap validation yielded an optimism-corrected AUC of 0.949, and the model showed good calibration.</p><p><strong>Conclusion: </strong>The combined model incorporating gender, mrTRG, and ΔADC% showed promising performance for the prediction of pathologic response after nCRT in patients with LARC and may support individualized treatment decision-making.</p>","PeriodicalId":520541,"journal":{"name":"Abdominal radiology (New York)","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}