NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-06-04DOI: 10.1038/s44384-025-00012-x
Andrew Langley, Allison Sweeney, Ronak T Shethia, Brooke Bednarke, Faizah Wulandana, Marvin Xavierselvan, Srivalleesha Mallidi
{"title":"Heterogeneous tumor blood oxygenation dynamics during phototherapy deciphered with real-time label-free photoacoustic imaging.","authors":"Andrew Langley, Allison Sweeney, Ronak T Shethia, Brooke Bednarke, Faizah Wulandana, Marvin Xavierselvan, Srivalleesha Mallidi","doi":"10.1038/s44384-025-00012-x","DOIUrl":"10.1038/s44384-025-00012-x","url":null,"abstract":"<p><p>Understanding the heterogeneity of tumor vascular function and oxygenation is key in individualizing treatments, especially with therapies that are ineffective in hypoxic microenvironments. Our previous work has demonstrated that ultrasound-guided photoacoustic imaging (US-PAI)-based blood oxygen saturation (StO<sub>2</sub>) measurements can be used as a surrogate marker for predicting the regionalized efficacy of photodynamic therapy (PDT). However, monitoring of StO<sub>2</sub> during therapy could provide additional insights, specifically informing \"on the spot\" dosing decisions. In this work, we demonstrate the heterogeneous oxygen consumption during PDT by integrating light delivery fibers with the US-PAI transducer and tested the setup on murine tumor models with vascular-targeting benzoporphyrin derivative (BPD) PDT. Besides mapping dose-dependent oxygen utilization in real time, we also show that areas of reoxygenation post-PDT retain vascular function, confirmed with immunohistochemistry. Our results demonstrate the high potential of US-PAI in heterogenous tumoral oxygenation mapping for online dosimetry of cancer therapies such as PDT.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-02-12DOI: 10.1038/s44384-024-00001-6
Michael J B Lotinga, Marc C Green, Antonio J Torija
{"title":"Human perception and response to sound from unmanned aircraft systems within ambient acoustic environments.","authors":"Michael J B Lotinga, Marc C Green, Antonio J Torija","doi":"10.1038/s44384-024-00001-6","DOIUrl":"10.1038/s44384-024-00001-6","url":null,"abstract":"<p><p>Potential opportunities for unmanned aircraft systems (UAS) to offer societal benefits are accompanied by noise impact risks. Accordingly, it is important to develop greater understanding of perception and response to UAS sound. A laboratory listening experiment was undertaken to address this aim by investigating psychoacoustics of UAS sound exposure. The experiment incorporated contextual auditory and soundscape factors by embedding spatially-rendered UAS sounds within urban acoustic environments. The UAS covered varying aircraft designs, operating modes and numbers of flights. The experiment was focussed on determining noticeability and noise annoyance. The results indicate that annoyance responses were influenced by UAS type, operational mode, sound characteristics, quantities of flights, and the ambient acoustic environments in which UAS events occurred. Annoyance also appeared to have associations with personal attitude towards advanced air mobility technology, and with classification of residence area. Noticeability appeared to be influenced by UAS type, operating mode, loudness and ambient environment.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-10-21DOI: 10.1038/s44384-025-00031-8
Rachel Burstow, Antonios N Pouliopoulos
{"title":"Evaluating the accuracy of acoustic holograms for precise spatial targeting within the brain.","authors":"Rachel Burstow, Antonios N Pouliopoulos","doi":"10.1038/s44384-025-00031-8","DOIUrl":"10.1038/s44384-025-00031-8","url":null,"abstract":"<p><p>Acoustic holography can reconstruct desired pressure fields and overcome phase aberrations caused by refractions in heterogeneous media, such as the skull. However, the accuracy of holographic targeting within the brain has not yet been thoroughly evaluated. We sought to characterize the holographic focusing limits for focused and unfocused single-element transducers. Holographic lenses enlarged the focal size by more than 4-fold. Bifocal lenses achieved foci separation of 7-68 mm and focal depths of 7-83 mm. Lenses were tested in silico and in free-field experiments, with RMS errors of 0.03-0.33. Focused transducers were preferable at low F numbers and were better-suited for murine brain targeting. However, planar transducers can focus over larger areas so have higher clinical relevance in the human brain. Finally, simulations with a human skull showed an RMS error < 0.01. This work provides valuable insight into the accuracy of acoustic holography, demonstrating that transducer design is essential for clinical brain applications.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"24"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12540184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-08-08DOI: 10.1038/s44384-025-00018-5
Tal Grutman, Mike Bismuth, Bar Glickstein, Tali Ilovitsh
{"title":"Implicit neural representation for scalable 3D reconstruction from sparse ultrasound images.","authors":"Tal Grutman, Mike Bismuth, Bar Glickstein, Tali Ilovitsh","doi":"10.1038/s44384-025-00018-5","DOIUrl":"10.1038/s44384-025-00018-5","url":null,"abstract":"<p><p>Although volumetric ultrasound is limited by cost and availability of 2D arrays, 3D volumes can be reconstructed from 2D slices if transducer position is known, which is not usually the case. Even with position data, existing algorithms for reconstruction are impractical due to their discrete nature that struggles with scale. We propose a 1D array on a programmable motor for scanning and implicit neural representations for continuous reconstruction. Our network's ability to sample at arbitrary positions was compared to classic algorithms, achieving x7.9 performance while maintaining accuracy. Based on these, a reconstruction pipeline was tested on simulated data with 93% accuracy using only 36 B-mode images. This was evaluated in-vivo to measure tumor volumes in mice, with 6.3% mean error. Our findings suggest implicit neural representations can reduce data needed to recreate volumes from 2D slices and replace interpolation methods to enable interactive analysis.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-11-03DOI: 10.1038/s44384-025-00023-8
S Kuznetsova, F Allein, V F Dal Poggetto, F-X Bécot, M Miniaci
{"title":"Sierpiński carpet-inspired hierarchical patterning of porous materials for sound absorption.","authors":"S Kuznetsova, F Allein, V F Dal Poggetto, F-X Bécot, M Miniaci","doi":"10.1038/s44384-025-00023-8","DOIUrl":"10.1038/s44384-025-00023-8","url":null,"abstract":"<p><p>Efficient sound absorption at low and mid frequencies is essential for mitigating anthropogenic noise but remains a scientific and engineering challenge. While porous materials are effective at medium and high frequencies, they typically require considerable thickness to absorb low-frequency sound. Inspired by the Sierpiński carpet, we propose a hierarchical pattern of through-thickness holes in porous materials to enhance low- and mid-frequency absorption. Numerical simulations and impedance tube measurements demonstrate significant performance gains (up to a 46% of improvement in absorption at 500 Hz using 10% less material for a thickness of 80 mm). This enhancement is attributed to the presence of small-scale geometric features that spatially localize the acoustic pressure field, increasing energy dissipation within the porous medium. This hierarchical approach holds promise for developing lightweight, high-performance panels for sound insulation applications, particularly where improved low- and mid-frequency absorption is required without increasing material bulk.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12583189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-04-07DOI: 10.1038/s44384-025-00006-9
Matthieu Malléjac, Maxime Volery, Hervé Lissek, Romain Fleury
{"title":"Active control of electroacoustic resonators in the audible regime: control strategies and airborne applications.","authors":"Matthieu Malléjac, Maxime Volery, Hervé Lissek, Romain Fleury","doi":"10.1038/s44384-025-00006-9","DOIUrl":"https://doi.org/10.1038/s44384-025-00006-9","url":null,"abstract":"<p><p>Passive sound mitigation techniques have garnered attention whether for absorption, isolation, reverberation or new wave phenomena observation. In parallel, a wide range of research has been devoted to active control strategies, which complement passive techniques, particularly for low-frequency. We review the main control techniques related with airborne acoustic wave in the audible regime, emphasizing electrodynamic loudspeakers and piezo-diaphragms, and their applications. We conclude by discussing perspectives in this evolving field.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-07-03DOI: 10.1038/s44384-025-00014-9
Jinyun Yuan, Hong Chen
{"title":"Sonobiopsy for sensitive and spatially targeted molecular diagnosis through integrating ultrasound with liquid biopsy.","authors":"Jinyun Yuan, Hong Chen","doi":"10.1038/s44384-025-00014-9","DOIUrl":"10.1038/s44384-025-00014-9","url":null,"abstract":"<p><p>Sonobiopsy uses focused ultrasound to enrich circulating biomarkers from ultrasound-targeted disease regions, enabling sensitive and spatially targeted molecular diagnosis through liquid biopsy. Since the concept of integrating ultrasound with liquid biopsy was introduced in 2009, the field has advanced to incorporate various ultrasound modalities for applications across a range of diseases. To drive clinical translation of sonobiopsy, it is essential to optimize focused ultrasound techniques, enhance biomarker analysis, and elucidate underlying mechanisms.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}