NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-04-24DOI: 10.1038/s44384-025-00008-7
Cameron A B Smith, Mengtong Duan, Jipeng Yan, Laura Taylor, Mikhail Shapiro, Meng-Xing Tang
{"title":"Achieving single cell acoustic localisation with deactivation super resolution.","authors":"Cameron A B Smith, Mengtong Duan, Jipeng Yan, Laura Taylor, Mikhail Shapiro, Meng-Xing Tang","doi":"10.1038/s44384-025-00008-7","DOIUrl":"https://doi.org/10.1038/s44384-025-00008-7","url":null,"abstract":"<p><p>Photo-activated localization microscopy (PALM) has been a game-changer, breaking the diffraction limit in spatial resolution. This study presents the Deactivation Super Resolution (DSR) method, which utilises the deactivation of genetically encodable contrast agents, enabling us to super-resolve and pinpoint individual cells with ultrasound as they navigate through structures which cannot be resolved by conventional B-Mode imaging. DSR takes advantage of Gas Vesicles (GVs), which are air-filled sub-micron particles that have been expressed in genetically engineered bacterial and mammalian cells to produce acoustic contrast. Our experimental results show that DSR can distinguish sub-wavelength microstructures that standard B-mode ultrasound images fail to resolve by super-localising individual mammalian cells. This study provides a proof of concept for the potential of DSR to serve as a super-resolution ultrasound technique for individual cell localisation, opening new horizons in the field.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-05-15DOI: 10.1038/s44384-025-00010-z
Feroz Ahmed, Carlos Ramos-Romero, Antonio J Torija, Mahdi Azarpeyvand
{"title":"Aeroacoustics and psychoacoustics characterization of a boundary layer ingesting ducted fan.","authors":"Feroz Ahmed, Carlos Ramos-Romero, Antonio J Torija, Mahdi Azarpeyvand","doi":"10.1038/s44384-025-00010-z","DOIUrl":"10.1038/s44384-025-00010-z","url":null,"abstract":"<p><p>A comprehensive wind tunnel investigation was conducted to analyze noise generation, propagation, and perception mechanisms in a boundary layer ingesting (BLI) ducted fan through integrated aeroacoustic and psychoacoustic assessments. The study examines interactions between an incoming adverse pressure gradient turbulent boundary layer flow, developed over a curved wall, and the ducted fan. The fundamental investigation confirms that the fan thrust regime influences aerodynamic, aeroacoustic, and psychoacoustic characteristics, exhibiting various haystacking phenomena. High-thrust operation induces a pronounced upstream suction effect, accelerating the boundary layer flow, amplifying bulk momentum, and intensifying turbulence ingestion, leading to fan aeroacoustics and associated fan haystacking in noise spectrum. In contrast, low-thrust operation minimally alters the boundary layer flow, with reduced suction and noise dominated by duct aeroacoustics and the associated duct haystacking due to interactions between ingested turbulence and the duct's acoustic field. The psychoacoustic assessments indicate that both fan and duct haystacking contribute to higher perceived noise in the high- and low-thrust regime, respectively.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-06-04DOI: 10.1038/s44384-025-00012-x
Andrew Langley, Allison Sweeney, Ronak T Shethia, Brooke Bednarke, Faizah Wulandana, Marvin Xavierselvan, Srivalleesha Mallidi
{"title":"Heterogeneous tumor blood oxygenation dynamics during phototherapy deciphered with real-time label-free photoacoustic imaging.","authors":"Andrew Langley, Allison Sweeney, Ronak T Shethia, Brooke Bednarke, Faizah Wulandana, Marvin Xavierselvan, Srivalleesha Mallidi","doi":"10.1038/s44384-025-00012-x","DOIUrl":"10.1038/s44384-025-00012-x","url":null,"abstract":"<p><p>Understanding the heterogeneity of tumor vascular function and oxygenation is key in individualizing treatments, especially with therapies that are ineffective in hypoxic microenvironments. Our previous work has demonstrated that ultrasound-guided photoacoustic imaging (US-PAI)-based blood oxygen saturation (StO<sub>2</sub>) measurements can be used as a surrogate marker for predicting the regionalized efficacy of photodynamic therapy (PDT). However, monitoring of StO<sub>2</sub> during therapy could provide additional insights, specifically informing \"on the spot\" dosing decisions. In this work, we demonstrate the heterogeneous oxygen consumption during PDT by integrating light delivery fibers with the US-PAI transducer and tested the setup on murine tumor models with vascular-targeting benzoporphyrin derivative (BPD) PDT. Besides mapping dose-dependent oxygen utilization in real time, we also show that areas of reoxygenation post-PDT retain vascular function, confirmed with immunohistochemistry. Our results demonstrate the high potential of US-PAI in heterogenous tumoral oxygenation mapping for online dosimetry of cancer therapies such as PDT.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-02-12DOI: 10.1038/s44384-024-00001-6
Michael J B Lotinga, Marc C Green, Antonio J Torija
{"title":"Human perception and response to sound from unmanned aircraft systems within ambient acoustic environments.","authors":"Michael J B Lotinga, Marc C Green, Antonio J Torija","doi":"10.1038/s44384-024-00001-6","DOIUrl":"10.1038/s44384-024-00001-6","url":null,"abstract":"<p><p>Potential opportunities for unmanned aircraft systems (UAS) to offer societal benefits are accompanied by noise impact risks. Accordingly, it is important to develop greater understanding of perception and response to UAS sound. A laboratory listening experiment was undertaken to address this aim by investigating psychoacoustics of UAS sound exposure. The experiment incorporated contextual auditory and soundscape factors by embedding spatially-rendered UAS sounds within urban acoustic environments. The UAS covered varying aircraft designs, operating modes and numbers of flights. The experiment was focussed on determining noticeability and noise annoyance. The results indicate that annoyance responses were influenced by UAS type, operational mode, sound characteristics, quantities of flights, and the ambient acoustic environments in which UAS events occurred. Annoyance also appeared to have associations with personal attitude towards advanced air mobility technology, and with classification of residence area. Noticeability appeared to be influenced by UAS type, operating mode, loudness and ambient environment.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-04-07DOI: 10.1038/s44384-025-00006-9
Matthieu Malléjac, Maxime Volery, Hervé Lissek, Romain Fleury
{"title":"Active control of electroacoustic resonators in the audible regime: control strategies and airborne applications.","authors":"Matthieu Malléjac, Maxime Volery, Hervé Lissek, Romain Fleury","doi":"10.1038/s44384-025-00006-9","DOIUrl":"https://doi.org/10.1038/s44384-025-00006-9","url":null,"abstract":"<p><p>Passive sound mitigation techniques have garnered attention whether for absorption, isolation, reverberation or new wave phenomena observation. In parallel, a wide range of research has been devoted to active control strategies, which complement passive techniques, particularly for low-frequency. We review the main control techniques related with airborne acoustic wave in the audible regime, emphasizing electrodynamic loudspeakers and piezo-diaphragms, and their applications. We conclude by discussing perspectives in this evolving field.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NPJ acousticsPub Date : 2025-01-01Epub Date: 2025-07-03DOI: 10.1038/s44384-025-00014-9
Jinyun Yuan, Hong Chen
{"title":"Sonobiopsy for sensitive and spatially targeted molecular diagnosis through integrating ultrasound with liquid biopsy.","authors":"Jinyun Yuan, Hong Chen","doi":"10.1038/s44384-025-00014-9","DOIUrl":"10.1038/s44384-025-00014-9","url":null,"abstract":"<p><p>Sonobiopsy uses focused ultrasound to enrich circulating biomarkers from ultrasound-targeted disease regions, enabling sensitive and spatially targeted molecular diagnosis through liquid biopsy. Since the concept of integrating ultrasound with liquid biopsy was introduced in 2009, the field has advanced to incorporate various ultrasound modalities for applications across a range of diseases. To drive clinical translation of sonobiopsy, it is essential to optimize focused ultrasound techniques, enhance biomarker analysis, and elucidate underlying mechanisms.</p>","PeriodicalId":520425,"journal":{"name":"NPJ acoustics","volume":"1 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}