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A Case of Phaeohyphomycosis Caused by Phaeoacremonium alvesii on the Dorsum of the Right Hand in Japan. 日本右手背嗜绿脓杆菌致褐丝酵母菌病1例。
Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.25-00025
Aya Takano, Ryotaro Ogawa, Julia Miyamoto, Noriko Umegaki, Sayaka Ban, Takashi Yaguchi, Katsuhiko Kamei, Masaru Tanaka, Takashi Harada, Sumiko Ishizaki
{"title":"A Case of Phaeohyphomycosis Caused by Phaeoacremonium alvesii on the Dorsum of the Right Hand in Japan.","authors":"Aya Takano, Ryotaro Ogawa, Julia Miyamoto, Noriko Umegaki, Sayaka Ban, Takashi Yaguchi, Katsuhiko Kamei, Masaru Tanaka, Takashi Harada, Sumiko Ishizaki","doi":"10.3314/mmj.25-00025","DOIUrl":"10.3314/mmj.25-00025","url":null,"abstract":"<p><p>A man in his seventies without immunocompromised background presented with a slowly enlarging skin lesion on the dorsum of his right hand that had developed 6 months prior to his visit to our hospital. At the initial examination, a 3-cm brownish plaque associated with mild pain was observed on the dorsum of the right hand. Histopathological examination revealed a mass of hyphae in the subcutaneous tissue that was positive for periodic acid-Schiff and Grocott's stains. Fungal culture of the skin tissue yielded black-brown, downy colonies. Based on nucleotide sequencing of the internal transcribed spacer region and the β-tubulin gene, the organism was identified as Phaeoacremonium alvesii. After oral administration of terbinafine (TBF) at 125 mg/day was initiated, the lesions gradually improved. The strain exhibited slightly reduced sensitivity to TBF (minimum inhibitory concentration: 1 μg/mL). More than six months of oral therapy was required to achieve remission of the skin lesions. P. alvesii is a recently classified species, redefined in 2005 based on β-tubulin gene analysis, with only a few reported cases of human infection.</p>","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 1","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147329126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Diagnosis and Management of Ocular Fungal Infections. 眼部真菌感染的临床诊断与治疗。
Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.26.011
Kiyofumi Mochizuki, Masayuki Inuzuka, Taishi Miyase, Ikumi Shiraki, Hideaki Kawakami
{"title":"Clinical Diagnosis and Management of Ocular Fungal Infections.","authors":"Kiyofumi Mochizuki, Masayuki Inuzuka, Taishi Miyase, Ikumi Shiraki, Hideaki Kawakami","doi":"10.3314/mmj.26.011","DOIUrl":"10.3314/mmj.26.011","url":null,"abstract":"<p><p>This review summarizes current knowledge on ocular fungal infections, with emphasis on the clinical characteristics, diagnostic approaches, and management of keratitis and endophthalmitis caused by uncommon fungal pathogens. Filamentous fungi such as Fusarium and Aspergillus often cause rapidly progressive disease, whereas Candida species typically infect eyes with preexisting ocular surface abnormalities or systemic risk factors. Diagnosis relies primarily on microscopy and culture, supplemented by molecular techniques where available. Management requires organism-directed antifungal therapy, with surgical intervention reserved for refractory or vision-threatening cases. Despite advances in diagnostic modalities and therapeutics, fungal keratitis and endophthalmitis remain important causes of visual morbidity, underscoring the need for early recognition and appropriate treatment.</p>","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 2","pages":"137-142"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory-Type Tinea Corporis from Trichophyton mentagrophytes Animal Type 3 with Suspected Infection from a Guinea Pig. 疑似豚鼠感染的3型毛癣动物炎症型体癣。
Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.25-00038
Misato Hosoi, Hitoshi Tsuchihashi, Masataro Hiruma, Nobuyuki Taguchi, Rui Kano, Rei Watanabe
{"title":"Inflammatory-Type Tinea Corporis from Trichophyton mentagrophytes Animal Type 3 with Suspected Infection from a Guinea Pig.","authors":"Misato Hosoi, Hitoshi Tsuchihashi, Masataro Hiruma, Nobuyuki Taguchi, Rui Kano, Rei Watanabe","doi":"10.3314/mmj.25-00038","DOIUrl":"https://doi.org/10.3314/mmj.25-00038","url":null,"abstract":"<p><p>An adlescent girl was bitten on the right middle finger while attempting to intervene in a fight among her three pet guinea pigs. She was initially treated by a local physician without improvement and was subsequently referred to the Department of Dermatology at our hospital. Direct microscopic examination of scales and crusts with KOH was positive, and she was diagnosed with tinea corporis. The isolated fungus was morphologically identified as belonging to the Trichophyton mentagrophytes complex, and topical luliconazole cream was administered. Molecular analysis based on the DNA sequence of the nuclear ribosomal internal transcribed spacer (ITS) 1 region revealed that the isolate belonged to ITS type II, corresponding to T. mentagrophytes animal type 3. These findings strongly suggested zoonotic transmission from the pet guinea pigs. This appears to be one of the very few reported cases of T. mentagrophytes animal type 3 isolated from a human lesion.</p>","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 3","pages":"183-185"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nomenclatural Changes of Fungal Pathogens Causing Dermatomycoses. 引起皮肤真菌病的真菌病原体的命名变化。
Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.26.012
Takashi Mochizuki
{"title":"Nomenclatural Changes of Fungal Pathogens Causing Dermatomycoses.","authors":"Takashi Mochizuki","doi":"10.3314/mmj.26.012","DOIUrl":"https://doi.org/10.3314/mmj.26.012","url":null,"abstract":"<p><p>With advances in molecular biology, the recognition of fungal species has been revised, and the nomenclature systems themselves have been changed to adopt the \"one-fungus-one-name\" concept, resulting in the names of many species being changed in recent years. This article provides an overview of recent changes in the names of fungi associated with skin diseases, with a particular focus on Malassezia species, some Trichophyton species including Trichophyton benhamiae and Trichophyton indotineae, along with several species causing deep dermatomycoses.</p>","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 3","pages":"177-181"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-Dose Antifungal Therapy Improves Sputum Rheology and Symptoms in Fungus-Associated Chronic Cough. 低剂量抗真菌治疗改善真菌相关慢性咳嗽的痰流变学和症状。
Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.26-00001
Haruhiko Ogawa, Yuka Uchida, Kazuo Satoh, Koichi Makimura
{"title":"Low-Dose Antifungal Therapy Improves Sputum Rheology and Symptoms in Fungus-Associated Chronic Cough.","authors":"Haruhiko Ogawa, Yuka Uchida, Kazuo Satoh, Koichi Makimura","doi":"10.3314/mmj.26-00001","DOIUrl":"https://doi.org/10.3314/mmj.26-00001","url":null,"abstract":"<p><p>In a pilot study of 12 patients with chronic productive cough, we retrospectively compared sputum viscoelasticity before macrolide antibiotic administration and the clinical effects of macrolide antibiotic administration between two groups with and without sputum fungal culture. The fungal culture-positive group (n = 6) showed significantly higher sputum rheological parameters in the high-strain region, particularly critical strain (γC), and reduced response to macrolide treatment. In 5 patients with fungus-associated chronic cough, a decrease in high-strain sputum viscoelasticity and improvement in cough and laryngeal abnormal sensations were observed after administration of low-dose antifungals.</p>","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 3","pages":"199-205"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tinea Cruris and Pedis Caused by Terbinafine-Resistant Trichophyton rubrum Treated with Luliconazole. 吕立康唑治疗耐特比萘芬性红毛癣致脚癣。
Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.25-00033
Sayaka Ohara, Hiromitsu Noguchi, Tadahiko Matsumoto, Masahide Kubo, Rui Kano, Takahiro Satoh
{"title":"Tinea Cruris and Pedis Caused by Terbinafine-Resistant Trichophyton rubrum Treated with Luliconazole.","authors":"Sayaka Ohara, Hiromitsu Noguchi, Tadahiko Matsumoto, Masahide Kubo, Rui Kano, Takahiro Satoh","doi":"10.3314/mmj.25-00033","DOIUrl":"https://doi.org/10.3314/mmj.25-00033","url":null,"abstract":"","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 2","pages":"149-150"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interdigital Tinea Pedis Caused by Terbinafine-Resistant Trichophyton rubrum Treated with Luliconazole. 吕立康唑治疗耐特比萘芬红毛癣致指间足癣。
Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.25-00032
Sayaka Ohara, Hiromitsu Noguchi, Tadahiko Matsumoto, Masahide Kubo, Honoka Nojo, Rui Kano
{"title":"Interdigital Tinea Pedis Caused by Terbinafine-Resistant Trichophyton rubrum Treated with Luliconazole.","authors":"Sayaka Ohara, Hiromitsu Noguchi, Tadahiko Matsumoto, Masahide Kubo, Honoka Nojo, Rui Kano","doi":"10.3314/mmj.25-00032","DOIUrl":"https://doi.org/10.3314/mmj.25-00032","url":null,"abstract":"","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 2","pages":"147-148"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Analysis of Clinical Filamentous Basidiomycetes and Development of Multiplex PCR for Rapid Identification. 临床丝状担子菌回顾性分析及多重PCR快速鉴定方法的建立。
Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.25-00031
Sayaka Ban, Isoto Yoshioka, Yugo Mori, Takashi Yaguchi
{"title":"Retrospective Analysis of Clinical Filamentous Basidiomycetes and Development of Multiplex PCR for Rapid Identification.","authors":"Sayaka Ban, Isoto Yoshioka, Yugo Mori, Takashi Yaguchi","doi":"10.3314/mmj.25-00031","DOIUrl":"10.3314/mmj.25-00031","url":null,"abstract":"<p><p>Pathogenic basidiomycetes are increasingly recognized as causative agents of mycoses, particularly allergic bronchopulmonary mycosis (ABPM), in humans. To clarify their clinical significance, we analyzed the fungal species, their sources and associated diseases of 650 basidiomycetous strains preserved at the Medical Mycology Research Center, Chiba University, from 2010 to 2024. Schizophyllum commune was the most frequently isolated species (60%), followed by Trametes spp. (9.5%), Irpex spp. (5.2%), and Bjerkandera adusta (4.3%). Most isolates originated from respiratory specimens and were associated with ABPM, pneumomycosis, or sinusitis. These fungi often cannot be identified in culture because of their limited morphological characteristics. Therefore, we developed a multiplex polymerase chain reaction (PCR) assay targeting the internal transcribed spacer region for the rapid discrimination of S. commune, B. adusta, Irpex spp., and Trametes spp. Species- and genus-specific forward and reverse primers yielded distinct amplicon sizes for each target. The assay demonstrated high specificity and showed no cross-reactivity with non-target fungi; the results were concordant with those of rDNA sequencing. Multiplex PCR provides a rapid, cost-effective tool for identifying clinically important basidiomycetes, facilitating the timely diagnosis and management of fungal respiratory diseases.</p>","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 1","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147329135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisiting Sapronoses Through Aspergillosis. 通过曲霉病重新审视皂甙。
Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.26.005
Takahito Toyotome
{"title":"Revisiting Sapronoses Through Aspergillosis.","authors":"Takahito Toyotome","doi":"10.3314/mmj.26.005","DOIUrl":"10.3314/mmj.26.005","url":null,"abstract":"<p><p>Zoonoses are generally defined as infections that are naturally transmitted between humans and other vertebrate animals. Among fungi, dermatophytes are well-established zoonotic pathogens. In contrast, many pathogenic molds are environmental saprophytes, with infections typically resulting from the direct uptake of fungal propagules-such as airborne spores-from soil, decaying organic matter, or other non-living reservoirs. Rather than being transmitted between animals and humans, these infections originate from environmental sources. In 1958, Terskikh introduced the term \"sapronosis\" (or \"saprozoonosis\") to describe such infections acquired from the environment rather than from other living hosts. In 2003, Hubálek expanded on this concept, providing a comprehensive list of major sapronoses and their causative agents, including Aspergillus fumigatus, the primary cause of aspergillosis. Aspergillosis is a fungal disease caused by species of the genus Aspergillus, typically acquired through inhalation of airborne spores from soil and other external environments. Although the environmental transmission of Aspergillus spp. has long been recognized, recent changes in human living environments, evolving animal husbandry practices, and global ecological shifts-including climate change and the human-mediated dispersal of pathogenic organisms-highlight the need to re-evaluate these fungi as sapronotic agents. In this review, we revisit the concept of sapronosis using aspergillosis as a representative example, drawing on investigations conducted in collaboration with colleagues involving penguins housed in zoos and aquariums and the characteristics of their captive environments. Through these studies, we aim to explore the implications of environmental fungal exposure for both human and animal health.</p>","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 1","pages":"67-70"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147329130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotypic Alterations upon Magnesium Addition in Trichosporonales Yeasts. 添加镁对毛孢酵母表型的影响。
Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.26.010
Keita Aoki, Takashi Sugita, Masako Takashima
{"title":"Phenotypic Alterations upon Magnesium Addition in Trichosporonales Yeasts.","authors":"Keita Aoki, Takashi Sugita, Masako Takashima","doi":"10.3314/mmj.26.010","DOIUrl":"10.3314/mmj.26.010","url":null,"abstract":"<p><p>Yeasts show few distinct morphological characteristics. The two basic forms of yeast, unicellular yeast and multicellular hyphal form, exhibit dimorphism. In a recent study on Trichosporon asahii, a dimorphic basidiomycetous yeast that causes trichosporonosis, the addition of magnesium induced hyphal formation and changes in organelle distribution. A detailed observation of organelle distribution revealed that the responses to magnesium addition varied widely among Trichosporonales yeasts. In this review, we show that differences in organelle phenotypes upon magnesium addition possibly contribute to the practical identification and classification of Trichosporonales yeasts.</p>","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 2","pages":"131-135"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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