Medical mycology journal最新文献

The Light and Shadow of Medical Mycology from the Perspective of a Return to the Origin. 回归本源视角下医学真菌学的光与影。

Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.26.007

Ken Iozumi

{"title":"The Light and Shadow of Medical Mycology from the Perspective of a Return to the Origin.","authors":"Ken Iozumi","doi":"10.3314/mmj.26.007","DOIUrl":"https://doi.org/10.3314/mmj.26.007","url":null,"abstract":"Medical mycology is a traditional field of medicine that has developed over a long history through the contributions of numerous researchers and clinicians. This paper focuses on the most influential individuals, discoveries, and inventions within the field, examining the development of medical mycology from the perspective of a return to its origins, including on-site investigations. This return to origins is not merely a historical retrospective but also an effort to reevaluate and deepen our understanding through practical research, aiming to explore the foundational studies that marked the beginning of medical mycology and its related disciplines. Furthermore, this paper highlights the conceptual meaning of the \"light and shadow\" of medical mycology. While the field has made substantial progress, it has often been overshadowed by the remarkable achievements of other disciplines, such as botany, symbolized by Linnaeus, and bacteriology, represented by Koch. This study attempts to reassess the history and significance of medical mycology. Additionally, it examines the resurgence of medical mycology and the dramatic paradigm shift triggered by a single publication from the United States. Through these considerations, this paper aims to provide a long-term and multidimensional reexamination of the progress of medical mycology.","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 2","pages":"103-116"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medication Adherence and Patient-Reported Experience with Miconazole Mucoadhesive Buccal Tablets Compared with Oral Gel in the Treatment of Oral Candidiasis. 米康唑黏附口腔片与口服凝胶治疗口腔念珠菌病的临床疗效比较。

Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.25-00039

Chiho Hiraga, Katsuhiko Sakai, Masaki Minabe, Takeshi Nomura

{"title":"Medication Adherence and Patient-Reported Experience with Miconazole Mucoadhesive Buccal Tablets Compared with Oral Gel in the Treatment of Oral Candidiasis.","authors":"Chiho Hiraga, Katsuhiko Sakai, Masaki Minabe, Takeshi Nomura","doi":"10.3314/mmj.25-00039","DOIUrl":"10.3314/mmj.25-00039","url":null,"abstract":"Background: We compared medication adherence and satisfaction between miconazole mucoadhesive buccal tablets (MBT) and miconazole oral gel (MOG) in patients with oral candidiasis.Methods: This observational study included patients diagnosed with oral candidiasis and treated with miconazole by our department between June 2021 and August 2024. MBT was prescribed as first-line therapy according to Infectious Diseases Society of America guidelines, whereas MOG was selected when MBT use was anticipated to be difficult (e.g., denture wearers). After approximately 14 days of therapy, patients completed a questionnaire on treatment completion, daily adherence, usability, and satisfaction. Baseline data were extracted from medical records. Statistical comparisons used Fisher's exact test for categorical variables and the Mann-Whitney U test for continuous variables.Results: Forty-six patients (Age median 77.0 years [IQR: 69.5-80.5], 72% female) were analyzed. Baseline characteristics were comparable between groups. The treatment completion rate was 79% for MOG and 67% for MBT (p = 0.510). Daily adherence was significantly higher in the MBT group (89%) than in the MOG group (53%, p = 0.015). The most frequent reason for non-completion in the MBT group was \"easy detachment\" of the tablet. Usability was rated as acceptable by approximately 70% of patients in both groups. While median satisfaction scores did not differ significantly, a higher proportion of MBT users reported high satisfaction (≥ 8/10).Conclusion: Once-daily MBT may improve daily adherence compared with MOG, particularly in elderly patients receiving multiple medications. However, detachment issues may limit completion rates, highlighting the importance of patient-specific formulation selection and administration strategies.","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 2","pages":"89-96"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Management of Antifungal-Resistant Dermatophytosis in Japan. 日本抗真菌耐药皮肤真菌病的临床管理。

Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.26.009

Hiromitsu Noguchi, Rui Kano

{"title":"Clinical Management of Antifungal-Resistant Dermatophytosis in Japan.","authors":"Hiromitsu Noguchi, Rui Kano","doi":"10.3314/mmj.26.009","DOIUrl":"10.3314/mmj.26.009","url":null,"abstract":"Dermatophytosis remains one of the most common superficial fungal infections worldwide, and antifungal-resistant strains have recently emerged as an increasing clinical concern. In Japan, the prevalence of terbinafine-resistant Trichophyton species is currently estimated to be 2%, with most isolates harboring squalene epoxidase (SQLE) gene mutations such as Leu393Phe and Phe397Leu. This review summarizes recent epidemiological findings and representative clinical cases to illustrate the practical management strategies for antifungal-resistant dermatophytosis in Japan. Three illustrative cases were presented. Case 1 involved Trichophyton interdigitale carrying a Phe397Leu mutation that was unresponsive to terbinafine but was successfully treated with topical efinaconazole and luliconazole. Case 2 described a cluster infection of terbinafine-resistant Trichophyton rubrum (Leu393Phe) in a group home, where oral fosravuconazole achieved complete cure. Case 3 reported five soldiers with terbinafine-resistant dermatophytosis caused by Phe397Leu or Phe415Ile mutations, which were likely associated with prolonged topical SQLE inhibitor use. Resistance is often induced by the long-term or intermittent application of SQLE inhibitors, including over-the-counter topical terbinafine and butenafine. For suspected terbinafine-resistant infections, non-SQLE azoles, such as luliconazole and lanoconazole, are recommended because of their 10- to 100-fold increased activity against Trichophyton species. Oral fosravuconazole and topical agents such as 10% efinaconazole or 5% luliconazole have proven effective for onychomycosis. Ongoing surveillance, appropriate antifungal stewardship, and timely adjustment of treatment regimens are essential to prevent the further spread of antifungal-resistant dermatophytosis.","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 2","pages":"125-129"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichophyton tonsurans Infection in Japan. 日本的疣毛癣菌感染。

Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.26.004

Yumi Ogawa

{"title":"Trichophyton tonsurans Infection in Japan.","authors":"Yumi Ogawa","doi":"10.3314/mmj.26.004","DOIUrl":"10.3314/mmj.26.004","url":null,"abstract":"The first cases of Trichophyton tonsurans infection outbreaks were reported in Japan beginning around the turn of the 21th century. Initial reports were of group infections among high school and college combat sports athletes. Gradually, the spread of infection to younger age groups, such as junior high school students, was confirmed. Today, T. tonsurans is considered one of the major causative organisms of tinea corporis and tinea capitis in Japan. The most common clinical manifestations of T. tonsurans infection are tinea corporis and tinea capitis. Tinea corporis can be difficult to distinguish from eczema, and most cases of tinea capitis are classified as being asymptomatic carriers. These presentations can make early diagnoses challenging. Diagnosis is often established by direct microscopic examination and fungal culture to isolate and identify the causative organism. In terms of treatment, T. tonsurans infection is primarily treated using an oral antifungal therapy.This review focuses on the status of T. tonsurans infections in Japan. T. tonsurans is an anthropophilic dermatophyte and may be difficult for the human immune system to eliminate. Hence, we must consistently keep T. tonsurans infection in mind during daily clinical practice.","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 1","pages":"61-65"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147329140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Kerion Celsi due to Trichophyton rubrum Successfully Treated with Fosravuconazole. Fosravuconazole成功治疗红毛癣所致角质瘤1例。

Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.26-00003

Chisato Une, Risa Ikutama, Rui Kano, Utako Kimura, Masataro Hiruma, Toshio Hasegawa

引用次数: 0

Development and Validation of a Direct Colony Real-Time PCR for Rapid and Specific Candida auris Detection. 快速特异耳念珠菌直接菌落实时PCR检测方法的建立与验证。

Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.25-00019

Takashi Umeyama, Tsuguto Fujimoto, Jun Ishikawa, Masahiro Abe, Nobuko Nakayama, Hiroko Tomuro, Minoru Nagi, Takayuki Shinohara, Yoshitsugu Miyazaki

{"title":"Development and Validation of a Direct Colony Real-Time PCR for Rapid and Specific Candida auris Detection.","authors":"Takashi Umeyama, Tsuguto Fujimoto, Jun Ishikawa, Masahiro Abe, Nobuko Nakayama, Hiroko Tomuro, Minoru Nagi, Takayuki Shinohara, Yoshitsugu Miyazaki","doi":"10.3314/mmj.25-00019","DOIUrl":"10.3314/mmj.25-00019","url":null,"abstract":"Candida auris, an emerging multidrug-resistant fungal pathogen, poses a significant diagnostic and infection control challenge with limited identification methodologies. To overcome this, we developed and validated a rapid, specific, and direct colony real-time PCR assay for C. auris identification without DNA extraction. Species-specific primers were designed using comparative genomics and subjected to rigorous experimental validations. The optimized assay using a selected primer pair (Candida-auris-5F/5R) successfully identified C. auris directly from the cultured colonies within two hours. It demonstrated high specificity against eight clinically relevant non-auris Candida species, and sufficient sensitivity (as low as 100 cells/reaction) for routine laboratory testing. This method significantly reduced the turnaround time, labor, and costs compared to conventional molecular techniques that require DNA extraction. Acknowledging the recent emergence of Clade I strains in Japan, the selected primer pairs and positive controls were distributed nationally to all 59 regional public health institutes by January 2025, establishing a standardized surveillance system. This assay is expected to play a key role in timely detection of C. auris, thereby improving patient care and outbreak management.","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147329109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive Fungal Infection Requiring Dif ferential Diagnosis from Miliary Tuberculosis Based on Imaging. 侵袭性真菌感染需与军旅结核鉴别诊断的影像学分析。

Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.25-00023

Yuki Kamikokura, Masanori Goto, Yasuhiro Umekage, Masayo Kamikokura, Kumi Takasawa, Taro Murakami, Akinori Tada, Yuta Takenaka, Nobuyuki Kobayashi, Ryota Shigaki, Hiraku Yanada, Masatoshi Sado, Naka Sakamoto, Mishie Tanino, Takaaki Sasaki, Akira Takasawa

{"title":"Invasive Fungal Infection Requiring Dif ferential Diagnosis from Miliary Tuberculosis Based on Imaging.","authors":"Yuki Kamikokura, Masanori Goto, Yasuhiro Umekage, Masayo Kamikokura, Kumi Takasawa, Taro Murakami, Akinori Tada, Yuta Takenaka, Nobuyuki Kobayashi, Ryota Shigaki, Hiraku Yanada, Masatoshi Sado, Naka Sakamoto, Mishie Tanino, Takaaki Sasaki, Akira Takasawa","doi":"10.3314/mmj.25-00023","DOIUrl":"10.3314/mmj.25-00023","url":null,"abstract":"Invasive fungal infections (IFIs) have increased in recent years due to population aging and a rising number of immunocompromised patients. The prognosis for IFIs remains poor, making accurate diagnosis and appropriate treatment essential. Low culture positivity rates and the difficulty in distinguishing IFIs from diseases such as tuberculosis on computed tomography imaging further complicate diagnosis and may delay. We encountered a case of invasive candidiasis leading to respiratory failure, in which differentiation from miliary tuberculosis on imaging was challenging. Autopsy revealed histopathological findings of eosinophilic exudates filling the alveolar spaces and poorly stained spherical fungi. Using scanning electron microscopy and DNA extraction from formalin-fixed, paraffin-embedded (FFPE) tissues, genetic analysis identified Debaryomyces hansenii, also known as Candida famata. FFPE tissue-based analytical techniques serve as valuable tools for understanding IFIs. If the causative pathogen can be identified during a patient's life, appropriate treatment can be selected, potentially improving the prognosis of IFIs.","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"67 1","pages":"11-18"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147329128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal-Host Interactions Based on Protein Interaction Experiments. 基于蛋白质相互作用实验的真菌与宿主相互作用。

Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.26.001

Tomoe Ichikawa, Yoshio Ishibashi

引用次数: 0

Terbinafine-Resistant Trichophyton indotineae. 特比萘芬耐药毛癣菌。

Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.25-00030

Yumie Tokuhisa, Hiromitsu Noguchi, Yuko Takita, Rui Kano

引用次数: 0

Zoonotic Trichophyton benhamiae Infections Derived from Guinea Pig. 来自豚鼠的人畜共患本氏毛癣菌感染。

Medical mycology journal Pub Date : 2026-01-01 DOI: 10.3314/mmj.25-00040

Sayaka Ohara, Hiromitsu Noguchi, Tadahiko Matsumoto, Masahide Kubo, Rui Kano

引用次数: 0