The American Journal of Gastroenterology最新文献_第3页

Autoimmune Hepatitis and the Pathways and Targets for Therapies. 自身免疫性肝炎与治疗途径和目标。

The American Journal of Gastroenterology Pub Date : 2024-10-25 DOI: 10.14309/ajg.0000000000003163

Brian J Wentworth,Mary McGrath,Sahil Khanna,Craig Lammert

引用次数: 0

Hepatic steatosis estimated by VCTE-derived CAP scores was associated with lower risks of liver-related events and all-cause mortality in patients with chronic liver disease. 根据 VCTE 得出的 CAP 评分估算出的肝脏脂肪变性与慢性肝病患者较低的肝脏相关事件风险和全因死亡率有关。

The American Journal of Gastroenterology Pub Date : 2024-10-25 DOI: 10.14309/ajg.0000000000003161

Nicole J Kim,Philip Vutien,Joleen A Borgerding,Lauren A Beste,Muyi Li,Abbey Barnard-Giustini,Kay M Johnson,George N Ioannou

{"title":"Hepatic steatosis estimated by VCTE-derived CAP scores was associated with lower risks of liver-related events and all-cause mortality in patients with chronic liver disease.","authors":"Nicole J Kim,Philip Vutien,Joleen A Borgerding,Lauren A Beste,Muyi Li,Abbey Barnard-Giustini,Kay M Johnson,George N Ioannou","doi":"10.14309/ajg.0000000000003161","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003161","url":null,"abstract":"INTRODUCTIONThe Controlled Attenuated Parameter (CAP) score derived from vibration-controlled transient elastography (VCTE, i.e. Fibroscan®) is a well-validated marker of hepatic steatosis. It is unclear if CAP scores are associated with risks of liver-related outcomes or all-cause mortality.METHODSIn this retrospective cohort study, we identified 7,587 U.S. Veterans (2,689 with cured hepatitis C [HCV], 1,523 with alcohol-associated liver disease [ALD], 3,375 with metabolic dysfunction-associated steatotic liver disease [MASLD]) who underwent VCTE between 5/2015-12/2021. We followed patients for new hepatic decompensation, hepatocellular carcinoma (HCC), and death from the VCTE date until 1/1/2022. Multivariable Cox-proportional hazards regression was used to assess for the associations between CAP measurements and clinical outcomes, adjusting for age, sex, race/ethnicity, body mass index, Charlson Comorbidity Index, diabetes, liver disease etiology, liver stiffness measurements, and FIB-4, and was reported separately by disease etiology and advanced fibrosis status.RESULTSOver a median follow-up time of ∼1.9 years, hepatic steatosis (grades 1-3 vs. 0) was associated with a lower risk of death (aHR 0.70, 95% CI: 0.57-0.85). Among patients with MASLD, hepatic steatosis was associated with a lower risk of decompensation (aHR 0.54, 95% CI: 0.32-0.90) and death (aHR 0.52, 95% CI: 0.37-0.73). These associations persisted in subgroup analyses of patients with advanced fibrosis and without cirrhosis.DISCUSSIONAmong patients who underwent VCTE in clinical practice, the presence of substantial hepatic steatosis estimated by the CAP score was associated with lower all-cause mortality among all patients and lower risk of decompensation and death among those with MASLD.","PeriodicalId":520099,"journal":{"name":"The American Journal of Gastroenterology","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142490511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inclusion of a Society-Endorsed Practice Guideline in Computed Tomography Reports Improves Post-Diverticulitis Colonoscopy Adherence. 在计算机断层扫描报告中加入协会认可的实践指南可提高憩室炎后结肠镜检查的依从性。

The American Journal of Gastroenterology Pub Date : 2024-10-25 DOI: 10.14309/ajg.0000000000003157

Luke T Chmielecki,Nathan Pham,Marisa Wu,Avneesh Gupta,Laura Chu,Paul C Schroy

引用次数: 0

Circumferential En Bloc Esophageal Mucosal Sloughing and Esophageal Cast. 食管黏膜环状脱落和食管铸型

The American Journal of Gastroenterology Pub Date : 2024-10-25 DOI: 10.14309/ajg.0000000000003150

Hamid Ullah,Shou-Jiang Tang

引用次数: 0

Raising the Bar: Is Hepatocellular Carcinoma Surveillance Warranted for Patients With Alcohol-Associated Cirrhosis? 提高标准：是否需要对酒精相关性肝硬化患者进行肝细胞癌监测？

The American Journal of Gastroenterology Pub Date : 2024-10-24 DOI: 10.14309/ajg.0000000000003123

Andrew M Moon

引用次数: 0

Treatment preference archetypes in eosinophilic esophagitis and their implications for therapy. 嗜酸性粒细胞食管炎的治疗偏好原型及其对治疗的影响。

The American Journal of Gastroenterology Pub Date : 2024-10-18 DOI: 10.14309/ajg.0000000000003133

Joy W Chang,Kelcie Brophy,Kerry A Ryan,Joel H Rubenstein,Evan S Dellon,Lauren P Wallner,Hyungjin Myra Kim,Raymond De Vries

{"title":"Treatment preference archetypes in eosinophilic esophagitis and their implications for therapy.","authors":"Joy W Chang,Kelcie Brophy,Kerry A Ryan,Joel H Rubenstein,Evan S Dellon,Lauren P Wallner,Hyungjin Myra Kim,Raymond De Vries","doi":"10.14309/ajg.0000000000003133","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003133","url":null,"abstract":"BACKGROUNDLittle is known about how patients make decisions about and prioritize, therapies and disease management in eosinophilic esophagitis (EoE). We aimed to systematically identify and characterize patient perspectives and attitudes that influence decision making for EoE management.METHODSTo understand the diverse attitudes and values of EoE patients, we designed a study using the Q-method. We iteratively developed 31 statements related to EoE disease management. Participants sorted statements by ranking from +4 (most agree) to -4 (most disagree). By-person factor analysis, using 2- and 3- factor rotation, revealed distinct preference archetypes.RESULTSThirty-four adults with EoE (mean age 40.9, 51.4% male, 82.9% White) were recruited from gastroenterology and allergy clinics from a single center. We identified two treatment-centered archetypes: Medication preference, driven by symptoms and the desire to minimize risk of complications, and Natural treatment preference, focusing on identifying trigger foods and diet adherence. Three-factor analysis revealed an additional archetype: Treatment ambivalent, a view of EoE as a mild and episodic (not chronic) disease with low priority to treat. Comparison by factor revealed 54% of those in the natural preference archetype were recategorized as treatment ambivalent, suggesting that they see natural treatment as a less complicated or milder strategy and may be at risk of nonadherence and reduced treatment uptake.CONCLUSIONSWe identified three distinct treatment preference archetypes among individuals with EoE, underscoring the need for personalized treatment strategies, especially for those favoring natural approaches but masking ambivalence, and may be at risk for nonadherence or loss to follow-up.","PeriodicalId":520099,"journal":{"name":"The American Journal of Gastroenterology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary Colonic Ganglioneuroma with Central Depression: A Rare Case with Unique Morphology. 伴有中央凹陷的单发结肠神经节瘤：形态独特的罕见病例

The American Journal of Gastroenterology Pub Date : 2024-10-18 DOI: 10.14309/ajg.0000000000003142

Masachika Saino,Toshio Kuwai,Shiro Oka

引用次数: 0

Expanding Insights on Ambulatory Reflux Monitoring: Future Directions and Clinical Integration. 拓展对非卧床反流监测的见解：未来方向与临床整合。

The American Journal of Gastroenterology Pub Date : 2024-10-18 DOI: 10.14309/ajg.0000000000003080

Francesco Calabrese,Andrea Pasta,Edoardo Vincenzo Savarino,Vincenzo Savarino,Edoardo Giovanni Giannini,Elisa Marabotto

引用次数: 0

Transverse colon penetration by migrated intrauterine device: a rare complication. 宫内节育器移位导致横结肠穿透：一种罕见的并发症。

The American Journal of Gastroenterology Pub Date : 2024-10-18 DOI: 10.14309/ajg.0000000000003144

Tae-Gyun Lee,Jin-Min Jung,Sun Jung Kim,Chang Woo Kim

引用次数: 0

Disproportionately Increasing Incidence of Inflammatory Bowel Disease in Females and the Elderly: An Update Analysis from the Global Burden of Disease Study 2021. 女性和老年人的炎症性肠病发病率不成比例地增加：2021 年全球疾病负担研究的最新分析》。

The American Journal of Gastroenterology Pub Date : 2024-10-18 DOI: 10.14309/ajg.0000000000003143

Pojsakorn Danpanichkul,Kwanjit Duangsonk,Agnes Hy Ho,Passisd Laoveeravat,Chawinthorn Vuthithammee,Disatorn Dejvajara,Vitchapong Prasitsumrit,Thanida Auttapracha,Busara Songtanin,Panu Wetwittayakhlang,Rashid N Lui,Gursimran Singh Kochhar,Siew C Ng,Francis A Farraye,Karn Wijarnpreecha

引用次数: 0