Journal of anesthesia and translational medicine最新文献

{"title":"Advances in biomarkers for myocardial injury after non-cardiac surgery.","authors":"Xinyu Li, Yutong Zhu, Ke Peng, Yufan Yang, Jing Yan, Yang Zhang, Hong Liu, Xisheng Shan, Fuhai Ji","doi":"10.1016/j.jatmed.2026.03.004","DOIUrl":"10.1016/j.jatmed.2026.03.004","url":null,"abstract":"<p><p>Myocardial injury after non-cardiac surgery (MINS) is a common and clinically important postoperative complication associated with increased short- and long-term mortality. As most cases lack typical ischemic symptoms, diagnosis relies primarily on systematic postoperative biomarker surveillance. Current guidelines recommend serial postoperative measurement of cardiac troponin (cTn) or high-sensitivity cTn, the reference-standard biomarker for myocardial necrosis, in patients at elevated perioperative risk. However, cTn demonstrates limited sensitivity during the early h following myocardial ischemia, underscoring the need for complementary biomarkers capable of detecting ischemic injury before the onset of irreversible myocardial necrosis or troponin elevation. This review summarizes recent advances in emerging circulating biomarkers for early MINS detection, including heart-type fatty acid-binding protein, ischemia-modified albumin, cardiac myosin-binding protein C, copeptin, and other markers reflecting ischemia, necrosis, inflammation, and fibrosis. We critically examine their underlying pathophysiological mechanisms, diagnostic performance, and release kinetics, highlighting their potential to shorten the diagnostic \"blind window\" associated with conventional biomarkers. The integration of multi-marker panels represents a promising strategy to enhance early diagnostic sensitivity and improve prognostic stratification. Nonetheless, large-scale prospective studies are required to validate their clinical utility and define their role in perioperative decision-making and guideline development.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 1","pages":"22-35"},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propofol treatment correlates with changes in pain sensitivity and thalamocortical glutamate/GABA balance in sleep-deprived mice.","authors":"Haorui Yang, Yongtao Gao, Yu'e Sun, Ke Peng, Nazneen Sudhan, Fei Xu, Zhusheng Chen, Gang Chen, Tao Xu, Xiaqing Ma","doi":"10.1016/j.jatmed.2026.03.002","DOIUrl":"10.1016/j.jatmed.2026.03.002","url":null,"abstract":"<p><strong>Background: </strong>Sleep disorders profoundly impair patients' daily quality of life and present substantial challenges to clinical management. Accumulating evidence has shown that propofol improves sleep architecture and quality in clinical practice, yet its mechanism in modulating pain linked to sleep disorders remains elusive. Given that chronic sleep disruption is often accompanied by impaired pain thresholds and imbalances between excitatory and inhibitory neurotransmitters, this study aimed to determine whether propofol alleviates sleep-deprivation-induced pain threshold reduction by modulating this neurotransmitter balance.</p><p><strong>Methods: </strong>A modified multi-platform water maze was used to establish a sleep-deprived mouse model simulating sleep disruption. Following tail vein administration of varying propofol doses, behavioral assessments were conducted to evaluate its effects on sleep states and pain thresholds. Concurrently, electroencephalogram (EEG) and electromyogram (EMG) recordings captured sleep rhythm alterations. To further investigate neurochemical mechanisms, 9.4 T MRI and amino acid metabolism analysis were employed to obtain magnetic resonance spectroscopy (MRS) data. Glutamate (Glu) and γ-aminobutyric acid (GABA) levels in the thalamus and cortex were measured to assess dynamic changes in the excitatory/inhibitory neurotransmitter balance.</p><p><strong>Results: </strong>Our results demonstrated that sleep deprivation significantly reduced the pain threshold in mice, which was accompanied by an imbalance in the thalamocortical Glu/GABA ratio. Propofol intervention markedly restored this neurotransmitter imbalance - the Glu/GABA metabolic ratio returned to a relatively stable level, and the reduced pain threshold was significantly improved. Concurrent EEG and EMG recordings revealed that propofol optimized sleep architecture and partially reversed sleep rhythm disturbances caused by sleep deprivation.</p><p><strong>Conclusions: </strong>In summary, propofol effectively alleviates sleep-deprivation-induced pain reduction in pain threshold. This analgesic effect is associated with the restoration of the dynamic equilibrium of excitatory/inhibitory neurotransmitters (Glu/GABA) in the thalamocortical circuit. Our findings provide novel experimental and neurochemical evidence supporting the potential application of propofol in sleep disorders and associated pain management, thereby offering a valuable reference for future clinical translational research.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 1","pages":"36-46"},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote assessment of instrumental activities of daily living and cognitive impairment in older surgical patients.","authors":"Yu Tong Lu, Aparna Saripella, Ellene Yan, Paras Kapoor, Yasmin Alhamdah, Nina Butris, Islam Sazzdual, Leif Erik Lovblom, Jean Wong, Frances Chung","doi":"10.1016/j.jatmed.2026.03.005","DOIUrl":"10.1016/j.jatmed.2026.03.005","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate the prevalence of instrumental activities of daily living (IADL) dependence in older surgical patients, its association with cognitive impairment, and risk factors associated with postoperative IADL dependence.</p><p><strong>Methods: </strong>In this multicenter prospective study, 307 older adults aged ≥ 65 years undergoing non-cardiac surgery were evaluated for IADL dependence pre- and postoperatively at 30, 90 and 180 days. Changes in IADL scores over time were analyzed using a linear mixed-effects model stratified by preoperative IADL status. The association between IADL and cognition was examined by stratification of cognitive status. Preoperative risk factors of IADL dependence at 30 and 180 days were explored using multivariable logistic regression models.</p><p><strong>Results: </strong>Preoperatively, 38% of patients were IADL dependent. Among preoperatively IADL dependent patients, we observed a decline in IADL at 30 days, with subsequent recovery to baseline by 90 days. Those who were IADL independent showed no change in their IADL scores. Regardless of baseline cognitive status, postoperative IADL trajectories were similar, with cognitively impaired and non-cognitively impaired patients exhibiting a temporary decline at 30 days, with recovery by 90 days. Orthopedic surgery and preoperative cognitive impairment were associated with higher adjusted odds of 30-day IADL dependence (aOR 2.81, 95% CI [1.33-6.39]; aOR 5.31, 95% CI [1.56-25.0], respectively), whereas older age and preoperative frailty were associated with long-term IADL dependence at 180 days (aOR 1.57, 95% CI [1.14, 2.18]; aOR 2.83, 95% CI [1.01-8.05], respectively).</p><p><strong>Conclusions: </strong>Older adults with preoperative IADL dependence experienced transient postoperative decline with recovery by 90 days, whereas independent patients maintained function. Preoperative IADL assessment may help identify patients at risk and guide postoperative care planning.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 1","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalographic phenotypes of postoperative delirium in the perioperative period.","authors":"Sanawaer Tuerhong, Linlin Han, Xu Ku, Ruili Ding, Xin Huang, Xiangdong Chen","doi":"10.1016/j.jatmed.2026.03.006","DOIUrl":"10.1016/j.jatmed.2026.03.006","url":null,"abstract":"<p><p>Postoperative delirium (POD) is a common and severe complication among older surgical patients. Perioperative electroencephalography (EEG) monitoring provides a noninvasive, real-time window into cerebral neural activity. Traditionally, EEG has been simplified into single indices, such as the bispectral index (BIS), to guide anesthetic depth titration. However, recent large-scale clinical trials have demonstrated that avoiding EEG suppression based solely on such indices does not reduce the incidence of POD. This discrepancy partly arises because conventional indices are primarily derived from frontal EEG signals and fail to fully exploit the multidimensional information distributed across the whole brain. This review highlights that high-dimensional features embedded in raw EEG-including spectral characteristics, oscillatory dynamics, brain network connectivity, and aperiodic components-serve as key biomarkers for identifying individual neural vulnerability and POD risk. We systematically summarize spatiotemporal EEG phenotypes associated with POD pathophysiology, encompassing age-related baseline features, intraoperative high-risk patterns (such as burst suppression), and abnormal emergence trajectories indicative of failed brain network reorganization. Accumulating evidence indicates that aberrations in these EEG features are closely associated with POD occurrence and adverse clinical outcomes. Therefore, future EEG interpretation must move beyond single \"depth\" indices toward a mechanism-driven assessment that integrates high-dimensional EEG features with individual baseline characteristics, thereby providing novel strategies for the precise prevention of POD.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 1","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute cerebral infarction caused by severe anaphylactic shock: A case report.","authors":"Mingyue Li, Yu Han, Jingping Wang","doi":"10.1016/j.jatmed.2026.03.001","DOIUrl":"10.1016/j.jatmed.2026.03.001","url":null,"abstract":"<p><strong>Background: </strong>Perioperative anaphylactic reactions, especially those induced by colloid solutions like gelatins, can lead to severe hypotension and tissue hypoperfusion, with potential serious complications.</p><p><strong>Case presentation: </strong>We present a rare case of acute cerebral infarction following severe anaphylaxis during sinus lesion resection under general anesthesia. A 16-year-old patient received succinylated gelatin for hypovolemia. Within 7 min, the patient developed profound hypotension (45/25 mmHg), tachycardia (139 bpm), and severe desaturation (63%), necessitating treatment with epinephrine and 35 min of continuous resuscitation Postoperatively, the patient developed headache and memory deficits, prompting an MRI that revealed an acute infarction. Follow-up MRI on postoperative day 27 showed significant lesion resolution accompanied by improvement in neurological symptoms.</p><p><strong>Conclusions: </strong>This case highlights cerebral ischemia as a potential sequela of anaphylaxis-induced hypotension, emphasizing prompt hemodynamic stabilization and neurologic vigilance in perioperative hypersensitivity reactions.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cocktail-style multifunctional resuscitation fluids: Where are we now in 2026?","authors":"Geoffrey L Liu, Lauren C Hollifield, Frank Chen, Henry Liu","doi":"10.1016/j.jatmed.2026.02.001","DOIUrl":"10.1016/j.jatmed.2026.02.001","url":null,"abstract":"<p><p>For over half a century, fluid resuscitation has traditionally included crystalloids for volume expansion and colloids for potential oncotic advantage. The paradigm, however, could be shifting now. The development of multifunctional resuscitation fluids is fast evolving. These fluids integrate multiple therapeutic components. Rather than serving as simple volume expanders, they function as advanced therapeutic platforms engineered to simultaneously target multiple pathological conditions. They correct hypovolemia, mitigate systemic inflammation and coagulopathy, improve organ perfusion and oxygen delivery, and support tissue recovery in conditions such as shock, endothelial dysfunction, and oxidative stress. This article reviews the basic concepts underpinning multifunctional resuscitation fluids and explores their potential clinical applications. It also assesses their advantages and limitations based on recent preclinical and early clinical trials, and outlines future directions necessary to translate these promising solutions from the bench to the bedside.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 1","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MANF improves cognitive function and attenuates neuroinflammation in APP/PS1 transgenic mice through the TLR4/MYD88/NF-κB signaling pathway.","authors":"Yanchao Tang, Enba Zhuo, Pengman Li, Chen Wang, Xudong Hu, Xuesheng Liu, Guanghong Xu, Qiying Shen","doi":"10.1016/j.jatmed.2025.12.005","DOIUrl":"10.1016/j.jatmed.2025.12.005","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by progressive cognitive decline, as well as pathological features such as β-amyloid (Aβ) plaque deposition, tau hyperphosphorylation, synaptic dysfunction, and neuronal loss. Growing evidence suggests that neuroinflammation, oxidative stress, and apoptosis play critical roles in the pathogenesis of AD, thereby contributing to neuronal damage and cognitive decline. Mesencephalic astrocyte-derived neurotrophic factor (MANF), an endoplasmic reticulum stress-inducible protein, has been shown to exert neuroprotective effects by modulating immune responses, alleviating oxidative stress, and suppressing apoptosis in various neurological disease models. These properties suggest that MANF could serve as a promising therapeutic candidate treating AD. This study investigated the therapeutic potential of MANF in improving cognitive function and ameliorating pathological changes in APP/PS1 transgenic (Tg) mice by modulating neuroinflammation and enhancing neural plasticity.</p><p><strong>Methods: </strong>Beginning at 10 months of age, male APP/PS1 transgenic mice received daily intraperitoneal injections of recombinant human MANF (rhMANF) at a dose of 1 μg/g for a duration of one month. Behavioral assessments, including the Morris water maze, open field, and fear conditioning tests, were conducted to evaluate cognitive function. Brain tissue was analyzed for β-amyloid (Aβ) deposition, neuroinflammation, oxidative stress, and neuronal apoptosis using immunofluorescence, immunohistochemistry, western blotting, and enzyme-linked immunosorbent assay. RNA sequencing (RNA-seq) and a BV2 microglial/HT22 neuronal co-culture system were used to further elucidate the mechanisms underlying MANF's effects.</p><p><strong>Results: </strong>rhMANF treatment significantly improved cognitive function in APP/PS1 Tg mice by reducing Aβ deposition, inhibiting microglial activation, and suppressing inflammatory cytokines (TNF-α, IL-1β, and IL-6). MANF also mitigated oxidative stress, reduced neuronal apoptosis, and restored synaptic protein levels, including those of Postsynaptic density protein-95(PSD95) and synaptophysin (SYN). In vitro studies confirmed that MANF effectively counteracts Aβ1-42-induced toxicity in the BV2/HT22 co-culture system. Transcriptomic analysis identified that MANF exerts its protective effects by regulating the TLR4/MYD88/NF-κB signaling pathway, thereby reducing inflammation and promoting synaptic plasticity.</p><p><strong>Conclusions: </strong>This study demonstrates the protective role of MANF in AD and establishes MANF as a promising therapeutic candidate for AD and aging-related neurodegenerative disorders.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"4 4","pages":"241-254"},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13001770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations for regional anaesthesia for the shoulder joint - Beyond the C5-C6 nerve roots.","authors":"Michelle Chong, Laura Girón-Arango, Anahi Perlas","doi":"10.1016/j.jatmed.2025.12.004","DOIUrl":"10.1016/j.jatmed.2025.12.004","url":null,"abstract":"<p><p>Shoulder pain in the perioperative setting remains a significant clinical challenge, with persistent postoperative discomfort reported in up to 22 % of patients following primary shoulder arthroplasty. Regional anesthesia plays a crucial role in multimodal analgesia, and the interscalene block (ISB) has traditionally been regarded as the standard technique for shoulder surgery. However, its proximity to the C5-C6 ventral rami carries risks, including phrenic nerve paresis and nerve injury. While these complications are often clinically insignificant in healthy individuals, they may cause respiratory issues in vulnerable patients, highlighting the need for safer and more customized alternatives. This educational review summarizes emerging regional anesthesia techniques that target sensory pathways of the shoulder while minimizing complications associated with ISB. It integrates evolving knowledge of shoulder innervation, surgical-specific analgesic considerations, postoperative pain trajectories, and the phenomenon of rebound pain. Additionally, the role of point-of-care diaphragmatic ultrasonography in perioperative risk stratification is explored. A strategy map aligning specific nerve block techniques with common shoulder procedures is presented to support individualized clinical decision-making. As medicine and technology advances, regional anesthesiologists are expected to expand their repertoire of shoulder analgesic techniques to deliver safer, patient-centred care. This review offers a comprehensive framework to guide evidence-informed block selection and enhance perioperative outcomes for diverse patient populations.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"4 4","pages":"255-266"},"PeriodicalIF":0.0,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13001781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intraoperative hypotension depth and duration on acute kidney injury after Type A acute aortic dissection repair: An observational cohort study based on early risk stratification models.","authors":"Zhou Zhou, Fan Jiang, Anran Dai, Zhixiang Li, Yaoyi Guo, Xinlong Zhang, Yue Feng, Rui Ding, Chen Chen, Kaizong Huang, Ruipeng Jia, Hongwei Shi, Sheng Lou, Jianjun Zou, Yanna Si","doi":"10.1016/j.jatmed.2025.12.003","DOIUrl":"10.1016/j.jatmed.2025.12.003","url":null,"abstract":"<p><strong>Background: </strong>The impact of adjusting intraoperative mean arterial pressure (MAP) management strategies on early detection and prevention of acute kidney injury (AKI) after Type A acute aortic dissection (TA-AAD) repair has not been elucidated. This study sought to investigate the association between different degrees of hypotension exposure and stage 3 AKI, and examine how intraoperative time-series dynamic variables influence the performance of risk stratification models.</p><p><strong>Methods: </strong>We analyzed intraoperative data and divided 336 adult patients into groups based on MAP below different thresholds (< 65, 60, 55, 50 mmHg). Logistic regression algorithms were used to identify and screen for predictors other than blood pressure (BP) features and develop initial model. Hypotensive exposure indicators, including cumulative time and area under the curve below a certain MAP threshold, were considered for confounding correction. Subsequently all independent predictors were incorporated to develop upgraded models. Predictive performance was assessed by area under the receiver operating characteristic curve (AUROC) and calibration curves.</p><p><strong>Results: </strong>227 patients (67.6 %) developed postoperative AKI, including 114 (33.9 %) stage 1, 54 (16.1 %) stage 2, and 59 (17.6 %) stage 3. Multivariate logistic regression analysis identified preoperative serum creatinine (odds ratio [OR] = 1.007 [95 % CI 1.002-1.015], P = 0.047), operation duration (OR = 1.007 [95 % CI, 1.002-1.012], P = 0.008) and intraoperative urine output (OR = 0.576 [95 % CI, 0.417-0.768], <i>P</i> < 0.001) as independent predictors of stage 3 AKI. After confounding correction, hypotensive exposure indicators were significant at all four thresholds, and ORs increased with decreasing thresholds. Integrating BP features yielded eight upgraded models with AUROC ranging from 0.797 to 0.805.</p><p><strong>Conclusions: </strong>With a worsening degree of intraoperative hypotension, i.e., lower absolute MAP thresholds and longer exposure times, the odds of stage 3 AKI risk after TA-AAD repair increased. Incorporating BP time-series variables into models could improve the accuracy of early prediction, while the two presentations of hypotension features yield scarcely any difference in predictive outcomes.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"4 4","pages":"267-276"},"PeriodicalIF":0.0,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13001768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practice guidelines for the prevention and management of postoperative nausea and vomiting (2025 edition).","authors":"Jiang Hu, Zhe Wang, Bin Ma, Tianlong Wang, E Wang, Weifeng Yu","doi":"10.1016/j.jatmed.2025.12.002","DOIUrl":"10.1016/j.jatmed.2025.12.002","url":null,"abstract":"<p><p>Postoperative nausea and vomiting (PONV) is a common postoperative complication that substantially influences patient recovery and healthcare quality. To further standardize PONV management in China, the Chinese Society of Anesthesiology, in collaboration with multidisciplinary experts, has developed the Clinical Practice Guidelines on Postoperative Nausea and Vomiting Management (2025 Edition) using evidence-based methodologies. This guideline addresses 21 clinical issues on PONV management and proposes 35 evidence-based recommendations covering risk-factor identification, selection of assessment tools, optimization of anesthesia techniques, and multimodal intervention strategies. Evidence quality is graded into four levels (high, moderate, low, and very low) using the GRADE system, with recommendation strength clearly indicated (strong/weak recommendations or good practice statements). The guidelines aim to establish China-specific standardized protocols to provide evidence-based guidance for anesthesiologists and healthcare professionals, supporting Enhanced Recovery After Surgery (ERAS) implementation.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"4 4","pages":"286-302"},"PeriodicalIF":0.0,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13001765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}