Doris Pierson, Rebecca Certoma, Joshua Hobbs, Xiaomei Cong, Jinlei Li
{"title":"A Narrative Review on Multimodal Spinal Anesthesia: Old Technique and New Use.","authors":"Doris Pierson, Rebecca Certoma, Joshua Hobbs, Xiaomei Cong, Jinlei Li","doi":"10.1016/j.jatmed.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.jatmed.2025.02.002","url":null,"abstract":"<p><p>Spinal anesthesia has a long history in providing safe and effective anesthesia and analgesia. Its continuous evolution in block placement techniques with or without ultrasound assistance, options of spinal needles, local anesthetics and adjuvants adopted based on spinal anesthesia onset rate, duration of action, and side effect profiles, makes spinal anesthesia an important modality in current early recovery after surgery for a broad-spectrum of surgical procedures including ambulatory lower extremity orthopedic procedures and major chest, abdominal, and spine surgeries.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"4 1","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interventional neuromodulation techniques for cervicogenic headache.","authors":"Natali Ariyoshi, Emily Qian, Rifat Abliz, Qiliang Chen","doi":"10.1016/j.jatmed.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.jatmed.2025.02.003","url":null,"abstract":"<p><p>Cervicogenic headache is a debilitating secondary headache condition that reduces the quality of life for many. Its etiology involves pathologies in one or more of the complex cervical structures, such as cervical muscles, ligaments, facet joints, intervertebral discs, and C1-3 nerve roots. Mainstream conservative treatments, such as medication and physical therapy, are designed to address these underlying pathologies. In addition, recent advancements in neurostimulation techniques can aid in treatment-resistant or intolerant cases. This narrative review aims to critically evaluate the current treatment options for cervicogenic headaches, with a special emphasis on the efficacy of novel neuromodulation techniques and identifying their strength and limitations in treating cervicogenic headaches.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"4 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael S Bodnar, Sierra Barber, Heather S L Jim, Jeffery Huang
{"title":"The role of ketamine and its enantiomer in managing depression and pain in cancer patients: A narrative review.","authors":"Michael S Bodnar, Sierra Barber, Heather S L Jim, Jeffery Huang","doi":"10.1016/j.jatmed.2024.10.005","DOIUrl":"10.1016/j.jatmed.2024.10.005","url":null,"abstract":"<p><p>Depression and pain are common comorbidities in cancer patients, and ketamine, a dissociative anesthetic, has shown potential in managing both. This review summarizes current literature on ketamine and its enantiomer, esketamine, in managing depression and pain in the oncologic population. Studies indicate that sub-anesthetic doses of intravenous ketamine and esketamine can alleviate postoperative depressive symptoms in cancer patients with a tolerable safety profile. Research into non-intravenous routes for depression management in the oncologic population remains limited. Ketamine has also proven effective in managing acute postoperative pain, particularly through intravenous administration. While alternative administration routes, such as local infiltration and intramuscular methods, show mixed results, they may provide viable options for patients averse to intravenous (IV). However, the effectiveness of ketamine for chronic cancer pain remains inconsistent. Overall, ketamine offers a promising approach for managing depression and pain in oncologic patients.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"3 4","pages":"155-165"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenjia Zhang, Xu Zhao, Piplu Bhuiyan, Henry Liu, Huafeng Wei
{"title":"Neuroprotective effects of dantrolene in neurodegenerative disease: Role of inhibition of pathological inflammation.","authors":"Wenjia Zhang, Xu Zhao, Piplu Bhuiyan, Henry Liu, Huafeng Wei","doi":"10.1016/j.jatmed.2024.04.002","DOIUrl":"10.1016/j.jatmed.2024.04.002","url":null,"abstract":"<p><p>Neurodegenerative diseases (NDs) refer to a group of diseases in which slow, continuous cell death is the main pathogenic event in the nervous system. Most NDs are characterized by cognitive dysfunction or progressive motor dysfunction. Treatments of NDs mainly target alleviating symptoms, and most NDs do not have disease-modifying drugs. The pathogenesis of NDs involves inflammation and apoptosis mediated by mitochondrial dysfunction. Dantrolene, approved by the US Food and Drug Administration, acts as a RyRs antagonist for the treatment of malignant hyperthermia, spasticity, neuroleptic syndrome, ecstasy intoxication and exertional heat stroke with tolerable side effects. Recently, dantrolene has also shown therapeutic effects in some NDs. Its neuroprotective mechanisms include the reduction of excitotoxicity, apoptosis and neuroinflammation. In summary, dantrolene can be considered as a potential therapeutic candidate for NDs.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"3 2","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141201570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}