Journal of anesthesia and translational medicine最新文献

{"title":"Tips and pearls for peripherals nerve blocks for foot surgery: A pictorial essay.","authors":"Laura Girón-Arango, Carlos Andrés Guzmán-Hernández, Philip Peng","doi":"10.1016/j.jatmed.2026.07.003","DOIUrl":"10.1016/j.jatmed.2026.07.003","url":null,"abstract":"<p><p>Ultrasound-guided regional anesthesia of the ankle and distal lower extremity is widely used for surgical anesthesia and postoperative analgesia. Success depends on a detailed understanding of nerve anatomy, anatomical variations, and sonoanatomy at clinically relevant levels. This pictorial essay reviews the relevant anatomy, sonoanatomy, and block-specific considerations of the sciatic nerve and its distal branches-including the tibial, common peroneal, sural, and saphenous nerves-with an emphasis on tips and pearls for ultrasound-guided regional anesthesia.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 3","pages":"186-195"},"PeriodicalIF":0.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on the application of nonsteroidal anti-inflammatory drugs for perioperative analgesia.","authors":"Shuai Zhao, Yingying Zhao, Min Xie, Yanhong Liu, Cen Cheng, Qian Lei, Bing Zhang, Xuemin Song, Xuesheng Liu, Foquan Luo, Fuhai Ji, Zhongyuan Xia, Jianjun Yang, Xiangdong Chen","doi":"10.1016/j.jatmed.2026.07.004","DOIUrl":"10.1016/j.jatmed.2026.07.004","url":null,"abstract":"<p><p>Although nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used in multimodal pain management under the concept of enhanced recovery after surgery (ERAS), adverse reactions and safety events caused by their unreasonable use have become increasingly prominent. Drawing on the latest literature and evidence-based medicine domestically and abroad, and based on the research and practice frontiers of domestic perioperative analgesia, this working group has reached a consensus on several key domain-including the application regimens of NSAIDs for perioperative analgesia, drug interactions, and precautions as well as prevention strategies in special populations-yielding 12 definitive recommendations. This consensus aims to provide guidance for the standardized selection and application of NSAIDs for perioperative analgesia, and to further promote the rational, safe, and effective use of NSAIDs.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 3","pages":"179-185"},"PeriodicalIF":0.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative blood pressure strategies and neurocognitive outcomes: A systematic review.","authors":"Paula Henríquez Miranda, Daniela Peña Pérez, Juan Pablo Maestre Aguancha, Mariela Alejandra Cabas Ramos, Juan Sebastián Cuellar Cadena, Francisco Javier Gómez Ballesta, Juan Pablo Alzate Granados","doi":"10.1016/j.jatmed.2026.06.002","DOIUrl":"10.1016/j.jatmed.2026.06.002","url":null,"abstract":"<p><strong>Background: </strong>Intraoperative blood pressure instability during anesthesia may compromise cerebral perfusion and has been associated with postoperative delirium and perioperative neurocognitive disorders. However, randomized evidence remains heterogeneous regarding whether targeted intraoperative blood pressure management strategies reduce postoperative neurocognitive complications compared with standard care.</p><p><strong>Methods: </strong>We conducted a systematic review of randomized controlled trials evaluating intraoperative blood pressure, perfusion-related, ventilatory, or anesthetic strategies in adult surgical patients. The review was registered in PROSPERO and reported according to PRISMA 2020. Searches were performed in PubMed, EMBASE, and LILACS, with no language or publication-status restrictions. Study selection, data extraction, and risk-of-bias assessment were performed independently by two reviewers. Risk of bias was evaluated using the Cochrane Risk of Bias 2 tool. Because of clinical and methodological heterogeneity in interventions, populations, neurocognitive definitions, and follow-up timing, findings were synthesized narratively without meta-analysis.</p><p><strong>Results: </strong>Thirteen randomized controlled trials were included. Protocolized interventions, including prophylactic vasopressor infusion, individualized blood pressure targets, ventilatory adjustment, and regional or combined anesthetic techniques, were generally associated with improved hemodynamic stability and selected early perioperative benefits. Individualized blood pressure management reduced altered consciousness from 15.9% to 5.4% in one trial, while prophylactic norepinephrine reduced intraoperative hypotension from 74% to 15% in another. High normocapnia markedly reduced cerebral desaturation events from 55.6% to 8.8%. Trials evaluating sedative or anesthetic regimens, including esketamine, remimazolam, dexmedetomidine, desflurane, sevoflurane, and propofol-based strategies, suggested possible benefits on hemodynamic stability, analgesic requirements, and early recovery markers. However, evidence for sustained reduction in postoperative delirium or long-term perioperative neurocognitive disorders remained limited and inconsistent.</p><p><strong>Conclusions: </strong>Protocolized intraoperative blood pressure and perfusion-related strategies may improve hemodynamic stability and reduce selected early perioperative complications. Nevertheless, current randomized evidence is insufficient to conclude that these strategies consistently prevent postoperative delirium or long-term perioperative neurocognitive disorders. Future trials should use standardized neurocognitive definitions, validated delirium instruments, longer follow-up, and complete reporting of absolute event rates and effect estimates.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 2","pages":"124-133"},"PeriodicalIF":0.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of functional disability in older surgical patients with and without probable cognitive impairment: A longitudinal prospective cohort study.","authors":"Ellene Yan, Yasmin Alhamdah, Nina Butris, Paras Kapoor, Leif Erik Lovblom, Jean Wong, David F Tang-Wai, Linda Mah, Shabbir Mh Alibhai, Maria Carmela Tartaglia, David He, Frances Chung","doi":"10.1016/j.jatmed.2026.06.001","DOIUrl":"10.1016/j.jatmed.2026.06.001","url":null,"abstract":"<p><strong>Background: </strong>Understanding the recovery trajectory of functional disability in older adults with cognitive impairment can enhance perioperative care through early identification of at-risk patients, risk stratification, and proactive post-discharge planning. This multicenter longitudinal study compared the prevalence and trajectory of functional disability preoperatively and at 30, 90, and 180 days postoperatively between 307 older non-cardiac surgical participants with and without probable cognitive impairment, and examined their incidence of adverse postoperative outcomes.</p><p><strong>Methods: </strong>Online and telephone assessments were administered to assess cognition and functional disability. Cognition was assessed using the Ascertain Dementia Eight-item Questionnaire (AD8), with a preoperative score ≥2 classifying probable cognitive impairment. Functional disability was self-reported preoperatively and at 30, 90, and 180 days postoperatively using the 12-item World Health Organization Disability Assessment Schedule 2.0, with scores ≥ 16% indicating functional disability exceeding a patient-acceptable symptom state.</p><p><strong>Results: </strong>Of 307 participants, 17% screened positive for probable cognitive impairment using the AD8 preoperatively. Participants with probable cognitive impairment had a significantly higher perioperative prevalence of functional disability than those without. Nevertheless, probable cognitive impairment did not modify the recovery pattern of functional disability. Additionally, probable cognitive impairment was associated with greater postoperative delirium (OR: 7.37 [95% CI 2.25, 25.97], <i>P</i> = 0.001) and 180-day emergency department visits (OR: 5.05 [95% CI 1.34, 18.92], <i>P</i> = 0.014) after age adjustment.</p><p><strong>Conclusions: </strong>A positive AD8 screen was associated with greater perioperative functional disability and adverse clinical outcomes. Despite this heightened risk, we did not find evidence that probable cognitive impairment modified the recovery trajectory of functional disability. Our exploratory study suggests that the AD8 may be useful in guiding patient-centered preoperative discussions and identifying patients with probable cognitive impairment who may warrant closer perioperative monitoring.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 2","pages":"115-123"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148348329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstructive fibrinous tracheal pseudomembrane complicated with bronchial mucus plug: A rare post-intubation complication case report.","authors":"Kairui Shi, Hong Yu, Jiangfeng Shen, Yumin Xu, Zheng Gu, Lin Jiang, Chun Yang","doi":"10.1016/j.jatmed.2026.04.001","DOIUrl":"10.1016/j.jatmed.2026.04.001","url":null,"abstract":"<p><strong>Background: </strong>Obstructive fibrinous tracheal pseudomembrane (OFTP) is a rare complication associated with endotracheal intubation. Elderly patients constitute a high-risk population for bronchial mucus plugging and sputum retention, either of which can lead to tracheal narrowing or even complete obstruction.</p><p><strong>Case presentation: </strong>We present the case of an 80-year-old female who developed chest tightness and dyspnea two days after extubation following a video-assisted thoracoscopic left upper lobectomy. After transfer to the intensive care unit, bronchoscopy was performed, revealing subglottic pseudomembrane-like material. Several pieces of irregular gray-white tissue were removed from the trachea using biopsy forceps to clear the foreign body. The patient was discharged one week later and was followed up in the outpatient clinic after two weeks, with no recurrence of subglottic pseudomembrane observed.</p><p><strong>Conclusions: </strong>OFTP is a rare cause of fatal airway obstruction following extubation and is often difficult to identify immediately. Mucus plugs frequently occur in elderly patients and can be directly visualized via bronchoscopy. Both conditions can be treated effectively through bronchoscopic removal.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 2","pages":"61-65"},"PeriodicalIF":0.0,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A web-based two-stage prediction model for postoperative pulmonary complications using preoperative and intraoperative data.","authors":"Anran Dai, Hao Liu, Yuqi Dai, Po Shen, Jian Chen, Jiayong Zhang, Chen Chen, Yuping Hu, Yanna Si, Jianjun Zou","doi":"10.1016/j.jatmed.2026.03.009","DOIUrl":"10.1016/j.jatmed.2026.03.009","url":null,"abstract":"<p><strong>Background: </strong>Most existing models for predicting postoperative pulmonary complications (PPCs) rely solely on preoperative variables and lack integration of intraoperative data or clinical tools for application.</p><p><strong>Methods: </strong>This study developed and externally validated logistic regression and machine learning (ML) models for predicting PPCs in non-cardiothoracic surgical patients undergoing general anesthesia. A cohort of 997 patients was randomly divided into training and test sets in a 7:3 ratio. The stepwise regression method was adopted to conduct feature screening on the preoperative dataset and the combined preoperative and intraoperative dataset, and a variety of ML algorithm models were developed. Model performance was evaluated using area under the receiver operating characteristic (AUROC), area under the precision-recall curve (AUPRC), brier score, sensitivity, specificity, precision, and F1-score. External validation was performed on an independent cohort of 286 patients from a different institution. The features of the optimized model were interpreted by introducing SHapley Additive exPlanations (SHAP) method.</p><p><strong>Results: </strong>The AUROC value of the logistic regression model using only preoperative variables in the test set was 0.828. After including intraoperative variables, the CatBoost model demonstrated superior performance, with an AUROC value of 0.927. In the preoperative model, C-reactive protein (CRP), American Society of Anesthesiologists (ASA) physical status classification, age, and smoking status were the most significant predictors. However, operative duration, CRP, age, and intraoperative blood loss were the dominant predictors of postoperative outcomes. External validation confirmed general applicability, with preoperative logistic regression and the Assess Respiratory Risk in Surgical Patients in Catalonia Tool (ARISCAT) yielding AUROC values of 0.827 and 0.796, respectively. The postoperative CatBoost model achieved an AUROC of 0.865, AUPRC of 0.809, sensitivity of 0.787, specificity of 0.921, and the lowest Brier score (0.132).</p><p><strong>Conclusions: </strong>The preoperative model enabled early risk stratification, while the postoperative model provided improved accuracy. A publicly accessible web-based calculator was developed to support clinical implementation and facilitate prospective validation.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 2","pages":"104-114"},"PeriodicalIF":0.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13254958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application value of frailty assessment tools in the perioperative period: A narrative review.","authors":"Haozhou Shen, Manling Ju, Xinyue Wu, Shanshan Shi, Jie Sun, Mi Tian","doi":"10.1016/j.jatmed.2026.04.002","DOIUrl":"10.1016/j.jatmed.2026.04.002","url":null,"abstract":"<p><p>Frailty is a clinical syndrome characterized by reduced physiological reserves and multisystem dysfunction, which markedly elevates the risk of postoperative complications and delayed functional recovery, and increases mortality. Amid the rapidly aging global population, the proportion of surgical patients with frailty is steadily increasing, presenting substantial challenges for perioperative management. Conventional preoperative assessment tools have significant limitations in identifying frailty and predicting surgical outcomes, while the clinical utility of emerging assessment methods requires further systematic evaluation. This review provides a comprehensive overview of preoperative frailty assessment tools. It critically examines recent advances from 2019 to 2025 and incorporates seminal foundational studies that established core concepts and validated key early instruments. The analysis evaluates their comparative efficacy, clinical utility in perioperative care, and existing limitations, aiming to offer scholars and clinicians a balanced and insightful perspective rather than an exhaustive summary of all available evidence.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 2","pages":"90-103"},"PeriodicalIF":0.0,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13234458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of cognitive impairment in older medical inpatients: A systematic review and meta-analysis.","authors":"Azasma Tanvir, Minji Jinny Kim, Glen Katsnelson, Felix Hu, Ellene Yan, Aparna Saripella, Marina Englesakis, Frances Chung","doi":"10.1016/j.jatmed.2026.03.008","DOIUrl":"10.1016/j.jatmed.2026.03.008","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment is common among older adults and is associated with adverse outcomes such as prolonged hospital stays and increased mortality. Many of the medical inpatients subsequently undergo surgical procedures, where cognitive impairment is known to influence perioperative risk, anesthetic management, and postoperative outcomes. No meta-analysis has comprehensively synthesized global data specific to cognitive impairment among medically hospitalized patients. We aimed to determine the global prevalence of cognitive impairment in older medical inpatients and explore variations by assessment method and region.</p><p><strong>Methods: </strong>We searched MEDLINE (Ovid), Embase, Cochrane Central, Cochrane Database of Systematic Reviews, and PsycINFO for relevant articles. We included patients ≥ 60 years old admitted to hospitals and studies examining prevalence of cognitive impairment. Excluded were elective surgical patients and non-hospital settings. Cognition was assessed by validated cognitive assessment tools, diagnostic instruments, or prior diagnosis. The primary outcome was the pooled prevalence of cognitive impairment in older patients admitted to hospitals. Subgroup analyses were conducted based on cognitive assessment tools, geographic regions, study type, and sample size.</p><p><strong>Results: </strong>Fifty-six studies (n = 62,853) were included. Mean age was 79.8 ± 7.7 years with 56% female. Meta-analysis revealed substantial variability across studies, with pooled prevalence estimates demonstrating high heterogeneity. The prevalence of newly suspected cognitive impairment/dementia using the Diagnostic and Statistical Manual of Mental Disorders and/or validated screening tools was 38% (95% CI: 33%-42%). The prevalence of pre-diagnosed cognitive impairment/dementia documented from medical records was 24% (95% CI: 19%-29%). The prevalence of dementia was higher in Western countries than Eastern countries [41% (95% CI: 32%-50%) vs 27% (95% CI: 21%-33%)].</p><p><strong>Conclusions: </strong>Cognitive impairment is prevalent among older medical inpatients. The variability in prevalence was dependent on assessment method and geographic region. Given the substantial heterogeneity and low to very low certainty of the evidence available, these prevalence estimates should be interpreted with caution.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 2","pages":"77-89"},"PeriodicalIF":0.0,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13213872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148059355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative neurophysiological monitoring (IONM) in neurosurgery: A critical appraisal of established practices, ongoing controversies, and future trajectories.","authors":"Yu'e Sun, Fei Xu, Nazneen Sudhan, Fuhai Ji, Ke Peng, Xiaqing Ma","doi":"10.1016/j.jatmed.2026.03.007","DOIUrl":"10.1016/j.jatmed.2026.03.007","url":null,"abstract":"<p><p>Intraoperative neurophysiological monitoring (IONM) has evolved from a novel technique into an evidence-based standard treatment method for high-risk neurosurgical and spinal surgeries. Its effectiveness is based on two interrelated pillars: optimized multimodal monitoring, mainly including motor and somatosensory evoked potentials (MEPs/SSEPs) as well as electromyography (EMG), and total intravenous anesthesia (TIVA) combined with a precise neuromuscular blockade-based anesthesia protocol. IONM significantly reduces neurological function damage during surgeries for spinal deformities, intramedullary tumors, acoustic neuromas, and gliomas in the brain functional area, redefining the standards of safe surgical practice. However, there are still certain challenges, including the difficulty in converting signal changes into clinical actions, controlling high false alarm rates, and overcoming technical/logistical obstacles in complex and lengthy surgeries. These objectively existing problems further highlight the importance of clinical judgment. Looking to the future, a key developmental direction involves transforming intraoperative neurophysiological monitoring (IONM) from a passive monitoring tool into a system capable of predictive guidance and comprehensive neuroprotection. Emerging models include artificial intelligence (AI) technologies for real-time analysis and technologies for fusing multimodal data into surgical \"dashboards\", but they still face significant obstacles in data quality, clinical validation, and human-centered design. Closed-loop systems and the application of neurobiomarker recognition to achieve neuroprotection remain enduring research topics. In summary, the development of IONM technology towards a more mature direction requires a coordinated planning scheme: establishing evidence-based standards, promoting data-driven discoveries through large-scale collaborative research, and achieving deep multidisciplinary integration within the surgical team. The ultimate goal is to make IONM an intelligent guiding tool that not only monitors but also actively optimizes surgical strategies to ensure the preservation of neural function.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 2","pages":"66-76"},"PeriodicalIF":0.0,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of the RGS12-GPX4-ACSL4 signaling axis in regulating ferroptosis during myocardial ischemia-reperfusion injury.","authors":"Congna Zi, Zhiwei Zhang, Tao Zhang","doi":"10.1016/j.jatmed.2026.03.003","DOIUrl":"10.1016/j.jatmed.2026.03.003","url":null,"abstract":"<p><p>Acute myocardial infarction (AMI) is one of the leading causes of death worldwide. Timely reperfusion therapy following AMI can effectively salvage ischemic cardiomyocytes. However, myocardial ischemia-reperfusion injury (MIRI), which inevitably occurs during the process of blood supply recovery, may affect the therapeutic outcome. During MIRI, various forms of cell death, such as apoptosis, autophagy and pyroptosis, are involved. Ferroptosis is a recently discovered form of programmed cell death. Studies have shown that ferroptosis is closely related to the progression of MIRI. In the regulation of ferroptosis, GPX4 inhibits ferroptosis by clearing lipid peroxides, whereas ACSL4 promotes lipid peroxidation and drives ferroptosis. In addition to known regulatory factors, recent studies have found that Regulator of RGS12, a key protein in the RGS family, plays an important role in ischemia-reperfusion injury. The deletion of Regulator of RGS12 significantly reduces the incidence of ferroptosis in cardiomyocytes, whereas its overexpression exacerbates ferroptosis. This phenomenon may be related to the regulation of iron metabolism-related signaling pathways by RGS12. This review aims to summarize the molecular mechanisms by which RGS12 influences the progression of ferroptosis through regulating GPX4 and ACSL4 expression, thereby contributing to MIRI.</p>","PeriodicalId":519929,"journal":{"name":"Journal of anesthesia and translational medicine","volume":"5 1","pages":"5-13"},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}