EJNMMI reports最新文献

{"title":"A case of Mazabraud's syndrome identified by FDG PET/CT.","authors":"Jie Liu, Xin Li, Jinping Fang, Hu Cai, Heqing Yi","doi":"10.1186/s41824-026-00312-9","DOIUrl":"10.1186/s41824-026-00312-9","url":null,"abstract":"<p><p>We present a case of 46-year-old man who underwent surgery for a right thigh myxoma 20 years ago. Due to a discovery of cervical metastatic squamous cell carcinoma of unknown primary(CMSCCUP), a ¹⁸F-FDG-PET/CT examination was taken and it revealed the recurrence of the right thigh intramuscular myxomas and multiple fibrous dysplasia in the right lower extremity bones, ultimately leading to the diagnosis of Mazabraud's syndrome. Due to its whole-body imaging capability, PET/CT can simultaneously detect the characteristic combination of fibrous dysplasia and intramuscular myxoma in Mazabraud's syndrome and effectively rule out malignant possibilities. It serves as an important imaging modality for the diagnosis of this syndrome.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual radiopharmaceutical activity in venous access devices during PET and SPECT imaging: a real-world clinical observational cohort study.","authors":"Rasmus Solem, Nourhan Al-Amiri, Ida Skarping","doi":"10.1186/s41824-026-00317-4","DOIUrl":"10.1186/s41824-026-00317-4","url":null,"abstract":"<p><strong>Background: </strong>In routine practice, radiopharmaceuticals are administered via a newly placed peripheral intravenous catheter (PIVC). However, many patients referred for nuclear medicine imaging already have a semipermanent venous access device in place, such as a central venous catheter, peripherally inserted central catheter, or subcutaneous implantable venous port. Evidence regarding residual radiopharmaceutical activity within preexisting devices-and its potential consequences for SPECT/PET image quality, diagnostic interpretation, and radiation safety-remains limited. This study aimed to quantify device-related residual radiopharmaceutical activity across commonly used access types and to assess any associated clinical impact during image review.</p><p><strong>Results: </strong>In this observational cohort study at Skåne University Hospital, Sweden, 167 patient administrations during SPECT or PET imaging between June 2023 and January 2026 were included (40% aged < 18 years). Residual activity was evaluated using ROI/VOI based quantification at the venous access site on reconstructed or planar images. Measurements were performed in an activity meter using PIVCs that had been removed from patients prior to imaging. In an experimental setting, representative venous access devices were flushed under controlled conditions to determine residual activity fraction. Residual activity was expressed both as absolute activity (MBq) and as the percentage of the administered activity. Across 214 measurements including 13 radiopharmaceuticals, residual activity was generally low: only 3.3% of the measurements (7/214) exceeded 5% of the administered activity. The highest absolute residual activity was 31 MBq ([^99mTc]pertechnetate, PIVC), and the highest proportional residual activity was 17.3% ([^99mTc]Tc-MAA, Midline). On clinical image review, no instance of device related residual activity was associated with impaired interpretation or reduced diagnostic confidence.</p><p><strong>Conclusions: </strong>In this real-world cohort, residual radiopharmaceutical activity within preexisting venous access devices was generally low and showed no discernible impact on visual clinical SPECT or PET interpretation. Prospective studies including a broader range of tracers, access devices, and quantitative endpoints are needed to more fully characterize the clinical implications of residual activity.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumour SUVmean and volume relates to its radiation absorbed dose.","authors":"Yung Hsiang Kao","doi":"10.1186/s41824-026-00319-2","DOIUrl":"10.1186/s41824-026-00319-2","url":null,"abstract":"","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13500436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT-less attenuation correction in a patient with BMI of 77.","authors":"Twyla Bartel, Mickalia Johnston, Tracy Yarbrough, Kelly Harris, LaTaaron White, Stephen Lokitz","doi":"10.1186/s41824-026-00314-7","DOIUrl":"10.1186/s41824-026-00314-7","url":null,"abstract":"","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated brainstem death: case presentation demonstrating preserved supratentorial perfusion on ^99mTc-bicisate brain scintigraphy.","authors":"Ghazal Shadmani, Amin Haghighat Jahromi","doi":"10.1186/s41824-026-00283-x","DOIUrl":"https://doi.org/10.1186/s41824-026-00283-x","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis of brain death (BD) is primarily clinical and usually straightforward when both supratentorial and infratentorial structures are irreversibly injured. In contrast, isolated catastrophic posterior fossa lesions-particularly those involving the brainstem-are uncommon and may demonstrate preserved supratentorial perfusion or cortical electrical activity on ancillary testing, even in the absence of brainstem function. This apparent dissociation is typically transient and invariably progresses to global cerebral circulatory arrest and death. Few reports have documented the natural evolution of this phenomenon, highlighting the rarity of such cases and their uniformly poor outcome.</p><p><strong>Case presentation: </strong>A 47-year-old woman with no known history of chronic seizure disorder presented in an obtunded state. On arrival, she experienced continuous seizures and the clinical status rapidly deteriorated. Initial head CT scan without contrast revealed basilar artery thrombosis. She received intravenous tissue plasminogen activator (tPA) and levetiracetam. She underwent mechanical thrombectomy with partial recanalization (TICI 2b). Despite intervention, neurologic examination remained poor with absent spontaneous respiration and brain stem reflexes. Subsequent non contrast head CT scan demonstrated worsening brain stem edema and obstructive hydrocephalus. Due to poor clinical status, a ^99mTc-bicisate brain perfusion scan was performed which demonstrated absent posterior fossa perfusion with preserved supratentorial tracer uptake. Due to this preserved supratentorial perfusion, life support was continued. Follow-up head CT scan without contrast revealed progression to diffuse cerebral edema, and massive trans tentorial and tonsillar herniation. The patient was later clinically declared brain dead. Organ donation followed in accordance with her previously expressed wishes.</p><p><strong>Conclusions: </strong>This is a rare case of isolated posterior fossa injury with preserved supratentorial perfusion compatible with \"brainstem death\". The case highlights the importance of ancillary testing in uncommon supra/infra tentorial dissociation to differentiate brain death from brainstem death.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise localization of phosphaturic mesenchymal tumor causing tumor-induced osteomalacia: the value of dual-tracer imaging with ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT.","authors":"Ting Ye, Xin Wen, Ruimin Wang","doi":"10.1186/s41824-026-00299-3","DOIUrl":"10.1186/s41824-026-00299-3","url":null,"abstract":"<p><p>Phosphaturic mesenchymal tumor (PMT) is a rare cause of tumor-induced osteomalacia (TIO), often presenting with nonspecific symptoms and small tumor size, leading to diagnostic challenges. We report a case of a 25-year-old male with progressive generalized bone pain, hypophosphatemia, and elevated alkaline phosphatase, initially misdiagnosed as spondyloarthritis and osteoporosis. Whole-body bone scintigraphy suggested metabolic bone disease. ¹⁸F-FDG PET/CT revealed a destructive lesion in the mandible with moderate uptake, whereas ⁶⁸Ga-DOTATATE PET/CT showed high somatostatin receptor expression, accurately localizing the PMT. Serum phosphate levels normalized rapidly after surgical resection. This case highlights the superior diagnostic value of ⁶⁸Ga-DOTATATE PET/CT over ¹⁸F-FDG PET/CT in localizing PMT, facilitating targeted treatment and avoiding prolonged morbidity.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13454022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148703310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal shifts in diagnostic testing for cardiac amyloidosis across U.S. health systems.","authors":"Issam Motairek, Bryan Abadie, Andrew Higgins, Zain N Jawad, Pavan Bhat, Andres Carmona Rubio, Mazen Hanna, Wael A Jaber","doi":"10.1186/s41824-026-00316-5","DOIUrl":"10.1186/s41824-026-00316-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate temporal trends in diagnostic testing for cardiac transthyretin amyloidosis (ATTR-CM) across U.S. health systems in the contemporary era.</p><p><strong>Methods: </strong>We conducted a retrospective, descriptive analysis using the TriNetX U.S. Collaborative Network, identifying patients diagnosed with wild-type or hereditary ATTR-CM between January 2017 and November 2025. ATTR-specific ICD-10 codes were combined with evidence of cardiac involvement, and patients with light-chain amyloidosis or plasma cell dyscrasias were excluded. Diagnostic testing, including technetium-99m (Tc-99m) bone scintigraphy, cardiac magnetic resonance imaging (CMR), and biopsy, was assessed within an extended diagnostic ascertainment window spanning 24 months before and 12 months after diagnosis.</p><p><strong>Results: </strong>The number of patients diagnosed with ATTR-CM increased markedly over time. Use of Tc-99m scintigraphy and CMR rose substantially in absolute terms, while biopsy utilization declined steadily. Dual-modality imaging increased modestly, and invasive histologic confirmation became progressively less common, indicating a shift toward imaging-based diagnosis.</p><p><strong>Conclusion: </strong>Between 2017 and 2025, diagnostic evaluation of ATTR-CM shifted decisively toward noninvasive imaging, with declining reliance on biopsy. Although imaging volume increased, proportional adoption did not keep pace with expanding case identification, underscoring the need for broader implementation of guideline-recommended diagnostic pathways.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic splenosis: a great mimic diagnosed by functional imaging.","authors":"Tatiana Lopez Sandoval, Sebastian Peláez Arroyave, Juan Carlos Ramirez Yepes, Tatiana Cadavid, Carlos Caicedo Zamudio","doi":"10.1186/s41824-026-00308-5","DOIUrl":"10.1186/s41824-026-00308-5","url":null,"abstract":"<p><p>Splenosis is defined as the heterotopic implantation of functional splenic tissue in extra-splenic compartments, usually secondary to traumatic or iatrogenic splenic rupture (1). Although it is most commonly found in the abdominal and pelvic cavities, implants have been reported in less common sites such as the thorax, liver, and subcutaneous tissue. Thoracic splenosis represents a diagnostic challenge, as it is usually an incidental finding, rarely symptomatic, and, from an imaging standpoint, can mimic malignant entities such as primary neoplasms or metastatic disease. We present two cases of splenosis diagnosed using nuclear medicine techniques, including the case of a 65-year-old woman with a history of gunshot wound, who required laparotomy, splenectomy, and left nephrectomy, in whom benign pleural and abdominal lesions were identified. Initial metabolic characterization using PET/CT and subsequent confirmation with 99mTc-HDRBC (Heat-Damaged Red Blood Cells) scintigraphy allowed us to establish the definitive diagnosis, avoiding unnecessary invasive procedures. Additionally, we describe a 58-year-old male with a history of blunt chest trauma and prostate cancer, in whom 18F-PSMA PET/CT suggested malignancy, but 99mTc-HDRBC scintigraphy confirmed multi-compartmental splenosis. This report highlights the importance of considering splenosis in the differential diagnosis of thoracic and abdominal nodular lesions in patients with a history of splenic trauma, as well as the value of functional imaging techniques in its accurate identification.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13402273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and representative experience after amyloid PET/CT in a real-world memory clinic: a mixed-methods observational study.","authors":"Giulia Richina, Nathalie Testart Dardel, Paolo Salvioni, Gilles Allali, John O Prior, Mario Jreige","doi":"10.1186/s41824-026-00310-x","DOIUrl":"10.1186/s41824-026-00310-x","url":null,"abstract":"<p><strong>Background: </strong>Amyloid PET/CT is increasingly used in the diagnostic evaluation of cognitive disorders; however, its real-world impact on patient and caregiver experiences remains insufficiently characterised. This study examined how amyloid PET results influence perceived diagnosis, emotional responses, behavioural adaptations, and daily life organisation.</p><p><strong>Methods: </strong>We conducted a retrospective-prospective monocentric mixed-methods study integrating clinical data from the CLEMENS registry, routine amyloid PET interpretations, and a structured telephone survey that included open-ended questions. Adults who underwent amyloid PET between 2015 and 2024 were contacted, and therapeutic representatives were interviewed when patients were unable to participate. Quantitative outcomes were compared between PET-positive and PET-negative individuals using Fisher's exact and nonparametric tests. Qualitative responses were analysed thematically and integrated with quantitative findings.</p><p><strong>Results: </strong>Twenty-one individuals completed the survey (12 PET-positive and 9 PET-negative individuals). PET-positive individuals were slightly older (72.4 vs. 68.9 years) and had lower MoCA scores (19.4 vs. 22.2) than PET-negative individuals. They exhibited major neurocognitive disorders (5/12 vs. 1/9) and behavioural adaptations (73% vs. 33%) more frequently. Emotional responses differed markedly by PET status: depressive mood (64% vs. 12.5%; p = 0.059) and shock/distress (42% vs. 22%) were more frequent among PET-positive individuals, whereas relief was more common among PET-negative individuals (50% vs. 18%). Qualitative themes indicated that PET-positive results were perceived as turning points associated with loss of autonomy and future uncertainty, while PET-negative results commonly provided reassurance and stability.</p><p><strong>Conclusion: </strong>Amyloid PET/CT influences not only diagnostic understanding but also the emotional, behavioural, and practical experiences of patients and representatives. PET-positive results are associated with a greater psychosocial burden, whereas PET-negative results provide reassurance. As amyloid PET becomes central to diagnostic and therapeutic pathways, patient-centred communication and supportive counselling will be essential.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13381417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative bone SPECT/CT-derived tumor burden as a prognostic biomarker in metastatic castration-resistant prostate cancer treated with Ra-223.","authors":"Yoshimitsu Fukushima, Go Kimura, Jun Akatsuka, Yoshimitsu Honda, Yujiro Nakaoka, Hiromitsu Hayashi, Shinichiro Kumita","doi":"10.1186/s41824-026-00309-4","DOIUrl":"10.1186/s41824-026-00309-4","url":null,"abstract":"<p><strong>Purpose: </strong>Metastatic castration-resistant prostate cancer (mCRPC) is bone-predominant, requiring objective imaging biomarkers to guide Ra-223 therapy. We evaluated overall metabolic bone volume (OMBV) and overall total bone uptake (OTBU) from bone SPECT/CT as prognostic markers in mCRPC patients treated with Ra-223.</p><p><strong>Methods: </strong>Thirty mCRPC patients underwent pre-treatment planar and SPECT/CT bone scintigraphy, with OMBV and OTBU derived using GI-BONE software. Overall survival (OS) was the primary endpoint; progression-free survival (PFS) and time to symptomatic skeletal event (TTSE) were secondary. Receiver operating characteristic analysis (Youden index) defined cut-offs for OS and TTSE independently. Treatment response was classified by composite changes in OMBV, OTBU, and bone scan index. OS, OMBV, and OTBU were analyzed by univariate Cox regression as continuous and dichotomized variables.</p><p><strong>Results: </strong>Baseline skeletal burden was substantial (median OMBV 1,191.21 cm³ [IQR 93.80-1,948.01]; median OTBU 9,746.18 [1,280.01- 17,587.11]); 87% had extent of disease grade 3-4. Post-treatment imaging in 24 patients yielded 10 responders (42%) and 14 non-responders (58%), with responder mean OMBV and OTBU reductions of 57% and 68%. Dichotomized baseline OMBV (hazard ratio [HR] 6.0320, 95% confidence interval [CI] 1.6880-21.5546; p < 0.001) and OTBU (HR 9.4492, 95% CI 2.0968-42.5826; p < 0.001) were significant predictors of OS. OMBV and OTBU were not significantly associated with PFS or TTSE.</p><p><strong>Conclusions: </strong>OMBV and OTBU from bone SPECT/CT may provide useful prognostic information in mCRPC patients undergoing Ra-223 therapy, offering objective quantification of skeletal tumor burden using widely available technology. Further validation in larger cohorts is warranted.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13357462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}