Gut microbes reports最新文献_第7页

Probiotic supplementation improves well-being and anxiety in healthy women: An exploratory, randomized, double-blind, placebo-controlled study. 益生菌补充剂改善健康女性的幸福感和焦虑：一项探索性、随机、双盲、安慰剂对照研究。

Gut microbes reports Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2543125

Daryn R Michael, Niall Coates, Joshua Kerry-Smith, Daniel A John, Eleri Hulme, Lauren Owen, Sue F Plummer

{"title":"Probiotic supplementation improves well-being and anxiety in healthy women: An exploratory, randomized, double-blind, placebo-controlled study.","authors":"Daryn R Michael, Niall Coates, Joshua Kerry-Smith, Daniel A John, Eleri Hulme, Lauren Owen, Sue F Plummer","doi":"10.1080/29933935.2025.2543125","DOIUrl":"10.1080/29933935.2025.2543125","url":null,"abstract":"The gut microbiota plays an important role in the maintenance of health and well-being throughout the life course but little is known about the impact of these changes on the balance of the microbiota and the well-being of women during their midlife transitional phase. In this exploratory, randomized, double-blind, placebo-controlled study, women (45 to 65 years old) received either a daily dose of probiotics or placebo for 4-months. Measurements of overall well-being included anxiety, depression, quality of life and sleep quality, gastrointestinal discomfort and changes to the fecal microbiota composition(ClinicalTrials.gov: NCT06507111). The women in the probiotic group showed a 40% reduction in anxiety, an 18.5% improvement in quality of life and indications of improved sleep, resulting in a significant 17.5% improvement in overall well-being compared to those in the placebo. Incidence rates of indigestion and stomach pains were reduced and Blautia sp. KLE 1732 was less abundant in the probotic group at the end of the study. Daily probiotic supplementation may support the well-being of women in their 40s - 60s.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"2 1","pages":"2543125"},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12940106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low incidence of cytolysin-positive E. faecalis and no correlation to survival in Danish patients with alcohol-associated hepatitis: A prospective cohort study. 丹麦酒精相关性肝炎患者溶细胞素阳性粪肠球菌发病率低且与生存率无相关性：一项前瞻性队列研究

Gut microbes reports Pub Date : 2025-09-03 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2549729

Frederik Cold, Julie Elm Heintz, Khaled Saoud Ali Ghathian, Poul Als Stenbøg, Lars Hestbjerg Hansen, Alexander Byth Carstens, Andreas Munk Petersen, Sofie Ingdam Halkjaer, Flemming Bendtsen, Henriette Ytting

{"title":"Low incidence of cytolysin-positive E. faecalis and no correlation to survival in Danish patients with alcohol-associated hepatitis: A prospective cohort study.","authors":"Frederik Cold, Julie Elm Heintz, Khaled Saoud Ali Ghathian, Poul Als Stenbøg, Lars Hestbjerg Hansen, Alexander Byth Carstens, Andreas Munk Petersen, Sofie Ingdam Halkjaer, Flemming Bendtsen, Henriette Ytting","doi":"10.1080/29933935.2025.2549729","DOIUrl":"10.1080/29933935.2025.2549729","url":null,"abstract":"Alcohol-associated hepatitis (AH) is a severe and life-threatening form of alcohol-associated liver disease with no approved treatments for reducing long-term mortality. Cytolysin-producing E. faecalis in the gut microbiota of AH patients has been reported as highly correlated to mortality. We investigated whether we could reproduce this correlation in a cohort of Danish patients with AH. Fecal samples from 28 hospitalized patients with AH were analyzed for cytolysin-producing E. faecalis and were followed for 1 y after hospital admission. The primary endpoint was comparison of 180-d mortality in AH patients with and without cytolysin-positive fecal samples. Three of twenty-eight (10.7%) fecal samples were identified as cytolysin-positive. There were no significant differences at baseline between cytolysin-positive and -negative patients in terms of age, Glasgow Alcoholic Hepatitis Score, Charlson Comorbidity Index or biochemical variables (INR, bilirubin, albumin). There was no difference in mortality between the groups 180 d after hospital admission; one of the three (33%) cytolysin-positive patients had died compared to 9 of the 25 (36%) cytolysin-negative (p-value for difference = 1.0). We report a low incidence of cytolysin-positive E. faecalis in hospitalized Danish AH patients and no greater risk of mortality compared to cytolysin-negative AH patients.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"2 1","pages":"2549729"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12940113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in gut microbiota characteristics along a type 2 diabetes risk gradient linked with family history. 肠道菌群特征的改变与家族史相关的2型糖尿病风险梯度

Gut microbes reports Pub Date : 2025-07-22 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2527766

Oscar Gitton-Quent, Mathilde Sola, Nicolas Maziers, Anne Hiol, Nicolas Dechamp, Emmanuelle Le Chatelier, Mathilde Touvier, Pilar Galan, Aymeric David, Christian Morabito, Alexandre Famechon, Benoit Quinquis, Mahendra Mariadassou, Patrick Veiga, Joel Dore, Magali Berland, Melanie Deschasaux-Tanguy

{"title":"Alterations in gut microbiota characteristics along a type 2 diabetes risk gradient linked with family history.","authors":"Oscar Gitton-Quent, Mathilde Sola, Nicolas Maziers, Anne Hiol, Nicolas Dechamp, Emmanuelle Le Chatelier, Mathilde Touvier, Pilar Galan, Aymeric David, Christian Morabito, Alexandre Famechon, Benoit Quinquis, Mahendra Mariadassou, Patrick Veiga, Joel Dore, Magali Berland, Melanie Deschasaux-Tanguy","doi":"10.1080/29933935.2025.2527766","DOIUrl":"10.1080/29933935.2025.2527766","url":null,"abstract":"Type 2 diabetes (T2D) is a major global health issue, with growing evidence linking it to gut microbiome changes. However, whether these alterations precede T2D onset and act as predictors, risk factors, or contributors remains unclear. This study analyzed the gut microbiota of 192 individuals from the French NutriNet-Santé cohort, divided into four groups: non-T2D adults with no (n = 47), one (n = 48), or two (n = 51) T2D-affected parents, and T2D-affected adults (n = 46). A progressive microbiota shift was observed in non-T2D groups based on parental history, converging toward the T2D profile. Changes included altered enterotype distribution, increased oral-associated species, disrupted ecological networks, and a shift in Gram-positive-to-negative ratios. Notably, Prevotella copri abundance increased, alongside bacteria potentially enhancing branched-chain amino acid (BCAA), lipopolysaccharide (LPS), and acetate production. Diet also influenced microbiota patterns, with sweet product intake, vitamin levels, and copper/zinc ratios playing roles. A gradual microbiome transition from non-diabetic to T2D participants underscores its association with family history-based risk. While these shifts may reflect or drive T2D progression, further studies are needed to confirm these findings and explore their potential for preventive strategies.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"2 1","pages":"2527766"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12940137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Landscape of flavonoid metabolism in human gut microbiome and its association with health and disease. 人类肠道微生物组类黄酮代谢的景观及其与健康和疾病的关系。

Gut microbes reports Pub Date : 2025-06-25 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2520788

Deepika Pateriya, Vishnu Prasoodanan P K, Joy Scaria, Vineet K Sharma

引用次数: 0

Actively expressed microbiota in mucosal biopsies of treatment-naïve ulcerative colitis patients. treatment-naïve溃疡性结肠炎患者粘膜活检中活性表达的微生物群。

Gut microbes reports Pub Date : 2025-06-05 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2512763

Line Strand Karlsholm, Rafi Ahmad, Hagar Taman, Christopher G Fenton, Ruth H Paulssen

{"title":"Actively expressed microbiota in mucosal biopsies of treatment-naïve ulcerative colitis patients.","authors":"Line Strand Karlsholm, Rafi Ahmad, Hagar Taman, Christopher G Fenton, Ruth H Paulssen","doi":"10.1080/29933935.2025.2512763","DOIUrl":"10.1080/29933935.2025.2512763","url":null,"abstract":"The gut microbiota contributes to an aberrant immune dysfunction associated with inflammatory bowel disease (IBD) and is believed to contribute to the disease development of ulcerative colitis (UC). In this study, a whole-transcriptomic data set containing mucosal tissue biopsies obtained from treatment-naïve UC patients (n = 33) and control subjects (n = 15) were utilized to determine potential differences in microbial compositions located at the site of inflammation. Transcriptomic sequences that mapped to the human genome were removed from the dataset. The remaining were mapped to their respective Operational Taxonomic Units (OTUs) resulting in an overview of the microbial composition at the genus level. Results showed an overall decrease in microbial diversity in mucosal UC patient samples. However, an increase of the opportunistic pathogens Acinetobacter and Comamonas was observed in UC samples. Comamonas is an environmental pathogen. In addition to their role in mild but persistent infections, Comamonas species may play a role in active UC. The experimental approach described here provides new insights into the UC microbiota composition directly at the site of inflammation, which could contribute to a better understanding of UC pathogenesis. The obtained results might provide an opportunity to investigate host-microbe interactions in active UC.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"2 1","pages":"2512763"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12940147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters. 补充两周的青少年双歧杆菌iVS-1可减轻乳糖消化不良患者与乳糖不耐受相关的症状。

Gut microbes reports Pub Date : 2025-06-04 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2508199

Monica Ramakrishnan, Tzu-Wen L Cross, Anna Clapp Organski, Sindusha Mysore Saiprasad, Abigayle M R Simpson, Daniel J Tancredi, Mallory J Van Haute, Chloe M Christensen, Zachery T Lewis, Thomas A Auchtung, Jens Walter, Robert Hutkins, Dennis A Savaiano

{"title":"Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters.","authors":"Monica Ramakrishnan, Tzu-Wen L Cross, Anna Clapp Organski, Sindusha Mysore Saiprasad, Abigayle M R Simpson, Daniel J Tancredi, Mallory J Van Haute, Chloe M Christensen, Zachery T Lewis, Thomas A Auchtung, Jens Walter, Robert Hutkins, Dennis A Savaiano","doi":"10.1080/29933935.2025.2508199","DOIUrl":"10.1080/29933935.2025.2508199","url":null,"abstract":"Probiotic supplements containing high β-galactosidase-producing bacteria may aid in the management of lactose intolerance. We previously isolated a strain of Bifidobacterium adolescentis, iVS-1, from the fecal sample of a human donor after consumption of galactooligosaccharides (GOS), a prebiotic derived from lactose. Therefore, it was hypothesized that iVS-1 might reduce symptoms associated with lactose maldigestion. Compared to other probiotic strains, iVS-1 had high β-galactosidase activity and reduced gas formation by fecal communities during in vitro fermentations of lactose or milk. A randomized placebo-controlled clinical trial was then conducted with 21 lactose maldigesters, randomized to receive either B. adolescentis iVS-1 (n = 11) or placebo (n = 10) daily for 2 weeks. Compared to the two-week run-in period, iVS-1 abundance was higher both at the end of the treatment period (p = 0.0005) and after the 2-week post-treatment period (p = 0.045). The iVS-1 group reported less overall daily symptoms during the treatment period when compared to placebo (p = 0.032) and had significant improvement for fecal urgency (p = 0.033) and diarrhea (p = 0.006). The metabolism of lactose, reduction of gas, and improvement of multiple gastrointestinal symptoms suggest that B. adolescentis iVS-1 may be an effective treatment for lactose intolerance. Trial Registration: The trial is registered at ClinicalTrials.gov (https://clinicaltrials.gov/study/NCT05668468).","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"2 1","pages":"2508199"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12940102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiome and lung cancer: mechanisms, interactions, and dietary interventions. 肠道微生物群与肺癌：机制、相互作用和饮食干预。

Gut microbes reports Pub Date : 2025-05-23 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2501313

Jayashri Chakraborty, Ngashepam Lanchenba Singh, Bhrigu Kumar Das

{"title":"Gut microbiome and lung cancer: mechanisms, interactions, and dietary interventions.","authors":"Jayashri Chakraborty, Ngashepam Lanchenba Singh, Bhrigu Kumar Das","doi":"10.1080/29933935.2025.2501313","DOIUrl":"10.1080/29933935.2025.2501313","url":null,"abstract":"Lung cancer continues to claim countless lives globally. Several studies have shown that the gut microbiome is vital in maintaining healthy lung function through the gut-lung axis. A comparison between the gut microflora of healthy volunteers and lung cancer patients revealed that changes in the composition of gut microflora occur in lung cancer patients. The gut microflora may contribute to lung cancer by influencing immune reactions, inflammatory pathways, bacterial metabolites modulating host metabolism, microbiome dysbiosis, genotoxicity, virulence, and bacteria-induced epigenetic alterations. Thus, it may be assumed that maintaining a healthy gut microflora could help prevent lung cancer. Nutraceuticals are specialized products designed to support health and address specific nutritional needs. They contain ingredients like vitamins, minerals, probiotics, polyphenols, and herbs to reduce the risk or impact of certain illnesses. Nutraceuticals, including probiotics and polyphenols, play a role in preventing and treating various cancers, including lung cancer, by modulating the gut microbiome. This review examines the link between the gut microbiome and lung cancer, how it contributes to cancer development, and the impact of dietary interventions - particularly probiotics, polyphenols, and dietary fibers - on lung cancer prevention and treatment.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"2 1","pages":"2501313"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12940159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

Gut microbes reports Pub Date : 2025-05-12 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2500151

引用次数: 0

Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysis. 粪便菌群移植后长期严重肠易激综合征的解决：一例报告和菌群分析。

Gut microbes reports Pub Date : 2025-04-20 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2487905

Elena Montenegro-Borbolla, Jeanine Wakim El-Khoury, Claire Bertelli, Alain Schoepfer, Benoît Guery, Tatiana Galperine

{"title":"Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysis.","authors":"Elena Montenegro-Borbolla, Jeanine Wakim El-Khoury, Claire Bertelli, Alain Schoepfer, Benoît Guery, Tatiana Galperine","doi":"10.1080/29933935.2025.2487905","DOIUrl":"10.1080/29933935.2025.2487905","url":null,"abstract":"The diagnosis and management of irritable bowel syndrome (IBS) is challenging due to its complex symptoms and inconsistent treatment responses. Given the important role of gut microbiota in gastrointestinal health, fecal microbiota transplantation (FMT) is a promising intervention. We describe the case of a 55-y-old woman without prior gastrointestinal issues who, following severe depression, developed multiple gastrointestinal symptoms, including abdominal pain, fluctuating bowel habits, and a persistent burning sensation in her mouth and upper gastrointestinal tract. At Lausanne University Hospital, she was diagnosed with IBS resistant to multiple lines of treatment and a multidisciplinary team proposed multiple oral FMTs. One-month post-FMT, her gastrointestinal symptoms significantly improved and remained better after a year, with only the burning sensation persisting. Analysis of pre- and post-FMT samples and donor material, using 16S rRNA amplicon metagenomics, revealed a 90% genus-level taxonomic overlap between the patient and the donor. The observed changes in the relative abundance of these genera, including the enrichment of beneficial gut commensals, as well as the elimination of IBS-associated genera likely supported her recovery. Overall, FMT led to substantial improvement in her long-standing gastrointestinal symptoms.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"2 1","pages":"2487905"},"PeriodicalIF":0.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12940158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study. 长双歧杆菌BB536和乳果糖的合成组合改善了与芳香乳酸相关的健康成人的存在性——一项单臂、开放标签研究

Gut microbes reports Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2490092

Riko Mishima, Ryuta Ejima, Satoshi Arai, Ayako Horigome, Eri Mitsuyama, Hiroki Kaneko, Kana Yamaguchi, Keita Kamezaki, Yuka Togashi, Kiyoshi Nakamura, Noriyuki Iwabuchi, Miyuki Tanaka, Toshitaka Odamaki, Shinji Fukuda, Yuji Naito

{"title":"Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study.","authors":"Riko Mishima, Ryuta Ejima, Satoshi Arai, Ayako Horigome, Eri Mitsuyama, Hiroki Kaneko, Kana Yamaguchi, Keita Kamezaki, Yuka Togashi, Kiyoshi Nakamura, Noriyuki Iwabuchi, Miyuki Tanaka, Toshitaka Odamaki, Shinji Fukuda, Yuji Naito","doi":"10.1080/29933935.2025.2490092","DOIUrl":"10.1080/29933935.2025.2490092","url":null,"abstract":"Gut microbiota and their metabolites are crucial for metabolic regulation, immunomodulation, and brain and mental functions via the brain-gut axis. Synbiotics offer an effective strategy for improving gut health by modulating gut microbiota, leading to improved physical and mental health. In the present study, an exploratory investigation into the effects of synbiotic yogurt on physical and mental health was conducted. Healthy adults consumed fermented milk containing Bifidobacterium longum subsp. longum BB536 (2 billion colony-forming units) and lactulose (4 g) daily for four weeks. Post-intervention, we observed an increase in bowel movement scores and improved life quality metrics, including both the WHO-HPQ absolute and relative presenteeism and the WHO-SUBI well-being score. In addition, significant increases in Bifidobacterium, butyric acid-producing bacteria, and various metabolites were observed. Furthermore, the well-being score correlated positively with Fusicatenibacter and short-chain fatty acids, whereas absolute presenteeism correlated positively with Bifidobacterium, aromatic lactic acids (ALAs), and homocysteine, and negatively with urocanic acid. Additionally, our analysis revealed that the presence of Bifidobacterium and aromatic amino acids in the gut influenced ALA production. The results indicate that synbiotic yogurt may improve bowel movement and life satisfaction, highlighting the importance of gut microbiota-derived metabolites in promoting overall well-being.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"2 1","pages":"2490092"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12940110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0