Consortium psychiatricum最新文献

{"title":"Association of Polygenic Risk Scores for Schizophrenia with Psychosis-Proneness Indicators in the General Population: A Narrative Review.","authors":"Margarita Alfimova","doi":"10.17816/CP15629","DOIUrl":"10.17816/CP15629","url":null,"abstract":"<p><strong>Background: </strong>Schizotypy (ST) and psychotic-like experiences and negative symptoms (PENS) are commonly used phenotypes in high-risk and early intervention research for schizophrenia and other non-affective psychoses. However, the origin of these phenotypes in the general population is poorly understood and their association with the genetic predisposition to psychoses has not yet been proven.</p><p><strong>Aim: </strong>The aim of this study is to answer the question of whether data on the relations of ST and PENS with polygenic risk scores for schizophrenia (SZ-PRS) support the hypothesis that these phenotypes are subclinical manifestations of genetic liability for schizophrenia.</p><p><strong>Methods: </strong>Literature describing these relations in the general population was analyzed. The literature search was performed in the PubMed database using the following keywords in English: ((\"schizotyp*\" OR \"psychotic-like experiences\" OR \"psychosis proneness\" OR \"psychotic experiences\") AND (\"polygenic risk\" OR \"genetic liability\" OR \"polygenic score\")); the search in eLIBRARY.RU was conducted using the Russian words for \"schizotypy\", \"schizotypal features\", \"psychotic experiences\", \"psychotic experience\", \"psychotic symptoms\", and \"polygenic risk\", covering publications from 2009 to 2024.</p><p><strong>Results: </strong>Of the identified records, 45 publications were found eligible. No expected positive correlations of SZ-PRS with common ST measures have been observed. For PENS, the results are inconsistent. Overall, SZ-PRS correlate more often with the PENS general factor and negative symptoms than with psychotic experiences <i>per se</i>.</p><p><strong>Conclusion: </strong>The literature does not provide convincing evidence of the association between SZ-PRS and ST/PENS. The search for the substantive psychological meaning of polygenic vulnerability to psychosis captured by SZ-PRS should be expanded to other personality processes and traits.</p>","PeriodicalId":519873,"journal":{"name":"Consortium psychiatricum","volume":"6 2","pages":"53-63"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern Concept of Depression Pathogenesis: The Contribution of I.P. Lapin's Research Team.","authors":"Nikolay Neznanov, Marianna Tumova, Victoria Freize, Ekaterina Gerasimchuk, Dmitriy Radionov, Maria Khobeysh, Larisa Malyshko, Maria Anokhina, Ekaterina Palchikova, Mikhail Sorokin","doi":"10.17816/CP15601","DOIUrl":"10.17816/CP15601","url":null,"abstract":"<p><strong>Background: </strong>The advent of neuroleptics and antidepressant therapy marked a significant step forward in clinical psychiatry. Numerous experiments worldwide had been dedicated to a search for the potential neurobiological mechanisms underlying the potency of new psychopharmacological drugs. The first laboratory of psychopharmacology in the USSR was established in 1960 at the Leningrad Psychoneurological Institute. It was headed by Professor Izyaslav Petrovich Lapin. The foundational article by Lapin I.P. and Oksenkrug G.F. (The Lancet, 1969) continues to be cited 55 years after its publication, which determines the interest in the role of this research team in shaping temporal concepts of the pathogenesis of depression and the development of psychopharmacology.</p><p><strong>Aim: </strong>To analyze the contribution of Lapin I.P. and his research team to the development of experimental approaches for studying the mechanisms of depression.</p><p><strong>Methods: </strong>We analyzed the articles and monographs authored by Professor Lapin I.P., both individually and in coauthorship, available in PubMed, Google Scholar, eLIBRARY.RU, and in the bibliographic collection of the V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology.</p><p><strong>Results: </strong>This analysis highlights the significance of Lapin I.P. and his scientific team's work in advancing our understanding of serotonin role in the mechanisms of depression and in the development of animal depression models. The scientific contribution of this team is an important milestone towards future research into the neurobiological mechanisms underlying depression, as well as the development of therapeutic approaches.</p><p><strong>Conclusion: </strong>Lapin's scientific publications and the work of his team in the field of psychopharmacology have had a significant impact on the development of neuroscience and continue to be of unquestionable importance in advancing scientific practice more than 50 years later.</p>","PeriodicalId":519873,"journal":{"name":"Consortium psychiatricum","volume":"6 2","pages":"77-84"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration Matters: Anticonvulsant Therapy Linked to Bone Loss in Interim Cross-Sectional Study.","authors":"Natalia Sivakova, Irina Abramova, Irina Trukhina, Varvara Rybasova, Mikhail Sorokin, Evgeny Kasyanov, Larisa Lukina, Vladimir Mikhailov, Galina Mazo","doi":"10.17816/CP15553","DOIUrl":"10.17816/CP15553","url":null,"abstract":"<p><strong>Background: </strong>Anticonvulsants are widely used in treating patients with mental and neurological disorders. Their long-term use increases the risk of a decrease in bone mineral density (BMD) and low-energy fractures. Despite the growing number of studies of drug-induced osteoporosis, the effect of anticonvulsants on bone microarchitecture remains poorly studied.</p><p><strong>Aim: </strong>To study the effect of treatment duration with different generations of anticonvulsants on bone mineral density and fracture risk.</p><p><strong>Methods: </strong>We examined 100 adult patients with epilepsy who had been on anticonvulsants for more than 12 months and 58 healthy subjects who had never taken anticonvulsants. All the participants underwent a general clinical and neuropsychological assessment, as well as bone densitometry using quantitative computed tomography in three regions of interest (lumbar vertebrae L1, L2 and femoral neck).</p><p><strong>Results: </strong>BMD reductions were observed in 47 patients (47%) taking anticonvulsants and 29 (50%) subjects in the control group. The mean duration of anticonvulsant therapy was 8.7 years (SD=8.05) in patients with normal BMD, 10.7 years (SD=7.07) in patients with osteopenia, and 9.5 years (SD=5.24) in patients with osteoporosis. Age was found to significantly affect BMD, while the duration of anticonvulsant therapy affected it to a lesser extent. Patients taking first-generation anticonvulsants had lower BMD (<i>p</i>=0.018). ROC analysis confirmed the existence of a relationship between the duration of anticonvulsant therapy and the risk of fractures (<i>p</i><0.001). The \"duration of anticonvulsant therapy\" threshold at the cut-off point corresponding to the highest Youden index value was 10 years.</p><p><strong>Conclusion: </strong>Long-term treatment with conventional anticonvulsants adversely affects BMD and can lead to pathological bone resorption, increasing the risk of fractures in patients. New-generation anticonvulsants did not show any significant negative impact on BMD. The results of this study indicate the need for further research to better understand the effects of anticonvulsants on bone tissue.</p>","PeriodicalId":519873,"journal":{"name":"Consortium psychiatricum","volume":"6 2","pages":"5-20"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Russian Version of the Inventory of Motivations for Suicide Attempts: Validation in a Clinical Sample of Adolescents.","authors":"Natalia Polskaya, Anna Basova, Anna Razvaliaeva, Yulia Severina","doi":"10.17816/CP15597","DOIUrl":"10.17816/CP15597","url":null,"abstract":"<p><strong>Background: </strong>Understanding the motives for suicide attempts is a necessary condition of suicide risk assessment in adolescents. However, there is a lack of measures in Russian that assess these motives, particularly, in adolescent populations. The Inventory of Motivations for Suicide Attempts (IMSA) measures a variety of theoretically grounded intrapersonal and interpersonal motives and can be used in adolescent samples.</p><p><strong>Aim: </strong>To validate the Russian version of the IMSA in a clinical sample of adolescents with suicidal behavior.</p><p><strong>Methods: </strong>The Russian-language adaptation of the IMSA was conducted on a clinical sample of 522 inpatient adolescents 12-17 years old (M=14.51±1.52), including 425 girls and 97 boys. All the adolescents were hospitalized in a psychiatric hospital due to a suicide attempt, suicidal intentions, or a history of suicide attempts. To test the convergent and discriminative validity of the Russian version of the IMSA, the Interpersonal Needs Questionnaire, Interpersonal Sensitivity Measure and Self-Concept Clarity Scale were used.</p><p><strong>Results: </strong>Confirmatory factor analysis showed that the original 10-factor structure did not have a good fit. After modifications and removal of 12 items an 8-factor structure emerged, which had the following scales: Hopelessness, Psychache, Escape, Burdensomeness, Low belongingness, Fearlessness, Problem-solving, Interpersonal motivations. A generalizing Intrapersonal motivations scale was also defined. The fit measures for the final model were as follows: χ²(df)=1,757.23(808); CFI=0.911; RMSEA=0.053 (<i>p</i>=0.087); SRMR=0.058. All the scales in the Russian version of the IMSA displayed satisfactory internal (above 0.8 except for Problem-solving) and retest reliability (above 0.6 except for Interpersonal motivations) and statistically significant positive correlations with scales from the Interpersonal Needs Questionnaire and Interpersonal Sensitivity Measure and negative correlations with Self-Concept Clarity Scale.</p><p><strong>Conclusion: </strong>The IMSA displayed satisfactory psychometric properties in a Russian adolescent inpatient sample and can be used to differentiate between the motives for suicide attempts in adolescents.</p>","PeriodicalId":519873,"journal":{"name":"Consortium psychiatricum","volume":"6 2","pages":"36-51"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the 5-HTTLPR Gene Variation of the SLC6A4 Serotonergic System in the Development of Addictive Disorders: A Narrative Review.","authors":"Alexey Krylov, Nadezhda Pavlova, Alexey Bochurov","doi":"10.17816/CP15611","DOIUrl":"10.17816/CP15611","url":null,"abstract":"<p><strong>Background: </strong>Addictive disorders remain a global problem, affecting health, society and the economy. The etiopathogenesis of addictions, which have a multifactorial nature, is poorly understood, making it difficult to develop personalized treatment approaches. Of particular interest is the <i>SLC6A4</i> gene, which regulates serotonergic transmission. The 5-HTTLPR variation of this gene is associated with the risk of addictions, but the data are contradictory due to the heterogeneity of clinical manifestations and pleiotropic effects of the gene. Integration of genetic, environmental and neurobiological factors into multidimensional models is becoming relevant.</p><p><strong>Aim: </strong>The aim of this study is to assess the role of 5-HTTLPR variations in the <i>SLC6A4</i> gene of the serotonergic system in the development of addictive disorders.</p><p><strong>Methods: </strong>The manuscripts were searched in the MEDLINE and eLIBRARY.RU databases using the keywords in Russian and English: \"SLC6A4\", \"5-HTTLPR\", \"addictive disorders\", \"pharmacogenetics\", \"serotonin\", \"antidepressants\", \"ethnic differences\". After eliminating duplicates and a two-stage screening (by titles/annotations and full-text analysis) of the 1,561 discovered papers, the final review included 41 publications that meet the stated inclusion criteria.</p><p><strong>Results: </strong>The S-allele of 5-HTTLPR is associated with an increased risk of addictions and comorbid affective disorders, but its role is ambiguous due to the heterogeneity of symptoms. Ethnic differences have been identified: the S-allele predominates (70.6-80.9%) in Asian populations, the L-allele in Europeans (38.5-66.7%). Unique neurobiological markers for S-allele carriers have not been established, and the pleiotropic effects of <i>SLC6A4</i> are also observed in other mental disorders, which reduces its specificity for addictions.</p><p><strong>Conclusion: </strong>The inconsistency of the data on 5-HTTLPR highlights the need to take into account ethnic specificity and develop multivariate models that integrate genetic, environmental and clinical factors. This will improve risk prediction (development of addictions), personalization of therapy and the effectiveness of pharmacogenetic approaches, reducing the likelihood of adverse reactions.</p>","PeriodicalId":519873,"journal":{"name":"Consortium psychiatricum","volume":"6 2","pages":"65-75"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"Comparative Analysis of Corpus Callosum Lipidome and Transcriptome in Schizophrenia and Healthy Brain\" (Consortium PSYCHIATRICUM, 2025, Volume 6, Issue 1, doi:10.17816/CP15491).","authors":"Maria Osetrova, Olga Efimova, Marina Zavolskova, Elena Stekolschikova, Gleb Vladimirov, Dmitry Senko, Tatiana Zhuravleva, Anna Morozova, Yana Zorkina, Denis Andreyuk, George Kostyuk, Evgeniy Nikolaev, Philipp Khaitovich","doi":"10.17816/CP15673","DOIUrl":"https://doi.org/10.17816/CP15673","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.17816/CP15491.].</p>","PeriodicalId":519873,"journal":{"name":"Consortium psychiatricum","volume":"6 2","pages":"85-86"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neurophysiological Features of Anticipation in Schizophrenia: A Cross-Sectional Study of Event-Related Potentials.","authors":"Ernest Rabinovich, Klavdiya Telesheva","doi":"10.17816/CP15558","DOIUrl":"10.17816/CP15558","url":null,"abstract":"<p><strong>Background: </strong>It is known that disorders of mental activity in schizophrenia patients may be caused by an impairment in the actualization of past experience during anticipation (prediction), which leads to impairment in constructing predictions, comparing incoming sensory information with the predictions, and updating the predictions. Previous studies have shown that the probability of an expected event affects the components of event-related potentials in mentally healthy individuals. However, it has not yet been studied how changes in the probability of an expected stimulus influence the behavior of individuals with schizophrenia and their event-related potential measures.</p><p><strong>Aim: </strong>To compare the influence of event probability on the characteristics of brain potentials in patients with schizophrenia and healthy individuals.</p><p><strong>Methods: </strong>The study included mentally healthy individuals and male schizophrenia patients. Electroencephalograms were recorded while participants performed a saccadic task within the Central Cue Posner's Paradigm under conditions of varying probability (50% and 80%) of target stimulus presentation. Pre-stimulus (Contingent Negative Variation) and post-stimulus (Mismatch Negativity and P3) components of event-related potentials were analyzed upon the presentation of two types of target stimuli: standard (presented on the same side as the cue stimulus) and deviant (presented on the opposite side), under conditions of 50% and 80% stimulus congruence probability.</p><p><strong>Results: </strong>The study involved 20 mentally healthy individuals and 18 schizophrenia patients. In healthy subjects, the amplitude of the contingent negative variation increased with high stimulus congruence probability, while the amplitude of the Mismatch Negativity (MMN) and P3 component was higher for deviant stimuli under conditions of high (80%) probability. In schizophrenia patients, changes in probability demonstrated no impact on the amplitude of the contingent negative wave, MMN, or P3.</p><p><strong>Conclusion: </strong>The characteristics of event-related potentials in patients with schizophrenia indicate impaired anticipation processes.</p>","PeriodicalId":519873,"journal":{"name":"Consortium psychiatricum","volume":"6 2","pages":"21-34"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Corpus Callosum Lipidome and Transcriptome in Schizophrenia and Healthy Brain.","authors":"Maria Osetrova, Olga Efimova, Marina Zavolskova, Elena Stekolschikova, Gleb Vladimirov, Dmitry Senko, Tatiana Zhuravleva, Anna Morozova, Yana Zorkina, Denis Andreyuk, George Kostyuk, Evgeniy Nikolaev, Philipp Khaitovich","doi":"10.17816/CP15491","DOIUrl":"10.17816/CP15491","url":null,"abstract":"<p><strong>Background: </strong>Functional and structural studies of the brain highlight the importance of white matter alterations in schizophrenia. However, molecular studies of the alterations associated with the disease remain insufficient.</p><p><strong>Aim: </strong>To study the lipidome and transcriptome composition of the corpus callosum in schizophrenia, including analyzing a larger number of biochemical lipid compounds and their spatial distribution in brain sections, and corpus callosum transcriptome data. To integrate the results of molecular approaches to create a comprehensive molecular perspective of the disease.</p><p><strong>Methods: </strong>A total of 8 brain tissue samples (4 from healthy controls (HC) + 4 from schizophrenia patients (SZ)) were analyzed using high-performance liquid chromatography with mass spectrometry (HPLC-MS) and RNA sequencing for transcriptome profiling. Additionally, 6 brain tissue samples (3 HC + 3 SZ) were analyzed using matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI). This approach enabled the characterization of mRNA and lipids in brain tissue samples, and the spatial distribution of selected lipids within brain sections.</p><p><strong>Results: </strong>The analysis revealed a general trend of reduced lipid levels in the corpus callosum of schizophrenia patients for lipid classes measured by mass spectrometric methods. Specifically, nine lipid classes detected via HPLC-MS showed significant differences in schizophrenia samples, with seven of them having lower median intensity. The results between HPLC-MS and MALDI-MSI were highly concordant. Transcriptome analysis identified 1,202 differentially expressed genes, clustered into four functional modules, one of which was associated with lipid metabolism.</p><p><strong>Conclusion: </strong>We identified a series of lipidome and transcriptome alterations in the corpus callosum of schizophrenia patients that were internally consistent and aligned well with previous findings on white matter lipidome changes in schizophrenia. These results add to the existing scope of molecular alterations associated with schizophrenia, shedding light on the biological processes potentially involved in its pathogenesis.</p>","PeriodicalId":519873,"journal":{"name":"Consortium psychiatricum","volume":"6 1","pages":"5-17"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on the Article \"Dialogical Structure of the Brain and the Ternary System of the Mind: The Neurosemiotics of Yuri Lotman\".","authors":"Alisa Andriushchenko","doi":"10.17816/CP15627","DOIUrl":"10.17816/CP15627","url":null,"abstract":"","PeriodicalId":519873,"journal":{"name":"Consortium psychiatricum","volume":"6 1","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motives for New Psychoactive Substances Consumption among Young Adults in Uzbekistan: A Qualitative Study Protocol.","authors":"Guzalkhon Zakhidova, Uladzimir Pikirenia, Timur Syunyakov, Mariya Prilutskaya","doi":"10.17816/CP15531","DOIUrl":"10.17816/CP15531","url":null,"abstract":"<p><strong>Background: </strong>New psychoactive substances (NPS) represent a global problem, especially among young people. In Central Asia, while the trafficking in NPS continues to grow, there remains a lack of data on the social, health and psychological consequences of their use.</p><p><strong>Aim: </strong>To investigate the motives behind the NPS use among young people in the Republic of Uzbekistan, as well as the medical and social characteristics of this group.</p><p><strong>Methods: </strong>The study will include young people (18-35 years) who have used NPS in the preceeding 30 days (on the basis of self-reports) or are undergoing rehabilitation and plan to cease the NPS use within the next 12-18 months. Semi-structured interviews will reveal the reasons for NPS use, risk perception, stigma, barriers to seeking help, and the need for preventive and rehabilitation services. Interviews will take place at the Republican Mental Health Center and two specialized rehabilitation centers in Uzbekistan between November 2024 and the completion of enrollment (25-30 participants), but no later than May 2025. Additionally, a focus group of psychiatrists, psychotherapists, narcologists, and psychologists will evaluate the level of awareness amongst health care professionals as regards of NPS use and its prevalence, medical, and social implications.</p><p><strong>Expected results: </strong>The study will identify the key motives of NPS use, usage patterns, and social and medical barriers of help-seeking. Findings will contribute to the development of prevention and rehabilitation strategies, including digital communication platforms and interactive educational programs.</p><p><strong>Conclusion: </strong>The study focuses on raising awareness about the consequences of NPS in the Republic of Uzbekistan. This is essential for developing effective public health prevention and rehabilitation programs.</p>","PeriodicalId":519873,"journal":{"name":"Consortium psychiatricum","volume":"6 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}