European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology最新文献_第8页

A randomized trial of postoperative adjuvant chemotherapy in non-small cell lung cancer (the second cooperative study). The Study Group of Adjuvant Chemotherapy for Lung Cancer (Chubu, Japan). 非小细胞肺癌术后辅助化疗的随机试验(第二项合作研究)。肺癌辅助化疗研究组(日本中部)。

IF 3.8

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Pub Date : 1995-02-01

{"title":"A randomized trial of postoperative adjuvant chemotherapy in non-small cell lung cancer (the second cooperative study). The Study Group of Adjuvant Chemotherapy for Lung Cancer (Chubu, Japan).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"A prospective randomized trial (the second cooperative study) was conducted from July 1985 to December 1987 to investigate the benefits of postoperative adjuvant chemotherapy in patients for whom non-small cell lung cancer had been resected completely. Patients were randomly assigned either to a chemotherapy group (group A) treated postoperatively with CDDP (66 mg/m2 x 1), ADM (26 mg/m2 x 1) and UFT (8 mg/kg/day) during 6 months, or to a control group (group B) which had undergone surgery only. Three hundred and thirty-three resected cases were registered. Among them, 24 cases (7.2%) were excluded, because of incomplete resection (15), pathologically benign tumour (3), small cell lung cancer (2) and other factors (4). Three hundred and nine cases were eligible: 155 cases in group A (p-Stage I 93, II 19, III 43) and 154 in group B (I 109, II 10, III 35). The 5-year survival rate in group A was 61.8%, and that in group B 58.1%. The 5-year disease-free survival rate for each group was 61.8% and 57.4%, respectively. There were no significant differences in the 5-year survival between the two groups. However, since a significant difference was observed between the two groups regarding pathological lymph node metastasis (pN), the prognostic factors were adjusted using Cox's proportional hazard model. Thereafter the adjusted survival rate and disease-free survival rate for group A became significantly higher than for group B (P = 0.044 and P = 0.036, respectively). Thus, from these results, it is concluded that the role of surgery for non-small cell lung cancer still remains of primary importance, and postoperative adjuvant chemotherapy is effective to improve the results of surgery and prolong life of patients with non-small cell lung cancer.","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"21 1","pages":"69-77"},"PeriodicalIF":3.8,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18849935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid cancer: a multivariate analysis on influence of treatment on long-term survival. 甲状腺癌:治疗对长期生存影响的多因素分析。

IF 3.8

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Pub Date : 1994-12-01

M D Staunton

{"title":"Thyroid cancer: a multivariate analysis on influence of treatment on long-term survival.","authors":"M D Staunton","doi":"","DOIUrl":"","url":null,"abstract":"Contemporary management of patients with follicular pattern thyroid cancer remains uncertain. This retrospective multivariate analysis studied 410 such patients treated in a cancer hospital in the years 1932-72 and providing a follow-up of 20 years. In papillary carcinoma thyroxine administration (P < 0.005) and surgery (P < 0.001) improved survival together with youth (P < 0.001) and being female (P < 0.05). In follicular carcinoma, thyroxine therapy (P < 0.001) increased survival as did surgery but it failed to reach significance (P = 0.19); increasing age (P < 0.001), stage M1 (P < 0.05) and 'complete' radiotherapy (P < 0.05) decreased survival. In anaplastic carcinoma survival was improved by thyroxine therapy (P < 0.001), a new finding, but decreased by stages T3 (P < 0.001) and M1 (P < 0.05); however, radiotherapy, the mainstay in control of local disease, did not increase survival. Overall, total thyroidectomy reduced local recurrence with an increase in complications and no operation gained a significant increase in survival. Radio-iodine achieved no benefit in survival which raises the possibility of confounding. Thyroxine therapy is indicated as initial treatment of follicular cell thyroid cancer.","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"20 6","pages":"613-21"},"PeriodicalIF":3.8,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18990495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic rearrangements in sporadic and familial gastric carcinomas detected with microsatellite markers. 微卫星标记检测散发性和家族性胃癌基因重排。

IF 3.8

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Pub Date : 1994-12-01

M Zelada-Hedman, L Iselius, P Gunvén, A Weger, M Nordenskjöld, L Skoog, A Lindblom

{"title":"Genetic rearrangements in sporadic and familial gastric carcinomas detected with microsatellite markers.","authors":"M Zelada-Hedman, L Iselius, P Gunvén, A Weger, M Nordenskjöld, L Skoog, A Lindblom","doi":"","DOIUrl":"","url":null,"abstract":"Ten gastric carcinomas were studied for loss of heterozygosity by analysis of 21 microsatellite markers from 14 different chromosomes. Four patients had a family history of gastro-intestinal cancer, and six tumours were considered sporadic. We also studied a new mechanism in tumourigenesis recently reported in hereditary non polyposis colon cancer, a defect in mismatch repair that is seen as gain of new bands by the use of dinucleotide repeat markers. Loss of heterozygosity was detected with two markers in one primary tumour and with the majority of markers in one metastasis from a sporadic gastric tumour. Gain of microsatellite bands was seen in one tumour from a gene carrier in a family with hereditary non-polyposis colon cancer and in one sporadic tumour. Two tumours from patients with a family history of gastric cancer showed no rearrangements. Our results suggest that different types of genes are involved in initiation and progression of gastric cancer in sporadic and familial gastric cancer.","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"20 6","pages":"667-73"},"PeriodicalIF":3.8,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18989143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term neuropathy after regional isolated perfusion with melphalan for melanoma of the limbs. 局部孤立灌注melphalan治疗四肢黑色素瘤后的长期神经病变。

IF 3.8

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Pub Date : 1994-12-01

B C Vrouenraets, A M Eggermont, J M Klaase, B N Van Geel, J A Van Dongen, B B Kroon

{"title":"Long-term neuropathy after regional isolated perfusion with melphalan for melanoma of the limbs.","authors":"B C Vrouenraets, A M Eggermont, J M Klaase, B N Van Geel, J A Van Dongen, B B Kroon","doi":"","DOIUrl":"","url":null,"abstract":"The incidence of long-term (> or = 3 months) neuropathy in 350 melanoma patients treated with single normothermic or 'mild' hyperthermic perfusion with melphalan in the period 1978 to 1990 was studied. Long-term neuropathy was encountered in 14 patients; in 10/51 patients (20%) after perfusion at the axillary level and in 4/247 patients (2%) after perfusion at the iliac level. After brachial and femoro-popliteal perfusions no long-term neuropathy was observed. Neuropathy, mainly consisting of paresis/paralysis of the hand and/or fingers, anaesthesia, and/or paraesthesiae, improved over a mean period of 16 (3-43) months in eight patients, but three patients still had serious neuropathy one year after perfusion. In another six patients little improvement was seen and four died with permanent neuropathy. Acute regional toxicity after perfusion and the application of 'mild' hyperthermia did not seem to influence the incidence of long-term neuropathy. This complication is probably a result of the isolating Esmarch rubber bandage being applied too tightly during perfusion at a proximal level. At the axillary level, where the brachial plexus lacks the protection from enveloping tissues, nerve damage is especially prone to occur. We recommend applying this bandage no tighter than is necessary to maintain the isolation of the circuit. This implies meticulous surgical isolation of the vascular system and accurate monitoring of leakage.","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"20 6","pages":"681-5"},"PeriodicalIF":3.8,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18989145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary small bowel malignant tumors. 原发性小肠恶性肿瘤。

IF 3.8

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Pub Date : 1994-12-01

J A Garcia Marcilla, F Sanchez Bueno, J Aguilar, P Parrilla Paricio

{"title":"Primary small bowel malignant tumors.","authors":"J A Garcia Marcilla, F Sanchez Bueno, J Aguilar, P Parrilla Paricio","doi":"","DOIUrl":"","url":null,"abstract":"We reviewed 69 patients who underwent surgery for primary malignant tumors of the small bowel over a 15-year period. Patients with periampullary lesions were excluded, as were those with known adenocarcinomas in other sites. There were 46 males (67%) and 23 females (33%) with an average age at presentation of 52.6 years (range 4-92). Of the 69 patients, four (6%) were asymptomatic. The mean duration of symptoms before diagnosis, in the remaining 65 symptomatic patients, was 3.6 months (range 1 day 1.2 years). The most frequent symptom was abdominal pain (83%), followed by nausea and/or vomiting (54%), and weight loss (43%). Abdominal mass was the most common finding on physical examination (29%), followed by abdominal distension (24%) and abdominal guarding and rigidity (14%). Laboratory examinations were normal in 26 patients (40%). Radiographic study of the duodenum and small bowel was abnormal in 87%. The diagnosis was suspected preoperatively in 51%. Lymphoma was the most common tumor (42%), followed by adenocarcinoma (38%), carcinoid (10%) and leyomiosarcomas (10%). In 41% the neoplasm was located in the jejunum, in 33% in the ileum, in 22% in the duodenum and in 4% multiple sites were found. Lymph node metastases were found in 45% and vascular invasion was found in 19%. Of the 65 symptomatic patients 43% presented as surgical emergencies, the rest had elective surgery. 61% had a curative resection, the rest were palliative or a bypass. The operative mortality rate was 10% and the morbidity rate was 24%. Ten patients underwent emergency surgery, developed a complication, giving a morbidity rate of 32% in this group. The 5-year overall survival was 43.25%. The 5-year survival for carcinoid tumors was 60% while the 5-year survival for small bowel malignant lymphoma and adenocarcinoma was 40 and 34.28% respectively.","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"20 6","pages":"630-4"},"PeriodicalIF":3.8,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18990497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size isn't important; the Forrest Unit. 大小并不重要;福雷斯特小组。

IF 3.8

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Pub Date : 1994-12-01

N E Beck, M Sampson, R Michell, R M Rainsbury

引用次数: 0

Curative endocavitary irradiation of small rectal cancers and preoperative radiotherapy in T2 T3 (T4) rectal cancer. A brief overview of the Lyon experience. 小直肠癌腔内放疗与T2、T3 (T4)直肠癌术前放疗的疗效。简要介绍一下里昂的经历。

IF 3.8

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Pub Date : 1994-12-01

J P Gerard, R Coquard, D Fric, L Ayzac, P Romestaing, J M Ardiet, F P Rocher, M H Baron, V Trillet-Lenoir

引用次数: 0

Long-term disease-free survival after isolated peritoneal metastasis from colonic cancer. 结肠癌腹膜转移后的长期无病生存。

IF 3.8

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Pub Date : 1994-12-01

W A Bleeker, E G de Vries, W V Dolsma, J Grond, R C Verschueren

引用次数: 0

Taxotere inhibits in-vitro growth of human colonic cancer cell lines. 泰索帝对人结肠癌细胞系体外生长的抑制作用。

IF 3.8

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Pub Date : 1994-12-01

E Karantanis, S Nicholson, D L Morris

{"title":"Taxotere inhibits in-vitro growth of human colonic cancer cell lines.","authors":"E Karantanis, S Nicholson, D L Morris","doi":"","DOIUrl":"","url":null,"abstract":"Taxotere a semisynthetic analogue of taxol, is prepared from a precursor extracted from needles of the tree, Taxus baccata. It is a mitotic spindle poison more potent than taxol, that increases the rate of microtubule assembly and inhibits depolymerization of microtubules. There has been little research on its effects on colorectal cancer. Five colorectal tumour cell lines were investigated using three modes: flow cytometry (to determine how Taxotere affects the cell cycle), MTT assay, (to examine the cytotoxicity of the drug), and measurement of tritiated thymidine uptake, (to see whether Taxotere affects the rate of DNA synthesis and cell turnover). A time-course experiment, using flow cytometry, showed effects beginning between 0 and 2 hours after exposure. 24-hour assays were conducted for flow cytometry, and showed large changes, arresting most cells in G2/M phases (e.g., cell line LIM 1215 exposed to 1 x 10(-6) M Taxotere showed 72% of cells in G2/M compared to 14.7% in controls). 24 and 48 hour assays were conducted for MTT and measurement of tritiated thymidine uptake. MTT showed significant inhibitory effects, with maximum inhibitions varying between 5 and 70% for different cell lines after 48 hours (P < 0.05), while uptake of tritiated thymidine was not altered. While Taxotere has dose-limited toxicity, our results suggest that many human colonic cancers will be sensitive to Taxotere.","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"20 6","pages":"653-7"},"PeriodicalIF":3.8,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18989141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The value of ultrasound in the evaluation of palpable breast tumours: a prospective study of 400 cases. 400例乳腺可触及肿瘤超声诊断价值的前瞻性研究。

IF 3.8

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Pub Date : 1994-12-01

C I Perre, V C Koot, P de Hooge, P Leguit

引用次数: 0