Journal of Pediatric and Neonatal Individualized Medicine最新文献

{"title":"Retinopathy of prematurity: Results from 10 years in a single neonatal intensive care unit","authors":"I. Coutinho, Catarina Pedrosa, M. Mota, S. Azeredo-Lopes, Cristina Santos, G. Pires, Susana Teixeira, M. Cunha","doi":"10.7363/060122","DOIUrl":"https://doi.org/10.7363/060122","url":null,"abstract":"Introduction: Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina of preterm newborns and is an important and preventable cause of visual impairment in childhood. This study aimed to assess the incidence and main risk factors associated with the development of ROP in the last 10 years at Hospital Prof. Doutor Fernando Fonseca in Lisbon, Portugal. Methods: Observational and retrospective study conducted between 2005 and 2014 at Hospital Prof. Doctor Fernando Fonseca. The study included newborns of gestational age < 32 weeks. We analyzed maternal, prenatal and neonatal factors associated with the development of ROP. Statistical analysis were performed with Statistical Package for Social Sciences (SPSS®) software. Univariate and multivariate analyses were performed and a multiple logistic regression model was carried out with a significance level α = 0.05. Results: 527 premature infants with a gestational age < 32 weeks were studied, of which 165 developed ROP. 60 of these patients needed treatment. In the univariate analysis, the risk factors for the development of ROP were maternal infection in pregnancy, low birth weight, low gestational age, low Apgar score at 5 minutes, need for oxygen therapy until the 28 th day of life, a high score on the CRIB and SNAPPE2 scales, use of surfactant, respiratory distress syndrome, persistence of patent ductus arteriosus, peri-intraventricular hemorrhage and neonatal sepsis. In the multiple logistic regression analysis, risk factors for ROP were the presence of neonatal sepsis, respiratory distress syndrome, persistence of patent ductus arteriosus and a high score on the neonatal SNAPPE2 scale. Conclusions: We found a ROP incidence rate of 31.3%, with risk factors similar to those observed in other studies.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2017-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46822419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOSCHCOWITZ SYNDROME IN TWIN PREGNANT WOMEN AFTER OOCYTES DONOR CYCLES: A CASE REPORT","authors":"M. Miranda, C. Alviggi, G. Nazzaro, E. Salzano, A. Conforti, M. Locci, G. Placido","doi":"10.7363/060125","DOIUrl":"https://doi.org/10.7363/060125","url":null,"abstract":"","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"531 1","pages":"1-51"},"PeriodicalIF":0.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we assess the severity of neonatal respiratory distress by ultrasound? A comparison of three methods.","authors":"F. Raimondi, F. Migliaro, L. Verdoliva, Diego Gragnaniello, G. Poggi, Carlo Sansone, R. Kosova, L. Capasso","doi":"10.7363/060236","DOIUrl":"https://doi.org/10.7363/060236","url":null,"abstract":"","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"6 1","pages":"12-13"},"PeriodicalIF":0.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of premature neonates born in a tertiary neonatal intensive care unit in Nairobi, Kenya","authors":"Atul Patel, Y. Kandasamy","doi":"10.7363/060113","DOIUrl":"https://doi.org/10.7363/060113","url":null,"abstract":"In this retrospective review, premature neonates less than 34 weeks gestation admitted to a tertiary neonatal intensive care unit (NICU) in Nairobi, Kenya from February 2012 to October 2015 were identified from medical records and database. There were 88 neonates admitted to the neonatal unit, out of which 78 survived. There were 10 pairs of twins and 1 set of triplets. The gestational age ranged from 26 weeks to 33.7 weeks gestation, with a mean gestation of 30.3 (± 1.8) weeks, and a mean birth weight of 1,508 (± 381) g. The smallest neonate who survived weighed 800 g. Smaller babies needed mechanical ventilation for a longer duration and stayed longer in NICU. Less than half of the neonates in our cohort received antenatal dexamethasone. We plan to have further discussion with the obstetricians to increase antenatal steroid use. Ten babies died during this period. With improved perinatal care in Kenya, we anticipate better survival and outcome of these preterm babies.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumothorax in neonates: a level III Neonatal Intensive Care Unit experience","authors":"I. Silva, F. Flôr-de-Lima, G. Rocha, Inês Alves, H. Guimarães","doi":"10.7363/050220","DOIUrl":"https://doi.org/10.7363/050220","url":null,"abstract":"Introduction: Pneumothorax occurs more frequently in the neonatal period than in any other period of life and is associated with increased mortality and morbidity. Several risk factors for pneumothorax, including respiratory pathology, invasive and non-invasive respiratory support, and predictors of mortality have been described.Objective: To evaluate the prevalence of pneumothorax, to assess risk factors and to describe the clinical characteristics, management and outcome of newborn infants with pneumothorax, as well as to identify predictors of mortality in these newborns.Methods: This retrospective case-control study included all newborns hospitalized in the Neonatal Intensive Care Unit (NICU) of “Centro Hospitalar Sao Joao”, Porto, Portugal, between 2003 and 2014, with the diagnosis of pneumothorax. A control group was selected among the newborns without pneumothoraces, admitted to the same NICU during the same period. The collected data included: demographics and perinatal data, pneumothorax characteristics, classification, treatment and clinical outcomes.Results: Our study included 240 neonates (80 with pneumothoraces and 160 controls), of whom 145 were male (60.4%). Median gestational age was 37 (24-40) weeks and median birthweight 2,613 (360-4,324) grams. The prevalence in our NICU was 1.5%. Pneumothorax was significantly associated with respiratory distress syndrome (RDS) (p = 0.010) and transient tachypnea of the newborn (TTN) (p < 0.001). Invasive mechanical ventilation (MV) (p = 0.016) and FiO2 ≥ 0.4 (p = 0.003), were independent risk factors for the development of pneumothoraces. The mortality rate was 13.8%. Hypotension, MV and thoracentesis followed by a chest tube insertion were found to be predictors of mortality in newborns with pneumothoraces, but pneumothorax per se was not a predictor of mortality.Conclusion: Pneumothorax is relatively frequent in the NICU. Its risk factors and predictors of mortality should be known in order to prevent and treat this critical situation. Pneumothorax itself was not a predictor of mortality, probably due to the adequate and prompt management used in the NICU.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71291054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy: temperature control during transport","authors":"S. Correia, A. Graça, I. Sampaio, C. Moniz, M. Machado","doi":"10.7363/050222","DOIUrl":"https://doi.org/10.7363/050222","url":null,"abstract":"This study aims to assess the adequacy of temperature control during transport of patients referred for therapeutic hypothermia at our centre and to evaluate the occurrence of complications when temperature control is not adequate. Transport data of patients (n = 37) referred during a period of 30 months was reviewed retrospectively, as well as our prospectively collected database of infants treated with hypothermia. We evaluated duration of transport, incidence of excessive cooling on admission and associated complications. Distance from the referring hospital and duration of the transport were not associated with excessive cooling. We then divided patients into two groups according to adequacy of temperature control during transport depending on the presence or absence of regular temperature recordings and compared study variables between the groups. A significant correlation was found between the lack of adequate temperature records during transport (n = 19) and excessive hypothermia on admission (42% vs. 11% for the group with adequate temperature monitoring). There was a trend towards increased incidence of coagulation problems for infants who had admission temperatures below 32.0°C. Passive cooling is simple and effective to ensure early achievement of neuroprotective temperature, but continuous temperature monitoring during transportation is mandatory in order to avoid excessive cooling.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71291063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The small intestinal mucosa and its stem cells","authors":"R. Ambu, C. Gerosa, Giorgia Locci, Eleonora Obinu, A. Ravarino, A. D. Magistris, A. Reali, P. Eyken, G. Faa, Silvia Nati, L. Vinci","doi":"10.7363/050224","DOIUrl":"https://doi.org/10.7363/050224","url":null,"abstract":"In the first part of this review a brief summary of the embryology and histology of the gastrointestinal tract is provided. In the second part intestinal stem cells (ISCs) are discussed. Several signaling pathways play a crucial role in the crypt base in the regulation of ISC proliferation and self-renewal; Wnt, Notch, BMP, Ephrin, JAK/STAT1, PTEN, AKT, PI3K and many more. Numerous investigators are involved in studying the location, number, and behavior of ISCs within the base of the intestinal crypts. Several markers are espressed by ISCs. Among these, Leucine-rich-repeat-containing G-protein-coupled receptor-5 (Lgr5), Sox9, Prominin-1, DCAMKL-1, EphB2, p-PTEN, p-AKT, Fgfr3, m-TER, and CD44. Stem cell therapy has shown promise for the treatment of some diseases characterized by tissue damage with ischemic and inflammatory lesions like inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC). Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextualized pain management in newborns","authors":"C. Bellieni, M. Tei, G. Buonocore","doi":"10.7363/050209","DOIUrl":"https://doi.org/10.7363/050209","url":null,"abstract":"Neonatal pain treatment requires personalization, and pain assessment should be contextualized to be effective. Here we summarize the available tools in neonatal analgesia, paying a special attention to highlight the personalization of antalgic behavior, both in assessment and in treatment of neonatal pain. Proceedings of the 11 th International Workshop on Neonatology and Satellite Meetings · Cagliari (Italy) · October 26 th -31 st , 2015 · From the womb to the adult Guest Editors: Vassilios Fanos (Cagliari, Italy), Michele Mussap (Genoa, Italy), Antonio Del Vecchio (Bari, Italy), Bo Sun (Shanghai, China), Dorret I. Boomsma (Amsterdam, the Netherlands), Gavino Faa (Cagliari, Italy), Antonio Giordano (Philadelphia, USA)","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem progenitor cells in the human pancreas","authors":"Giorgia Locci, A. Pinna, A. Dessì, Eleonora Obinu, C. Gerosa, M. A. Marcialis, Maria Cristina Pintus, M. Angiolucci, V. Fanos, R. Ambu, G. Faa","doi":"10.7363/050223","DOIUrl":"https://doi.org/10.7363/050223","url":null,"abstract":"Early pancreas development, given its complexity, is generally considered as a paradigm for branching morphogenesis and for the development of two organs in one: the Langherans islets, programmed to secrete hormones into the bloodstream, and the exocrine pancreas compartment, composed of two major cell types, acinar and ductal cells, devoid to secrete digestive enzymes into the duodenum through a branched network of ducts. Exocrine and endocrine pancreas are generally presumed to originate from a common multi-lineage progenitor cell (MPC), emerging within the definitive endoderm surrounding the posterior foregut. Bipotential precursors committed to the pancreatic fate originate the MPC, that are considered the progenitors of all pancreatic cells operating in the mature pancreas, including acinar, ductal, endocrine and stromal cell types. Pluripotent stem cells (PSCs) are able to differentiate into several cell types, including acinary cells, duct cells and islet cells, depending on certain transcription factors, which function in a coordinated way during pancreas development. The epidemiological entity of pancreatic diseases such as diabetes mellitus and issues regarding the management of the diabetic patient have constantly stimulated the great current interest aimed at regenerative pancreatic medicine. Several studies in rats have demonstrated the existence of stem/progenitor cells in the adult pancreas and have clarified the mechanism by which pancreatic stem cells differentiate into acinar, ductal and endocrine cells. In this context, the cellular microenvironment called “niche” plays a major role in inducing differentiation of stem/progenitor cells by adequate cellular signals. Within the niche, undifferentiated pluripotent cells give rise to asymmetrically dividing daughter cells. The main purpose of this work was to identify stem cells and progenitor cells in the human pancreas during intrauterine development in relation to what is already known in the adult pancreas and in experimental models. Proceedings of the 2nd International Course on Perinatal Pathology (part of the 11th International Workshop on Neonatology · October 26th-31st, 2015) · Cagliari (Italy) · October 31st, 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobehavioral outcomes of school-age children born preterm: a preliminary study in the Arabic community","authors":"M. Alqahtani","doi":"10.7363/050211","DOIUrl":"https://doi.org/10.7363/050211","url":null,"abstract":"Introduction: Preterm survivors from the neonatal intensive care unit (NICU) are considered as high risk group for some neurobehavioral impairments such as cognitive disabilities, developmental delays, social/emotional limitations, attention-deficit/hyperactivity disorder (ADHD), and academic difficulties. Objective: The current study aimed to investigate the neurobehavioral outcome of premature infants in Saudi Arabia at the school age. Methods: At the school age, preterm children (range 23-29 weeks or ≤ 1.52 kg) born from April, 2006 through September, 2008, and who were admitted following birth to a NICU, were evaluated with several neurobehavioral tools. Results: This study includes 53 preterm children, who were followed up at the chronological age that ranged from 6.4-8.0 years. The results of the neurobehavioral assessments showed in general normal social adaptive levels and cognitive abilities, with mean total score of about 91.0 and 90.0, respectively. The prevalence of ADHD among preterm children was high, with result of 34.0% for the inattentive type and 11.3% for the hyperactive/impulsive type. None of the preterm children repeats a grade, but 22.6% utilize a form of special educational supports. Some of the preterm children showed poor school performance in reading skills, writing skills and mathematics skills, with percentages of 26.4%, 28.3% and 15.1%, respectively. Conclusions: The present results emphasize that preterm children are a group of high-risk children who need regular follow-up to track the developmental conditions and to provide the early developmental intervention for optimal outcome.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71291034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}