小肠黏膜及其干细胞

IF 0.3 Q4 PEDIATRICS

Journal of Pediatric and Neonatal Individualized Medicine Pub Date : 2016-08-18 DOI:10.7363/050224

R. Ambu, C. Gerosa, Giorgia Locci, Eleonora Obinu, A. Ravarino, A. D. Magistris, A. Reali, P. Eyken, G. Faa, Silvia Nati, L. Vinci

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引用次数: 2

摘要

在这篇综述的第一部分，简要总结了胃肠道的胚胎学和组织学。第二部分对肠干细胞进行了讨论。隐窝碱基在ISC增殖和自我更新的调控中发挥着重要的信号通路;Wnt, Notch, BMP, Ephrin, JAK/STAT1, PTEN, AKT, PI3K等等。许多研究者参与研究肠隐窝底部ISCs的位置、数量和行为。ISCs表达几种标记物。其中，富含亮氨酸重复序列的g蛋白偶联受体-5 (Lgr5)、Sox9、prominent in-1、DCAMKL-1、EphB2、p-PTEN、p-AKT、Fgfr3、m-TER和CD44。干细胞疗法已经显示出治疗一些以缺血性和炎症性病变为特征的组织损伤疾病的希望，如炎症性肠病(IBD)和坏死性小肠结肠炎(NEC)。第二届围产期病理学国际课程论文集(第11届新生儿国际研讨会的一部分·2015年10月26日至31日)·卡利亚里(意大利)·2015年10月31日·干细胞:现在和未来客座编辑:Gavino Faa, Vassilios Fanos, Antonio Giordano

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The small intestinal mucosa and its stem cells

In the first part of this review a brief summary of the embryology and histology of the gastrointestinal tract is provided. In the second part intestinal stem cells (ISCs) are discussed. Several signaling pathways play a crucial role in the crypt base in the regulation of ISC proliferation and self-renewal; Wnt, Notch, BMP, Ephrin, JAK/STAT1, PTEN, AKT, PI3K and many more. Numerous investigators are involved in studying the location, number, and behavior of ISCs within the base of the intestinal crypts. Several markers are espressed by ISCs. Among these, Leucine-rich-repeat-containing G-protein-coupled receptor-5 (Lgr5), Sox9, Prominin-1, DCAMKL-1, EphB2, p-PTEN, p-AKT, Fgfr3, m-TER, and CD44. Stem cell therapy has shown promise for the treatment of some diseases characterized by tissue damage with ischemic and inflammatory lesions like inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC). Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano

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来源期刊

Journal of Pediatric and Neonatal Individualized Medicine PEDIATRICS-

CiteScore

1.00

自引率

25.00%

发文量

审稿时长

12 weeks

期刊介绍： The Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) is a peer-reviewed interdisciplinary journal which provides a forum on new perspectives in pediatric and neonatal medicine. The aim is to discuss and to bring readers up to date on the latest in research and clinical pediatrics and neonatology. Special emphasis is on developmental origin of health and disease or perinatal programming and on the so-called ‘-omic’ sciences. Systems medicine blazes a revolutionary trail from reductionist to holistic medicine, from descriptive medicine to predictive medicine, from an epidemiological perspective to a personalized approach. The journal will be relevance to clinicians and researchers concerned with personalized care for the newborn and child. Also medical humanities will be considered in a tailored way. Article submission (original research, review papers, invited editorials and clinical cases) will be considered in the following fields: fetal medicine, perinatology, neonatology, pediatrics, developmental programming, psychology and medical humanities.