SciEnggJ Pub Date : 2024-06-04 DOI: 10.54645/202417supifi-23

C. W. Turalde, Al Joseph Molina, Mario B. Prado, Erlyn Sana

{"title":"Impact of the organ-system integrated curriculum on the research productivity of a Philippine government medical school: An ARIMA-based bibliometric analysis","authors":"C. W. Turalde, Al Joseph Molina, Mario B. Prado, Erlyn Sana","doi":"10.54645/202417supifi-23","DOIUrl":"https://doi.org/10.54645/202417supifi-23","url":null,"abstract":"The organ-system integrated (OSI) curriculum was pioneered in the country by the U.P. College of Medicine (UPCM) in 2004. Data on its impact on research productivity was lacking. This study aims to describe the trends in research productivity of UPCM in a time series and the impact of OSI implementation on publication trends. Relevant electronic databases (PubMed, Scopus, and WPRIM) were searched from the earliest indexed record until December 2023. The auto-regressive integrated moving average (ARIMA) time series analysis was used to compare the actual and predicted trends during the OSI implementation using the pre-OSI trend. A total of 2,705 articles were included. Acta Medica Philippina is the journal with the highest number of publications (n = 420, 20.24%). Although there is a considerable rise in the number of publications utilizing evidence synthesis and qualitative design, observational studies remain as the most common design (n = 293, 2021-2023 period). The leading clinical departments are Neurosciences and Medicine. The departments of Biochemistry and Clinical Epidemiology take the lead among basic sciences departments. Despite the glaring uptrend in publications concurrent with OSI implementation, the actual trend is not significantly different from the predicted trend (LR chi2(1) = 0.37; Prob > chi2 = 0.5432). The OSI curriculum did not significantly change the trend of productivity. Medical curriculum designers should revisit strategies dedicated for research competencies. It is imperative to include activities for qualitative and mixed-methods designs. Future studies should consider relevant critical events in the time series forecasting models and the scientific outputs in the grey literature.","PeriodicalId":518923,"journal":{"name":"SciEnggJ","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141267109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intradialytic massage for leg cramps among hemodialysis patients: A single-center, randomized crossover trial 血液透析患者腿部抽筋的椎管内按摩：单中心随机交叉试验

SciEnggJ Pub Date : 2024-04-24 DOI: 10.54645/202417supejr-14

Krizia Mari Anne Ramos-Daguman, Ed Jico Conde, Henry Angelo Go, Vince Bryan Viscayno, Monalisa Lim Dungca, Marissa Elizabeth Lim

{"title":"Intradialytic massage for leg cramps among hemodialysis patients: A single-center, randomized crossover trial","authors":"Krizia Mari Anne Ramos-Daguman, Ed Jico Conde, Henry Angelo Go, Vince Bryan Viscayno, Monalisa Lim Dungca, Marissa Elizabeth Lim","doi":"10.54645/202417supejr-14","DOIUrl":"https://doi.org/10.54645/202417supejr-14","url":null,"abstract":"Background: Leg cramps are commonly experienced by hemodialysis patients, and its persistence may lead to treatment noncompliance. Limited studies are available examining the efficacy of intradialytic massage on reducing leg cramps. Objectives: To determine the efficacy of intradialytic leg massage on reducing leg cramps among patients undergoing maintenance hemodialysis at the East Avenue Medical Center. Methodology: This is a single-center, randomized crossover trial. A total of 44 adult patients were randomized in a 1:1 ratio into two groups—Group A (intradialytic massage followed by control) and Group B (control followed by intradialytic massage). Each patient underwent the first assigned intervention for 2 weeks, followed by a washout period of 4 weeks, then the second intervention was performed for another 2 weeks. The primary outcomes were the change in frequency, duration, and intensity of cramps. The secondary outcome was patient quality of life. Results: A higher proportion of patients during the intervention period did not experience cramps post-intervention than during the control period; however, the results were not statistically significant (p=0.2059). The median change in frequency, duration, and intensity of leg cramps did not significantly differ between intervention and control (p>0.05). Moreover, quality of life measures were not significantly different between the two groups (p>0.05). Conclusion: Intradialytic massage alone is not efficacious in reducing leg cramp frequency, duration, and intensity. Moreover, intradialytic massage failed to improve the quality of life of patients undergoing hemodialysis treatment. Underlying factors that lead to leg cramps should be addressed through comprehensive and individualized interventions.","PeriodicalId":518923,"journal":{"name":"SciEnggJ","volume":"35 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140661209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity and novelty of venom peptides from Conus (Asprella) rolani revealed by analysis of its venom duct transcriptome 通过分析柯纳斯（Asprella）毒液导管转录组揭示其毒液肽的多样性和新颖性

SciEnggJ Pub Date : 2024-04-22 DOI: 10.54645/202417supqch-42

Ryoichi Taguchi, Dan Jethro M Masacupan, Arturo Lluisma

{"title":"Diversity and novelty of venom peptides from Conus (Asprella) rolani revealed by analysis of its venom duct transcriptome","authors":"Ryoichi Taguchi, Dan Jethro M Masacupan, Arturo Lluisma","doi":"10.54645/202417supqch-42","DOIUrl":"https://doi.org/10.54645/202417supqch-42","url":null,"abstract":"Conus species in the sub-genus Asprella are poorly studied because they inhabit deep-water habitats. To date, only a few peptides have been characterized from this clade. In this study, the venom duct transcriptome of a member of this clade, Conus rolani, was mined for potential conopeptides. Using a high-throughput RNA sequencing platform (Illumina) and a multiple k-mer de novo assembly, we found 103 putative conopeptide precursor amino acid sequences, including the few peptides previously reported for this species. The sequences, predominantly novel based on amino acid sequence, were diverse, comprising 36 gene superfamilies (including the “unassigned” superfamilies). As observed in other Conus species, the O1 gene superfamily was the most diverse (12 distinct sequences) but interestingly none of the sequences were found to contain the conserved amino acids associated with certain bioactivities in peptides found in piscivorous Conus species. The O2 superfamily was also highly diverse but con-ikot-ikot and an unassigned superfamily (MMSRMG) were more diverse than the rest of the superfamilies. In terms of gene expression levels, the understudied MEFRR paralog of the ancestral divergent M---L-LTVA superfamily was found to be the most highly expressed in the transcriptome, suggesting a novel role. Additionally, a conopeptide with high sequence similarity to A2 secretory group XII phospholipases is the first reported member of this phospholipase group in Conus and potentially represents a novel superfamily, expanding the catalog of known phospholipases present in cone snail venoms. The discovery of these putative conopeptides provides the first but early glimpse of the diversity and novelty of the peptides in the Asprella group and sets the stage for their functional characterization.","PeriodicalId":518923,"journal":{"name":"SciEnggJ","volume":"27 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140677751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of interdependent happiness among health science students during the COVID-19 pandemic COVID-19 大流行期间健康科学专业学生相互依存幸福感的预测因素

SciEnggJ Pub Date : 2024-04-19 DOI: 10.54645/202417supavr-28

Demuel Dee Berto, D. D. Dasig, Leticia Ibanez, Marlon L. Bayot

{"title":"Predictors of interdependent happiness among health science students during the COVID-19 pandemic","authors":"Demuel Dee Berto, D. D. Dasig, Leticia Ibanez, Marlon L. Bayot","doi":"10.54645/202417supavr-28","DOIUrl":"https://doi.org/10.54645/202417supavr-28","url":null,"abstract":"There are limited studies on the impact of the COVID-19 pandemic on the mental health of Filipino health science students, mainly those correlating a unique culturally related construct, such as interdependent happiness (IDH), to physiologic, health, and psychosocial factors. Cross-sectional data were collected to investigate the factors predicting the IDH of students at a private university during the COVID-19 pandemic. A seven-part online survey was completed by 180 respondents using convenience sampling. There was no evidence of multicollinearity issues in any of the independent variables. The findings revealed that 100% of respondents had poor sleep quality, a morning chronotype, and better eating habits. The majority (81%) had low levels of physical activity, low levels of social support (60%), and average levels of IDH (36.1%). Bivariate analyses revealed that sleep quality and chronotype were negatively associated with IDH. Dietary habits and social support were found to have a moderately positive relationship with IDH. Physical activity was not found to be significantly related to IDH. Regression analysis revealed three variables significantly associated with IDH: sleep quality, dietary habits, and social support. When age, gender, college, year level, family income, body mass index, and grade point average were all considered, there were no significant differences in the IDH of health science students. This study shows that sleep quality, dietary habits, and social support all predict IDH and should be considered when managing the psychological impact of COVID-19 or any future pandemics among students.","PeriodicalId":518923,"journal":{"name":"SciEnggJ","volume":" 561","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140682325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heated tobacco products: Potentials of harm reduction, improvement of indoor air quality and the need for further studies 加热烟草制品：减少危害、改善室内空气质量的潜力和进一步研究的必要性

SciEnggJ Pub Date : 2024-04-15 DOI: 10.54645/2024171pwy-56

Aldwin Camance

{"title":"Heated tobacco products: Potentials of harm reduction, improvement of indoor air quality and the need for further studies","authors":"Aldwin Camance","doi":"10.54645/2024171pwy-56","DOIUrl":"https://doi.org/10.54645/2024171pwy-56","url":null,"abstract":"Air pollution is a major concern in the Philippines, with indoor and outdoor air pollution among the highest causes of mortality in the country. However, the latest regulations deal only with ambient outdoor air pollution. Indoor air pollution is seldom monitored or studied. Most of the official government monitoring data also deal with outdoor air pollution even if Filipinos spend more than 80% of their time indoors. Smoking indoors can be a cause of excess air pollutants in the indoor setting. Heated Tobacco products, newly introduced in the country, have been reported to reduce the harm of exposure to users to air pollutants. We investigated this through the review of 282 studies, research papers, books, and narratives about HTP use and their effects. These studies show reduced release of harmful and potentially harmful compounds (HPHC) in the aerosol and lower concentrations of HPHCs in the indoor environment when using HTPs as compared to tobacco smoke. Short term pre-clinical studies also show a reduction in the biomarkers for potential exposure to these HPHCs and risk calculations have shown a reduction in cancer potencies across populations. While long-term epidemiological studies are still required to determine with finality the risks that HTP use may have, there is already wide agreement in the initial results that the complete switch to HTP use from cigarette smoking presents less risks of harm. The review, however, shows that much has to be studied about the manner by which HTPs can affect indoor air quality in tropical countries such as the Philippines.","PeriodicalId":518923,"journal":{"name":"SciEnggJ","volume":"41 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overexpressed yeast Bax inhibitor (Bxi1p/Ybh3p) is a calcium channel in E. coli 过表达的酵母 Bax 抑制剂（Bxi1p/Ybh3p）是大肠杆菌中的钙通道

SciEnggJ Pub Date : 2024-02-28 DOI: 10.54645/202417suppmf-87

James Mullin, John Kalhorn, Julia D. Aguiar, Madelyn Crago, Nicholas Mello, Amanda Raffa, Alexander Strakosha, Nicanor Austriaco, O.P.

{"title":"Overexpressed yeast Bax inhibitor (Bxi1p/Ybh3p) is a calcium channel in E. coli","authors":"James Mullin, John Kalhorn, Julia D. Aguiar, Madelyn Crago, Nicholas Mello, Amanda Raffa, Alexander Strakosha, Nicanor Austriaco, O.P.","doi":"10.54645/202417suppmf-87","DOIUrl":"https://doi.org/10.54645/202417suppmf-87","url":null,"abstract":"Human Bax Inhibitor-1 (HsBI-1/TMBIM6) is the founding member of the evolutionary conserved TMBIM superfamily of proteins that share sequence homology within the transmembrane Bax inhibitor-containing motif (TMBIM). Mechanistically, BI-1/TMBIM6 and all the other mammalian TMBIM proteins appear to be involved in the maintenance of calcium homeostasis, and the crystal structure of a bacterial TMBIM protein, BsYetJ, suggests that the protein is a pH-sensitive calcium leak. The budding yeast, Saccharomyces cerevisiae, has a single TMBIM family member (YNL305C) named Bxi1p/Ybh3p. To determine the function Bxi1p/Ybh3p, we overexpressed Bxi1p-GFP in E. coli to interrogate its putative calcium channel function. We show that bacterial cells expressing Bxi1p-GFP are more permeable to calcium than controls. Our data suggests that yeast Bax inhibitor (Bxi1p) is a calcium channel in E. coli, lending support to our proposal that Bxi1p is a bona fide member of the TMBIM family of proteins. Finally, parallel experiments also revealed that the human Bax Inhibitor-1 (HsBI1/TMBIM6) is also a calcium channel in bacteria.","PeriodicalId":518923,"journal":{"name":"SciEnggJ","volume":"115 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140527654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of EEG signals for the detection of epileptic seizures using feature extraction 利用特征提取分析脑电信号以检测癫痫发作

SciEnggJ Pub Date : 2024-02-13 DOI: 10.54645/202417supcqp-72

Ravikumar Kandagatla, V. J. Naidu, P.S. Sreenivasa Reddy, Veera Kavya Pandilla, Marriwada Joshitha, Chanamala Rakesh

引用次数: 0

A single switch high gain multilevel boost converter with switched inductor topology for photovoltaic applications 采用开关电感拓扑结构的光伏应用单开关高增益多电平升压转换器

SciEnggJ Pub Date : 2024-02-12 DOI: 10.54645/202417supdwr-69

Akkela Krishnaveni, Rajender Boini

{"title":"A single switch high gain multilevel boost converter with switched inductor topology for photovoltaic applications","authors":"Akkela Krishnaveni, Rajender Boini","doi":"10.54645/202417supdwr-69","DOIUrl":"https://doi.org/10.54645/202417supdwr-69","url":null,"abstract":"This paper proposes a new transformer-less single-switch high-gain dc-dc converter for solar power systems. The suggested converter is created by supplementing the conventional boost converter with a switched inductor cell plus a voltage multiplier stage. The converter has several benefits, including a high voltage conversion ratio, reduced voltage stress on semiconducting switches and diodes, a reduction in the need for gate drivers because only one switch is used, as well as constant input current to prolong the lifespan of the photovoltaic cell. The analytical waveforms of the recommended converter can be seen in the continuous conduction mode (CCM). The analysis of voltage stress is done. In the presence of parasitic components, increased voltage gain and efficiency were also obtained.The proposed high-gain converter topology is compared to recently published high-gain converter topologies in terms of performance. Using PSIM, a high-gain dc-dc converter's performance is studied and analysed with regard to its low switching voltage stress. The suggested converter is successful in stepping up 20V to 400V at 160W power capacity, while offering a continuous input source current at 95% efficiency.","PeriodicalId":518923,"journal":{"name":"SciEnggJ","volume":"128 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140527761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical content, antioxidant capacity, and in vitro antibacterial activity of bran extracts of Philippine rice (Oryza sativa) cultivars 菲律宾水稻（Oryza sativa）栽培品种麸皮提取物的植物化学成分含量、抗氧化能力和体外抗菌活性

SciEnggJ Pub Date : 2024-01-19 DOI: 10.54645/2024171ztj-34

R. Manaois, J. E. Zapater, Amelia Morales, Jay Carl Cacerez

{"title":"Phytochemical content, antioxidant capacity, and in vitro antibacterial activity of bran extracts of Philippine rice (Oryza sativa) cultivars","authors":"R. Manaois, J. E. Zapater, Amelia Morales, Jay Carl Cacerez","doi":"10.54645/2024171ztj-34","DOIUrl":"https://doi.org/10.54645/2024171ztj-34","url":null,"abstract":"Rice bran is a by-product of the milling process that contains compounds with possible therapeutic properties. However, it is underutilized. This study assessed the phytochemical content, namely free, bound, and total phenolic (TPC), flavonoid (TFC), and anthocyanin (TAC) contents; antioxidant capacity using the 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging assay; and in vitro antibacterial activity of crude extracts from the bran of six (one white, two red, three black) selected Philippine rice varieties. Cyanidin-3-glucoside (C3G) and trans-ferulic acid (TFA) were quantified through High-Performance Liquid Chromatography. The in vitro antibacterial activities of extracts (0.1, 0.5, and 0.7 g/mL) against the gram-positive food pathogens Staphylococcus aureus and Clostridium perfringens were evaluated by agar well diffusion assay. Of the five samples, the red rice Kamanga recorded the highest free phenolics (121.01 mg gallic acid equivalents (GAE)/g), TFC (90.14 mg rutin hydrate equivalents/g), and DPPH antioxidant capacity (368.23 µmol Trolox equivalents/g). Generally, black brans had higher TAC, especially Ominio (17.81 mg C3G equivalents/g), which also had the highest bound phenolic content (125.6 mg GAE/g). C3G was only detected on black brans, with at least six-fold more in Ominio than in the other tested varieties. Only the extracts from pigmented varieties, except Ominio, displayed inhibitory potential against the food pathogens, implying that C3G is not the major component imparting the inhibitory activity in the black rice varieties. Therefore, pigmented rice brans can be explored as cheap sources of phytochemicals with antioxidant capacities and natural antibacterial agents for the food and pharmaceutical industries.","PeriodicalId":518923,"journal":{"name":"SciEnggJ","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140531104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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