The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology最新文献

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Electrogastrography in Patients with Functional Dyspepsia, Joint Hypermobility, and Diabetic Gastroparesis. 功能性消化不良、关节活动亢进和糖尿病性胃轻瘫患者的胃电图研究。
IF 1.2
Abdullah Al Kafee, Talar Cilacı, Yusuf Kayar, Aydın Akan
{"title":"Electrogastrography in Patients with Functional Dyspepsia, Joint Hypermobility, and Diabetic Gastroparesis.","authors":"Abdullah Al Kafee,&nbsp;Talar Cilacı,&nbsp;Yusuf Kayar,&nbsp;Aydın Akan","doi":"10.5152/tjg.2021.20853","DOIUrl":"https://doi.org/10.5152/tjg.2021.20853","url":null,"abstract":"<p><strong>Background: </strong>Transcutaneous electrogastrography is a novel modality to assess the human stomach's gastric myoelectrical activity. The purpose of this study was to compare functional dyspepsia, joint hypermobility, and diabetic gastroparesis patients with healthy control subjects in terms of gastric motility abnormalities through electrogastrography evaluations, and to then evaluate the correlation among variations in their blood parameters.</p><p><strong>Methods: </strong>This study analyzed 120 subjects with functional dyspepsia (n = 30), joint hypermobility (n = 30), diabetic gastroparesis (n = 30), and control subjects (n = 30). The electrogastrography parameters included the dominant frequency, dominant power, power ratio, and instability coefficient, which were analyzed preprandially and postprandially. Although there are similar studies in the literature, there is no other study in which all groups have been studied together, as in our study.</p><p><strong>Results: </strong>The electrogastrography results showed that preprandial dominant frequency (P = .031*), dominant power (P = .047*), and instability coefficient (P = .043*), and postprandial dominant frequency (P = .041*) and dominant power (P = .035*) results were statistically significant among the functional dyspepsia, joint hypermobility, diabetic gastroparesis, and control groups. There was no significant difference found in terms of power ratio (P = .114) values. However, only glucose (P = .04*) and calcium (P = .04*) levels showed statistical significance. Several blood tests including hemoglobin (P = .032*), creatinine (P= .045*), calcium (P = .037*), potassium (P= .041*), white blood cells (P = .038*), and alanine aminotransferase (P = .031*) also showed correlation with the dominant frequency, power ratio, and instability coefficient parameters.</p><p><strong>Conclusions: </strong>This joint methodology demonstrated that it is possible to differentiate between functional dyspepsia, joint hypermobility, and diabetic gastroparesis patients from healthy subjects by using electrogastrography. Moreover, the majority of patients showed adequate gastric motility in response to food.</p>","PeriodicalId":518528,"journal":{"name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","volume":" ","pages":"182-189"},"PeriodicalIF":1.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128354/pdf/tjg-33-3-182.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Autoimmune Liver Diseases: The Value of Geographic Differences. 自身免疫性肝病:地理差异的价值。
IF 1.2
Linda Beenet
{"title":"Autoimmune Liver Diseases: The Value of Geographic Differences.","authors":"Linda Beenet","doi":"10.5152/tjg.2022.21196","DOIUrl":"https://doi.org/10.5152/tjg.2022.21196","url":null,"abstract":"","PeriodicalId":518528,"journal":{"name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","volume":" ","pages":"271"},"PeriodicalIF":1.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128339/pdf/tjg-33-3-271.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Cirrhotic Patients with Acute-on-Chronic Liver Failure". 对“中性粒细胞/淋巴细胞比值在肝硬化伴急性/慢性肝衰竭患者中的预后价值”的评论。
IF 1.2
Fangbin Weng
{"title":"Comment on \"Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Cirrhotic Patients with Acute-on-Chronic Liver Failure\".","authors":"Fangbin Weng","doi":"10.5152/tjg.2022.21190","DOIUrl":"https://doi.org/10.5152/tjg.2022.21190","url":null,"abstract":"","PeriodicalId":518528,"journal":{"name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","volume":" ","pages":"272"},"PeriodicalIF":1.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128581/pdf/tjg-33-3-272.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Helicobacter pylori Infection Associated with Celiac Disease? A Meta-analysis. 幽门螺杆菌感染与乳糜泻有关吗?一个荟萃分析。
IF 1.2
Min Yue, Qiang Chen, Xinxin Zhou, Lan Li, Chao Lu
{"title":"Is Helicobacter pylori Infection Associated with Celiac Disease? A Meta-analysis.","authors":"Min Yue,&nbsp;Qiang Chen,&nbsp;Xinxin Zhou,&nbsp;Lan Li,&nbsp;Chao Lu","doi":"10.5152/tjg.2022.21360","DOIUrl":"https://doi.org/10.5152/tjg.2022.21360","url":null,"abstract":"<p><strong>Background: </strong>Some studies have reported the correlation between Helicobacter pylori and celiac disease (CD), but the results lack consistency. This meta-analysis aimed to quantify the relationship between H. pylori and CD. In addition, the study also analyzed the impact of H. pylori on the symptoms and classification of CD.</p><p><strong>Methods: </strong>Studies published up to September 1, 2020 on 3 databases - EMBASE, MEDICINE, and PubMed - were searched. The statistical data of articles which met the requirements were collated and extracted.</p><p><strong>Results: </strong>Twenty-five papers and 141 355 participants were finally enrolled. The results showed that the H. pylori infection rate of CD patients was 0.57 times greater compared to controls (OR = 0.57, 95% CI [0.44, 0.75]), while statistical differences were also seen in the subgroups of children (OR = 0.53, 95% CI [0.33, 0.85]) and adults (OR = 0.63, 95% CI [0.49, 0.81]). Furthermore, patients having CD with H. pylori were more likely to have symptoms of abdominal pain, diarrhea, and distension (OR = 2.5, 95% CI [1.35, 4.62]) (OR = 1.56, 95% CI [1.09, 2.24]) (OR = 2.75, 95% CI [1.74, 4.35]). However, H. pylori has no effect on CD classification.</p><p><strong>Conclusion: </strong>The study confirmed that there is a correlation between H. pylori and CD, but the causality cannot be clarified. A demonstration of a causal role of H. pylori in CD in future prospective studies could have important therapeutic implications.</p>","PeriodicalId":518528,"journal":{"name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","volume":" ","pages":"205-212"},"PeriodicalIF":1.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128522/pdf/tjg-33-3-205.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39885430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Turkish Validity-Reliability Study of the Celiac Disease-Specific Pediatric Quality of Life Scale. 乳糜泻特异性儿童生活质量量表的土耳其效度-信度研究
IF 1.2
Cemal Koçak, Semih Sandal, Meltem Çöl, Aydan Kansu Tanca, Zarife Kuloğlu, Ceyda Tuna Kırsaçlıoğlu
{"title":"Turkish Validity-Reliability Study of the Celiac Disease-Specific Pediatric Quality of Life Scale.","authors":"Cemal Koçak,&nbsp;Semih Sandal,&nbsp;Meltem Çöl,&nbsp;Aydan Kansu Tanca,&nbsp;Zarife Kuloğlu,&nbsp;Ceyda Tuna Kırsaçlıoğlu","doi":"10.5152/tjg.2022.21242","DOIUrl":"https://doi.org/10.5152/tjg.2022.21242","url":null,"abstract":"<p><strong>Background: </strong>Celiac disease is an autoimmune enteropathy triggered by the presence of gluten. There are Celiac Disease Dutch-Child Quality of Life Scale, Celiac-Specific Pediatric Quality of Life Scale for children/adolescents patients to measure the quality of life. In this study, due to lack of quality of life scales for children with celiac in Turkey, we aimed at Turkish adaptation of the Celiac-Specific Pediatric Quality of Life Scale.</p><p><strong>Methods: </strong>This methodological study was conducted in Ankara University Faculty of Medicine, Cebeci Hospital Hospital between July 2019 and July 2020. A total of 192 children were included. Reliability was demonstrated by the Cronbach's alpha coefficient. Structural validity was evaluated using explanatory factor analysis and confirmatory factor analysis. The Statistical Package for Social Sciences (SPSS) 22.0 and Amos were used in analyses.</p><p><strong>Results: </strong>In 8-12 age groups; Cronbach's alpha was 0.92 in negative emotions dimension, 0.88 in school dimension, and 0.74 in enjoyment dimension. In explanatory factor analysis, Kaiser-Meyer-Olkin measure of sampling adequacy value was 0.698, Bartlett's test of sphericity was significant (P < .001). Variance explained was 75.8%. In confirmatory factor analysis, X2/df was 3.26, root mean square error of approximation value was 0.07, comparative fit index value was 0.96. In 13-18 age groups; Cronbach's alpha was 0.87 in social dimension, 0.84 in uncertainty dimension, 0.78 in isolation dimension, and 0.83 in limitations dimension. In explanatory factor analysis, Kaiser-Meyer-Olkin measure of sampling adequacy was 0.684, Bartlett's test of sphericity was significant (P < .001). Variance explained was 68.6%. In confirmatory factor analysis, X2/sd value was 3.78, root mean square error of approximation value was 0.061, and comparative fit index value was 0.961.</p><p><strong>Conclusion: </strong>Cronbach's alpha values of the groups were found to be above 0.70. Kaiser-Meyer-Olkin values were above 0.5 in terms of sample size, Bartlett's tests for sphericity were significant in terms of correlations between variables, root mean square error of approximation values were below 0.08, comparative fit index and goodness of fit index values were above 0.95 in terms of model fit. If the scales have been found to be valid and reliable, it is recommended for use in Turkey.</p>","PeriodicalId":518528,"journal":{"name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","volume":" ","pages":"248-256"},"PeriodicalIF":1.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128598/pdf/tjg-33-3-248.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39885431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extending the Common Sense Model to Explore the Impact of Visceral Sensitivity on Quality of Life in Inflammatory Bowel Disease. 扩展常识模型,探索炎性肠病患者内脏敏感性对生活质量的影响。
IF 1.2
Bree Hayes, Rebecca Burgell, Pragalathan Apputhurai, Mayur Garg, Simon R Knowles
{"title":"Extending the Common Sense Model to Explore the Impact of Visceral Sensitivity on Quality of Life in Inflammatory Bowel Disease.","authors":"Bree Hayes,&nbsp;Rebecca Burgell,&nbsp;Pragalathan Apputhurai,&nbsp;Mayur Garg,&nbsp;Simon R Knowles","doi":"10.5152/tjg.2021.201158","DOIUrl":"https://doi.org/10.5152/tjg.2021.201158","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease is associated with poor quality of life. The aim of the cross-sectional study was to extend the common sense model to explore the impact of inflammatory bowel disease activity on quality of life and the potential mediating roles of illness perceptions, visceral sensitivity, coping styles, acceptance, and psychological distress.</p><p><strong>Methods: </strong>A total of 141 inflammatory bowel disease patients (86 with Crohn's disease and 55 with ulcerative colitis; 74 males, 65 females, and 2 gender non-specific, mean age 40.43 years) from 2 metropolitan hospital inflammatory bowel disease outpatient clinics participated. Measures included disease activity (Crohn's Disease Activity Index, Simple Clinical Colitis Activity Index), illness perceptions (Brief Illness Perceptions Questionnaire), visceral sensitivity (Visceral Sensitivity Index), coping styles (Brief Coping Operations Preference Enquiry), acceptance (Acceptance and Action Questionnaire-II), psychological distress (Depression, Anxiety, and Stress Scale), and European Health Interview Survey-Quality of Life (EUROHIS-QoL).</p><p><strong>Results: </strong>A structural equation model of the extended common sense model was found to have a good fit (χ2(10) = 10.07, P = .43, root mean square error of approximation = 0.01, standardized root mean residual = 0.04, comparative index fit = 1.00, Tucker-Lewis index = 1.00, goodness-of-fit = 0.98). After controlling for irritable bowel syndrome diagnosis, the impact of disease activity on quality of life was statistically mediated by illness perceptions, maladaptive coping styles, and psychological distress. In addition, visceral sensitivity bordered on influencing the impact of disease activity and illness perceptions on quality of life through psychological distress.</p><p><strong>Conclusions: </strong>This study demonstrates that together with illness perceptions and coping styles, visceral sensitivity plays an important role in an individual's adaption to living with inflammatory bowel disease.</p>","PeriodicalId":518528,"journal":{"name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","volume":" ","pages":"103-110"},"PeriodicalIF":1.2,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128579/pdf/tjg-33-2-103.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Statins in Hepatitis B or C Patients Is Associated With Reduced Hepatocellular Carcinoma Risk: A Systematic Review and Meta-Analysis. 乙型或丙型肝炎患者服用他汀类药物与降低肝细胞癌风险相关:一项系统综述和荟萃分析
IF 1.2
Zhiguo Li, Ying Li, Xiaoke Li, Ludan Zhang, Nanqi Zhao, Hongbo Du, Bo Zhou, Yong'an Ye
{"title":"Statins in Hepatitis B or C Patients Is Associated With Reduced Hepatocellular Carcinoma Risk: A Systematic Review and Meta-Analysis.","authors":"Zhiguo Li,&nbsp;Ying Li,&nbsp;Xiaoke Li,&nbsp;Ludan Zhang,&nbsp;Nanqi Zhao,&nbsp;Hongbo Du,&nbsp;Bo Zhou,&nbsp;Yong'an Ye","doi":"10.5152/tjg.2020.19656","DOIUrl":"https://doi.org/10.5152/tjg.2020.19656","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma is the world's leading cause of cancer-related death. Chronic hepatitis B virus and hepatitis C virus infection cause liver cancer. The aim of this study was to investigate the relationship between statins and the risk of hepatocellular carcinoma in patients with hepatitis B or C.</p><p><strong>Methods: </strong>We systematically searched Web of Science, Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database from their inception to January 2019. We included studies that reported the hepatocellular carcinoma incidence among hepatitis B virus- or hepatitis C virus-infected patients or hepatitis B virus- or hepatitis C virus-related cirrhotic patients, evaluated and clearly defined exposure to statins, provided effective comparison groups, and reported risk estimates. Inclusion was not otherwise restricted. Summary relative risk estimates with 95% CIs were calculated using a random-effects model.</p><p><strong>Results: </strong>Meta-analysis of 10 studies showed that statin users had a significantly lower risk of hepatocellular carcinoma (relative risk = 0.47, 95% CI = 0.38-0.56) with significant heterogeneity. In 7 hepatitis studies, using statin was associated with a 53% reduction in the incidence of hepatocellular carcinoma (relative risk = 0.47, 95% CI = 0.43-0.50) with substantial heterogeneity. In 3 cirrhosis studies, the incidence of hepatocellular carcinoma in statin users was significantly reduced by 55% (relative risk = 0.45, 95% CI = 0.30-0.61) with no heterogeneity.</p><p><strong>Conclusion: </strong>Statins reduce the hepatocellular carcinoma risk among patients infected with hepatitis B virus or hepatitis C virus. This chemoprotective association is more pronounced in hepatitis B virus or hepatitis C virus-associated cirrhotic patients.</p>","PeriodicalId":518528,"journal":{"name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","volume":" ","pages":"136-144"},"PeriodicalIF":1.2,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128600/pdf/tjg-33-2-136.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Evaluation of the Liver and Pancreas by 2D Shear Wave Elastography in Pediatric Wilson's Disease. 二维横波弹性成像对小儿肝豆状核变性肝脏和胰腺的评价。
IF 1.2
Sibel Yavuz, Ferhat Can Pişkin, Cemil Oktay, Süreyya Soyupak, Gökhan Tümgör
{"title":"Evaluation of the Liver and Pancreas by 2D Shear Wave Elastography in Pediatric Wilson's Disease.","authors":"Sibel Yavuz,&nbsp;Ferhat Can Pişkin,&nbsp;Cemil Oktay,&nbsp;Süreyya Soyupak,&nbsp;Gökhan Tümgör","doi":"10.5152/tjg.2022.21545","DOIUrl":"https://doi.org/10.5152/tjg.2022.21545","url":null,"abstract":"<p><strong>Background: </strong>The primary aim of the study was to demonstrate parenchymal changes in the liver and pancreas related to copper accumulation using ultrasound in pediatric patients with Wilson's disease and secondly, to investigate the effectiveness of two-dimensional shear wave elastography in the diagnosis of involvement of these organs.</p><p><strong>Methods: </strong>Patients with Wilson's disease (n = 25) who were treated and followed at our center were evaluated prospectively. In addition to routine clinical assessments, eye examination, laboratory analyses, and abdominal ultrasound imaging, all patients underwent tissue stiffness measurements from the liver and pancreas (head, body and tail) by two-dimensional shear wave elastography. The data obtained from the WD patients were compared with those of age- and sex-matched healthy controls (n = 37).</p><p><strong>Results: </strong>Liver elastography measurements showed significantly increased tissue stiffness in the patient group than in control subjects (P < .001). While there was no significant difference between the groups in the tissue thickness of pancreatic head, body, and tail, tissue stiffness was significantly reduced in the patient group (P < .001). Disease duration was significantly associated and moderately correlated with liver tissue stiffness (r = 0.417, P = .038) but not significantly associated with pancreatic tissue stiffness.</p><p><strong>Conclusion: </strong>In the early stages of Wilson's disease, parenchymal changes occur in the liver and pancreas, which cannot be detected by conventional ultrasonography imaging but may be demonstrated by two-dimensional shear wave elastography. Ultrasound elastography is an easy to use, non-invasive, and promising method that provides numerical data on the early changes in tissue stiffness, allowing for objective monitoring of Wilson's disease patients who require lifelong follow-up.</p>","PeriodicalId":518528,"journal":{"name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","volume":" ","pages":"161-167"},"PeriodicalIF":1.2,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128336/pdf/tjg-33-2-161.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39885428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Counseling in Inflammatory Bowel Diseases: A Question, an Observation, and a Proposal. 炎症性肠病的咨询:一个问题,一个观察和一个建议。
IF 1.2
Rinaldo Pellicano
{"title":"Counseling in Inflammatory Bowel Diseases: A Question, an Observation, and a Proposal.","authors":"Rinaldo Pellicano","doi":"10.5152/tjg.2022.201133","DOIUrl":"https://doi.org/10.5152/tjg.2022.201133","url":null,"abstract":"","PeriodicalId":518528,"journal":{"name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","volume":" ","pages":"168"},"PeriodicalIF":1.2,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128523/pdf/tjg-33-2-168.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Long-Term Tenofovir and Entecavir Treatment on Bone Mineral Density in Patients with Chronic Hepatitis B. 替诺福韦和恩替卡韦长期治疗对慢性乙型肝炎患者骨密度的影响。
IF 1.2
Resul Kahraman, Abdurrahman Şahin, Oğuzhan Öztürk, Turan Çalhan, Süleyman Sayar, Evren Kanat, Levent Doğanay, Kamil Özdil
{"title":"Effects of Long-Term Tenofovir and Entecavir Treatment on Bone Mineral Density in Patients with Chronic Hepatitis B.","authors":"Resul Kahraman,&nbsp;Abdurrahman Şahin,&nbsp;Oğuzhan Öztürk,&nbsp;Turan Çalhan,&nbsp;Süleyman Sayar,&nbsp;Evren Kanat,&nbsp;Levent Doğanay,&nbsp;Kamil Özdil","doi":"10.5152/tjg.2020.18024","DOIUrl":"https://doi.org/10.5152/tjg.2020.18024","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate the long-term effects of tenofovir disoproxil fumarate and entecavir treatment on bone mineral density and evaluated the fracture risk assessment tool score in patients with chronic hepatitis B.</p><p><strong>Methods: </strong>A total of 58 chronic hepatitis B patients treated with tenofovir disoproxil fumarate (n = 40) and entecavir (n = 18) were included in this prospective study from 2012 to 2016. To evaluate bone mineral density, dual-X-ray absorptiometry, fracture risk assessment tool, and laboratory examinations were performed in all patients first at baseline and second at the end of the study.</p><p><strong>Results: </strong>Age, sex, body mass index, fibrosis score, and viral load were similar in both groups. The mean follow-up was 33 months in the tenofovir disoproxil fumarate group and 31 months in the entecavir group. In patients treated with entecavir, there was no statistically significant difference between baseline and second bone mineral density including lumbar spine (L) and total hip T score. In patients treated with tenofovir disoproxil fumarate, there was a significant difference in the second bone mineral density compared with baseline bone mineral density for L3 (P = .033) and the major fracture risk assessment tool score (P = .03). When patients were divided into 3 groups (normal bone mineral density, osteopenic, and osteoporotic), there was a significant increase in the number of osteopenic patients in the total hip T score after tenofovir disoproxil fumarate treatment (P = .034).</p><p><strong>Conclusion: </strong>Our results suggest a decrease in the bone mineral density for lumbar spine (L3), an increase in the number of patients with hip osteopenia, and major fracture risk assessment tool score after long-term tenofovir disoproxil fumarate treatment in patients with rechronic hepatitis B.</p>","PeriodicalId":518528,"journal":{"name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","volume":" ","pages":"35-43"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128468/pdf/tjg-33-1-35.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39705985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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