JAMA最新文献

{"title":"WHO Announces Mpox Global Plan, Appeals for Funding.","authors":"Samantha Anderer","doi":"10.1001/jama.2024.19128","DOIUrl":"https://doi.org/10.1001/jama.2024.19128","url":null,"abstract":"","PeriodicalId":518009,"journal":{"name":"JAMA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The US Presidential Election's High Stakes for the Future of Medicine.","authors":"Nicole Huberfeld,Elizabeth McCuskey,Michael R Ulrich","doi":"10.1001/jama.2024.19952","DOIUrl":"https://doi.org/10.1001/jama.2024.19952","url":null,"abstract":"","PeriodicalId":518009,"journal":{"name":"JAMA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What to Know About the Recent Rise in Parvovirus B19 Infections.","authors":"Rita Rubin","doi":"10.1001/jama.2024.19694","DOIUrl":"https://doi.org/10.1001/jama.2024.19694","url":null,"abstract":"","PeriodicalId":518009,"journal":{"name":"JAMA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Promise and Perils of Diversity Action Plans for Clinical Trials.","authors":"Tanvee Varma,Barbara E Bierer,Andrew Hantel","doi":"10.1001/jama.2024.18225","DOIUrl":"https://doi.org/10.1001/jama.2024.18225","url":null,"abstract":"","PeriodicalId":518009,"journal":{"name":"JAMA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Action Needed to Ease Parental Stress, US Surgeon General Warns.","authors":"Samantha Anderer","doi":"10.1001/jama.2024.19130","DOIUrl":"https://doi.org/10.1001/jama.2024.19130","url":null,"abstract":"","PeriodicalId":518009,"journal":{"name":"JAMA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Immune Checkpoint Inhibitor-Induced Diabetes Identified.","authors":"Samantha Anderer","doi":"10.1001/jama.2024.19134","DOIUrl":"https://doi.org/10.1001/jama.2024.19134","url":null,"abstract":"","PeriodicalId":518009,"journal":{"name":"JAMA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemistry Matters—From a Putative Peptide to Effective Treatments for Diabetes and Obesity","authors":"Svetlana Mojsov","doi":"10.1001/jama.2024.17571","DOIUrl":"https://doi.org/10.1001/jama.2024.17571","url":null,"abstract":"In this Viewpoint, 2024 Lasker-DeBakey Clinical Medical Research Award winner Svetlana Mojsov describes her discovery of GLP-1 (7-37), the biologically active incretin that led to development of effective GLP-1 analogues for treating diabetes and obesity.","PeriodicalId":518009,"journal":{"name":"JAMA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speed Limits","authors":"Eleanor R. Menzin","doi":"10.1001/jama.2024.16273","DOIUrl":"https://doi.org/10.1001/jama.2024.16273","url":null,"abstract":"In this narrative medicine essay, a pediatrician discusses the ambiguity of diagnoses of patients and settles on honestly admitting when the parameters are unclear with an explanation of the range of possibilities.","PeriodicalId":518009,"journal":{"name":"JAMA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AIDS in Africa—Impact of Research","authors":"Quarraisha Abdool Karim, Salim S. Abdool Karim","doi":"10.1001/jama.2024.18271","DOIUrl":"https://doi.org/10.1001/jama.2024.18271","url":null,"abstract":"In this Viewpoint, 2024 Lasker-Bloomberg Public Service Award winners Quarraisha Abdool Karim and Salim S. Abdool Karim discuss their journey in AIDS research in South Africa and the local and global health impact of this research.","PeriodicalId":518009,"journal":{"name":"JAMA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Stratification in Nonischemic Dilated Cardiomyopathy Using CMR Imaging","authors":"Christian Eichhorn, David Koeckerling, Rohin K. Reddy, Maddalena Ardissino, Marek Rogowski, Bernadette Coles, Lukas Hunziker, Simon Greulich, Isaac Shiri, Norbert Frey, Jens Eckstein, Stephan Windecker, Raymond Y. Kwong, George C. M. Siontis, Christoph Gräni","doi":"10.1001/jama.2024.13946","DOIUrl":"https://doi.org/10.1001/jama.2024.13946","url":null,"abstract":"ImportanceAccurate risk stratification of nonischemic dilated cardiomyopathy (NIDCM) remains challenging.ObjectiveTo evaluate the association of cardiac magnetic resonance (CMR) imaging–derived measurements with clinical outcomes in NIDCM.Data SourcesMEDLINE, Embase, Cochrane Library, and Web of Science Core Collection databases were systematically searched for articles from January 2005 to April 2023.Study SelectionProspective and retrospective nonrandomized diagnostic studies reporting on the association between CMR imaging–derived measurements and adverse clinical outcomes in NIDCM were deemed eligible.Data Extraction and SynthesisPrespecified items related to patient population, CMR imaging measurements, and clinical outcomes were extracted at the study level by 2 independent reviewers. Random-effects models were fitted using restricted maximum likelihood estimation and the method of Hartung, Knapp, Sidik, and Jonkman.Main Outcomes and MeasuresAll-cause mortality, cardiovascular mortality, arrhythmic events, heart failure events, and major adverse cardiac events (MACE).ResultsA total of 103 studies including 29 687 patients with NIDCM were analyzed. Late gadolinium enhancement (LGE) presence and extent (per 1%) were associated with higher all-cause mortality (hazard ratio [HR], 1.81 [95% CI, 1.60-2.04]; <jats:italic>P</jats:italic> < .001 and HR, 1.07 [95% CI, 1.02-1.12]; <jats:italic>P</jats:italic> = .02, respectively), cardiovascular mortality (HR, 2.43 [95% CI, 2.13-2.78]; <jats:italic>P</jats:italic> < .001 and HR, 1.15 [95% CI, 1.07-1.24]; <jats:italic>P</jats:italic> = .01), arrhythmic events (HR, 2.69 [95% CI, 2.20-3.30]; <jats:italic>P</jats:italic> < .001 and HR, 1.07 [95% CI, 1.03-1.12]; <jats:italic>P</jats:italic> = .004) and heart failure events (HR, 1.98 [95% CI, 1.73-2.27]; <jats:italic>P</jats:italic> < .001 and HR, 1.06 [95% CI, 1.01-1.10]; <jats:italic>P</jats:italic> = .02). Left ventricular ejection fraction (LVEF) (per 1%) was not associated with all-cause mortality (HR, 0.99 [95% CI, 0.97-1.02]; <jats:italic>P</jats:italic> = .47), cardiovascular mortality (HR, 0.97 [95% CI, 0.94-1.00]; <jats:italic>P</jats:italic> = .05), or arrhythmic outcomes (HR, 0.99 [95% CI, 0.97-1.01]; <jats:italic>P</jats:italic> = .34). Lower risks for heart failure events (HR, 0.97 [95% CI, 0.95-0.98]; <jats:italic>P</jats:italic> = .002) and MACE (HR, 0.98 [95% CI, 0.96-0.99]; <jats:italic>P</jats:italic> < .001) were observed with higher LVEF. Higher native T1 relaxation times (per 10 ms) were associated with arrhythmic events (HR, 1.07 [95% CI, 1.01-1.14]; <jats:italic>P</jats:italic> = .04) and MACE (HR, 1.06 [95% CI, 1.01-1.11]; <jats:italic>P</jats:italic> = .03). Global longitudinal strain (GLS) (per 1%) was not associated with heart failure events (HR, 1.06 [95% CI, 0.95-1.18]; <jats:italic>P</jats:italic> = .15) or MACE (HR, 1.03 [95% CI, 0.94-1.14]; <jats:italic>P</jats:italic> =","PeriodicalId":518009,"journal":{"name":"JAMA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}