Annals of clinical epidemiology最新文献

Erratum to: Evaluating optimal rehabilitation strategies in ICU: study protocol for a multicentre cohort study to assess Physical Activity dosing, Muscle mass, and physICal outcomeS (IPAMICS study). 评估ICU最佳康复策略：一项多中心队列研究的研究方案，以评估体力活动剂量、肌肉质量和身体结果（IPAMICS研究）。

Annals of clinical epidemiology Pub Date : 2026-03-05 eCollection Date: 2026-07-01 DOI: 10.37737/ace.24014E

Yasunari Morita, Shinichi Watanabe, Nobuto Nakanishi, Akihito Tampo, Kenzo Ishii, Keisuke Suzuki, Yoshie Hirota, Yuji Naito, Naoya Sato, Hiroyoshi Yano, Tomohiro Yoshikawa, Atsushi Ishihara, Hiroyasu Inoue, Keibun Liu, Shigeru Koba, Kasumi Satoh, Kensuke Nakamura

引用次数: 0

Erratum to: A new electronic medical record database linked to claims data and discharge abstract data (the RWD database) in Japan: Study design and profile. 勘误：与日本索赔数据和出院摘要数据（RWD数据库）相关联的新电子病历数据库：研究设计和概况。

Annals of clinical epidemiology Pub Date : 2026-01-09 eCollection Date: 2026-04-01 DOI: 10.37737/ace.24009E

Yasuyuki Okumura, Takashi Fujiwara, Hironobu Tokumasu, Takeshi Kimura, Shiro Hinotsu

引用次数: 0

Linkage of medical administrative claims and long-term care claims in DeSC database. DeSC数据库中医疗行政索赔和长期护理索赔的联系。

Annals of clinical epidemiology Pub Date : 2025-12-02 eCollection Date: 2026-07-01 DOI: 10.37737/ace.26012

Yoshihisa Miyamoto, Akira Okada, Yusuke Sasabuchi

{"title":"Linkage of medical administrative claims and long-term care claims in DeSC database.","authors":"Yoshihisa Miyamoto, Akira Okada, Yusuke Sasabuchi","doi":"10.37737/ace.26012","DOIUrl":"https://doi.org/10.37737/ace.26012","url":null,"abstract":"The DeSC database, launched in 2020 by DeSC Healthcare Co., Ltd. is a commercially available Japanese administrative medical claims and health checkup database. Recently, long-term care insurance (LTCI) claims data-covering care-need levels, monthly care benefits, service utilization, and cost information-have been integrated into the database. We showed that the distributions of the seven care-need levels were highly similar between the DeSC database and the official report by the Ministry of Health, Labour and Welfare. This similarity supports the representativeness and reliability of the DeSC database for epidemiological analyses using care-need status, particularly in the Advanced Elderly Medical Service System. This integrated dataset bridges critical information gaps and offers substantial advantages for health services research and epidemiological studies through individual-level linkage of medical, pharmacy, and LTCI claims. This study provides an overview of the LTCI claims data and available data items in the DeSC database and discusses future research prospects, with a particular focus on the linkage between medical and LTCI claims.","PeriodicalId":517436,"journal":{"name":"Annals of clinical epidemiology","volume":"8 3","pages":"101-104"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cefazolin Dose-Response-based Correlation of Weight With Orthopaedic Implant-related Surgical-site Infections. 头孢唑林体重与骨科植入物相关手术部位感染的剂量-反应相关性

Annals of clinical epidemiology Pub Date : 2025-12-02 eCollection Date: 2026-07-01 DOI: 10.37737/ace.26010

Masaki Hatano, Yusuke Sasabuchi, Koji Yamada, Shotaro Aso, Hisatoshi Ishikura, Takeyuki Tanaka, Sakae Tanaka, Hideo Yasunaga

{"title":"Cefazolin Dose-Response-based Correlation of Weight With Orthopaedic Implant-related Surgical-site Infections.","authors":"Masaki Hatano, Yusuke Sasabuchi, Koji Yamada, Shotaro Aso, Hisatoshi Ishikura, Takeyuki Tanaka, Sakae Tanaka, Hideo Yasunaga","doi":"10.37737/ace.26010","DOIUrl":"https://doi.org/10.37737/ace.26010","url":null,"abstract":"Background: This study aimed to evaluate the association of the initial body weight-stratified cefazolin antimicrobial prophylaxis (AMP) dose and surgical-site infection (SSI) in major orthopedic implant surgery.Methods: This nationwide, retrospective cohort study used data from the Diagnosis Procedure Combination database. We included patients (age ≥18 years) who underwent major orthopedic implant surgery between July 2010 and March 2022. Patients underwent surgery with an initial cefazolin dose of either 1 g (1 g cefazolin group) or 2 g (2 g cefazolin group). Primary outcome was in-hospital SSI. Restricted cubic spline functions were used to estimate the nonlinear association of body weight-stratified cefazolin dose with the outcome and between cefazolin dose per weight and the outcome.Results: Among the 408,487 participants, 394,731 and 13,756 were in the 1 g and 2g cefazolin groups, respectively. The 1 g cefazolin group, but not the 2 g cefazolin group, showed a J-shaped relationship between body weight and SSI, which increased continuously beyond 50 kg, in an increased risk of SSI with body weight. A reverse J-shaped relationship was observed between cefazolin dose per weight and SSI, with an increased risk of SSI at <20 mg/kg.Conclusion: An increased risk of SSI was observed with 1 g cefazolin, but not with 2 g cefazolin, as an initial AMP with higher body weight among adults weighing >50 kg.","PeriodicalId":517436,"journal":{"name":"Annals of clinical epidemiology","volume":"8 3","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of self-reported fractures in a follow-up survey of the Japan Multi-Institutional Collaborative Cohort study. 日本多机构合作队列研究的一项随访调查证实了自我报告的骨折。

Annals of clinical epidemiology Pub Date : 2025-12-02 eCollection Date: 2026-07-01 DOI: 10.37737/ace.26009

Takaomi Kobayashi, Yuichiro Nishida, Takuma Furukawa, Chisato Shimanoe, Keitaro Tanaka, Megumi Hara

{"title":"Validation of self-reported fractures in a follow-up survey of the Japan Multi-Institutional Collaborative Cohort study.","authors":"Takaomi Kobayashi, Yuichiro Nishida, Takuma Furukawa, Chisato Shimanoe, Keitaro Tanaka, Megumi Hara","doi":"10.37737/ace.26009","DOIUrl":"https://doi.org/10.37737/ace.26009","url":null,"abstract":"Background: This study aimed to validate self-reported fractures in the Japan Multi-Institutional Collaborative Cohort (J-MICC).Methods: Of the 10,332 participants who were followed up for 10 years, 1,137 individuals with self-reported fractures were included. Among them, 201 individuals were randomly selected, and 192 individuals with available medical records were analyzed. A false-positive fracture was defined as a self-reported fracture without a clinical diagnosis or record. We calculated the positive predictive value (PPV) stratified by the number of years from injury to response. Multivariate logistic regression analysis was used to elucidate the factors influencing false-positive fractures and to calculate the odds ratios (ORs) with 95% confidence intervals (CIs). The dependent variable was false-positive fractures, and the independent variables included factors such as fracture site, age, sex, body mass index, education, multisite fractures, multiple fractures, and number of years from injury to response.Results: The average age at the time of injury was 69.6 years (range, 50-80 years), and 48 individuals (25.0%) were male. Fractures were reported in the spine (41 individuals, 21.4%), upper limbs (57 individuals, 29.7%), lower limbs (71 individuals, 37.0%), and other locations (23 individuals, 11.9%), respectively. The PPV was 85.4% (164/192 individuals; 95% CI, 79.7-89.7) and was >90% if the period from injury to response was within 3 years. False-positive fractures were significantly associated with a period from injury to response >3 years (OR, 3.46; 95% CI, 1.43-8.37).Conclusions: elf-reported fractures are useful outcomes; however, recall periods >3 years may increase the risk of misclassification.","PeriodicalId":517436,"journal":{"name":"Annals of clinical epidemiology","volume":"8 3","pages":"73-82"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the revision of the recommended vaccination schedule for preventing vertical transmission of hepatitis B virus on vaccination status of infants in Japan. 修订预防乙型肝炎病毒垂直传播推荐疫苗接种时间表对日本婴儿疫苗接种状况的影响

Annals of clinical epidemiology Pub Date : 2025-12-02 eCollection Date: 2026-07-01 DOI: 10.37737/ace.26011

Hayato Yamana, Sachiko Ono, Nobuaki Michihata, Kohei Uemura, Hideo Yasunaga

{"title":"Effect of the revision of the recommended vaccination schedule for preventing vertical transmission of hepatitis B virus on vaccination status of infants in Japan.","authors":"Hayato Yamana, Sachiko Ono, Nobuaki Michihata, Kohei Uemura, Hideo Yasunaga","doi":"10.37737/ace.26011","DOIUrl":"https://doi.org/10.37737/ace.26011","url":null,"abstract":"Background: In 1986, a strategy of vaccinating infants at 2, 3, and 5 months of age was implemented in Japan to prevent the vertical transmission of the hepatitis B virus. This strategy was revised in 2013 to vaccinate infants at birth, 1 month, and 6 months of age. We aimed to evaluate the effect of this policy change on the vaccination status of infants born to mothers with positive hepatitis B surface antigen.Methods: We identified infants born between April 2009 and March 2021 from the JMDC Claims Database. Administration of hepatitis B immunoglobulin at birth was used to identify infants who received preventive measures against vertical transmission. The timing of hepatitis B vaccine administration within 12 months of birth was compared between old (born between April 2009 and September 2013) and new (born between October 2013 and March 2021) groups.Results: Among the 77,797 and 510,584 infants born before and after October 1 2013, respectively, 190 (0.24%) and 732 (0.14%) were analyzed. The proportion of infants receiving at least one dose of the vaccine increased from 63% to 96% (p < 0.001). The proportion of infants who received timely first, second, and third doses of vaccines changed from 54% to 90% (p < 0.001), 46% to 59% (p = 0.002), and 39% to 31% (p = 0.034), respectively.Conclusions: The change in strategy against the vertical transmission of hepatitis B virus resulted in an increased rate of receiving the first dose of the vaccine and a decreased rate of timely completion of the recommended doses.","PeriodicalId":517436,"journal":{"name":"Annals of clinical epidemiology","volume":"8 3","pages":"93-100"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Changes of practice on out of hospital cardiopulmonary arrest during the COVID-19 pandemic: a cross-sectional survey of SOS-KANTO 2017 study. 2019冠状病毒病大流行期间院外心肺骤停实践的变化：SOS-KANTO 2017研究的横断面调查

Annals of clinical epidemiology Pub Date : 2025-11-21 eCollection Date: 2026-01-01 DOI: 10.37737/ace.24003E

Nobuya Kitamura, Takashi Tagami, Munekazu Takeda, Koichiro Shinozaki

引用次数: 0

Introduction to case-crossover study design for drug-drug interaction. 介绍药物-药物相互作用的病例-交叉研究设计。

Annals of clinical epidemiology Pub Date : 2025-11-18 eCollection Date: 2026-04-01 DOI: 10.37737/ace.26008

Qiuyan Yu, Angel Ys Wong

引用次数: 0

Effect of a financial incentive scheme on promoting prescription of biosimilars: a interrupted time-series analyses. 财政激励计划对促进生物仿制药处方的影响：中断时间序列分析。

Annals of clinical epidemiology Pub Date : 2025-11-18 eCollection Date: 2026-04-01 DOI: 10.37737/ace.26007

Takahito Morita, Yusuke Sasabuchi, Hideo Yasunaga

{"title":"Effect of a financial incentive scheme on promoting prescription of biosimilars: a interrupted time-series analyses.","authors":"Takahito Morita, Yusuke Sasabuchi, Hideo Yasunaga","doi":"10.37737/ace.26007","DOIUrl":"10.37737/ace.26007","url":null,"abstract":"Background: In Japan, biosimilars have the potential to reduce drug expenditure because their official price is lower than the price of the original products. To promote biosimilars, the Japanese government introduced a new financial incentive scheme for medical institutions to prescribe biosimilars to outpatients in April 2020. However, the impact of the incentive remains unevaluated. Hence, in this study, we conducted an interrupted time-series analysis to evaluate the impact of the incentive scheme on biosimilar prescription.Methods: We used the DeSC database in Japan. From this database, we included 3,348 patients who required self-injection and were prescribed insulin, human growth hormone, or etanercept. Interrupted time-series analyses were conducted by fitting Prais-Winsten linear regression models to assess the association of the financial incentive with the outcomes, namely, monthly proportions of biosimilar prescriptions between April 2019 and March 2021.Results: No significant changes were observed in the monthly proportion of biosimilar prescriptions immediately after the introduction of the incentive. The sustained effect, representing the effect of the intervention over time, was also not significant.Conclusions: Our study suggests that the financial incentive introduced in April 2020 in Japan was not associated with an increase in biosimilar prescriptions.","PeriodicalId":517436,"journal":{"name":"Annals of clinical epidemiology","volume":"8 2","pages":"54-61"},"PeriodicalIF":0.0,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Fight Retinal Blindness! registry: An international treatment outcomes registry for retinal diseases. 对抗视网膜失明！登记：视网膜疾病的国际治疗结果登记。

Annals of clinical epidemiology Pub Date : 2025-07-24 eCollection Date: 2026-01-01 DOI: 10.37737/ace.26004

Yohei Hashimoto, Daniel Barthelmes, Mark Gillies

引用次数: 0