Indonesian Journal of Biomedicine and Clinical Sciences最新文献

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Improvement in left ventricle geometry and function after kidney transplantation 肾移植后左心室几何形状和功能的改善

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-01-17 DOI: 10.22146/inajbcs.v56i01.11774

Baiq Gerisa Rahmi Faharani, Hasanah Mumpuni, Yulia Wardhani, Metalia Puspitasari, Raden Heru Prasanto, Iri Kuswadi, Anggoro Budi Hartopo

{"title":"Improvement in left ventricle geometry and function after kidney transplantation","authors":"Baiq Gerisa Rahmi Faharani, Hasanah Mumpuni, Yulia Wardhani, Metalia Puspitasari, Raden Heru Prasanto, Iri Kuswadi, Anggoro Budi Hartopo","doi":"10.22146/inajbcs.v56i01.11774","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i01.11774","url":null,"abstract":"Chronic kidney disease (CKD) is associated with remodeling of the left ventricle (LV), affecting both its geometry and function. Kidney transplantation in patients with stage 5 CKD may lead to improvements in LV remodeling and result in better cardiac function. The aim of the study was to determine changes and improvements in LV geometry and function after kidney transplantation in patients with stage 5 CKD. This was an observational study conducted by collecting secondary data from the Hospital's Kidney Transplantation Registry, Dr. Sardjito General Hospital spanning the years 2017 to 2020. The study employed a comparative design, contrasting the results before and after treatment (kidney transplantation). We compared transthoracic echocardiographic parameters for LV geometry and function before and after kidney transplantation. The evaluation timeframe after kidney transplantation was divided into <12 and ³12 mo. A total of 27 patients qualified for inclusion in this study. In the <12 mon (n=20) evaluation group, there was a reduction in proportion of LV hypertrophy from 70% to 45%. There was an increase in global LV systolic function (ejection fraction) from 60.1±10.95% to 67.85±6.48% (p=0.014), and a decrease in LV diastolic dysfunction from 45% to 15% (p=0.07). In the ³12 mon (n=11) evaluation group, there was a decrease in the proportion of LV hypertrophy from 81.8 to 54.5%, an increase in global LV systolic function (ejection fraction) from 57.73±13.07% to 69.36±6.12% (p=0.011), and a decreased LV diastolic dysfunction from 63.6% to 0% (p=0.016). In conclusion, significant changes in LV geometry and function are observed following kidney transplantation, indicating improvements in these parameters. There are improvements in LV systolic function started at <12 mo and in LV diastolic function at ³12 mo after kidney transplantation.","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"94 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of fat mass and obesity associate (FTO) single nucleotide polymorphisms in the first intron and obesity risk among Indonesians 印尼人脂肪量与肥胖相关性（FTO）第一内含子单核苷酸多态性与肥胖风险的关系

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-01-17 DOI: 10.22146/inajbcs.v56i01.11771

Benedikta Diah Saraswati, Luluk Yunaini, Dwi Anita Suryandari

{"title":"Association of fat mass and obesity associate (FTO) single nucleotide polymorphisms in the first intron and obesity risk among Indonesians","authors":"Benedikta Diah Saraswati, Luluk Yunaini, Dwi Anita Suryandari","doi":"10.22146/inajbcs.v56i01.11771","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i01.11771","url":null,"abstract":"Obesity is one of the global pandemics characterized by an excessive fat buildup due to disruption of energy homeostasis in the body. As obesity is a risk factor for many other non-communicable diseases such as diabetes and coronary heart disease, it is crucial to understand the risk factors that contribute to the pathogenesis of obesity. Although obesity is mainly caused due to unhealthy lifestyles, genetic predisposition also plays a part in the pathogenesis of obesity. Individuals who carry risk alleles for genes that control energy balance in the body have a greater risk of developing obesity. Fat mass and obesity associate (FTO) is a gene strongly correlated with obesity and is widely expressed in the hypothalamus. This gene is predicted to have 89 common variations that affect obesity-related phenotypes. Among Indonesians, the three most studied single nucleotide polymorphisms (SNPs) in the first intron of the FTO gene are rs1421085, rs17817449, and rs9939609. They are strongly associated with obesity’s related traits such as weight gain, fat mass, body mass index (BMI), waist, and hip sizes. rs993609 is the most studied among diverse ethnicities in Indonesia, with AA genotype and allele A as a risk allele.","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"153 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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