Indonesian Journal of Biomedicine and Clinical Sciences最新文献

The effect of infection on mortality in acute coronary syndrome patients at Dr. Sardjito General Hospital, Yogyakarta 日惹萨吉托博士综合医院急性冠状动脉综合征患者感染对死亡率的影响

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-06-05 DOI: 10.22146/inajbcs.v56i2.13445

Naila Vinidya Putri, D. Anggrahini, Hendry Purnasidha Bagaswoto

{"title":"The effect of infection on mortality in acute coronary syndrome patients at Dr. Sardjito General Hospital, Yogyakarta","authors":"Naila Vinidya Putri, D. Anggrahini, Hendry Purnasidha Bagaswoto","doi":"10.22146/inajbcs.v56i2.13445","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i2.13445","url":null,"abstract":"Ischemic heart disease is the second most significant health burden in Indonesia and the world. The prevalence of coronary heart disease patients in Yogyakarta is predicted to experience a continuous increase. In Sardjito Hospital, mortality rate of acute coronary syndrome (ACS) patients reaches 15%, with pneumonia infection identified as one of the predictors. Despite this high mortality rate, there is a lack of studies addressing the contribution of infectious comorbidities to mortality incidence among ACS patients. This study aimed to investigate the e ffect of infectious comorbidities on the incidence of mortality among ACS patients and its mortality rate in Sardjito Hospital. This study used a cross-sectional design in 794 patients diagnosed with ACS and registered in the SCIENCE registry from January to December 2022 at Sardjito Hospital. The analysis was conducted using the Chi-square method to determine the effect of infectious comorbidities on mortality among ACS patients and a logistic regression test to evaluate the correlation between variables. Based on bivariate analysis, it was found that infectious comorbidities increased mortality rate among ACS patients (p<0.001, OR=2.22[1.46-3.38]), reaching 5.2%. The bivariate analysis between confounding factors and outcome of patients showed that obesity, dyslipidemia, and revascularization significantly influenced the results of ACS patients. Based on multivariate analysis, it was discovered that infectious comorbidities, obesity, diabetes, dyslipidemia, and revascularization had a significant association with mortality of patients with ACS. Furthermore, infectious comorbidities increased the odds of mortality for ACS patients by 2.04 times. Infectious comorbidities increased the incidence of mortality in ACS patients by 2.04 times with mortality rate of 5.2%. \u0000 ","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"57 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141383298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic T lymphocyte associated antigen-4 (CTLA4) expression with renal cell carcinoma subtype and staging 细胞毒性 T 淋巴细胞相关抗原-4 (CTLA4) 的表达与肾细胞癌亚型和分期的关系

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-06-03 DOI: 10.22146/inajbcs.v56i2.13467

Muhammad Faham Sangundo, I. Soerohardjo, D. S. Heriyanto

{"title":"Cytotoxic T lymphocyte associated antigen-4 (CTLA4) expression with renal cell carcinoma subtype and staging","authors":"Muhammad Faham Sangundo, I. Soerohardjo, D. S. Heriyanto","doi":"10.22146/inajbcs.v56i2.13467","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i2.13467","url":null,"abstract":"In Indonesia, approximately 45% of renal cell carcinoma (RCC) patients are at an advanced stage that requires checkpoint inhibition combination immunotherapy. Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is associated with poor prognosis of RCC and it is the first checkpoint developed in cancer immunotherapy. This study aimed to investigate CTLA-4 expression among RCC subtypes and staging. Formalin fixed paraffin embedded (FFPE) tissue of RCC patients from 2018-2020 were obtained from the Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta. Expression of CTLA-4 among RCC subtypes and stage was measured using quantitative reverse-transcription polymerase chain reaction (qRT-PCR) and compared. Among the 40 patients involved in this study, the CTLA-4 expression was higher in papillary RCC/pRCC (95.88 + 31.58) compared to clear cell RCC/ccRCC (90.94 + 43.05). However, no significantly different in CTL-4 expression based on histologic subtypes and tumor stage (p>0.05). In conclusion, neither the histologic subtype nor the tumor stage of RCC can be predicted by CTLA-4 expression.","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"53 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141388518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The accuracy of fine needle aspiration biopsy (FNAB) in diagnosing musculoskeletal lesion 细针穿刺活检术（FNAB）诊断肌肉骨骼病变的准确性

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-03-19 DOI: 10.22146/inajbcs.v56i01.12462

A. S. Sumpono, J. Yunus, Yeshua Putra Krisnugraha, E. Dwianingsih

{"title":"The accuracy of fine needle aspiration biopsy (FNAB) in diagnosing musculoskeletal lesion","authors":"A. S. Sumpono, J. Yunus, Yeshua Putra Krisnugraha, E. Dwianingsih","doi":"10.22146/inajbcs.v56i01.12462","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i01.12462","url":null,"abstract":"Fine needle aspiration biopsy (FNAB) is a relatively non-invasive diagnosis of musculoskeletal lesions that is very challenging in some musculoskeletal cases. This study aimed to evaluate the diagnostic utility of FNAB in musculoskeletal lesions. This was a retrospective cross-sectional study involving 180 musculoskeletal patients who underwent FNAB procedure, with or without ultrasound-guided in the Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta between 2018 and 2021. The obtained data were then statistically analyzed for sensitivity, specificity, and accuracy. Of 180 cases, 90 (50%) were confirmed with histopathology examination. Further analysis revealed that 33 cases were confirmed positive, 45 patients were true negative, 2 cases were false positive, and 10 were cases false negative. The overall diagnostic sensitivity, specificity, and accuracy of FNAB in musculoskeletal lesions were 76.8, 95.7, and 83%, respectively. FNAB can lead to misinterpretation in cases that show similar morphologic features. Therefore, clinical information and imaging results are necessary to be correlated. In conclusion, FNAB is an efficient and effective technique for early diagnosis in musculoskeletal cases. FNAB can be used to establish the diagnosis of an inoperable tumor because of its high accuracy.","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"17 S2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of multivessel coronary artery disease on early and late clinical outcome in ST-Segment elevation myocardial infarction patients who underwent percutaneous coronary intervention: insight from Indonesia 多支血管冠状动脉疾病对接受经皮冠状动脉介入治疗的 ST 段抬高型心肌梗死患者早期和晚期临床预后的影响：印度尼西亚的启示

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-03-18 DOI: 10.22146/inajbcs.v56i01.12536

A. Damarkusuma, N. Taufiq, Hendry Purnasidha Bagaswoto, Firandi Saputra, Daniel Sukmadja, B. Setianto

{"title":"Impact of multivessel coronary artery disease on early and late clinical outcome in ST-Segment elevation myocardial infarction patients who underwent percutaneous coronary intervention: insight from Indonesia","authors":"A. Damarkusuma, N. Taufiq, Hendry Purnasidha Bagaswoto, Firandi Saputra, Daniel Sukmadja, B. Setianto","doi":"10.22146/inajbcs.v56i01.12536","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i01.12536","url":null,"abstract":"It is estimated that 15 people for every 1000 Indonesian residents suffer from cardiovascular disease (CVD) including ST-segment elevation myocardial infarction (STEMI). Percutaneous coronary intervention (PCI) is often performed in patients with STEMI. Several factors affect clinical outcome after PCI procedure including multivessel coronary artery disease. This study aimed to measure the impact of multivessel coronary artery disease on the early and late outcomes of STEMI patients undergoing PCI procedures. This was a prospective cohort study on STEMI patients undergoing PCI procedures from the period of August to December 2021. Two expected cohorts were performed i.e. patients who suffered from single-vessel disease (SVD) and patients who suffered from multivessel disease (MVD). Forty six patients with STEMI were enrolled in this study consisting of 24 (52.17%) patients with MVD and 22 (47.83%) patients with SVD. No significant difference in baseline characteristics between MVD and SVD groups was observed (p > 0.05). The MVD group (91.67%) used a more radial percutaneous approach compared with the SVD group (54.55%; p = 0.04). In addition, no significant difference between the SVD group and the MVD group in major adverse cardiovascular events (MACE) and echocardiographic outcome after 90-d follow up was observed (p > 0.05). In conclusion, MVD has similar impacts on early and late clinical outcomes compared with SVD in STEMI patients undergoing PCI procedures.","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"264 13‐16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140233544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The correlation between interleukin-4 (IL-4) and programmed cell death-ligand 2 (PD-L2) expression with clinicopathological characteristics on prostate cancer 白细胞介素-4（IL-4）和程序性细胞死亡配体 2（PD-L2）的表达与前列腺癌临床病理特征的相关性

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-03-08 DOI: 10.22146/inajbcs.v56i01.12438

Ragil Unggul Prakoso, R. Danarto, I. Soerohardjo, Yurisal Akhmad Dany, E. Dwianingsih

{"title":"The correlation between interleukin-4 (IL-4) and programmed cell death-ligand 2 (PD-L2) expression with clinicopathological characteristics on prostate cancer","authors":"Ragil Unggul Prakoso, R. Danarto, I. Soerohardjo, Yurisal Akhmad Dany, E. Dwianingsih","doi":"10.22146/inajbcs.v56i01.12438","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i01.12438","url":null,"abstract":"Prostate cancer (PCa) is the most frequent cancer diagnosed worldwide and the second most common malignancy in men. IL-4 is one of cytokines related to the inflammation process. An increase level of IL-4 in patients with PCa might be related to progression to castrate-resistance prostate cancer. Programmedcell death-ligand 2 (PD-L2) plays an important role in the anti-tumor immune system, however the exact mechanism is not fully understood. This study aimed to investigate the correlation between IL-4 and PD-L2 expression with the clinicopathological characteristic of PCa. The IL-4 and PD-L2 examinations wereperformed using quantitative real-time polymerase chain reaction (qRT-PCR) while clinicopathological characteristics were described by the Gleason score and International Society of Urological Pathology (ISUP) grade. Data collected were then analyzed using Pearson and Spearman test. In total, 20 patients withPCa tissue were collected between 2015 and 2020. The mean level of IL-4 and PDL2 were higher in metastatic PCa/M-PCa (105.64 and 665.42 ng/mL) compared to non-metastatic PCa/NM-PCa (41.62 and 215.06 ng/mL). A significant difference with medium correlation between IL-4 and PD-L2 with Gleason score and ISUPgrade was observed on all samples (p = 0.035 and 0.045; r = 0.454 and 0.473). However, no significant difference with weak correlation was observed on each group (p = 0.136 and 0.858; r = 0.065 and 0.506). Interestingly, there was a significant difference with very strong correlation observed between IL-4 andPD-L2, both on all samples (p = 0.001; r = 0.955) and on each group (p = 0.001 and 0.001; r = 0.917 and 0.955). In conclusion, there is a correlation between IL-4 and PD-L2 with the clinicopathological characteristics of PCa.","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"44 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of patients associated with antibiotic use among gastrointestinal surgery at the Academic Hospital, Universitas Gadjah Mada 加札马达大学学术医院胃肠道手术中与抗生素使用相关的患者特征

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-02-13 DOI: 10.22146/inajbcs.v56i01.12181

Pingki Arum Saskiya, Taufiqurohman, C. Wiedyaningsih

{"title":"Characteristics of patients associated with antibiotic use among gastrointestinal surgery at the Academic Hospital, Universitas Gadjah Mada","authors":"Pingki Arum Saskiya, Taufiqurohman, C. Wiedyaningsih","doi":"10.22146/inajbcs.v56i01.12181","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i01.12181","url":null,"abstract":"Digestive surgery is a treatment for diseases of the parts of the body involved in digestion, which has a fairly high risk of infection. The study aimed to obtain a description of the types and specific characteristics of patients and the rationality of antibiotic use among digestive surgery patients. This study was conducted using observational analysis. Data on antibiotic use was collected prospectively from medical records of digestive surgery inpatients at the Academic Hospital Universitas Gadjah Mada (UGM) from January to March 2023. The Gyssens method was used to evaluate qualitatively the use of antibiotics. A total of 76 patients met the inclusion and exclusion criteria. No significant difference between the number of male and female patients was identified. The results showed that 24 (31.58%) acute appendicitis patients are the primary diagnosis most often encountered in patients undergoing digestive surgery. The most frequently used prophylactic antibiotics for digestive surgery patients were ceftriaxone (53.85%) and cefazolin (41.03%). Meanwhile, the most frequently used therapeutic antibiotics were ceftriaxone (41.94%) and levofloxacin (29.03%). The Gyssens analysis shows that large irrational use of antibiotics is still observed.","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"622 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between CDK4 expression and overall survival of osteosarcoma patients CDK4 表达与骨肉瘤患者总生存期的关系

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-02-13 DOI: 10.22146/inajbcs.v56i01.11896

Faizah Dwi Tirtasari, Fikar Arsyad Hakim, Yudha Mathan Sakti, Sumadi Lukman Anwar, Rheza Gandi Bawono, Ery Kus Dwianingsih

{"title":"Association between CDK4 expression and overall survival of osteosarcoma patients","authors":"Faizah Dwi Tirtasari, Fikar Arsyad Hakim, Yudha Mathan Sakti, Sumadi Lukman Anwar, Rheza Gandi Bawono, Ery Kus Dwianingsih","doi":"10.22146/inajbcs.v56i01.11896","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i01.11896","url":null,"abstract":"Osteosarcoma is the most common primary bone tumor malignancy, accounting for 30 - 80% of all primary bone tumors. It is presented in a bimodal distribution manner with the age of onset divided into two groups, 10-20 and >60 y.o. Various factors have significance in the patient's prognosis, including the expression of cyclin-dependent kinase 4 (CDK4). This CDK4 has an essential role in the pathogenesis of osteosarcoma through inactivation of the Rb gene, which is associated with the patient's survival. This study was conducted to evaluate the correlation between CDK4 expression and the survival of osteosarcoma patients. It was a cross-sectional study involving 50 patients diagnosed with osteosarcoma based on clinical, radiological, and histopathological examination. Available formalin-fixed paraffin-embedded (FFPE) samples were retrieved for immunohistochemical (IHC) staining of CDK4. The survival data was collected from medical records. CDK4 expression and survival data were analyzed statistically using the Kaplan-Meier curve. Out of 50 subjects, CDK4 was found to be expressed in 38 samples (76%). The group with negative CDK4 showed a slightly longer overall survival (by 0.2 mo) than the positive CDK4 group. However, these results were not statistically significant (p = 0.821). In conclusion, the overexpression of CDK4 may not directly affect the survival rate in osteosarcoma. Other factors need to be considered to understand the complexity of the disease.","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"672 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effectiveness of topical vitamin D3 for dry skin in elderly 外用维生素 D3 对老年人皮肤干燥的疗效

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-01-27 DOI: 10.22146/inajbcs.v56i01.11961

He Yeon Asva Nafaisa, Fajar Waskito, Rony Martien, Retno Danarti

引用次数: 0

Correlation between type of surgery and incidence of postoperative venous thromboembolism (VTE) 手术类型与术后静脉血栓栓塞症（VTE）发生率之间的相关性

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-01-23 DOI: 10.22146/inajbcs.v56i01.11888

Supomo, Budi Mulyono, Usi Sukorini, Adika Zhulhi Arjana, Tandean Tommy Novenanto

{"title":"Correlation between type of surgery and incidence of postoperative venous thromboembolism (VTE)","authors":"Supomo, Budi Mulyono, Usi Sukorini, Adika Zhulhi Arjana, Tandean Tommy Novenanto","doi":"10.22146/inajbcs.v56i01.11888","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i01.11888","url":null,"abstract":"Venous thromboembolism (VTE) is a significant complication in patients after undergoing major surgery. The type of surgery is believed correlated with the incidence of VTE. This study aimed to evaluate the correlation between type of surgery and incidence of VTE among patients who underwent major surgery. It was a retrospective study conducted in Dr. Sardjito General Hospital, Yogyakarta using medical record data of patients who underwent major surgery and were diagnosed with VTE between 2016 and 2020. Patients were grouped by surgery type, and length of stay (LoS). All caused deaths were also analyzed. Among 29,120 patients who underwent major surgery, 76 (0.26%) experienced VTE with females patients accounting for 75%. The mean age of the patients was 55 yr. All VTE cases had the mean LoS of 25 d. The highest proportion of patients who experienced VTE were patients who underwent tumor removal (67.0%) followed by trauma patients (18.4%). A significant difference in the incidence of mortality between the surgical groups was reported (p = 0.02). Post-cardiology had the highest risk of mortality (OR=7.46; 95% CI: 0.322 - 172.61) while age had the lowest risk of mortality (OR=1.01; 95% CI: 0.953 - 1.071). In conclusion, surgery type is correlated with the incidence of VTE. Surgery due to cancer and trauma has a higher risk of VTE compared to the others.","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"148 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140497957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible total atrioventricular block in a very high-risk non-ST-elevation myocardial infarction (NSTEMI) during conservative treatment in a limited resource setting: a case report 在资源有限的情况下，一名极高风险的非 ST 段抬高型心肌梗死（NSTEMI）患者在保守治疗期间出现可逆性完全性房室传导阻滞：病例报告

Indonesian Journal of Biomedicine and Clinical Sciences Pub Date : 2024-01-23 DOI: 10.22146/inajbcs.v56i01.11889

Susanti Mareta Anggraeni, Ruth Grace Aurora

{"title":"Reversible total atrioventricular block in a very high-risk non-ST-elevation myocardial infarction (NSTEMI) during conservative treatment in a limited resource setting: a case report","authors":"Susanti Mareta Anggraeni, Ruth Grace Aurora","doi":"10.22146/inajbcs.v56i01.11889","DOIUrl":"https://doi.org/10.22146/inajbcs.v56i01.11889","url":null,"abstract":"Total atrioventricular (AV) block is the most common type of conduction disorder found in acute coronary syndrome (ACS), which requires timely recognition and treatment. This case report aimed to present conservative medical treatment for managing total AV block (TAVB) in a very high-risk non-ST-elevation myocardial infarction (NSTEMI) in a rural area. We reported a patient with TAVB in a very high-risk NSTEMI. The patient was hemodynamically unstable and needed immediate percutaneous coronary intervention (PCI). Due to limited facilities and difficult access to immediate PCI, the patient was treated conservatively with the NSTEMI protocol. Epinephrine, as a β-adrenergic agonist, was administered to improve hemodynamic status. During conservative treatment, TAVB was converted into the first-degree AV block on the third day of intensive care. In a setting where revascularization strategies and pacemaker implantation are not feasible, administration of antithrombotic agents and β-adrenergic agonists can be considered to manage TAVB with NSTEMI with close monitoring. \u0000 ","PeriodicalId":517341,"journal":{"name":"Indonesian Journal of Biomedicine and Clinical Sciences","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140499210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0