W. Meulebroeck, Hugo Thienpont, Herman Goossens, Pieter Moons, Heidi Ottevaere
{"title":"A rapid and quantitative absorption-based measurement to study the impact of antibiotics on bacterial growth","authors":"W. Meulebroeck, Hugo Thienpont, Herman Goossens, Pieter Moons, Heidi Ottevaere","doi":"10.1088/2515-7647/ad4c41","DOIUrl":"https://doi.org/10.1088/2515-7647/ad4c41","url":null,"abstract":"\u0000 Given the global rise in antimicrobial resistance levels, an urgent need exists to obtain the Minimal Inhibitory Concentration (MIC) of an antibiotic as early as possible. In this paper we present the first test results of a light-based concept where the interaction of a laser beam with the drug-bacterium sample is used for calculating MIC values within 6 hours after cultivation. For this preliminary study, a total of 163 drug-bacterium pairs were tested and benchmarked with broth microdilution (BMD). The pathogen set included Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus, Staphylococcus capitis, Staphylococcus cohnii, Staphylococcus epidermis, Staphylococcus haemolyticus, Enterococcus and Streptococcus pneumoniae. The selected drugs belonged to 10 different classes. The method under investigation showed a categorical concordance of 86.1% and an essential agreement of 80.3% with BMD. Due to its simplicity, the concept can be easily implemented on existing commercial platforms. This research shows a promise for further studies potentially leading to a novel concept that can be employed to rapidly determine MIC values.","PeriodicalId":517326,"journal":{"name":"Journal of Physics: Photonics","volume":"94 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140973320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dynamic control of spontaneous emission using magnetized InSb higher-order-mode antennas","authors":"Sina Aghili, Rasoul Alaee, Amirreza Ahmadnejad, Ehsan Mobini, Mohamadreza Mohamadpour, Carsten Rockstuhl, Ksenia Dolgaleva","doi":"10.1088/2515-7647/ad4c34","DOIUrl":"https://doi.org/10.1088/2515-7647/ad4c34","url":null,"abstract":"\u0000 We exploit InSb’s magnetic-induced optical properties to design THz sub-wavelength antennas that actively tune the radiative decay rates of dipole emitters at their proximity. The proposed designs include a spherical InSb antenna and a cylindrical Si-InSb hybrid antenna that demonstrate distinct behaviors. The former dramatically enhances both radiative and non-radiative decay rates in the epsilon-near-zero region due to the dominant contribution of the Zeeman splitting electric octupole mode. The latter realizes significant radiative decay rate enhancement via magnetic octupole mode, mitigating the quenching process and accelerating the photon production rate. A deep learning-based optimization of emitter positioning further enhances the quantum efficiency of the proposed hybrid system. These novel mechanisms are promising for tunable THz single-photon sources in integrated quantum networks.","PeriodicalId":517326,"journal":{"name":"Journal of Physics: Photonics","volume":"63 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140972308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Quintero Balbas, Luca Pezzati, Barbara Cattaneo, Valentina Righetti, J. Striová
{"title":"3D scanning of daguerreotypes","authors":"D. Quintero Balbas, Luca Pezzati, Barbara Cattaneo, Valentina Righetti, J. Striová","doi":"10.1088/2515-7647/ad41ab","DOIUrl":"https://doi.org/10.1088/2515-7647/ad41ab","url":null,"abstract":"\u0000 Daguerreotypes are historical photographic images made on mirror-like metallic plates. These are heritage objects whose shape cannot be measured with invasive techniques, like contact probes, but the high reflectivity of their surfaces makes the use of non-invasive, 3D-measuring optical techniques challenging. Moreover, the dark areas resulting from their degradation produce a very high contrast, which add extra difficulties to their measurement. In the last few years, several strategies have been developed to overcome the limitations of optical techniques when measuring reflective metallic surfaces. Many of these solutions are not applicable to the study of cultural heritage artifacts, as they are invasive. We attempted the use of conoscopic holography in a 3D-scanning system using a double-exposure strategy. This is a promising option for 3D measuring of daguerreotypes, as we experimentally demonstrated in this work. We present the results obtained from the analyses of two 19th-century daguerreotypes with different superficial conditions. The double-exposure allowed us to obtain high-quality data from the entire object surface. This enabled the measurement of micro-scale details related to the manufacturing process and/or to the corrosion deposits. The proposed methodology can be exploited to monitor the overall health of highly reflective metallic objects but also the outcomes of some conservation treatments, such as cleaning.","PeriodicalId":517326,"journal":{"name":"Journal of Physics: Photonics","volume":"53 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140675769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spatial-to-spectral phase coupling mechanisms in bulk continuum generation","authors":"Benjamin Maingot, Nicolas Forget, Aurelie Jullien","doi":"10.1088/2515-7647/ad41ac","DOIUrl":"https://doi.org/10.1088/2515-7647/ad41ac","url":null,"abstract":"\u0000 We study the coherence properties of continuum generation in YAG crystals seeded by 180-fs pulses at 1035nm when the driving beam exhibits small fluctuations of the spatial phase. The relative stability of the continuum spectral phase is first assessed as a function of the driver wavefront aberrations. Furthermore, we evidence and quantify a coupling mechanism between these fluctuations and the spectral phase of the continuum. The coupling coefficients increase with the spectral broadening and are also unexpectedly large (up to tens of rad/rad at ≃750nm). Experimental evidence supports that longitudinal shifts of the position of the filament within the crystal are responsible for such strong effects.","PeriodicalId":517326,"journal":{"name":"Journal of Physics: Photonics","volume":"43 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140676112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yue Zhou, David Grass, Warren S Warren, Martin C Fischer
{"title":"Non-destructive three-dimensional Imaging of artificially degraded CdS paints by pump-probe microscopy","authors":"Yue Zhou, David Grass, Warren S Warren, Martin C Fischer","doi":"10.1088/2515-7647/ad3e65","DOIUrl":"https://doi.org/10.1088/2515-7647/ad3e65","url":null,"abstract":"\u0000 Cadmium sulfide (CdS) pigments have degraded in several well-known artworks, but the influence of pigment properties and environmental conditions on the degradation process have yet to be fully understood. Traditional non-destructive analysis techniques primarily focus on macroscopic degradation, whereas microscopic information is typically obtained with invasive techniques that require sample removal. Here, we demonstrate the use of pump-probe microscopy to nondestructively visualize the three-dimensional structure and degradation progress of CdS pigments in oil paints. CdS pigments, reproduced following historical synthesis methods, were reproduced as oil paints and artificially aged by exposure to high relative humidity (RH) and light. The degradation of CdS to CdSO4·xH2O was confirmed by both FTIR (Fourier-transform infrared) and XPS (X-ray photoelectron spectroscopy) experiments. During the degradation process, optical pump-probe microscopy was applied to track the degradation progress in single grains, and volumetric imaging revealed early CdS degradation of small particles and on the surface of large particles. This indicates that the particle dimension influences the extent and evolution of degradation of historical CdS. In addition, the pump-probe signal decrease in degraded CdS is observable before visible changes to the eye, demonstrating that pump-probe microscopy is a promising tool to detect early-stage degradation in artworks.","PeriodicalId":517326,"journal":{"name":"Journal of Physics: Photonics","volume":"40 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140705363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justin Schumacher, Raymundo Rodriguez López, Kirill Larin, F. Manns, G. Scarcelli
{"title":"Functional effects of the spatial-varying lens mechanical properties in accommodation","authors":"Justin Schumacher, Raymundo Rodriguez López, Kirill Larin, F. Manns, G. Scarcelli","doi":"10.1088/2515-7647/ad3e55","DOIUrl":"https://doi.org/10.1088/2515-7647/ad3e55","url":null,"abstract":"\u0000 Lens biomechanical properties are critical for our eyes to accommodate. While it’s well understood that lens mechanical properties change with age, different experimental techniques have been used over the years, with varying results on how the lens modulus changes. In this study, we developed a spatial-varying elasticity model to characterize the overall elastic modulus of the lens and establish its effect on accommodation. First, to validate the model, ex vivo porcine lenses underwent compression testing using biopsy punches of different diameter to change the percentage of nucleus within samples. Importantly, we found that, indeed, changing nucleus/cortex spatial ratio produces dramatic (~7-fold) increase in overall sample modulus. Next, in vivo clinical measurements of the spatial-varying lens modulus were used to generate a simplified mechanical-optical model of accommodation. We defined a paraboloid lens with patient-derived modulus and geometry measurements, and a statics simulation and ray tracing analysis was performed through the deformed and undeformed lens. The resulting accommodation estimates agree with general accommodation expectations.","PeriodicalId":517326,"journal":{"name":"Journal of Physics: Photonics","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140711080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plasmonic tuning of nano-antennas for super-gain light amplification","authors":"Ö. E. Aşırım, Mustafa Kuzuoglu","doi":"10.1088/2515-7647/ad3d1c","DOIUrl":"https://doi.org/10.1088/2515-7647/ad3d1c","url":null,"abstract":"\u0000 Nanoscale conductive materials are often used for inducing localized free electron oscillations known as plasmons. This is due to their high electronic excitability under optical irradiation owing to their super-small volume. Recently, plasmons have been of interest for enhancing the gain-bandwidth product of optical amplifiers. There are currently two well-established mechanisms for light amplification. The first one is via stimulated emission of radiation (lasers) using a given energy source and often an optical feedback mechanism. The second one is based on the nonlinear coupling of a low-intensity input wave and a high-intensity pump wave for energy exchange (parametric amplifiers). Both techniques have shortcomings. Lasers have a small operation bandwidth and offer a limited gain, but require moderate energy pumping to operate. Whereas optical parametric amplifiers (OPAs) offer a high operation bandwidth along with a much higher optical gain, with the drawback of requiring intense pumping to be functional. The aim of this paper is to introduce a technique that combines the advantages and eliminates the drawbacks of both techniques in the nanoscale to allow for a better amplification performance in integrated optical devices. This is achieved by inducing a plasmonic chirp in conductive nanomaterials a.k.a nano-antennas, which enables the confinement of an enormous electric energy density that can be coupled to an input beam for amplification. Using the Finite Difference Time Domain (FDTD) numerical-method with the material parameters of well-known semiconductors, intramaterial condensation of electric energy density is observed in semiconductor nano-antennas for certain plasmonic chirp-frequencies which enables broadband high-gain optical amplification based on free-electron oscillations that is promising for small-scale optical devices requiring a high gain-bandwidth product. The results are in good agreement with semiempirical data.","PeriodicalId":517326,"journal":{"name":"Journal of Physics: Photonics","volume":"504 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140719403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew T Meek, Franziska Busse, Nils M. Kronenberg, Vinh San Dinh, Kim Berghaus, Jonathan Booth, G. Scarcelli, M. Gather
{"title":"A multi-modal microscope for integrated mapping of cellular forces and Brillouin scattering with high resolution","authors":"Andrew T Meek, Franziska Busse, Nils M. Kronenberg, Vinh San Dinh, Kim Berghaus, Jonathan Booth, G. Scarcelli, M. Gather","doi":"10.1088/2515-7647/ad3d1a","DOIUrl":"https://doi.org/10.1088/2515-7647/ad3d1a","url":null,"abstract":"\u0000 Mechanical forces and stiffness play key roles in the health and development of cells and tissue, but despite the physical connection between these quantities, they cannot be monitored in parallel in most cases. Here, we introduce a fully integrated microscope that combines a method for high-resolution cell force imaging (elastic resonator interference stress microscopy, ERISM) with non-contact mapping of the elastic properties of cells (via Brillouin microscopy). In order to integrate both techniques, we had to account for the strong back reflection on the surface of the microcavity used for ERISM measurements as well as the local destruction of the cavity under illumination for Brillouin microscopy measurements. Therefore, we developed an elastic optical microcavity with minimal absorption that can perform ERISM measurements without sustaining laser damage during Brillouin microscopy. Furthermore, an unequal-arm Michelson interferometer was designed to suppress the back reflection of the laser on the ERISM microcavity surface using division by amplitude interference to reduce the reflected light and enhance the Brillouin signal. We show the utility of our integrated microscope by simultaneously mapping cellular forces and Brillouin shifts in cultures of fibroblast cells.","PeriodicalId":517326,"journal":{"name":"Journal of Physics: Photonics","volume":"186 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140719752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenfang Li, Dylan Brown, A. Vylegzhanin, Zohreh Shahrabifarahani, Aswathy B. Raj, Jinjin Du, S. Nic Chormaic
{"title":"Atom-light interactions using optical nanofibres - A perspective","authors":"Wenfang Li, Dylan Brown, A. Vylegzhanin, Zohreh Shahrabifarahani, Aswathy B. Raj, Jinjin Du, S. Nic Chormaic","doi":"10.1088/2515-7647/ad3d19","DOIUrl":"https://doi.org/10.1088/2515-7647/ad3d19","url":null,"abstract":"\u0000 Complete control of light-matter interactions at a single quantum level is critical for quantum science applications such as precision measurement and information processing. Nanophotonic devices, developed with recent advancements in nanofabrication techniques, can be used to tailor the interactions between single photons and atoms. One example of such a nanophotonic device is the optical nanofibre, which provides an excellent platform due to the strongly confined transverse light fields, long interaction length, low loss, and diverse optical modes. This facilitates a strong interaction between atoms and guided light, revealing chiral atom-light processes and the prospect of waveguide quantum electrodynamics. This paper highlights recent advances, experimental techniques, and future perspectives of the optical nanofibre-atom hybrid quantum platform.","PeriodicalId":517326,"journal":{"name":"Journal of Physics: Photonics","volume":"259 2‐3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140719849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Kitahama, Mariko Egawa, Prabhat K. Dwivedi, William Yang, Keisuke Goda
{"title":"An emerging tool in healthcare: Wearable surface-enhanced raman spectroscopy","authors":"Y. Kitahama, Mariko Egawa, Prabhat K. Dwivedi, William Yang, Keisuke Goda","doi":"10.1088/2515-7647/ad38f6","DOIUrl":"https://doi.org/10.1088/2515-7647/ad38f6","url":null,"abstract":"\u0000 This perspective explores the progressive domain of wearable surface-enhanced Raman spectroscopy (SERS), underscoring its potential to revolutionize healthcare. As an advanced variation of traditional Raman spectroscopy, SERS offers heightened sensitivity in detecting molecular vibrations. Applied in wearable technology, it provides a mechanism for continuous, non-invasive, real-time monitoring of chemical and biomolecular processes in the human body through biofluids such as sweat and tears. This underscores its immense potential in enabling early disease detection and facilitating personalized medicine. However, the adoption of wearable SERS is not without challenges, which include device miniaturization, reliable biofluid sampling, user comfort, biocompatibility, and data interpretation. Nevertheless, this perspective emphasizes that the fast-paced advancements in nanotechnology and data sciences render these challenges surmountable. In summary, the perspective presents wearable SERS as a promising innovation in healthcare's future landscape. It has the potential to enhance individual health outcomes significantly and lower healthcare costs by promoting a preventive health management approach.","PeriodicalId":517326,"journal":{"name":"Journal of Physics: Photonics","volume":"114 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140370729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}