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Exposure to Ambient Particulate Matter during Pregnancy: Implications for Infant Telomere Length 孕期暴露于环境颗粒物质：对婴儿端粒长度的影响

Air Pub Date : 2024-02-03 DOI: 10.3390/air2010002

Nina E. Ahlers, Jue Lin, Sandra J. Weiss

{"title":"Exposure to Ambient Particulate Matter during Pregnancy: Implications for Infant Telomere Length","authors":"Nina E. Ahlers, Jue Lin, Sandra J. Weiss","doi":"10.3390/air2010002","DOIUrl":"https://doi.org/10.3390/air2010002","url":null,"abstract":"Background: Growing evidence suggests that air pollution may influence fetal development, with potential consequences for later health. Alteration of telomere length (TL) is one possible mediating mechanism for the link between fetal exposure to air pollution and the development of disease. However, the few studies exploring associations between prenatal pollution and infant TL have assessed varied trimesters of pregnancy and shown mixed results. The aim of this study was to examine the differential relationships between prenatal exposure to air pollutant PM2.5 during the first, second, and third trimesters of pregnancy with infant TL at one month of age. Methods: Women (n = 74) were recruited in obstetric clinics during their third trimester. Data on PM2.5 exposure for each woman’s residential area during each trimester was acquired from the regional Air Quality Management District. At one month postnatal, a salivary sample was collected from the infant, which provided DNA for the telomere assay. Women completed questionnaires about stressors in their lives, perceived stress, depression, and sociodemographics for inclusion as covariates. Multiple linear regression was used to analyze the results. Results: PM2.5 exposure during the second (β = 0.31, p = 0.003) and third (β = 0.24, p = 0.02) trimesters was associated with longer infant TL. Exposure in the first trimester was not related to TL. Covariates of maternal depression and age and infant female sex were also associated with longer TL. Variables in the model contributed to 34% of the variance in TL (F = 10.58, p = 0.000). Discussion: Fetal programming of longer telomeres in response to pollution may have adaptive value in preparing the neonate for a postnatal environment that is less than optimal in terms of air quality. Alternatively, longer telomeres may forecast later health risks, considering established links between longer TL and diseases such as cancer. Future research needs to address how prenatal pollution interacts with TL to influence health over time.","PeriodicalId":517268,"journal":{"name":"Air","volume":"48 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139896332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to Ambient Particulate Matter during Pregnancy: Implications for Infant Telomere Length 孕期暴露于环境颗粒物质：对婴儿端粒长度的影响

Air Pub Date : 2024-02-03 DOI: 10.3390/air2010002

Nina E. Ahlers, Jue Lin, Sandra J. Weiss

{"title":"Exposure to Ambient Particulate Matter during Pregnancy: Implications for Infant Telomere Length","authors":"Nina E. Ahlers, Jue Lin, Sandra J. Weiss","doi":"10.3390/air2010002","DOIUrl":"https://doi.org/10.3390/air2010002","url":null,"abstract":"Background: Growing evidence suggests that air pollution may influence fetal development, with potential consequences for later health. Alteration of telomere length (TL) is one possible mediating mechanism for the link between fetal exposure to air pollution and the development of disease. However, the few studies exploring associations between prenatal pollution and infant TL have assessed varied trimesters of pregnancy and shown mixed results. The aim of this study was to examine the differential relationships between prenatal exposure to air pollutant PM2.5 during the first, second, and third trimesters of pregnancy with infant TL at one month of age. Methods: Women (n = 74) were recruited in obstetric clinics during their third trimester. Data on PM2.5 exposure for each woman’s residential area during each trimester was acquired from the regional Air Quality Management District. At one month postnatal, a salivary sample was collected from the infant, which provided DNA for the telomere assay. Women completed questionnaires about stressors in their lives, perceived stress, depression, and sociodemographics for inclusion as covariates. Multiple linear regression was used to analyze the results. Results: PM2.5 exposure during the second (β = 0.31, p = 0.003) and third (β = 0.24, p = 0.02) trimesters was associated with longer infant TL. Exposure in the first trimester was not related to TL. Covariates of maternal depression and age and infant female sex were also associated with longer TL. Variables in the model contributed to 34% of the variance in TL (F = 10.58, p = 0.000). Discussion: Fetal programming of longer telomeres in response to pollution may have adaptive value in preparing the neonate for a postnatal environment that is less than optimal in terms of air quality. Alternatively, longer telomeres may forecast later health risks, considering established links between longer TL and diseases such as cancer. Future research needs to address how prenatal pollution interacts with TL to influence health over time.","PeriodicalId":517268,"journal":{"name":"Air","volume":"15 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139893289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study on the Impact of Air Pollution on Health Status of Traffic Police Personnel in Kolkata, India 关于空气污染对印度加尔各答交通警察健康状况影响的研究

Air Pub Date : 2024-01-23 DOI: 10.3390/air2010001

Sayanti Kar, Santanu Chowdhury, Tanya Gupta, Dipsita Hati, Arindam De, Ziniya Ghatak, Tahsin Tinab, Iffa Tasnim Rahman, Shreyashi Chatterjee, Abhishek RoyChowdhury

{"title":"A Study on the Impact of Air Pollution on Health Status of Traffic Police Personnel in Kolkata, India","authors":"Sayanti Kar, Santanu Chowdhury, Tanya Gupta, Dipsita Hati, Arindam De, Ziniya Ghatak, Tahsin Tinab, Iffa Tasnim Rahman, Shreyashi Chatterjee, Abhishek RoyChowdhury","doi":"10.3390/air2010001","DOIUrl":"https://doi.org/10.3390/air2010001","url":null,"abstract":"The global concern of escalating ambient air pollution and its profound impact on human health is paramount. While traffic police personnel are critical for maintaining the road safety and transportation system of any city in India, they are susceptible to occupational health risks due to ambient air pollution. This study investigated health challenges faced by traffic police personnel due to prolonged exposure to air pollutants prevalent in traffic-congested areas, including particulate matter (PM2.5 and PM10), nitrogen dioxide, and sulfur dioxide. The first phase of this study collected and analyzed secondary air quality data over five years (2019–2023) across six locations in Kolkata, India. The second phase employed a questionnaire-based survey to assess the health implications of air pollution exposure. The survey questionnaire captured information on physical health symptoms, stress-related indicators, lifestyle habits, and work hours of around 100 police personnel from Kolkata with indoor (control group) and outdoor (exposed group) work responsibilities. The results of this study established a strong positive correlation between air pollution and a range of health issues experienced by the exposed group. The outcome of this study is significant for urban planning, policy formulation, and public health interventions geared toward minimizing the adverse impacts of air pollution on traffic police personnel.","PeriodicalId":517268,"journal":{"name":"Air","volume":"143 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140497985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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